LOCUS       AF046079                3583 bp    mRNA    linear   HUM 05-AUG-1999
DEFINITION  Homo sapiens similar to protein kinase (BUBR1) mRNA, complete cds.
ACCESSION   AF046079
VERSION     AF046079.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3583)
  AUTHORS   Cahill,D.P., Lengauer,C., Yu,J., Riggins,G.J., Willson,J.K.,
            Markowitz,S.D., Kinzler,K.W. and Vogelstein,B.
  TITLE     Mutations of mitotic checkpoint genes in human cancers
  JOURNAL   Nature 392 (6673), 300-303 (1998)
   PUBMED   9521327
REFERENCE   2  (bases 1 to 3583)
  AUTHORS   Cahill,D.P., Lengauer,C.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-FEB-1998) Oncology, Johns Hopkins, 424 North Bond
            Street Room 109, Baltimore, MD 21231
REFERENCE   3  (bases 1 to 3583)
  AUTHORS   Cahill,D.P., Lengauer,C.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-1999) Oncology, Johns Hopkins, 424 North Bond
            Street Room 109, Baltimore, MD 21231
  REMARK    Sequence update by submitter
COMMENT     On Aug 5, 1999 this sequence version replaced AF046079.1.
FEATURES             Location/Qualifiers
     source          1..3583
                     /db_xref="H-InvDB:HIT000064012"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14-q21"
     gene            1..3583
                     /gene="BUBR1"
     CDS             43..3195
                     /gene="BUBR1"
                     /note="similar to protein kinase"
                     /codon_start=1
                     /protein_id="AAC12730.2"
                     /translation="MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGA
                     LAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLL
                     ERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAE
                     EYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFE
                     SSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFD
                     ENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVP
                     AVLPSFTPYVEETAQQPVMTPCKIEPSINHILSTRKPGKEEGDPLQRVQSHQQASEEK
                     KEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEME
                     KKLKEIQTTQQERTGDQQEETMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARET
                     SLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAVLKTSES
                     ITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHE
                     IMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTLSIKKLSPIIEDSREATHS
                     SGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS
                     AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSS
                     QPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYITH
                     EITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSY
                     SVDLRVQLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVF
                     WDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFDTTFQSH
                     LNKALWKVGKLTSPGALLFQ"
     variation       161
                     /gene="BUBR1"
                     /replace="t"
     variation       324
                     /gene="BUBR1"
                     /replace="g"
     variation       1088
                     /gene="BUBR1"
                     /replace="g"
     variation       1206
                     /gene="BUBR1"
                     /replace="a"
     variation       1665
                     /gene="BUBR1"
                     /replace="c"
     variation       1895
                     /gene="BUBR1"
                     /replace="c"
     variation       3306
                     /gene="BUBR1"
                     /replace="g"
BASE COUNT         1140 a          719 c          791 g          933 t
ORIGIN      
        1 aaaggcctgc agcaggacga ggacctgagc caggaatgca ggatggcggc ggtgaagaag
       61 gaagggggtg ctctgagtga agccatgtcc ctggagggag atgaatggga actgagtaaa
      121 gaaaatgtac aacctttaag gcaagggcgg atcatgtcca cgcttcaggg agcactggca
      181 caagaatctg cctgtaacaa tactcttcag cagcagaaac gggcatttga atatgaaatt
      241 cgattttaca ctggaaatga ccctctggat gtttgggata ggtatatcag ctggacagag
