LOCUS AF046078 3446 bp mRNA linear HUM 07-APR-1998
DEFINITION Homo sapiens protein kinase (BUB1) mRNA, complete cds.
ACCESSION AF046078
VERSION AF046078.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3446)
AUTHORS Cahill,D.P., Lengauer,C., Yu,J., Riggins,G.J., Willson,J.K.,
Markowitz,S.D., Kinzler,K.W. and Vogelstein,B.
TITLE Mutations of mitotic checkpoint genes in human cancers
JOURNAL Nature 392 (6673), 300-303 (1998)
PUBMED 9521327
REFERENCE 2 (bases 1 to 3446)
AUTHORS Cahill,D.P., Lengauer,C.L., Kinzler,K.W. and Vogelstein,B.
TITLE Direct Submission
JOURNAL Submitted (05-FEB-1998) Oncology, Johns Hopkins, 424 North Bond
Street Room 109, Baltimore, MD 21231
FEATURES Location/Qualifiers
source 1..3446
/db_xref="H-InvDB:HIT000064011"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q12-q14"
gene 1..3446
/gene="BUB1"
CDS 50..3307
/gene="BUB1"
/codon_start=1
/product="protein kinase"
/protein_id="AAC12729.1"
/translation="MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEY
LITLLEHLMKEFLDKKKYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLY
IAWAGHLEAQGELQHASAVLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSE
PLHNVQVLNQMITSKSNPGNNMACISKNQGSELSGVISSACDKESNMERRVITISKSE
YSVHSSLASKVDVEQVVMYCKEKLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYM
KRKEANAFEEQLLKQKMDELHKKLHQVVETSHEDLPASQERSEVNPARMGPSVGSQQE
LRAPCLPVTYQQTPVNMEKNPREAPPVVPPLANAISAALVSPATSQSIAPPVPLKAQT
VTDSMFAVASKDAGCVNKSTHEFKPQSGAEIKEGCETHKVANTSSFHTTPNTSLGMVQ
ATPSKVQPSPTVHTKEALGFIMNMFQAPTLPDISDDKDEWQSLDQNEDAFEAQFQKNV
RSSGAWGVNKIISSLSSAFHVFEDGNKENYGLPQPKNKPTGARTFGERSVSRLPSKPK
EEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDFTSAAQLASTPFHKLPVESVHILED
KENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEKSPKQALSSHMYSASLLRLSQPA
AGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGN
PWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAF
AQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAH
LFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEII
HGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQ
CVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNE
FFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK"
BASE COUNT 1072 a 706 c 749 g 919 t
ORIGIN
1 ttctagtttg cggttcaggt ttgccgctgc cggccagcgt cctctggcca tggacacccc
61 ggaaaatgtc cttcagatgc ttgaagccca catgcagagc tacaagggca atgaccctct
121 tggtgaatgg gaaagataca tacagtgggt agaagagaat tttcctgaga ataaagaata
181 cttgataact ttactagaac atttaatgaa ggaattttta gataagaaga aataccacaa
241 tgacccaaga ttcatcagtt attgtttaaa atttgctgag tacaacagtg acctccatca
301 attttttgag tttctgtaca accatgggat tggaaccctg tcatcccctc tgtacattgc
361 ctgggcgggg catctggaag cccaaggaga gctgcagcat gccagtgctg tccttcagag
421 aggaattcaa aaccaggctg aacccagaga gttcctgcaa caacaataca ggttatttca
481 gacacgcctc actgaaaccc atttgccagc tcaagctaga acctcagaac ctctgcataa
541 tgttcaggtt ttaaatcaaa tgataacatc aaaatcaaat ccaggaaata acatggcctg
601 catttctaag aatcagggtt cagagctttc tggagtgata tcttcagctt gtgataaaga
661 gtcaaatatg gaacgaagag tgatcacgat ttctaaatca gaatattctg tgcactcatc
721 tttggcatcc aaagttgatg ttgagcaggt tgttatgtat tgcaaggaga agcttattcg
