LOCUS AF051851 5678 bp mRNA linear HUM 21-OCT-1998 DEFINITION Homo sapiens supervillin mRNA, complete cds. ACCESSION AF051851 VERSION AF051851.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5678) AUTHORS Pestonjamasp,K.N., Pope,R.K., Wulfkuhle,J.D. and Luna,E.J. TITLE Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily JOURNAL J. Cell Biol. 139 (5), 1255-1269 (1997) PUBMED 9382871 REFERENCE 2 (bases 1 to 5678) AUTHORS Pope,R.K., Pestonjamasp,K.N., Smith,K.P., Wulfkuhle,J.D., Strassel,C.P., Lawrence,J.B. and Luna,E.J. TITLE Cloning, characterization, and chromosomal localization of human superillin (SVIL) JOURNAL Genomics 52 (3), 342-351 (1998) PUBMED 9867483 REFERENCE 3 (bases 1 to 5678) AUTHORS Pope,R.K. TITLE Direct Submission JOURNAL Submitted (28-FEB-1998) Cell Biology, University of Massachusetts Medical Center, Worcester Foundation Campus, 222 Maple Avenue, Shrewsbury, MA 01545, USA FEATURES Location/Qualifiers source 1..5678 /db_xref="H-InvDB:HIT000064271" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10p11.2" /tissue_type="kidney" CDS 101..5467 /note="membrane-associated F-actin binding protein; previously known as p205" /codon_start=1 /product="supervillin" /protein_id="AAC64696.1" /translation="MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMR ASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKA ERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESS RDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAH DLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPR CTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLR RLQDRSLTQPITTEEVVIAATLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEK LALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVN TSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPL VEGSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESK YAVPRRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRK FSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGE IKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAG RSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLA SPTAITPVASAICGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVG GMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPK LTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKM SSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQT RLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRAT YIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDK LVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGT FDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRS NEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQ FEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVR AAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGG MVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKA LIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDA LGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQE DLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGK NLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKL CKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKA KGLF" misc_feature 1058..1069 /note="encodes potential SV40-like nuclear localization signal" misc_feature 2381..2431 /note="encodes potential nucleoplasmin-like nuclear localization signal" misc_feature 2519..2542 /note="encodes ATP/GTP-binding motif (P-loop)" misc_feature 2879..2893 /note="encodes potential SV40-like nuclear localization signal" misc_feature 3140..3319 /note="encodes region similar to villin/gelsolin segment 2; region contains actin binding motif" misc_feature 