      301 cagaactatc ctcaaggtgg gaaagagagt aatatgtcaa cgttattaga aagagctgta
      361 gaagcactac aaggagaaaa acgatattat agtgatcctc gatttctcaa tctctggctt
      421 aaattagggc gtttatgcaa tgagcctttg gatatgtaca gttacttgca caaccaaggg
      481 attggtgttt cacttgctca gttctatatc tcatgggcag aagaatatga agctagagaa
      541 aactttagga aagcagatgc gatatttcag gaagggattc aacagaaggc tgaaccacta
      601 gaaagactac agtcccagca ccgacaattc caagctcgag tgtctcggca aactctgttg
      661 gcacttgaga aagaagaaga ggaggaagtt tttgagtctt ctgtaccaca acgaagcaca
      721 ctagctgaac taaagagcaa agggaaaaag acagcaagag ctccaatcat ccgtgtagga
      781 ggtgctctca aggctccaag ccagaacaga ggactccaaa atccatttcc tcaacagatg
      841 caaaataata gtagaattac tgtttttgat gaaaatgctg atgaggcttc tacagcagag
      901 ttgtctaagc ctacagtcca gccatggata gcacccccca tgcccagggc caaagagaat
      961 gagctgcaag caggcccttg gaacacaggc aggtccttgg aacacaggcc tcgtggcaat
     1021 acagcttcac tgatagctgt acccgctgtg cttcccagtt tcactccata tgtggaagag
     1081 actgcacaac agccagttat gacaccatgt aaaattgaac ctagtataaa ccacatccta
     1141 agcaccagaa agcctggaaa ggaagaagga gatcctctac aaagggttca gagccatcag
     1201 caagcgtctg aggagaagaa agagaagatg atgtattgta aggagaagat ttatgcagga
     1261 gtaggggaat tctcctttga agaaattcgg gctgaagttt tccggaagaa attaaaagag
     1321 caaagggaag ccgagctatt gaccagtgca gagaagagag cagaaatgca gaaacagatt
     1381 gaagagatgg agaagaagct aaaagaaatc caaactactc agcaagaaag aacaggtgat
     1441 cagcaagaag agacgatgcc tacaaaggag acaactaaac tgcaaattgc ttccgagtct
     1501 cagaaaatac caggaatgac tctatccagt tctgtttgtc aagtaaactg ttgtgccaga
     1561 gaaacttcac ttgcggagaa catttggcag gaacaacctc attctaaagg tcccagtgta
     1621 cctttctcca tttttgatga gtttcttctt tcagaaaaga agaataaaag tcctcctgca
     1681 gatcccccac gagttttagc tcaacgaaga ccccttgcag ttctcaaaac ctcagaaagc
     1741 atcacctcaa atgaagatgt gtctccagat gtttgtgatg aatttacagg aattgaaccc
     1801 ttgagcgagg atgccattat cacaggcttc agaaatgtaa caatttgtcc taacccagaa
     1861 gacacttgtg actttgccag agcagctcgt tttgtatcca ctccttttca tgagataatg
     1921 tccttgaagg atctcccttc tgatcctgag agactgttac cggaagaaga tctagatgta
     1981 aagacctctg aggaccagca gacagcttgt ggcactatct acagtcagac tctcagcatc
     2041 aagaagctga gcccaattat tgaagacagt cgtgaagcca cacactcctc tggcttctct
     2101 ggttcttctg cctcggttgc aagcacctcc tccatcaaat gtcttcaaat tcctgagaaa
     2161 ctagaactta ctaatgagac ttcagaaaac cctactcagt caccatggtg ttcacagtat
     2221 cgcagacagc tactgaagtc cctaccagag ttaagtgcct ctgcagagtt gtgtatagaa
     2281 gacagaccaa tgcctaagtt ggaaattgag aaggaaattg aattaggtaa tgaggattac
     2341 tgcattaaac gagaatacct aatatgtgaa gattacaagt tattctgggt ggcgccaaga
     2401 aactctgcag aattaacagt aataaaggta tcttctcaac ctgtcccatg ggacttttat
     2461 atcaacctca agttaaagga acgtttaaat gaagattttg atcatttttg cagctgttat
     2521 caatatcaag atggctgtat tgtttggcac caatatataa actgcttcac ccttcaggat
     2581 cttctccaac acagtgaata tattacccat gaaataacag tgttgattat ttataacctt
     2641 ttgacaatag tggagatgct acacaaagca gaaatagtcc atggtgactt gagtccaagg
     2701 tgtctgattc tcagaaacag aatccacgat ccctatgatt gtaacaagaa caatcaagct
     2761 ttgaagatag tggacttttc ctacagtgtt gaccttaggg tgcagctgga tgtttttacc
     2821 ctcagcggct ttcggactgt acagatcctg gaaggacaaa agatcctggc taactgttct
     2881 tctccctacc aggtagacct gtttggtata gcagatttag cacatttact attgttcaag
     2941 gaacacctac aggtcttctg ggatgggtcc ttctggaaac ttagccaaaa tatttctgag
     3001 ctaaaagatg gtgaattgtg gaataaattc tttgtgcgga ttctgaatgc caatgatgag
     3061 gccacagtgt ctgttcttgg ggagcttgca gcagaaatga atggggtttt tgacactaca
     3121 ttccaaagtc acctgaacaa agccttatgg aaggtaggga agttaactag tcctggggct
     3181 ttgctctttc agtgagctag gcaatcaagt ctcacagatt gctgcctcag agcaatggtt
     3241 gtattgtgga acactgaaac tgtatgtgct gtaatttaat ttaggacaca tttagatgca
     3301 ctaccattgc tgttctactt tttggtacag gtatattttg acgtcactga tattttttat
     3361 acagtgatat acttactcat ggccttgtct aacttttgtg aagaactatt ttattctaaa
     3421 cagactcatt acaaatggtt accttgttat ttaacccatt tgtctctact tttccctgta
     3481 cttttcccat ttgtaatttg taaaatgttc tcttatgatc accatgtatt ttgtaaataa
     3541 taaaatagta tctgttaaaa aaaaaaaaaa aaaaaaaaaa aaa
//