LOCUS AF053754 3240 bp mRNA linear HUM 01-JAN-2000 DEFINITION Homo sapiens electrogenic Na+ bicarbonate cotransporter form 2 (NBC) mRNA, complete cds. ACCESSION AF053754 VERSION AF053754.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3240) AUTHORS Romero,M.F. TITLE Cloning of a second electrogenic Na/HCO3 cotransporter, hKid-NBC or hK-NBC-2, from human kidney JOURNAL Unpublished REFERENCE 2 (bases 1 to 3240) AUTHORS Romero,M.F. TITLE Direct Submission JOURNAL Submitted (15-MAR-1998) Physiology & Biophysics, Case Western Reserve University, School of Medicine, 2119 Abington Rd, Cleveland, OH 44106-4790, USA FEATURES Location/Qualifiers source 1..3240 /db_xref="H-InvDB:HIT000064539" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="4" /map="4q11-q14" /tissue_type="kidney" /note="obtained using MEDE_f and ERHTSC_r primers" gene 1..3240 /gene="NBC" CDS 1..3240 /gene="NBC" /function="mediates the transport of one Na+ with multiple HCO3- ions" /note="hKid-NBC; activity blocked by stilbene compounds,DIDS and SITS; activity not effected by absence of Cl-" /codon_start=1 /product="electrogenic Na+ bicarbonate cotransporter form 2" /protein_id="AAF21719.1" /translation="MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRR HKRKTGHKEKKEKERISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEEDDS PAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFE LRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKK SNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMK KLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKA KSYHEIGRAIATLMSDEVFHDIAYKAKDRRDLIAGIDEFLDEVIVLPPGEWDPAIRIE PPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDI KRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGT AVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCL ILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTL FSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGNLV GNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFC VIDALVGVGTPKLIVPSEFKPTSPNRGWFVPPFGENPWWVCLAAAIPALLVTILIFMD QQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLK METETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMRV ASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVA AIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVISEKDKKKKEDEKKKKKKKGSLDSD NDDSDCPYSEKVPSIKIPMDIMEQQPFLSDSKPSDRERPPTFLERHTSC" BASE COUNT 870 a 733 c 760 g 877 t ORIGIN 1 atggaggatg aagctgtcct ggacagaggg gcttccttcc tcaagcatgt gtgtgatgaa 61 gaagaagtag aaggccacca taccatttac atcggagtcc atgtgccgaa gagttacagg 121 agaaggagac gtcacaagag aaagacaggg cacaaagaaa agaaggaaaa ggagagaatc 181 tctgagaact actctgacaa atcagatatt gaaaatgctg atgaatccag cagcagcatc 241 ctaaaacctc tcatctctcc tgctgcagaa cgcatccgat tcatcttggg agaggaggat 301 gacagcccag ctccccctca gctcttcacg gaactggatg agctgctggc cgtggatggg 361 caggagatgg agtggaagga aacagccagg tggatcaagt ttgaagaaaa agtggaacag 421 ggtggggaaa gatggagcaa gccccatgtg gccacattgt cccttcatag tttatttgag 481 ctgaggacat gtatggagaa aggatccatc atgcttgatc gggaggcttc ttctctccca 541 cagttggtgg agatgattgt tgaccatcag attgagacag gcctattgaa acctgaactt 601 aaggataagg tgacctatac