3557..3559 /note="encodes potential tyrosine phosphorylation site" misc_feature 4022..4045 /note="encodes potential RNA binding motif" misc_feature 4232..4405 /note="encodes region similar to villin/gelsolin segment 5; region contains unmapped actin binding site" misc_feature 5321..5467 /note="encodes region similar to villin headpiece; region contains actin binding motif" BASE COUNT 1596 a 1417 c 1558 g 1106 t ORIGIN 1 taaccacgaa agaggaatcg atgctcagct tttagttgca cttcctaaag ttgcagaatt 61 aagacaaatc tttgaaccaa agaagaaaga attcttagaa atgaaaagaa aagaaagaat 121 tgccaggcgc ctggaaggga ttgaaaatga cactcagccc atcctcttgc agagctgcac 181 aggattggtg actcaccgcc tgctggagga agacacccct cgatacatga gagccagcga 241 ccctgccagc ccccacatcg gccgatcaaa tgaagaggag gaaacttctg attcttctct 301 agaaaagcaa actcgatcca aatactgcac agaaacctcc ggtgtccacg gtgactcacc 361 ctatggttcg ggtaccatgg acacccacag tctggagtcc aaagccgaaa gaattgcaag 421 gtacaaagca gaaagaaggc gacagctggc agagaagtat gggctgactc tggatcccga 481 ggccgactcc gagtatttat cccgctatac caagtccagg aaggagcctg atgctgtcga 541 gaagcgggga ggaaaaagtg acaaacagga agagtcaagc agagatgcka gttctctgta 601 ccccgggacc gagacgatgg ggctcaggac ctgtgccggt gaatccaagg actatgccct 661 ccatgtgggt gacggctctt ccgacccgga ggtgctgctg aacatagaaa accaaagacg 721 aggtcaagag ctgagtgcca cccggcaggc ccatgacctg tccccagcag ccgagagttc 781 ctcgaccttc tctttctctg ggcgagactc ctccttcact gaagtgccac ggtcccccaa 841 gcacgcccac agctcctccc tgcagcaggc agcctcccgg agcccctcct ttggtgaccc 901 acagctatcc cctgaggccc gacccaggtg cacttcacat tcagaaacgc caactgtcga 961 tgatgaagaa aaggtggatg aacgagccaa gctgagcgtc gccgccaaga ggttgctttt 1021 cagggagatg gaaaaatctt ttgatgaaca aaatgttcca aagcgacgct caagaaacac 1081 agctgtggag cagaggctac gccgtctgca ggacaggtcc ctcacccagc ccatcaccac 1141 tgaagaggtg gtcatcgcag ccacattgca ggcctctgct caccaaaagg ccttagccaa 1201 ggaccagaca aatgagggca aagagcttgc tgagcaagga gaacctgatt cctccactct 1261 aagcttggcc gaaaagttgg ccttgtttaa caaattgtcc cagccagtct caaaagcgat 1321 ttctacccgg aacagaatag acacgagaca gaggagaatg aacgctcgct atcaaactca 1381 gccagtcaca ctgggagagg tggagcaggt gcagagtgga aagctcattc ctttctcacc 1441 tgccgtgaac acatcagtgt ctaccgtagc atccacggtt gctccaatgt atgccggaga 1501 tcttcgcaca aagccacctc ttgaccacaa tgcaagtgcc actgactata agttttcttc 1561 ttcaatagaa aattcggact ctccagttag aagcattctg aaatcgcaag cttggcagcc 1621 tttggtagag ggtagcgaga acaagggaat gttgagagaa tatggagaga cagaaagcaa 1681 gagagctttg acaggtcgag acagtgggat ggagaagtat gggtcctttg aggaagcaga 1741 agcatcctac cccatcctga accgagccag ggaaggagac agccataagg aatctaaata 1801 tgctgttccc agaagaggaa gcctggaacg ggcgaaccct cccatcaccc acctcgggga 1861 tgaaccgaag gaattttcca tggctaaaat gaatgcacaa ggaaacttgg acttgaggga 1921 caggctgccc tttgaagaga aggtggaggt ggagaatgtt atgaaaagga agttttcact 1981 aagagcggca gagttcgggg agcccacttc cgagcagacg gggacagctg ctgggaaaac 2041 tattgctcaa accacagccc ccgtgtcctg gaagccccag gattcttcgg aacagccaca 2101 ggagaagctc tgcaagaatc catgtgcgat gtttgctgct ggagagatca aaacgccgac 2161 aggggagggc cttcttgact cacccagcaa aaccatgtct attaaagaaa gattggcact 2221 gttgaagaaa agcggggagg aagattggag aaacagactc agcaggaggc aggagggcgg 2281 caaggcgccg gccagcagcc tgcacaccca ggaagcaggg cggtccctca tcaagaagcg 2341 ggtcacagaa agtcgagaga gccaaatgac gattgaggag aggaagcagc tcatcactgt 2401 gagagaggag gcctggaaga cgagaggcag aggagcggcc aacgactcga cccagttcac 2461 tgtggctggc aggatggtga agaaaggttt ggcgtcacct actgccataa ccccagtagc 2521 ctcagccatt tgcggtaaaa caagaggcac cacacccgtt tccaaacccc tggaagatat 2581 cgaagccaga ccagatatgc agttagaatc ggacctgaag ttggacaggc tggaaacctt 2641 tctaagaagg ctgaataaca aagttggcgg