LOCUS AF053641 3569 bp mRNA linear HUM 10-SEP-1998
DEFINITION Homo sapiens brain cellular apoptosis susceptibility protein (CSE1)
mRNA, complete cds.
ACCESSION AF053641
VERSION AF053641.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3569)
AUTHORS Brinkmann,E., Bera,T., Wellmann,A., Pastan,I. and Brinkmann,U.
TITLE Tissue Specific Alternatively Spliced Variants of hCSE1/CAS
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3569)
AUTHORS Brinkmann,E. and Brinkmann,U.
TITLE Direct Submission
JOURNAL Submitted (10-MAR-1998) Laboratory of Molecular Biology, National
Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..3569
/db_xref="H-InvDB:HIT000064532"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="20"
/map="20q13"
/tissue_type="brain; spinal cord; peripheral nerves"
gene 1..3569
/gene="CSE1"
CDS 124..3039
/gene="CSE1"
/note="CAS"
/codon_start=1
/product="cellular apoptosis susceptibility protein"
/protein_id="AAC35008.1"
/translation="MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPL
LLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLS
SPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRY
RHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKL
FYSLNFQDLPEFWEGNMETWMNNFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAA
LYAQKYDEEFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLF
EDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRG
LCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQ
ANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLI
NHLQAGSIVVHTYAAHALERLFTMRGPNNATLFTAAEIAPFVEILLTNLFKALTLPGS
SENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICL
SIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSY
MALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIASAAADKIPGLLGVFQKLIAS
KANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYC
IKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKKICAVGITKLLTECPPM
MDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPXYQTAFSQLAFAGKKEH
DPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAASVTLL"
misc_feature 3148..3550
/gene="CSE1"
/note="alternative 3 end; may affect mRNA stability or
translation"
polyA_site 3190
/gene="CSE1"
polyA_site 3551
/gene="CSE1"
/note="polyA tail"
BASE COUNT 1085 a 695 c 699 g 1088 t
ORIGIN
1 gtcgcgccat tttgccgggg tttgaatgtg aggcggagcg gcggcaggag cggatagtgc
61 cagctacggt ccgcggctgg ggttccctcc tccgtttctg tatccccacg agatcctata
121 gcaatggaac tcagcgatgc aaatctgcaa acactaacag aatatttaaa gaaaacactt
181 gatcctgatc ctgccatccg acgtccagct gagaaatttc ttgaatctgt tgaaggaaat
241 cagaattatc cactgttgct tttgacatta ctggagaagt cccaggataa tgttatcaaa
301 gtatgtgctt cagtaacatt caaaaactat attaaaagga actggagaat tgttgaagat
361 gaaccaaaca aaatttgtga agccgatcga gtggccatta aagccaacat agtgcacttg
421 atgcttagca gcccagagca aattcagaag cagttaagtg atgcaattag cattattggc
481 agagaagatt ttccacagaa atggcctgac ttgctgacag aaatggtgaa tcgctttcag
541 agtggagatt tccatgttat taatggagtc ctccgtacag cacattcatt atttaaaaga
601 taccgtcatg aatttaagtc aaacgagtta tggactgaaa ttaagcttgt tctggatgcc
661 tttgctttgc ctttgactaa tctttttaag gccactattg aactctgcag tacccatgca
721 aatgatgcct ctgccctgag gattctgttt tcttccctga tcctgatctc aaaattgttc
781 tatagtttaa actttcagga tctccctgaa ttttgggaag gtaatatgga aacttggatg
