LOCUS       AF053754                3240 bp    mRNA    linear   HUM 01-JAN-2000
DEFINITION  Homo sapiens electrogenic Na+ bicarbonate cotransporter form 2
            (NBC) mRNA, complete cds.
ACCESSION   AF053754
VERSION     AF053754.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3240)
  AUTHORS   Romero,M.F.
  TITLE     Cloning of a second electrogenic Na/HCO3 cotransporter, hKid-NBC or
            hK-NBC-2, from human kidney
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3240)
  AUTHORS   Romero,M.F.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-MAR-1998) Physiology & Biophysics, Case Western
            Reserve University, School of Medicine, 2119 Abington Rd,
            Cleveland, OH 44106-4790, USA
FEATURES             Location/Qualifiers
     source          1..3240
                     /db_xref="H-InvDB:HIT000064539"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q11-q14"
                     /tissue_type="kidney"
                     /note="obtained using MEDE_f and ERHTSC_r primers"
     gene            1..3240
                     /gene="NBC"
     CDS             1..3240
                     /gene="NBC"
                     /function="mediates the transport of one Na+ with multiple
                     HCO3- ions"
                     /note="hKid-NBC; activity blocked by stilbene
                     compounds,DIDS and SITS; activity not effected by absence
                     of Cl-"
                     /codon_start=1
                     /product="electrogenic Na+ bicarbonate cotransporter form
                     2"
                     /protein_id="AAF21719.1"
                     /translation="MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRR
                     HKRKTGHKEKKEKERISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEEDDS
                     PAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFE
                     LRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKK
                     SNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMK
                     KLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKA
                     KSYHEIGRAIATLMSDEVFHDIAYKAKDRRDLIAGIDEFLDEVIVLPPGEWDPAIRIE
                     PPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDI
                     KRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGT
                     AVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCL
                     ILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTL
                     FSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGNLV
                     GNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFC
                     VIDALVGVGTPKLIVPSEFKPTSPNRGWFVPPFGENPWWVCLAAAIPALLVTILIFMD
                     QQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLK
                     METETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMRV
                     ASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVA
                     AIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVISEKDKKKKEDEKKKKKKKGSLDSD
                     NDDSDCPYSEKVPSIKIPMDIMEQQPFLSDSKPSDRERPPTFLERHTSC"
BASE COUNT          870 a          733 c          760 g          877 t
ORIGIN      
        1 atggaggatg aagctgtcct ggacagaggg gcttccttcc tcaagcatgt gtgtgatgaa
       61 gaagaagtag aaggccacca taccatttac atcggagtcc atgtgccgaa gagttacagg
      121 agaaggagac gtcacaagag aaagacaggg cacaaagaaa agaaggaaaa ggagagaatc
      181 tctgagaact actctgacaa atcagatatt gaaaatgctg atgaatccag cagcagcatc
      241 ctaaaacctc tcatctctcc tgctgcagaa cgcatccgat tcatcttggg agaggaggat
