LOCUS AF049910 7758 bp mRNA linear HUM 24-NOV-2000
DEFINITION Homo sapiens TACC1 (TACC1) mRNA, complete cds.
ACCESSION AF049910
VERSION AF049910.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7758)
AUTHORS Still,I.H., Hamilton,M., Vince,P., Wolfman,A. and Cowell,J.K.
TITLE Cloning of TACC1, an embryonically expressed, potentially
transforming coiled coil containing gene, from the 8p11 breast
cancer amplicon
JOURNAL Oncogene 18 (27), 4032-4038 (1999)
PUBMED 10435627
REFERENCE 2 (bases 1 to 7758)
AUTHORS Still,I.H.
TITLE Direct Submission
JOURNAL Submitted (19-FEB-1998) Neurosciences, Cleveland Clinic Foundation,
9500 Euclid Avenue, Cleveland, OH 44195, USA
FEATURES Location/Qualifiers
source 1..7758
/db_xref="H-InvDB:HIT000064223"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p11"
/dev_stage="embryo"
gene 1..7758
/gene="TACC1"
CDS 321..2738
/gene="TACC1"
/codon_start=1
/product="TACC1"
/protein_id="AAC32327.1"
/translation="MAFSPWQILSPVQWAKWTWSAVRGGAAGEDEAGGPEGDPEEEDS
QAETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLV
AEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDST
DISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNS
CPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTS
PLLGDARFQKSPPDIKETPGTLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEAR
KALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESP
SFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNE
ILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEK
LASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEED
GSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEW
KKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLN
SVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEK
LDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELI
AKLGKTD"
BASE COUNT 2209 a 1665 c 1778 g 2106 t
ORIGIN
1 cagaggtcta gcagccgggc gccgcgggcc gggggcctga ggaggccaca ggacgggcgt
61 cttcccggct agtggagccc ggcgcggggc ccgctgcggc cgcaccgtga ggggaggagg
121 ccgaggagga cgcggcgccg gctgccggcg ggaggaagcg ctccaccagg gcccccgacg
181 gcactcgttt aaccacatcc gcgcctctgc tggaaacgct tgctggcgcc tgtcaccggt
241 tccctccatt ttgaaaggga aaaaggctct ccccacccat tcccctgccc ctaggagctg
301 gagccggagg agccgcgctc atggcgttca gcccgtggca gatcctgtcc cccgtgcagt
361 gggcgaaatg gacgtggtct gcggtacgcg gcggggccgc cggcgaggac gaggctggcg
421 ggcccgaggg cgaccccgag gaggaggatt cgcaagccga gaccaaatcc ttgagtttca
481 gctcggattc tgaaggtaat tttgagactc ctgaagctga aaccccgatc cgatcacctt
541 tcaaggagtc ctgtgatcca tcactcggat tggcaggacc tggggccaaa agccaagaat
601 cacaagaagc tgatgaacag cttgtagcag aagtggttga aaaatgttca tctaagactt
661 gttctaaacc ttcagaaaat gaagtgccac agcaggccat tgactctcac tcagtcaaga
721 atttcagaga agaacctgaa catgatttta gcaaaatttc catcgtgagg ccattttcaa