781 tggggaatca gaattttcct ttgaagaatt gagagcccag aaatacaatc aacggagaaa
841 gcatgagcaa tgggtaaatg aagacagaca ttatatgaaa aggaaagaag caaatgcttt
901 tgaagaacag ctattaaaac agaaaatgga tgaacttcat aagaagttgc atcaggtggt
961 ggagacatcc catgaggatc tgcccgcttc ccaggaaagg tccgaggtta atccagcacg
1021 tatggggcca agtgtaggct cccagcagga actgagagcg ccatgtcttc cagtaaccta
1081 tcagcagaca ccagtgaaca tggaaaagaa cccaagagag gcacctcctg ttgttcctcc
1141 tttggcaaat gctatttctg cagctttggt gtccccagcc accagccaga gcattgctcc
1201 tcctgttcct ttgaaagccc agacagtaac agactccatg tttgcagtgg ccagcaaaga
1261 tgctggatgt gtgaataaga gtactcatga attcaagcca cagagtggag cagagatcaa
1321 agaagggtgt gaaacacata aggttgccaa cacaagttct tttcacacaa ctccaaacac
1381 atcactggga atggttcagg caacgccatc caaagtgcag ccatcaccca ccgtgcacac
1441 aaaagaagca ttaggtttca tcatgaatat gtttcaggct cctacacttc ctgatatttc
1501 tgatgacaaa gatgaatggc aatctctaga tcaaaatgaa gatgcatttg aagcccagtt
1561 tcaaaaaaat gtaaggtcat ctggggcttg gggagtcaat aagatcatct cttctttgtc
1621 atctgctttt catgtgtttg aagatggaaa caaagaaaat tatggattac cacagcctaa
1681 aaataaaccc acaggagcca ggacctttgg agaacgctct gtcagcagac ttccttcaaa
1741 accaaaggag gaagtgcctc atgctgaaga gtttttggat gactcaactg tatggggtat
1801 tcgctgcaac aaaaccctgg cacccagtcc taagagccca ggagacttca catctgctgc
1861 acaacttgcg tctacaccat tccacaagct tccagtggag tcagtgcaca ttttagaaga
1921 taaagaaaat gtggtagcaa aacagtgtac ccaggcgact ttggattctt gtgaggaaaa
1981 catggtggtg ccttcaaggg atggaaaatt cagtccaatt caagagaaaa gcccaaaaca
2041 ggccttgtcg tctcacatgt attcagcatc cttacttcgt ctgagccagc ctgctgcagg
2101 tggggtactt acctgtgagg cagagttggg cgttgaggct tgcagactca cagacactga
2161 cgctgccatt gcagaagatc caccagatgc tattgctggg ctccaagcag aatggatgca
2221 gatgagttca cttgggactg ttgatgctcc aaacttcatt gttgggaacc catgggatga
2281 taagctgatt ttcaaacttt tatctgggct ttctaaacca gtgagttcct atccaaatac
2341 ttttgaatgg caatgtaaac ttccagccat caagcccaag actgaatttc aattgggttc
2401 taagctggtc tatgtccatc accttcttgg agaaggagcc tttgcccagg tgtacgaagc
2461 tacccaggga gatctgaatg atgctaaaaa taaacagaaa tttgttttaa aggtccaaaa
2521 gcctgccaac ccctgggaat tctacattgg gacccagttg atggaaagac taaagccatc
2581 tatgcagcac atgtttatga agttctattc tgcccactta ttccagaatg gcagtgtatt
2641 agtaggagag ctctacagct atggaacatt attaaatgcc attaacctct ataaaaatac
2701 ccctgaaaaa gtgatgcctc aaggtcttgt catctctttt gctatgagaa tgctttacat
2761 gattgagcaa gtgcatgact gtgaaatcat tcatggagac attaaaccag acaatttcat
2821 acttggaaac ggatttttgg aacaggatga tgaagatgat ttatctgctg gcttggcact
2881 gattgacctg ggtcagagta tagatatgaa actttttcca aaaggaacta tattcacagc
2941 aaagtgtgaa acatctggtt ttcagtgtgt tgagatgctc agcaacaaac catggaacta
3001 ccagatcgat tactttgggg ttgctgcaac agtatattgc atgctctttg gcacttacat
3061 gaaagtgaaa aatgaaggag gagagtgtaa gcctgaaggt ctttttagaa ggcttcctca
3121 tttggatatg tggaatgaat tttttcatgt tatgttgaat attccagatt gtcatcatct
3181 tccatctttg gatttgttaa ggcaaaagct gaagaaagta tttcaacaac actatactaa
3241 caagattagg gccctacgta ataggctaat tgtactgctc ttagaatgta agcgttcacg
3301 aaaataaaat ttggatatag acagtcctta aaaatcacac tgtaaatatg aatctgctca
3361 ctttaaacct gttttttttt catttattgt ttatgtaaat gtttgttaaa aataaatccc
3421 atggaatatt tccatgtaaa aaaaaa
//