LOCUS AF046079 3583 bp mRNA linear HUM 05-AUG-1999 DEFINITION Homo sapiens similar to protein kinase (BUBR1) mRNA, complete cds. ACCESSION AF046079 VERSION AF046079.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3583) AUTHORS Cahill,D.P., Lengauer,C., Yu,J., Riggins,G.J., Willson,J.K., Markowitz,S.D., Kinzler,K.W. and Vogelstein,B. TITLE Mutations of mitotic checkpoint genes in human cancers JOURNAL Nature 392 (6673), 300-303 (1998) PUBMED 9521327 REFERENCE 2 (bases 1 to 3583) AUTHORS Cahill,D.P., Lengauer,C.L., Kinzler,K.W. and Vogelstein,B. TITLE Direct Submission JOURNAL Submitted (05-FEB-1998) Oncology, Johns Hopkins, 424 North Bond Street Room 109, Baltimore, MD 21231 REFERENCE 3 (bases 1 to 3583) AUTHORS Cahill,D.P., Lengauer,C.L., Kinzler,K.W. and Vogelstein,B. TITLE Direct Submission JOURNAL Submitted (05-AUG-1999) Oncology, Johns Hopkins, 424 North Bond Street Room 109, Baltimore, MD 21231 REMARK Sequence update by submitter COMMENT On Aug 5, 1999 this sequence version replaced AF046079.1. FEATURES Location/Qualifiers source 1..3583 /db_xref="H-InvDB:HIT000064012" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="15" /map="15q14-q21" gene 1..3583 /gene="BUBR1" CDS 43..3195 /gene="BUBR1" /note="similar to protein kinase" /codon_start=1 /protein_id="AAC12730.2" /translation="MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGA LAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLL ERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAE EYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFE SSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFD ENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVP AVLPSFTPYVEETAQQPVMTPCKIEPSINHILSTRKPGKEEGDPLQRVQSHQQASEEK KEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEME KKLKEIQTTQQERTGDQQEETMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARET SLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAVLKTSES ITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHE IMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTLSIKKLSPIIEDSREATHS SGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSS QPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYITH EITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSY SVDLRVQLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVF WDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFDTTFQSH LNKALWKVGKLTSPGALLFQ" variation 161 /gene="BUBR1" /replace="t" variation 324 /gene="BUBR1" /replace="g" variation 1088 /gene="BUBR1" /replace="g" variation 1206 /gene="BUBR1" /replace="a" variation 1665 /gene="BUBR1" /replace="c" variation 1895 /gene="BUBR1" /replace="c" variation 3306 /gene="BUBR1" /replace="g" BASE COUNT 1140 a 719 c 791 g 933 t ORIGIN 1 aaaggcctgc agcaggacga ggacctgagc caggaatgca ggatggcggc ggtgaagaag 61 gaagggggtg ctctgagtga agccatgtcc ctggagggag atgaatggga actgagtaaa 121 gaaaatgtac aacctttaag gcaagggcgg atcatgtcca cgcttcaggg agcactggca 181 caagaatctg cctgtaacaa tactcttcag cagcagaaac gggcatttga atatgaaatt 241 cgattttaca ctggaaatga ccctctggat gtttgggata ggtatatcag ctggacagag 301 cagaactatc ctcaaggtgg gaaagagagt aatatgtcaa cgttattaga aagagctgta 361 gaagcactac aaggagaaaa acgatattat agtgatcctc gatttctcaa tctctggctt 421 aaattagggc gtttatgcaa tgagcctttg gatatgtaca gttacttgca caaccaaggg 481 attggtgttt cacttgctca gttctatatc tcatgggcag aagaatatga agctagagaa 541 aactttagga aagcagatgc gatatttcag gaagggattc aacagaaggc tgaaccacta 601 gaaagactac agtcccagca ccgacaattc caagctcgag tgtctcggca