gatgcacgaa acggtgctca ctgtcaccgg 2701 caaatctgtg aaggaggtga tgaagccaga tgatgatgaa acctttgcca aattttaccg 2761 cagcgtggat tataatatgc caagaagtcc tgtggagatg gatgaggact tcgatgtcat 2821 tttcgatcct tatgcaccca aattgacgtc ttccgtggcc gagcacaagc gggcagttag 2881 gcccaagcgc cgggttcagg cctccaaaaa ccccctgaaa atgctggcgg caagagaaga 2941 tctccttcag gaatacactg agcagagatt aaacgttgcc ttcatggagt caaagcggat 3001 gaaagtagaa aagatgtctt ccaactccaa cttctcagaa gtcaccctgg cgggtttagc 3061 cagtaaagaa aacttcagca acgtcagcct gcggagcgtc aacctgacgg aacagaactc 3121 taacaacagc gccgtgccct acaagaggct gatgctgttg cagattaaag gaagaagaca 3181 tgtgcagacc aggctggtgg aacctcgagc ttcggcgctc aacagtgggg actgcttcct 3241 cctgctctct ccccactgct gcttcctgtg ggtaggagag tttgcaaacg tcatagaaaa 3301 ggcgaaggcc tcagaacttg caactttaat tcagacaaag agggaacttg gttgtagagc 3361 tacttatatc caaaccattg aagaaggaat taatacacac actcatgcag ccaaagactt 3421 ctggaagctt ctgggtggcc aaaccagtta ccaatctgct ggagacccaa aagaagatga 3481 actctatgaa gcagccataa tagaaactaa ctgcatttac cgtctcatgg atgacaaact 3541 tgttcctgat gacgactact gggggaaaat tccgaagtgc tcccttctgc aacccaaaga 3601 ggtactggtg tttgattttg gtagtgaagt ttacgtatgg catgggaaag aagtcacatt 3661 agcacaacga aaaatagcat ttcagctggc aaagcactta tggaatggaa cctttgacta 3721 tgagaactgt gacatcaatc ccctggatcc tggagaatgc aatccgctta tccccagaaa 3781 aggacagggg cggcccgact gggcgatatt tgggagactt actgaacaca atgagacgat 3841 tttgttcaaa gagaagtttc tggattggac ggaactgaag agatcgaatg agaagaaccc 3901 cggggaactt gcccagcaca aggaagaccc caggactgat gtcaaggcat acgatgtgac 3961 acggatggtg tccatgcccc agacgacagc aggcaccatc ctggacggag tgaacgtcgg 4021 ccgtggctat ggcctggtgg aaggacacga caggaggcag tttgagatca ccagcgtttc 4081 cgtggatgtc tggcacatcc tggaattcga ctatagcagg ctccccaaac aaagcatcgg 4141 gcagttccat gagggggatg cctatgtggt caagtggaag ttcatggtga gcacggcagt 4201 gggaagtcgc cagaagggag agcactcggt gagggcagcc ggcaaagaga agtgcgtcta 4261 cttcttctgg caaggccggc actccaccgt gagtgagaag ggcacgtcgg cgctgatgac 4321 ggtggagctg gacgaggaaa ggggggccca ggtccaggtt ctccagggaa aggagccccc 4381 ctgtttcctg cagtgtttcc agggggggat ggtggtgcac tcggggaggc gggaagagga 4441 agaagaaaat gtgcaaagtg agtggcggct gtactgcgtg cgtggagagg tgcccgtgga 4501 agggaatttg ctggaagtgg cctgtcactg tagcagcctg aggtccagaa cttccatggt 4561 ggtgcttaac gtcaacaagg ccctcatcta cctgtggcac ggatgcaaag cccaggccca 4621 cacgaaggag gtcggaagga ccgctgcgaa caagatcaag gaacaatgtc ccctggaagc 4681 aggactgcat agtagcagca aagtcacaat acacgagtgt gatgaaggct ccgagccact 4741 cggattctgg gatgccttag gaaggagaga caggaaagcc tacgattgca tgcttcaaga 4801 tcctggaagt tttaacttcg cgccccgcct gttcatcctc agcagctcct ctggggattt 4861 tgcagccaca gagtttgtgt accctgcccg agccccctct gtggtcagtt ccatgccctt 4921 cctgcaggaa gatctgtaca gcgcgcccca gccagcactt ttccttgttg acaatcacca 4981 cgaggtgtac ctctggcaag gctggtggcc catcgagaac aagatcactg gttccgcccg 5041 catccgctgg gcctccgacc ggaagagtgc gatggagact gtgctccagt actgcaaagg 5101 aaaaaatctc aagaaaccag cccccaagtc ttaccttatc cacgctggtc tggagcccct 5161 gacattcacc aatatgtttc ccagctggga gcacagagag gacatcgctg agatcacaga 5221 gatggacacg gaagtttcca atcagatcac cctcgtggaa gacgtcttag ccaagctctg 5281 taaaaccatt tacccgctgg ccgacctcct ggccaggcca ctcccggagg gggtcgatcc 5341 tctgaagctt gagatctatc tcaccgacga agacttcgag tttgcactag acatgacgag 5401 ggatgaatac aacgccctgc ccgcctggaa gcaggtgaac ctgaagaaag caaaaggcct 5461 gttctgagtg gggagacgcc agaggagcct cacggtcacg tccaacaaca ccactgcacc 5521 agggaaatgg atatatattt ttggactggt gtttttcaca aagtattttt caatcagagt 5581 tttcagaacc tgacattgtt aaagatactg cttgtcccgg agttgtgtat tttgtaaatg 5641 ttcaagggaa ctgtttggaa acttctttcc accattca //