LOCUS AF053755 4417 bp mRNA linear HUM 01-JAN-2000
DEFINITION Homo sapiens bicarbonate transporter (BT) mRNA, complete cds.
ACCESSION AF053755
VERSION AF053755.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4417)
AUTHORS Romero,M.F.
TITLE Cloning of a HCO3 transporter, NT2-NBC, from human brain, similar
to both the Anion exchangers (AEs) and the Na/Bicarbonate
Cotransporters (NBCs)
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 4417)
AUTHORS Romero,M.F.
TITLE Direct Submission
JOURNAL Submitted (15-MAR-1998) Physiology & Biophysics, Case Western
Reserve University, School of Medicine, 2119 Abington Rd,
Cleveland, OH 44106-4790, USA
FEATURES Location/Qualifiers
source 1..4417
/db_xref="H-InvDB:HIT000064540"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE 649838 and 664517"
/cell_line="NT2 neuronal precursor"
/cell_type="neuroepithelial"
gene 1..4417
/gene="BT"
/note="similar to Mus musculus sequence presented in
GenBank Accession Number AA166155"
CDS 20..3022
/gene="BT"
/codon_start=1
/product="bicarbonate transporter"
/protein_id="AAF21720.1"
/translation="MAVTQFIHFREEIMGNMFFIIIFSTKDKLCYRDGEEYEWKETAR
WLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLD
NMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERN
GILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVL
VGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIAT
LMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRK
IPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSL
QCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTI
LGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIXLWTSFLCIVLVATDASSLVCYITRF
TEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLA
QWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFL
SSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHP
ERGWIISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLD
LLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTG
LMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPD
LIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTK
RELSWLDDLMPESKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALK
YSPDKPVSVKISFEDEPRKKYVDAETSL"
BASE COUNT 1298 a 747 c 884 g 1487 t
ORIGIN
1 actagaaaga aactgctaga tggctgtaac acagttcatc catttccgtg aagagatcat
61 ggggaatatg ttcttcatca tcatcttcag taccaaggat aaactgtgtt acagagatgg
121 agaagaatat gaatggaaag aaactgctag atggctgaaa tttgaagagg atgttgaaga
181 tggcggtgac cgatggagta aaccttatgt ggcaactctc tctttgcaca gtctttttga
241 actaaggagt tgcatcctca atggaacagt catgctggat atgagagcaa gcactctaga
301 tgaaatagca gatatggtat tagacaacat gatagcttct ggccaattag acgagtccat
361 acgagagaat gtcagagaag ctcttctgaa gagacatcat catcagaatg agaaaagatt
421 caccagtcgg attcctcttg ttcgatcttt tgcagatata ggcaagaaac attctgaccc
481 tcacttgctt gaaaggaatg gtattttggc ctctccccag tctgctcctg gaaacttgga
541 caatagtaaa agtggagaaa ttaaaggtaa tggaagtggt ggaagcagag aaaatagtac
601 tgttgacttc agcaaggttg atatgaattt catgagaaaa attcctacgg gtgctgaggc
661 atccaacgtc ctggtgggcg aagtagactt tttggaaagg ccaataattg catttgtgag
721 actggctcct gctgtcctcc ttacagggtt gactgaggtc cctgttccaa ccaggttttt
781 gtttttgtta ttgggtccag cgggcaaggc accacagtac catgaaattg gacgatcaat
841 agccactctc atgacagatg agattttcca tgatgtagct tataaagcaa aagacagaaa
901 tgacctctta tctggaattg atgaattttt agatcaagta actgtcctac ctccaggaga
961 gtgggatcct tctatacgca tagaaccacc aaaaagtgtc ccttctcagg aaaagagaaa
1021 gattcctgtg tttcacaatg gatctacccc cacactgggt gagactccta aagaggccgc
1081 tcatcatgct gggcctgagc tacagaggac tggacggctt tttggtggtt tgatacttga
1141 catcaaaagg aaagcacctt ttttcttgag tgacttcaag gatgcattaa gcctgcagtg
1201 cctggcctcg attcttttcc tatactgtgc ctgtatgtct cctgtaatca cttttggagg
1261 gctgcttgga gaagctacag aaggcagaat aagtgcaata gagtctcttt ttggagcatc