      301 gacagcccag ctccccctca gctcttcacg gaactggatg agctgctggc cgtggatggg
      361 caggagatgg agtggaagga aacagccagg tggatcaagt ttgaagaaaa agtggaacag
      421 ggtggggaaa gatggagcaa gccccatgtg gccacattgt cccttcatag tttatttgag
      481 ctgaggacat gtatggagaa aggatccatc atgcttgatc gggaggcttc ttctctccca
      541 cagttggtgg agatgattgt tgaccatcag attgagacag gcctattgaa acctgaactt
      601 aaggataagg tgacctatac tttgctccgg aagcaccggc atcaaaccaa gaaatccaac
      661 cttcggtccc tggctgacat tgggaagaca gtctccagtg caagtaggat gtttaccaac
      721 cctgataatg gtagcccagc catgacccat aggaatctga cttcctccag tctgaatgac
      781 atttctgata aaccggagaa ggaccagctg aagaataagt tcatgaaaaa attgccacgt
      841 gatgcagaag cttccaacgt gcttgttggg gaggttgact ttttggatac tcctttcatt
      901 gcctttgtta ggctacagca ggctgtcatg ctgggtgccc tgactgaagt tcctgtgccc
      961 acaaggttct tgttcattct cttaggtcct aaggggaaag ccaagtccta ccacgagatt
     1021 ggcagagcca ttgccaccct gatgtctgat gaggtgttcc atgacattgc ttataaagca
     1081 aaagacaggc gcgacctgat tgctggtatt gatgagttcc tagatgaagt catcgtcctt
     1141 ccacctgggg aatgggatcc agcaattagg atagagcctc ctaagagtct tccatcctct
     1201 gacaaaagaa agaatatgta ctcaggtgga gagaatgttc agatgaatgg ggatacgccc
     1261 catgatggag gtcacggagg aggaggacat ggggattgtg aagaattgca gcgaactgga
     1321 cggttctgtg gtggactaat taaagacata aagaggaaag cgccattttt tgccagtgat
     1381 ttttatgatg ctttaaatat tcaagctctt tcggcaattc tcttcattta tctggcaact
     1441 gtaactaatg ctatcacttt tggaggactg cttggggatg ccactgacaa catgcagggc
     1501 gtgttggaga gtttcctggg cactgctgtc tctggagcca tcttttgcct ttttgctggt
     1561 caaccactca ctattctgag cagcaccgga cctgtcctag tttttgagag gcttctattt
     1621 aatttcagca aggacaataa ttttgactat ttggagtttc gcctttggat tggcctgtgg
     1681 tccgccttcc tatgtctcat tttggtagcc actgatgcca gcttcttggt tcaatacttc
     1741 acacgtttca cggaggaggg cttttcctct ctgattagct tcatctttat ctatgatgct
     1801 ttcaagaaga tgatcaagct tgcagattac taccccatca actccaactt caaagtgggc
     1861 tacaacactc tcttttcctg tacctgtgtg ccacctgacc cagctaatat ctcaatatct
     1921 aatgacacca cactggcccc agagtatttg ccaactatgt cttctactga catgtaccat
     1981 aatactacct ttgactgggc atttttgtcg aagaaggagt gttcaaaata cggaggaaac
     2041 ctcgtcggga acaactgtaa ttttgttcct gatatcacac tcatgtcttt tatcctcttc
     2101 ttgggaacct acacctcttc catggctctg aaaaaattca aaactagtcc ttattttcca
     2161 accacagcaa gaaaactgat cagtgatttt gccattatct tgtccattct catcttttgt
     2221 gtaatagatg ccctagtagg cgtgggcacc ccaaaactaa ttgtgccaag tgagttcaag
     2281 ccaacaagtc caaaccgagg ttggttcgtt ccaccgtttg gagaaaaccc ctggtgggtg
     2341 tgccttgctg ctgctatccc ggctttgttg gtcactatac tgattttcat ggaccaacaa
     2401 attacagctg tgattgtaaa caggaaagaa cataaactca agaaaggagc agggtatcac
     2461 ttggatctct tttgggtggc catcctcatg gttatatgct ccctcatggc tcttccgtgg
     2521 tatgtagctg ctacggtcat ctccattgct cacatcgaca gtttgaagat ggagacagag
     2581 acttctgcac ctggagaaca accaaagttt ctaggagtga gggaacaaag agtcactgga
     2641 acccttgtgt ttattctgac tggtctgtca gtctttatgg ctcccatctt gaagtttata
     2701 cccatgcctg tactctatgg tgtgttcctg tatatgagag tagcatccct taatggtgtg
     2761 cagttcatgg atcgtctgaa gctgcttctg atgcctctga agcatcagcc tgacttcatc
     2821 tacctgcgtc atgttcctct gcgcagagtc cacctgttca ctttcctgca ggtgttgtgt
     2881 ctggccctgc tttggatcct caagtcaacg gtggctgcta tcatttttcc agtaatgatc
     2941 ttggcacttg tagctgtcag aaaaggcatg gactacctct tctcccagca tgacctcagc
     3001 ttcctggatg atgtcatttc agaaaaggac aagaaaaaga aggaggatga gaagaaaaag
     3061 aaaaagaaga agggaagtct ggacagtgac aatgatgatt ctgactgccc atactcagaa
     3121 aaagttccaa gtattaaaat tccaatggac atcatggaac agcaaccttt cctaagcgat
     3181 agcaaacctt ctgacagaga aagaccacca acattccttg aacgccacac atcatgctaa
//