LOCUS AF047347 3794 bp mRNA linear HUM 09-JUN-1998
DEFINITION Homo sapiens adaptor protein X11alpha mRNA, complete cds.
ACCESSION AF047347
VERSION AF047347.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3794)
AUTHORS Borg,J.P., Yang,Y., De Taddeo-Borg,M., Margolis,B. and Turner,R.S.
TITLE The X11alpha protein slows cellular amyloid precursor protein
processing and reduces Abeta40 and Abeta42 secretion
JOURNAL J. Biol. Chem. 273 (24), 14761-14766 (1998)
PUBMED 9614075
REFERENCE 2 (bases 1 to 3794)
AUTHORS Borg,J.-P., de Taddeo-Borg,M. and Margolis,B.
TITLE Direct Submission
JOURNAL Submitted (09-FEB-1998) University of Michigan Medical Center,
Howard Hughes Medical Institute, MSRBII, Room 4570, 1150 West
Medical Center Drive, Ann Arbor, MI 48109-0650, USA
FEATURES Location/Qualifiers
source 1..3794
/db_xref="H-InvDB:HIT000064116"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q13-q21"
/tissue_type="brain"
/dev_stage="adult"
CDS 240..2753
/note="amyloid precursor protein binding partner"
/codon_start=1
/product="adaptor protein X11alpha"
/protein_id="AAC39766.1"
/translation="MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQ
QHYVGRHQRGRALEDLRAQLGQEEEERGECLARSASTESGFHNHTDTAEGDVIAAARD
GYDAERAQDPEDESAYAVQYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEA
MNAAYSGYVYTHRLFHRGEDEPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQ
ERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAE
VKQSMSSQSLDKAAEDMPEAEQDLERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEA
GQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCD
DQRPMDGDSPSPGSSSPLGAESSSTSLHPSDPVEASTNKESRKSLASFPTYVEVPGPC
DPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKMAQKLAKSRKKAPE
GESQPMTEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLMARRRMPRS
NSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPE
DLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPT
VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIV
RCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVA
TPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI"
misc_feature 1602..2087
/note="encodes phosphotyrosine binding (PTB) domain"
misc_feature 2109..2711
/note="encodes two PSD-95/Dlg/ZO-1 (PDZ) domains"
BASE COUNT 858 a 1136 c 1104 g 695 t
ORIGIN
1 gaattcggca acgaggggcg gcggcggcgg cggcggcagc tgcggcggga gaagatggtg
61 gcgctggagg cagcagcggc tggagcggag ctttattccc aggcttggca ccagcgctgt
121 cactagcgcc gcctgctccc gcgggcccgc ggacccagct gtcaggcaag cccagtggag
181 caaaatgaga gcgcagtgag ccgggcccag cttctctcct agccgttccg actcccacca
241 tgaaccactt ggaggggtct gcggaggtgg aggtgaccga cgaggcggca ggtggggagg
301 tgaacgagtc ggtggaggcc gacctggagc accccgaggt ggaagaggaa cagcagcagc
361 cgccgcagca gcagcactat gtgggccgcc accagcgcgg gcgagccctc gaggacctcc
421 gcgcccagct cggccaggag gaagaggagc gcggggaatg cctggcgcgc tcagccagca
481 cggagagcgg cttccacaac cacacggaca ccgccgaggg cgacgtgatc gccgcggccc
541 gcgacggcta cgatgcggag cgcgcgcagg accccgagga cgagagcgcc tatgctgtgc
601 agtaccggcc cgaggccgag gagtacacgg agcaggcaga ggccgagcac gccgaggcca
661 cgcaccgccg cgcgctgccc aaccacctgc acttccactc gctggagcac gaggaagcca
721 tgaatgcggc ctactcaggc tacgtctaca cgcaccggct cttccaccgc ggtgaggacg
781 agccctactc cgagccctat gccgactacg gcggcctcca ggagcacgtg tacgaggaga
841 taggggacgc gcccgagctg gacgcacgcg acggcctgcg gctctacgag caggagcgcg
901 acgaggcggc cgcgtaccgc caggaggccc tgggcgcgcg gctgcaccat tacgacgagc