781 tagaaacgaa ggattccacg gatatctcgg cagtcctcgg aacaaaagca gctcatggct
841 gtgtaactgc agtctcaggc aaggctctgc cttccagccc gccagacgcc ctccaggacg
901 aggcgatgac agaaggcagc atgggggtca ccctcgaggc ctccgcagaa gctgatctaa
961 aagctggcaa ctcctgtcca gagcttgtgc ccagcagaag aagcaagctg agaaagccca
1021 agcctgtccc cctgaggaag aaagcaattg gaggagagtt ctcagacacc aacgctgctg
1081 tggagggcac acctctcccc aaggcatcct atcacttcag tcctgaagag ttggatgaga
1141 acacaagtcc tttgctagga gatgccaggt tccagaagtc tccccctgac attaaagaaa
1201 ctcccggcac tctcagtagt gacaccaacg actcaggggt tgagctgggg gaggagtcga
1261 ggagctcacc tctcaagctt gagtttgatt tcacagaaga tacaggaaac atagaggcca
1321 ggaaagccct tccaaggaag cttggcagga aactgggtag cacactgact cccaagatac
1381 aaaaagatgg catcagtaag tcagcaggtt tagaacagcc tacagaccca gtggcacgag
1441 acgggcctct ctcccaaaca tcttccaagc cagatcctag tcagtgggag agccccagct
1501 tcaacccctt tgggagccac tctgttctgc agaactcccc acccctctct tctgagggct
1561 cctaccactt tgacccagat aactttgacg aatccatgga tccctttaaa ccaactacga
1621 ccttaacaag cagtgacttt tgttctccca ctggtaatca cgttaatgaa atcttagaat
1681 cacccaagaa ggcaaagtcg cgtttaataa cgagtggctg taaggtgaag aagcatgaaa
1741 ctcagtctct cgccctggat gcatgttctc gggatgaagg ggcagtgatc tcccagattt
1801 cagacatttc taatagggat ggccatgcta ctgatgagga gaaactggca tccacgtcat
1861 gtggtcagaa atcagctggt gccgaggtga aaggtgagcc agaggaagac ctggagtact
1921 ttgaatgttc caatgttcct gtgtctacca taaatcatgc gttttcatcc tcagaagcag
1981 gcatagagaa ggagacgtgc cagaagatgg aagaagacgg gtccactgtg cttgggctgc
2041 tggagtcctc tgcagagaag gcccctgtgt cggtgtcctg tggaggtgag agccccctgg
2101 atgggatctg cctcagcgaa tcagacaaga cagccgtgct caccttaata agagaagaga
2161 taattactaa agagattgaa gcaaatgaat ggaagaagaa atacgaagag acccggcaag
2221 aagttttgga gatgaggaaa attgtagctg aatatgaaaa gactattgct caaatgattg
2281 aagatgaaca aaggacaagt atgacctctc agaagagctt ccagcaactg accatggaga
2341 aggaacaggc cctggctgac cttaactctg tggaaaggtc cctttctgat ctcttcagga
2401 gatatgagaa cctgaaaggt gttctggaag ggttcaagaa gaatgaagaa gccttgaaga
2461 aatgtgctca ggattactta gccagagtta aacaagagga gcagcgatac caggccctga
2521 aaatccacgc agaagagaaa ctggacaaag ccaatgaaga gattgctcag gttcgaacaa
2581 aagcaaaggc tgagagtgca gctctccatg ctggactccg caaagagcag atgaaggtgg
2641 agtccctgga aagggccctg cagcagaaga accaagaaat tgaagaactg acaaaaatct
2701 gtgatgagct gattgcaaag ctgggaaaga ctgactgaga cactccccct gttagctcaa
2761 cagatctgca tttggctgct tctcttgtga ccacaattat cttgccttat ccaggaataa
2821 ttgccccttt gcagagaaaa aaaaaaaact taaaaaaagc acatgcctac tgctgcctgt
2881 cccgctttgc tgccaatgca acagccctgg aagaaaccct agagggttgc atagtctaga
2941 aaggagtgtg acctgacagt gctggagcct cctagtttcc ccctatgaag gttcccttag
3001 gctgctgagt ttgggtttgt gatttatctt tagtttgttt taaagtcatc tttactttcc
3061 caaatgtgtt aaatttgtaa ctcctctttg gggtcttctc caccacctgt ctgatttttt