tttgctccgg aagcaccggc atcaaaccaa gaaatccaac 661 cttcggtccc tggctgacat tgggaagaca gtctccagtg caagtaggat gtttaccaac 721 cctgataatg gtagcccagc catgacccat aggaatctga cttcctccag tctgaatgac 781 atttctgata aaccggagaa ggaccagctg aagaataagt tcatgaaaaa attgccacgt 841 gatgcagaag cttccaacgt gcttgttggg gaggttgact ttttggatac tcctttcatt 901 gcctttgtta ggctacagca ggctgtcatg ctgggtgccc tgactgaagt tcctgtgccc 961 acaaggttct tgttcattct cttaggtcct aaggggaaag ccaagtccta ccacgagatt 1021 ggcagagcca ttgccaccct gatgtctgat gaggtgttcc atgacattgc ttataaagca 1081 aaagacaggc gcgacctgat tgctggtatt gatgagttcc tagatgaagt catcgtcctt 1141 ccacctgggg aatgggatcc agcaattagg atagagcctc ctaagagtct tccatcctct 1201 gacaaaagaa agaatatgta ctcaggtgga gagaatgttc agatgaatgg ggatacgccc 1261 catgatggag gtcacggagg aggaggacat ggggattgtg aagaattgca gcgaactgga 1321 cggttctgtg gtggactaat taaagacata aagaggaaag cgccattttt tgccagtgat 1381 ttttatgatg ctttaaatat tcaagctctt tcggcaattc tcttcattta tctggcaact 1441 gtaactaatg ctatcacttt tggaggactg cttggggatg ccactgacaa catgcagggc 1501 gtgttggaga gtttcctggg cactgctgtc tctggagcca tcttttgcct ttttgctggt 1561 caaccactca ctattctgag cagcaccgga cctgtcctag tttttgagag gcttctattt 1621 aatttcagca aggacaataa ttttgactat ttggagtttc gcctttggat tggcctgtgg 1681 tccgccttcc tatgtctcat tttggtagcc actgatgcca gcttcttggt tcaatacttc 1741 acacgtttca cggaggaggg cttttcctct ctgattagct tcatctttat ctatgatgct 1801 ttcaagaaga tgatcaagct tgcagattac taccccatca actccaactt caaagtgggc 1861 tacaacactc tcttttcctg tacctgtgtg ccacctgacc cagctaatat ctcaatatct 1921 aatgacacca cactggcccc agagtatttg ccaactatgt cttctactga catgtaccat 1981 aatactacct ttgactgggc atttttgtcg aagaaggagt gttcaaaata cggaggaaac 2041 ctcgtcggga acaactgtaa ttttgttcct gatatcacac tcatgtcttt tatcctcttc 2101 ttgggaacct acacctcttc catggctctg aaaaaattca aaactagtcc ttattttcca 2161 accacagcaa gaaaactgat cagtgatttt gccattatct tgtccattct catcttttgt 2221 gtaatagatg ccctagtagg cgtgggcacc ccaaaactaa ttgtgccaag tgagttcaag 2281 ccaacaagtc caaaccgagg ttggttcgtt ccaccgtttg gagaaaaccc ctggtgggtg 2341 tgccttgctg ctgctatccc ggctttgttg gtcactatac tgattttcat ggaccaacaa 2401 attacagctg tgattgtaaa caggaaagaa cataaactca agaaaggagc agggtatcac 2461 ttggatctct tttgggtggc catcctcatg gttatatgct ccctcatggc tcttccgtgg 2521 tatgtagctg ctacggtcat ctccattgct cacatcgaca gtttgaagat ggagacagag 2581 acttctgcac ctggagaaca accaaagttt ctaggagtga gggaacaaag agtcactgga 2641 acccttgtgt ttattctgac tggtctgtca gtctttatgg ctcccatctt gaagtttata 2701 cccatgcctg tactctatgg tgtgttcctg tatatgagag tagcatccct taatggtgtg 2761 cagttcatgg atcgtctgaa gctgcttctg atgcctctga agcatcagcc tgacttcatc 2821 tacctgcgtc atgttcctct gcgcagagtc cacctgttca ctttcctgca ggtgttgtgt 2881 ctggccctgc tttggatcct caagtcaacg gtggctgcta tcatttttcc agtaatgatc 2941 ttggcacttg tagctgtcag aaaaggcatg gactacctct tctcccagca tgacctcagc 3001 ttcctggatg atgtcatttc agaaaaggac aagaaaaaga aggaggatga gaagaaaaag 3061 aaaaagaaga agggaagtct ggacagtgac aatgatgatt ctgactgccc atactcagaa 3121 aaagttccaa gtattaaaat tccaatggac atcatggaac agcaaccttt cctaagcgat 3181 agcaaacctt ctgacagaga aagaccacca acattccttg aacgccacac atcatgctaa //