961 gctccgacgg cgagtccgac agccccgaga aggaggccga gttcgcgccc tacccgcgca
1021 tggacagcta cgagcaggag gaggacatcg accagatagt ggccgaggtg aagcagagca
1081 tgagctcgca gagcctcgac aaggcagccg aggacatgcc tgaggccgag caggacctgg
1141 agcgtccccc taccccggcc gggggtcgcc ccgacagccc cgggctgcag gcgccggcgg
1201 ggcagcagcg ggcggtgggc cccgcgggcg gcggcgaggc ggggcagcgg tacagcaagg
1261 agaagcgcga tgccatctcg ctggccatca aggacatcaa ggaggccatc gaggaggtga
1321 aaaccaggac catccgttcg ccttacaccc ccgacgagcc caaagagccc atctgggtca
1381 tgcgccagga cattagcccc accagggact gtgacgacca gaggccgatg gacggagatt
1441 ctccgtctcc tggcagctcc tcccccttgg gtgcagagtc atcaagcaca tctcttcacc
1501 ccagtgaccc tgtggaagcg tccactaata aagagtcaag aaaaagcttg gcttcattcc
1561 caacctacgt tgaagttccg ggaccctgcg accccgaaga cttgatcgat ggaatcattt
1621 ttgccgccaa ttaccttggc tccactcagc tgctctcaga caaaactcct tccaaaaacg
1681 tgcgcatgat gcaggcccag gaagccgtaa gcaggatcaa gatggcccag aaattagcca
1741 aaagcaggaa gaaggctcct gaaggcgaat ctcagccaat gactgaagtg gatctcttca
1801 tttctaccca gagaatcaaa gtgctgaacg ccgacacaca ggagacaatg atggaccacc
1861 ctctgaggac catttcctac attgcggaca ttgggaacat cgttgtgctg atggcccgcc
1921 ggcggatgcc tcgctccaac tcccaggaga acgtggaagc gtcccaccca tcccaggatg
1981 ggaaaaggca gtacaagatg atctgccacg tcttcgagtc tgaggatgct cagctgattg
2041 cacagtccat cggacaggca tttagcgtgg cataccagga attcctcagg gccaatggga
2101 ttaaccccga agatctcagc cagaaggagt atagtgacct gctcaatacc caggacatgt
2161 acaacgatga cctgatccac ttctccaagt cggaaaactg taaagatgtt ttcatagaga
2221 agcagaaagg agaaatccta ggtgtggtga ttgtggagtc tggctgggga tccatcctcc
2281 ccaccgtgat cattgccaac atgatgcatg gtggccctgc ggagaaatct gggaagctga
2341 atatcggtga ccagatcatg tccattaatg gcaccagcct ggtgggcctg cctctgtcca
2401 cctgccagag cattattaag ggcttaaaga atcagtcccg agtcaagctg aatatcgtga
2461 gatgtcctcc ggtgaccacc gtgttaatca gaagaccaga ccttcgctac cagctcggtt
2521 tcagcgtcca gaatggaatt atctgcagcc tcatgcgagg gggaatagct gagagaggag
2581 gcgtccgtgt ggggcaccgg atcattgaaa tcaatggaca gagcgtcgtg gccacccccc
2641 acgagaagat cgtccacatt ctctccaatg ctgttgggga gattcatatg aagacaatgc
2701 cagccgcgat gtacaggctg ctgacggccc aggagcagcc tgtttacatc tgaccgcggc
2761 cacacgcggt ggcatgcatg gaggactctc ctcttcgtgg ttgtgtttct cgtgctgcat
2821 ccctgtgtcc actgagactt tcccctctcg cgcccagcat ttggttttac acaggaagag
2881 aagaatccac aaggacctct ttactctctc cgatttgctt tttttttttt tttttttcaa
2941 taccagggaa gtttcgtatg cactcccttg aggatggaga gcagccagca cccacctggt
3001 actgacccag gaccatcctg gagggctttc tgggtgtgtc cagggggtgg gctgtcactg
3061 cttgagggag aatcctccct tcccaggagg tgcagacttc ttaaaaggag ctcgcggggc
3121 agcaaagcag ctgattcagc agtgcctaaa acccagttgc tgatccctgc tctctgagtt
3181 tatctgtggg aatgtggtag tacccagggc cagcccacgt cattaaggtt atgcactgcc
3241 tgccatgtag ttggggcacc atacattatt tcttcccaga atctctgagc caaccttaaa
3301 cctcttctat tgctagttct aatttcaacg tatgtgtgtt ttctaatacg agccttctca
3361 ccccaggata aaaggggaaa taactgcctt gggcaaggac accatagtgt cacagagagc
3421 ttggcaattc atggggcatc tgaagcttta ccaggttgtc ctcaagttat caaccattag
3481 ataaacacag gcaggtactg tctgcttctc tctctctcac acacacacac acacacacag
3541 tcccattcgg atatcaccct tccctgctcc caccaccagt gagacaagct gaagattagg
3601 cacacagatc ccctggaaac ccacctctct ggaaggtccc ttccctggca ggtggtcagg
3661 caggcggggg ctgttcagcc tcatcctgag agacctgtcc tctctgtgct gaggtccagc
3721 ccctccagca ccactttggc ttatcgtatc ctcctcctgg acttnccctc tctgccgaac
3781 acacatccca ggcg
//