LOCUS AF043472 2097 bp mRNA linear HUM 04-JAN-2000
DEFINITION Homo sapiens Shab-related delayed-rectifier K+ channel alpha
subunit (KCNS3) mRNA, complete cds.
ACCESSION AF043472
VERSION AF043472.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2097)
AUTHORS Shepard,A.R. and Rae,J.L.
TITLE Electrically silent potassium channel subunits from human lens
epithelium
JOURNAL Am. J. Physiol. 277 (3 Pt 1), C412-C424 (1999)
PUBMED 10484328
REFERENCE 2 (bases 1 to 2097)
AUTHORS Rae,J.L. and Shepard,A.R.
TITLE Direct Submission
JOURNAL Submitted (16-JAN-1998) Physiology and Biophysics, Mayo Foundation,
200 1st Street, SW, Rochester, MN 55905, USA
FEATURES Location/Qualifiers
source 1..2097
/db_xref="H-InvDB:HIT000063745"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p24"
/tissue_type="lens epithelium"
gene 1..2097
/gene="KCNS3"
CDS 132..1607
/gene="KCNS3"
/note="electrically silent"
/codon_start=1
/product="Shab-related delayed-rectifier K+ channel alpha
subunit"
/protein_id="AAC13164.1"
/translation="MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKL
LTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQE
IEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFD
TLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVD
DPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKE
EESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVG
ISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCII
CGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQRMHA
FITSLSSVGIVVSDPDSTDASSIEDNEDICNTTSLENCTAK"
variation 1479
/gene="KCNS3"
/note="this polymorphism would result in an Ala-->Thr
change in the amino acid translation"
/replace="a"
BASE COUNT 532 a 478 c 511 g 576 t
ORIGIN
1 agcttcttgg atgatgatgg acgtcccacc gggcaggatg aaggcagagc gtgtggcatc
61 tccacctcaa gggtgcagcc tgatcttcct cttctccctt gccagccagc actctgcctt
121 ctgtatccac catggtgttt ggtgagtttt tccatcgccc tggacaagac gaggaacttg
181 tcaacctgaa tgtggggggc tttaagcagt ctgttgacca aagcaccctc ctgcggtttc
241 ctcacaccag actggggaag ctgcttactt gccattctga agaggccatt ctggagctgt
301 gtgatgatta cagtgtggcc gataaggaat actactttga tcggaatccc tccttgttca
361 gatatgtttt gaatttttat tacacgggga agctgcatgt catggaggag ctgtgcgtat
421 tctcattctg ccaggagatc gagtactggg gcatcaacga gctcttcatt gattcttgct
481 gcagcaatcg ctaccaggaa cgcaaggagg aaaaccacga gaaggactgg gaccagaaaa
541 gccatgatgt gagtaccgac tcctcgtttg aagagtcgtc tctgtttgag aaagagctgg
601 agaagtttga cacactgcga tttggtcagc tccggaagaa aatctggatt agaatggaga
661 atccagcgta ctgcctgtcc gctaagctta tcgctatctc ctccttgagc gtggtgctgg
721 cctccatcgt ggccatgtgc gttcacagca tgtcggagtt ccagaatgag gatggagaag
781 tggatgatcc ggtgctggaa ggagtggaga tcgcgtgcat tgcctggttc accggggagc
841 ttgccgtccg gctggctgcc gctccttgtc aaaagaaatt ctggaaaaac cctctgaaca
901 tcattgactt tgtctctatt attcccttct atgccacgtt ggctgtagac accaaggagg
961 aagagagtga ggatattgag aacatgggca aggtggtcca gatcctacgg cttatgagga
1021 ttttccgaat tctaaagctt gcccggcact cggtaggact tcggtcttta ggtgccacac
1081 tgagacacag ctaccatgaa gttgggcttc tgcttctctt cctctctgtg ggcatttcca
1141 ttttctctgt gcttatctac tccgtggaga aagatgacca cacatccagc ctcaccagca
1201 tccccatctg ctggtggtgg gccaccatca gcatgacaac tgtgggctat ggagacaccc
1261 acccggtcac cttggcggga aagctcatcg ccagcacatg catcatctgt ggcatcttgg
1321 tggtggccct tcccatcacc atcatcttca acaagttttc caagtactac cagaagcaaa
1381 aggacattga tgtggaccag tgcagtgagg atgcaccaga gaagtgtcat gagctacctt
1441 actttaacat tagggatata tatgcacagc ggatgcacgc cttcattacc agtctctctt
1501 ctgtaggcat tgtggtgagc gatcctgact ccacagatgc ttcaagcatt gaagacaatg
1561 aggacatttg taacaccacc tccttggaga attgcacagc aaaatgagcg ggggtgtttg
1621 tgcctgtttc tcttatcctt tcccaacatt aggttaacac agctttataa acctcagtgg
1681 gttcgttaaa atcatttaat tctcagggtg tacctttcca gccatagttg gacattcatt
1741 gctgaattct gaaatgatag aattgtcttt atttttctct gtgaggtcaa ttaaatgcct
1801 tgttctgaaa tttatttttt acaagagaga gttgtgatat agtttggaat ataagataaa
1861 tggtattggg tggggtttgt ggctacagct tatgcatcat tctgtgtttg tcatttactc
1921 acattgagct aactttaaat tactgacaag tagaatcaaa ggtgcagctg actgagacga
1981 catgcatgta agatccacaa aatgagacaa tgcatgtaaa tccatgctca tgttctaaac
2041 atggaaacta ggagcctaat aaacttccta attcagtacg aaaaaaaaaa aaaaaaa
//