1321 attaactggg attgcctatt cattgtttgc tgggcaacct ctaacaatat tggggagcac
1381 aggtccagtt ctagtgtttg aaaaaatttt atataaattc tgcagagatt atcaactttc
1441 ttatctgtct ttaagaacca gtattrgtct gtggacttct tttttgtgca ttgttttggt
1501 tgcaacagat gcaagcagcc ttgtgtgtta tattactcga tttacagaag aggcttttgc
1561 agcccttatt tgcatcatat tcatctacga ggctttggag aagctctttg atttaggaga
1621 aacatatgca tttaatatgc acaacaactt agataaactg accagctact catgtgtatg
1681 tactgaacct ccaaacccca gcaatgaaac tctagcacaa tggaagaaag ataatataac
1741 agcacacaat atttcctgga gaaatcttac tgtttctgaa tgtaaaaaac ttcgtggtgt
1801 attcttgggg tcagcttgtg gtcatcatgg accttatatt ccagatgtgc tcttttggtg
1861 tgtcatcttg tttttcacaa cattttttct gtcttcattc ctcaagcaat ttaagaccaa
1921 gcgttacttt cctaccaagg tgcgatcgac aatcagtgat tttgctgtat ttctcacaat
1981 agtaataatg gttacaattg actaccttgt aggagttcca tctcctaaac ttcatgttcc
2041 tgaaaaattt gagcctactc atccagagag agggtggatc ataagcccac tgggagataa
2101 tccttggtgg accttattaa tagctgctat tcctgctttg ctttgtacca ttctcatctt
2161 tatggatcaa caaatcacag ctgtaattat aaacagaaag gaacacaaat tgaagaaagg
2221 agctggctat caccttgatt tgctcatggt tggcgttatg ttgggagttt gctctgtcat
2281 gggacttcca tggtttgtgg ctgcaacagt gttgtcaata agtcatgtca acagcttaaa
2341 agttgaatct gaatgttctg ctccagggga acaacccaag tttttgggaa ttcgtgaaca
2401 gcgggttaca gggctaatga tttttattct aatgggcctc tctgtgttca tgacttcagt
2461 cctaaagttt attccaatgc ctgttctgta tggtgttttc ctttatatgg gagtttcctc
2521 attaaaagga atccagttat ttgaccgtat aaaattattt ggaatgcctg ctaagcatca
2581 gcctgatttg atatacctcc gttatgtgcc gctctggaag gtccatattt tcacagtcat
2641 tcagcttact tgtttggtcc ttttatgggt gataaaagtt tcagctgctg cagtggtttt
2701 tcccatgatg gttcttgcat tagtgtttgt gcgcaaactc atggacctgt gtttcacgaa
2761 gagagaactt agttggcttg atgatcttat gccagaaagt aagaaaaaga aagaagatga
2821 caaaaagaaa aaagagaaag aggaagctga acggatgctt caagacgatg atgatactgt
2881 gcaccttcca tttgaagggg gaagtctctt gcaaattcca gtcaaggccc taaaatatag
2941 tcctgataaa cctgtgagtg tgaaaataag ttttgaagat gaaccaagaa agaaatacgt
3001 ggatgctgaa acttcattat agaattgaac caagaggcat tatacatata gatatataca
3061 tatgtaatgt gtgcgtatca tgtcactata tataagaata ttgtatgtca tgctgtttat
3121 gtgtgactac cgggttttta aaagtagtgt ctggagtttg taatgagcac cgtggagact
3181 atgtatttaa tgaaatgctc tctttgaagt gaggtacatg gttcttaact attcaaatat
3241 ttattctgtt agaaaaaaaa attttctgtt ttgcaataga aggatgtgga gaaatgcttt
3301 cagtctactt ttcttaaatc tctgttcatc agtggcaatt cgtaaaaacc ttaagtgata
3361 ctttgtttat atgtttataa tttttaggtg tttcctgaaa ttttcacata ttatttcact
3421 tttgttagtg ctttatggga agaataggga gtctatacca gtgctgtggg aaaaatggta
3481 acatttcagg gcttctctat ttgtgtttca tttctgtaga tgtccatcgt gtttcactaa
3541 ctggcgtttt cttagccata gagatgactg tagaacaata gaaactttaa taatgatagt
3601 ttttaacttt tatgtttaaa ttttttttaa atcttaaaac cttcatatct aggtatccat
3661 tgtgacagac aagtaaaatt gcaggtgatt tgataattaa gcacccatac catttataac
3721 ttctgaattt aaaaagttat acaatgccag tttgcaatag ttgattttga tgcctttgta
3781 gaatattttt tctgaatcct tatgctcttt taaagccaat gattcccact ctgttctctg
3841 ccttgtctct ctttgtctta aaatgcttta gtttccatca ggttcaagtt cttgactatt
3901 attctcttat aagtagtagg cgtaaataat caggagttag aattctctca gaagggtcta
3961 tgatcagtat tactttatta agaattacct ttcattttct ctttatgtta ttctttcact
4021 tttgtagatt acatttaata gcttgttacc tgtgatttta ttttaaaata tttattttga
4081 tatgatgctt aaatattata taaacatttg gaaaagtaac aaatagagta aattgttaat
4141 gtaaatagtt ggtgcttact ttcatttatg tttattatct taaagcaatt gatagatttt
4201 acatctttga tataaagcac tgccatattt atattttaaa aggaaattag acattttata
4261 tgtagctcag attaatgaca tttttatttt gtgtattagt ttttgctttt ctgagctttt
4321 taaagtctaa caaatctttt tagtcatctt ttatatactt ttagttccac atgaaataaa
4381 tgttgttaag cctgtaaaaa aaaaaaaaaa aaaaaaa
//