841 aataatttcc atactctctt aacattggat aataagcttt tacaaactga tgatgaagag
901 gaagccggct tattggagct cttaaaatcc cagatttgtg ataatgccgc actctatgca
961 caaaagtacg atgaagaatt ccagcgatac ctgcctcgtt ttgttacagc catctggaat
1021 ttactagtta caacgggtca agaggttaaa tatgatttgt tggtaagtaa tgcaattcaa
1081 tttctggctt cagtttgtga gagacctcat tataagaatc tatttgagga ccagaacacg
1141 ctgacaagta tctgtgaaaa ggttattgtg cctaacatgg aatttagagc tgctgatgaa
1201 gaagcatttg aagataattc tgaggagtac ataaggagag atttggaagg atctgatatt
1261 gatactagac gcagggctgc ttgtgatctg gtacgaggat tatgcaagtt ttttgaggga
1321 cctgtgacag gaatcttctc tggttatgtt aattccatgc tgcaggaata cgcaaaaaat
1381 ccatctgtca actggaaaca caaagatgca gccatctacc tagtgacatc tttggcatca
1441 aaagcccaaa cacagaagca tggaattaca caagcaaatg aacttgtaaa cctaactgag
1501 ttctttgtga atcacatcct ccctgattta aaatcagcta atgtgaatga atttcctgtc
1561 cttaaagctg acggtatcaa atatattatg atttttagaa atcaagtgcc aaaagaacat
1621 cttttagtct cgattcctct cttgattaat catcttcaag ctggaagtat tgttgttcat
1681 acttacgcag ctcatgctct tgaacggctc tttactatgc gagggcctaa caatgccact
1741 ctctttacag ctgcagaaat cgcaccgttt gttgagattc tgctaacaaa ccttttcaaa
1801 gctctcacac ttcctggctc ttcagaaaat gaatatatta tgaaagctat catgagaagt
1861 ttttctctcc tacaagaagc cataatcccc tacatcccta ctctcatcac tcagcttaca
1921 cagaagctat tagctgttag taagaaccca agcaaacctc actttaatca ctacatgttt
1981 gaagcaatat gtttatccat aagaataact tgcaaagcta accctgctgc tgttgtaaat
2041 tttgaggagg ctttgttttt ggtgtttact gaaatcttac aaaatgatgt gcaagaattt
2101 attccatacg tctttcaagt gatgtctttg cttctggaaa cacacaaaaa tgacatcccg
2161 tcttcctata tggccttatt tcctcatctc cttcagccag tgctttggga aagaacagga
2221 aatattcctg ctctagtgag gcttcttcaa gcattcttag aacgcggttc aaacacaata
2281 gcaagtgctg cagctgacaa aattcctggg ttactaggtg tctttcagaa gctgattgca
2341 tccaaagcaa atgaccacca aggtttttat cttctaaaca gtataataga gcacatgcct
2401 cctgaatcag ttgaccaata taggaaacaa atcttcattc tgctattcca gagacttcag
2461 aattccaaaa caaccaagtt tatcaagagt tttttagtct ttattaattt gtattgcata
2521 aaatatgggg cactagcact acaagaaata tttgatggta tacaaccaaa aatgtttgga
2581 atggttttgg aaaaaattat tattcctgaa attcagaagg tatctggaaa tgtagagaaa
2641 aagatctgtg cggttggcat aaccaaatta ctaacagaat gtcccccaat gatggacact
2701 gagtatacca aactgtggac tccattatta cagtctttga ttggtctttt tgagttaccc
2761 gaagatgata ccattcctga tgaggaacat tttattgaca tagaagatac accagratat
2821 cagactgcct tctcacagtt ggcatttgct gggaaaaaag agcatgatcc tgtaggtcaa
2881 atggtgaata accccaaaat tcacctggca cagtcacttc acaagttgtc taccgcctgt
2941 ccaggaaggg ttccatcaat ggtgagcacc agcctgaatg cagaagcgct ccagtatctc
3001 caagggtacc ttcaggcagc cagtgtgaca ctgctttaaa ctgcattttt ctaatgggct
3061 aaacccagat ggtttcctag gaaatcacag gcttctgagc acagctgcat taaaacaaag
3121 gaagttctcc ttttgaactt gtcacgaatt ccatcttgta aaggatatta aatgttgctt
3181 taacctgaac cttgagcaaa ttagttggtt tgtgtgatca tacagttatg tgggtggctt
3241 ctagtttgca acttcaaggg acaagtatta atagttcagt gtatggcgtt ggtttgtgtt
3301 gagcgtttgc acggtttgga taatcttaaa ttttgacgga cactgtggag actttnctgt
3361 tactaaatcc ttttgttttg aagctgttgc tatttgtatt tctcttgtcc tttatatttt
3421 ttgtctgttt atttacgctt ttattggaaa tgtgaataag taaagaatta cttgtgttac
3481 ttgccaagca gtgcacattt catagtttca aatctgtaat cagcaataaa aatcctaaaa
3541 tatgtaccta aaaaaaaaaa aaaaaaaaa
//