3121 tgtgatctgt ttaatctttt aattttttag tatcagtggt tttatttaag gagacagttt
3181 ggcctattgt tacttccaat ttataatcaa gaaggggctc tggatcccct tttaaattac
3241 acacactctc acacacatac atgtatgttt atagatgctg ctgctctttt ccctgaagca
3301 tagtcaagta agaactgctc tacagaagga catatttcct tggatgtgag accctatttt
3361 gaaatagagt cctgactcag aacaccaact taagaatttg ggggattaaa gatgtgaaga
3421 ccacagtctt gggttttcat atctggagaa gactatttgc catgacgttt tgttgccctg
3481 gtatttggac actcctcagc tttaatgggt gtggcccctt tagggttagt cctcagacta
3541 atgatagtgt ctgctttctg catgaacggc aatatgggac tccctccaag ctagggtttg
3601 gcaagtctgc cctagagtca tttactctcc tctgcctcca tttgttaata cagaatcaac
3661 atttagtctt cattatcttt tttttttttt ttgagacaga gtttcgatct attttaagta
3721 tgtgaagaaa atctacttgt aaaaggctca gatcttaatt aaaaggtaat tgtagcacat
3781 taccaattat aaggtgaaga aatgtttttt cccaagtgtg atgcattgtt cttcagatgt
3841 tgaaaagaaa gcaaaaaata ccttctaact taagacagaa tttttaacaa aatgagcagt
3901 aaaagtcaca tgaaccactc caaaaatcag tgcattttgc atatttttaa acaaagacag
3961 cttgttgaat actgagaaga ggagtgcaag gagaaggtct gtactaacaa agccaaattc
4021 ctcaagctct tactggactc agttcagagt ggtgggccat taaccccaac atggaatttt
4081 tccatataaa tctcaatgaa ttccctttca tttgaatagg caaacccaaa tccatgcaag
4141 tgttttaaag cactgtcctg tcttaatctt acatgctgaa agtcttcatg gtgatatgca
4201 ctatattcag tatacgtatg ttttcctact tctcttgtaa aactgttgca tgatccaact
4261 tcagcaatga attgtgccta gtggagaacc tctatagatc ttaaaaaatg aattattctt
4321 tagcagtgta ttactcacat gggtgcaatc tttagcccca gggaggtcaa taatgtcttt
4381 taaagccaga agtcacattt taccaatatg catttatcat aattggtgct taggctgtat
4441 attcaagcct gttgtcttaa cattttgtat aaaaaagaac aacagaaatt atctgtcatt
4501 tgagaagtgg cttgacaatc atttgagctt tgaaagcagt cactgtggtg taatatgaat
4561 gctgtcctag tggtcatagt accaagggca cgtgtctccc cttggtataa ctgatttcct
4621 ttttagtcct ctactgctaa ataagttaat tttgcatttt gcagaaagaa acattgattg
4681 ctaaatcttt ttgctgctgt gttttggtgt tttcatgttt acttgtttta tattgatctg
4741 ttttaagtat gagaggctta tagtgccctc cattgtaaat ccatagtcat ctttttaagc
4801 ttattgtgtt taagaaagta gctatgtgtt aaacagaggt gatggcagcc cttccctagc
4861 acactggtgg aagagacccc ttaagaacct gaccccagtg aatgaagctg atgcacaggg
4921 acgaccaaag gaccttcgtt aagtgataat tgtcctggcc tctcagccat gaccgttatg
4981 aggaaatatc ccccattcga acttaacaga tgcctcctct ccaaagagaa ttaaaatcgt
5041 agcttgtaca gatcaagaga atatactggg cagaatgaag tatgtttgtt tatttttctt
5101 taaaaataaa ggattttgga actctggaga gtaagaatat agtatagagt ttgcctcaac
5161 acatgtgagg gccaaataac ctgctagcta ggcagtaata aactctgtta cagaagagaa
5221 aaagggccgg gcacagtggc ttattcctgt aatcccaaca ctgtggaagg ccgaggcagg
5281 aggatcactt gagtccagga gtttgaaacc tacctaggca acatggtgaa accttgtctc
5341 taccaaaata aaaattagct gggcatggtg gcacgtgcct gtggtcccag ctacttggga
5401 ggctgaggtg ggagcctggg aggtcaaggc tgcagtgagc catgatcatg ccactgcact
