LOCUS       AF045161                2181 bp    mRNA    linear   HUM 06-MAR-1998
DEFINITION  Homo sapiens cyclin T mRNA, complete cds.
ACCESSION   AF045161
VERSION     AF045161.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2181)
  AUTHORS   Wei,P., Garber,M.E., Fang,S.M., Fischer,W.H. and Jones,K.A.
  TITLE     A novel CDK9-associated C-type cyclin interacts directly with HIV-1
            Tat and mediates its high-affinity, loop-specific binding to TAR
            RNA
  JOURNAL   Cell 92 (4), 451-462 (1998)
   PUBMED   9491887
REFERENCE   2  (bases 1 to 2181)
  AUTHORS   Wei,P., Garber,M.E., Fang,S.M., Fischer,W.H. and Jones,K.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JAN-1998) Regulatory Biology, The Salk Institute,
            10010 N. Torrey Pines Road, La Jolla, CA 92037, USA
FEATURES             Location/Qualifiers
     source          1..2181
                     /db_xref="H-InvDB:HIT000063975"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="270 cR from top"
                     /clone_lib="Jurkat"
     CDS             1..2181
                     /function="C-type cyclin partner for CDK9 (PITALRE)"
                     /note="87 kDa nuclear protein; required for RNAPII
                     transcription elongation at many genes; interacts
                     specifically with the transcriptional activation domain of
                     HIV-1 Tat; binds co-operatively with Tat to TAR RNA;
                     TAK/P-TEFb transcription elongation factor complex
                     component; confirmed by peptide sequence analysis of the
                     HeLa cyclin T protein; is widely expressed"
                     /codon_start=1
                     /product="cyclin T"
                     /protein_id="AAC39638.1"
                     /translation="MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANL
                     LQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLE
                     HVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKC
                     TQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDG
                     KHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDE
                     KTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRW
                     LSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEY
                     RAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERP
                     FLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKE
                     KHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFS
                     SSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLS
                     FSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFE
                     FVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK"
BASE COUNT          642 a          560 c          455 g          524 t
ORIGIN      
        1 atggagggag agaggaagaa caacaacaaa cggtggtatt tcactcgaga acagctggaa
       61 aatagcccat cccgtcgttt tggcgtggac ccagataaag aactttctta tcgccagcag
      121 gcggccaatc tgcttcagga catggggcag cgtcttaacg tctcacaatt gactatcaac
      181 actgctatag tatacatgca tcgattctac atgattcagt ccttcacaca gttccctgga
      241 aattctgtgg ctccagcagc cttgtttcta gcagctaaag tggaggagca gcccaaaaaa
      301 ttggaacatg tcatcaaggt agcacatact tgtctccatc ctcaggaatc ccttcctgat
      361 actagaagtg aggcttattt gcaacaagtt caagatctgg tcattttaga aagcataatt
      421 ttgcagactt taggctttga actaacaatt gatcacccac atactcatgt agtaaagtgc
      481 actcaacttg ttcgagcaag caaggactta gcacagactt cttacttcat ggcaaccaac
      541 agcctgcatt tgaccacatt tagcctgcag tacacacctc ctgtggtggc ctgtgtctgc
      601 attcacctgg cttgcaagtg gtccaattgg gagatcccag tctcaactga cgggaagcac
      661 tggtgggagt atgttgacgc cactgtgacc ttggaacttt tagatgaact gacacatgag
      721 tttctacaga ttttggagaa aactcccaac aggctcaaac gcatttggaa ttggagggca
      781 tgcgaggctg ccaagaaaac aaaagcagat gaccgaggaa cagatgaaaa gacttcagag
      841 cagacaatcc tcaatatgat ttcccagagc tcttcagaca caaccattgc aggtttaatg
      901 agcatgtcaa cttctaccac aagtgcagtg ccttccctgc cagtctccga agagtcatcc
      961 agcaacttaa ccagtgtgga gatgttgccg ggcaagcgtt ggctgtcctc ccaaccttct
     1021 ttcaaactag aacctactca gggtcatcgg actagtgaga atttagcact tacaggagtt
     1081 gatcattcct taccacagga tggttcaaat gcatttattt cccagaagca gaatagtaag
     1141 agtgtgccat cagctaaagt gtcactgaaa gaataccgcg cgaagcatgc agaagaattg
     1201 gctgcccaga agaggcaact ggagaacatg gaagccaatg tgaagtcaca atatgcatat
     1261 gctgcccaga atctcctttc tcatcatgat agccattctt cagtcattct aaaaatgccc
     1321 atagagggtt cagaaaaccc cgagcggcct tttctggaaa aggctgacaa aacagctctc
     1381 aaaatgagaa tcccagtggc aggtggagat aaagctgcgt cttcaaaacc agaggagata
     1441 aaaatgcgca taaaagtcca tgctgcagct gataagcaca attctgtaga ggacagtgtt
     1501 acaaagagcc gagagcacaa agaaaagcac aagactcacc catctaatca tcatcatcat
     1561 cataatcacc actcacacaa gcactctcat tcccaacttc cagttggtac tgggaacaaa
     1621 cgtcctggtg atccaaaaca tagtagccag acaagcaact tagcacataa aacctatagc
     1681 ttgtctagtt ctttttcctc ttccagttct actcgtaaaa ggggaccctc tgaagagact
     1741 ggaggggctg tgtttgatca tccagccaag attgccaaga gtactaaatc ctcttcccta
     1801 aatttctcct tcccttcact tcctacaatg ggtcagatgc ctgggcatag ctcagacaca
     1861 agtggccttt ccttttcaca gcccagctgt aaaactcgtg tccctcattc gaaactggat
     1921 aaagggccca ctggggccaa tggtcacaac acgacccaga caatagacta tcaagacact
     1981 gtgaatatgc ttcactccct gctcagtgcc cagggtgttc agcccactca gcctactgca
     2041 tttgaatttg ttcgtcctta tagtgactat ctgaatcctc ggtctggtgg aatctcctcg
     2101 agatctggca atacagacaa accccggcca ccacctctgc catcagaacc tcctccacca
     2161 cttccacccc ttcctaagta a
//