aactctgttg 661 gcacttgaga aagaagaaga ggaggaagtt tttgagtctt ctgtaccaca acgaagcaca 721 ctagctgaac taaagagcaa agggaaaaag acagcaagag ctccaatcat ccgtgtagga 781 ggtgctctca aggctccaag ccagaacaga ggactccaaa atccatttcc tcaacagatg 841 caaaataata gtagaattac tgtttttgat gaaaatgctg atgaggcttc tacagcagag 901 ttgtctaagc ctacagtcca gccatggata gcacccccca tgcccagggc caaagagaat 961 gagctgcaag caggcccttg gaacacaggc aggtccttgg aacacaggcc tcgtggcaat 1021 acagcttcac tgatagctgt acccgctgtg cttcccagtt tcactccata tgtggaagag 1081 actgcacaac agccagttat gacaccatgt aaaattgaac ctagtataaa ccacatccta 1141 agcaccagaa agcctggaaa ggaagaagga gatcctctac aaagggttca gagccatcag 1201 caagcgtctg aggagaagaa agagaagatg atgtattgta aggagaagat ttatgcagga 1261 gtaggggaat tctcctttga agaaattcgg gctgaagttt tccggaagaa attaaaagag 1321 caaagggaag ccgagctatt gaccagtgca gagaagagag cagaaatgca gaaacagatt 1381 gaagagatgg agaagaagct aaaagaaatc caaactactc agcaagaaag aacaggtgat 1441 cagcaagaag agacgatgcc tacaaaggag acaactaaac tgcaaattgc ttccgagtct 1501 cagaaaatac caggaatgac tctatccagt tctgtttgtc aagtaaactg ttgtgccaga 1561 gaaacttcac ttgcggagaa catttggcag gaacaacctc attctaaagg tcccagtgta 1621 cctttctcca tttttgatga gtttcttctt tcagaaaaga agaataaaag tcctcctgca 1681 gatcccccac gagttttagc tcaacgaaga ccccttgcag ttctcaaaac ctcagaaagc 1741 atcacctcaa atgaagatgt gtctccagat gtttgtgatg aatttacagg aattgaaccc 1801 ttgagcgagg atgccattat cacaggcttc agaaatgtaa caatttgtcc taacccagaa 1861 gacacttgtg actttgccag agcagctcgt tttgtatcca ctccttttca tgagataatg 1921 tccttgaagg atctcccttc tgatcctgag agactgttac cggaagaaga tctagatgta 1981 aagacctctg aggaccagca gacagcttgt ggcactatct acagtcagac tctcagcatc 2041 aagaagctga gcccaattat tgaagacagt cgtgaagcca cacactcctc tggcttctct 2101 ggttcttctg cctcggttgc aagcacctcc tccatcaaat gtcttcaaat tcctgagaaa 2161 ctagaactta ctaatgagac ttcagaaaac cctactcagt caccatggtg ttcacagtat 2221 cgcagacagc tactgaagtc cctaccagag ttaagtgcct ctgcagagtt gtgtatagaa 2281 gacagaccaa tgcctaagtt ggaaattgag aaggaaattg aattaggtaa tgaggattac 2341 tgcattaaac gagaatacct aatatgtgaa gattacaagt tattctgggt ggcgccaaga 2401 aactctgcag aattaacagt aataaaggta tcttctcaac ctgtcccatg ggacttttat 2461 atcaacctca agttaaagga acgtttaaat gaagattttg atcatttttg cagctgttat 2521 caatatcaag atggctgtat tgtttggcac caatatataa actgcttcac ccttcaggat 2581 cttctccaac acagtgaata tattacccat gaaataacag tgttgattat ttataacctt 2641 ttgacaatag tggagatgct acacaaagca gaaatagtcc atggtgactt gagtccaagg 2701 tgtctgattc tcagaaacag aatccacgat ccctatgatt gtaacaagaa caatcaagct 2761 ttgaagatag tggacttttc ctacagtgtt gaccttaggg tgcagctgga tgtttttacc 2821 ctcagcggct ttcggactgt acagatcctg gaaggacaaa agatcctggc taactgttct 2881 tctccctacc aggtagacct gtttggtata gcagatttag cacatttact attgttcaag 2941 gaacacctac aggtcttctg ggatgggtcc ttctggaaac ttagccaaaa tatttctgag 3001 ctaaaagatg gtgaattgtg gaataaattc tttgtgcgga ttctgaatgc caatgatgag 3061 gccacagtgt ctgttcttgg ggagcttgca gcagaaatga atggggtttt tgacactaca 3121 ttccaaagtc acctgaacaa agccttatgg aaggtaggga agttaactag tcctggggct 3181 ttgctctttc agtgagctag gcaatcaagt ctcacagatt gctgcctcag agcaatggtt 3241 gtattgtgga acactgaaac tgtatgtgct gtaatttaat ttaggacaca tttagatgca 3301 ctaccattgc tgttctactt tttggtacag gtatattttg acgtcactga tattttttat 3361 acagtgatat acttactcat ggccttgtct aacttttgtg aagaactatt ttattctaaa 3421 cagactcatt acaaatggtt accttgttat ttaacccatt tgtctctact tttccctgta 3481 cttttcccat ttgtaatttg taaaatgttc tcttatgatc accatgtatt ttgtaaataa 3541 taaaatagta tctgttaaaa aaaaaaaaaa aaaaaaaaaa aaa //