5461 ccatcctggg tgacagcaag atcttgtctc aaaaaaaaaa aaaaaaacca ggagtgaaaa
5521 aggaaagtag aaggcagctg ctggcctaga tgttggtttg ggaatattag gtgatcctgt
5581 tgagattctg gatccagagc aatttcttta gcttttgact ttgccaaagt gtagatagcc
5641 tttatccagc agtattttaa gtggggaatg caacgtgagg ccaactgaac aattcccccc
5701 gtggctgccc agatagtcac agtcaaggtt ggagagtctc cttccagcca gtgacctacc
5761 caaacctttt gttctgtaaa actgctctgg aaataccggg aagcccagtt ttctcacgtg
5821 gtttctagct tcttcagact cagcccaaat taggaagtgc agaagcacat gatggtgaaa
5881 aacctaggat ttggcagcct tccagaatgg tatggaatct gagggaagat ttatgtttcg
5941 ttttggagga tagctcaagt tgaattttct ttccagccag ttaccctttc aacctaccca
6001 tactttgtac aactcttaca caaatactta gatatttatt agatagccct gaattcactc
6061 taattataaa cagggagtgt aaactgcccc cagatgttcc tgggctgggt aaaagcagct
6121 ggagtgaagc actcattttc cataaaggta acaaagggca gctcagtggt tactcaagct
6181 caaaagggtt tttttaagag caagcattgg ttaagtctgt gtatactgag ttggaagtga
6241 tttcagcaca ttctttttta gtgggagtga aagttctgaa gccccctttt aacttcctct
6301 tggtttttca ttataattgg tagccatctc atgaactgtc tctgactgtt gtctctttgt
6361 ggtcatgtga ttgtgagctt gctttctgac ttgcatttct gactttatcc tgttgttagg
6421 aagatagaaa ctaggttttg aaagattaca tgattcaagc gagggatttt aaagtaaaga
6481 tgtatttatt ctgaagaatc taaaagataa cagattattt gcttatgaaa gaacaatata
6541 gtctgggaat cccagaatgt caagccaaag gtctaagaag tcatctcctt caaatacttt
6601 aataaagaag tatttcgagg agatatctgt ccaaaaaggt ttgactggcc tccagattcc
6661 agttattttt aaaaagcaac ttaccactaa atccttgagt ctccatagag taacagtaaa
6721 gaaactgatg taacagactc tcctctcaaa ggatctcctc tggaagagac tatcagcggc
6781 agatctctcc agggaagacc catcccctag tgccagagct tgcatcctgg agactaaaga
6841 ttgcactttt ttgtagtttt ttgtccaaat gcaatcccat ttctgtgcct cttagcatgc
6901 agttagattt ggacaaacaa gattcctaag gaatgacttt attaactata atatggttac
6961 agctattata taaatatata ttctggttat agttctaata tggagatgtt gtgtgcaatg
7021 ctggcctgtg gtggtctgtg taatgcttta acttgtatgg aggaggccag gctcagagct
7081 gagatgtggc ctgaaccttc cctgtatcga tcctttaatt tagaactgtc aagatgtcac
7141 tttctccccc tctgcctttt agtggtatct gacatatact caaaacagta atttcctggt
7201 cacatcatta actgctaatt ctgtatttat aaagaatttt cagatggaca tgtacaaatt
7261 tgaactcaaa ccatccccag tccagataca gggcagcgtg taggtgacca caccagagcc
7321 tcagcctcgg tccttctcag ccgtcgggat aggatccagg catttctttt aaatctcaga
7381 ggtagcagta aacttttcag tattgctgtt agcaagtgtg tgtttgccaa tagataccca
7441 ttatactaat gtgccaagta aatgttcatt gcacatctgc ttccactgtg ttcccacggg
7501 tgccatgaag tgtgtgagga gcccctcatc tggagggatg agtgctgcgt tgactactgc
7561 tatcaggatt gtgttgtgtg gaatattcat ctacataaat tttatatgca cagtaatttc
7621 cctttttata tgtcaagtaa ctatttgtaa aagttatact cacaaattat tataatgatt
7681 actaatatat tttttccatg tttcattgcc tgaataaaaa ctgtttacca ctgttaaaaa
7741 aaaaaaaaaa aaaaaaaa
//