LOCUS AF042838 4693 bp mRNA linear HUM 24-JUL-2016
DEFINITION Homo sapiens MEK kinase 1 (MEKK1) mRNA, partial cds.
ACCESSION AF042838
VERSION AF042838.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4693)
AUTHORS Xia,Y., Wu,Z., Su,B., Murray,B. and Karin,M.
TITLE JNKK1 organizes a MAP kinase module through specific and sequential
interactions with upstream and downstream components mediated by
its amino-terminal extension
JOURNAL Genes Dev. 12 (21), 3369-3381 (1998)
PUBMED 9808624
REFERENCE 2 (bases 1 to 4693)
AUTHORS Xia,Y., Su,B. and Karin,M.
TITLE Direct Submission
JOURNAL Submitted (13-JAN-1998) Pharmacology, University of California at
San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
FEATURES Location/Qualifiers
source 1..4693
/db_xref="H-InvDB:HIT000063706"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="T cells; B cells"
gene <1..4693
/gene="MEKK1"
CDS <1..4488
/gene="MEKK1"
/note="protein kinase MEKK1"
/codon_start=1
/product="MEK kinase 1"
/protein_id="AAC97073.1"
/translation="PSPEAGGGGGALKASSARAAAAGLLREAGSGGRERADWRRRQLR
KVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRRG
AHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDR
PEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQ
ASAASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDG
FSPYSPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCAHGT
FCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKF
VSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHH
HCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQP
LAGSRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALR
RLSHDVSGALLLANGESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVC
ADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQL
SISTLLELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLC
LIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSR
RIYLSSARMVTTVPHVFSKLLEMLSVSSVSTHFTRMRRRLMAYADEVEIAEAIQLGVE
DTLQRQQHNSFCRHLFPTTIWKPQRTVPLECTVHLEKTGKGLCATKLSASSEDISERL
ARISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSPLSHHSQLMFPALSTPSSS
TPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPVFT
QSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDDSFGLSSNSSNCC
YTSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAEN
DDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQVALPIVPQLQVENGEDIIIIQQ
DTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRN
TSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSK
YGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARL
ASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEK
HSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTT
W"
BASE COUNT 1340 a 1102 c 1143 g 1108 t
ORIGIN
1 ccgagccctg aggcaggcgg cggcggagga gccctcaagg cgagcagcgc gcgcgcggct
61 gccgcgggac tgctgcggga ggcgggcagc gggggccgcg agcgggcgga ctggcggcgg
121 cggcagctgc gcaaagtgcg gagtgtggag ctggaccagc tgcctgagca gccgctcttc
181 cttgccgcct caccgccggc ctcctcgact tccccgtcgc cggagcccgc ggacgcagcg
241 gggagtggga ccggcttcca gcctgtggcg gtgccgccgc cccacggagc cgccagccgg
301 cgcggcgccc accttaccga gtcggtggcg gcgccggaca gcggcgcctc gagtcccgca
361 gcggccgagc ccggggagaa gcgggcgccc gccgccgagc cgtctcctgc agcggccccc
421 gccggtcgtg agatggagaa taaagaaact ctcaaagggt tgcacaagat ggatgatcgt
481 ccagaggaac gaatgatcag ggagaaactg aaggcaacct gtatgccagc ctggaagcac
541 gaatggttgg aaaggagaaa taggcgaggg cctgtggtgg taaaaccaat cccagttaaa
601 ggagatggat ctgaaatgaa tcacttagca gctgagtctc caggagaggt ccaggcaagt
661 gcggcttcac cagcttccaa aggccgacgc agtccttctc ctggcaactc cccatcaggt
721 cgcacagtga aatcagaatc tccaggagta aggagaaaaa gagtttcccc agtgcctttt
781 cagagtggca gaatcacacc accccgaaga gccccttcac cagatggctt ctcaccatat
841 agccctgagg aaacaaaccg ccgtgttaac aaagtgatgc gggccagact gtacttactg
901 cagcagatag ggcctaactc tttcctgatt ggaggagaca gcccagacaa taaataccgg
961 gtgtttattg ggcctcagaa ctgcagctgt gcacatggaa cattctgtat tcatctgcta
1021 tttgtgatgc tccgggtgtt tcaactagaa ccttcagacc caatgttatg gagaaaaact
1081 ttaaagaatt ttgaggttga gagtttgttc cagaaatatc acagtaggcg tagctcaagg
1141 atcaaagctc catctcgtaa caccatccag aagtttgttt cacgcatgtc aaattctcat
1201 acattgtcat catctagtac ttctacatct agttcagaaa acagcataaa ggatgaagag
1261 gaacagatgt gtcctatttg cttgttgggc atgcttgatg aagaaagtct tacagtgtgt
1321 gaagacggct gcaggaacaa gctgcaccac cactgcatgt caatttgggc agaagagtgt
1381 agaagaaata gagaaccttt aatatgtccc ctttgtagat ctaagtggag atctcatgat
1441 ttctacagcc acgagttgtc aagtcctgtg gattcccctt cttccctcag agctgcacag
1501 cagcaaaccg tacagcagca gcctttggct ggatcacgaa ggaatcaaga gagcaatttt
1561 aaccttactc attatggaac tcagcaaatc cctcctgctt acaaagattt agctgagcca
1621 tggattcagg tgtttggaat ggaactcgtt ggctgcttat tttctagaaa ctggaatgtg
1681 agagagatgg ccctcaggcg tctttcccat gatgtcagtg gggccctgct gttggcaaat
1741 ggggagagca ctggaaattc tgggggcagc agtggaagca gcccgagtgg gggagccacc
1801 agtgggtctt cccagaccag tatctcagga gatgtggtgg aggcatgctg cagcgttctg
1861 tcaatggtct gtgctgaccc tgtctacaaa gtgtacgttg ctgctttaaa aacattgaga
1921 gccatgctgg tatatactcc ttgccacagt ttagcggaaa gaatcaaact tcagagactt
1981 ctccagccag ttgtagacac catcctagtc aaatgtgcag atgccaatag ccgcacaagt
2041 cagctgtcca tatcaacact gttggaactg tgcaaaggcc aagcaggaga gttggcagtt
2101 ggcagagaaa tactaaaagc tggatccatt ggtattggtg gtgttgatta tgtcttaaat
2161 tgtattcttg gaaaccaaac tgaatcaaac aattggcaag aacttcttgg ccgcctttgt
2221 cttatagata gactgttgtt ggaatttcct gctgaatttt atcctcatat tgtcagtact
2281 gatgtttcac aagctgagcc tgttgaaatc aggtataaga agctgctgtc cctcttaacc
2341 tttgctttgc agtccattga taattcccac tcaatggttg gcaaactttc cagaaggatc
2401 tacttgagtt ctgcaagaat ggttactaca gtaccccatg tgttttcaaa actgttagaa
2461 atgctgagtg tttccagtgt ttccactcac ttcaccagga tgcgtcgccg tttgatggct
2521 tatgcagatg aggtggaaat tgccgaagcc atccagttgg gcgtagaaga cactttacaa
2581 cgacaacaac acaacagctt ttgcaggcat ctgttcccaa caactatctg gaaaccacag
2641 agaacagttc cccttgagtg cacagtccat ttagagaaaa ctggaaaagg attatgtgct
2701 acaaaattga gtgccagttc agaggacatt tctgagagac tggccaggat ttcagtagga
2761 ccttctagtt caacaacaac aacaacaaca acaacagagc aaccaaagcc aatggttcaa
2821 acaaaaggca gaccccacag tcagtgtttg aactcctctc ctttatctca tcattcccaa
2881 ttaatgtttc cagccttgtc aaccccttct tcttctaccc catctgtacc agctggcact
2941 gcaacagatg tctctaagca tagacttcag ggattcattc cctgcagaat accttctgca
3001 tctcctcaaa cacagcgcaa gttttctcta caattccaca gaaactgtcc tgaaaacaaa
3061 gactcagata aactttcccc agtctttact cagtcaagac ccttgccctc cagtaacata
3121 cacaggccaa agccatctcg acctacccca ggtaatacaa gtaaacaggg agatccctca
3181 aaaaatagca tgacacttga tctgaacagt agttccaaat gtgatgacag ctttggcttg
3241 agcagcaata gtagtaattg ctgttatacc agtgacgaga cagtgttcac cccagtagag
3301 gagaaatgca gattagatgt caatacagag ctcaactcca gtattgagga ccttcttgaa
3361 gcatctatgc cttcaagtga tacaacagta acttttaagt cagaagttgc tgtcctgtct
3421 cctgaaaagg ctgaaaatga tgatacctac aaagatgatg tgaatcataa tcaaaagtgc
3481 aaagagaaga tggaagctga agaagaagaa gctttagcaa ttgccatggc aatgtcagcg
3541 tctcaggtag ccctccccat agttcctcag ctgcaggttg aaaatggaga agatatcatc
3601 attattcaac aggatacacc agagactcta ccaggacata ccaaagcaaa acaaccgtat
3661 agagaagaca ctgaatggct gaaaggtcaa cagataggcc ttggagcatt ttcttcttgt
3721 tatcaggctc aagatgtggg aactggaact ttaatggctg ttaaacaggt gacttatgtc
3781 agaaacacat cttctgagca agaagaagta gtagaagcac taagagaaga gataagaatg
3841 atgagccatc tgaatcatcc aaacatcatt aggatgttgg gagccacgtg tgagaagagc
3901 aattacaatc tcttcattga atggatggca gggggatcgg tggctcattt gctgagtaaa
3961 tatggagcct tcaaagaatc agtagttatt aactacactg aacagttact ccgtggactt
4021 tcgtatctcc atgaaaacca aatcattcac agagatgtca aaggtgccaa tttgctaatt
4081 gacagcactg gtcagagact aagaattgca gattttggag ctgcagccag gttggcatca
4141 aaaggaactg gtgcaggaga gtttcaggga caattactgg ggacaattgc atttatggca
4201 cctgaggtac taagaggtca acagtatgga aggagctgtg atgtatggag tgttggctgt
4261 gctattatag aaatggcttg tgcaaaacca ccatggaatg cagaaaaaca ctccaatcat
4321 cttgctttga tatttaagat tgctagtgca actactgctc catcgatccc ttcacatttg
4381 tctcctggtt tacgagatgt ggctcttcgt tgtttagaac ttcaacctca ggacagacct
4441 ccatcaagag agctactgaa gcatccagtc tttcgtacta catggtagcc aattatacag
4501 atcaactacg tagaaacagg atgctcaaca agagaaaaaa aacttgtggg gaaccacatt
4561 gatatctacg gccatgatgc cactgaacag ctatgaacga ggccagtggg gaacccttac
4621 ctaagtatgt gattgacaaa tcatgatctg tacctaagct cagtatgcaa aagcccaaac
4681 tagtgcagaa act
//