LOCUS       AF040990                4956 bp    mRNA    linear   HUM 06-FEB-1998
DEFINITION  Homo sapiens roundabout 1 (robo1) mRNA, complete cds.
ACCESSION   AF040990
VERSION     AF040990.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4956)
  AUTHORS   Kidd,T., Brose,K., Mitchell,K.J., Fetter,R.D., Tessier-Lavigne,M.,
            Goodman,C.S. and Tear,G.
  TITLE     Roundabout controls axon crossing of the CNS midline and defines a
            novel subfamily of evolutionarily conserved guidance receptors
  JOURNAL   Cell 92 (2), 205-215 (1998)
   PUBMED   9458045
REFERENCE   2  (bases 1 to 4956)
  AUTHORS   Kidd,T., Brose,K., Mitchell,K.J., Fetter,R.D.,
            Tessier-Lavigne,M.T., Goodman,C.S. and Tear,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JAN-1998) MCB, UC Berkeley, Berkeley, CA 94720, USA
FEATURES             Location/Qualifiers
     source          1..4956
                     /db_xref="H-InvDB:HIT000063633"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..4956
                     /gene="robo1"
     CDS             1..4956
                     /gene="robo1"
                     /note="H-Robo1; axon guidance receptor homolog"
                     /codon_start=1
                     /product="roundabout 1"
                     /protein_id="AAC39575.1"
                     /translation="MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPI
                     PTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWY
                     KGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHN
                     ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERI
                     TIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD
                     DSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN
                     MVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL
                     LFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA
                     DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG
                     VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSK
                     PEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGL
                     KPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHN
                     PTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD
                     LRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSW
                     QPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAAST
                     GAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVF
                     SIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAA
                     QPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNL
                     MLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMN
                     NGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNT
                     GGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNI
                     SVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTAT
                     LTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVS
                     DMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSAS
                     EEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQ
                     CPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPT
                     AQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPRE
                     AQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSR
                     GSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES"
BASE COUNT         1480 a         1230 c         1186 g         1060 t
ORIGIN      
        1 atgaaatgga aacatgttcc ttttttggtc atgatatcac tcctcagctt atccccaaat
       61 cacctgtttc tggcccagct tattccagac cctgaagatg tagagagggg gaacgaccac
      121 gggacgccaa tccccacctc tgataacgat gacaattcgc tgggctatac aggctcccgt
      181 cttcgtcagg aagattttcc acctcgcatt gttgaacacc cttcagacct gattgtctca
      241 aaaggagaac ctgcaacttt gaactgcaaa gctgaaggcc gccccacacc cactattgaa
      301 tggtacaaag ggggagagag agtggagaca gacaaagatg accctcgctc acaccgaatg
      361 ttgctgccga gtggatcttt atttttctta cgtatagtac atggacggaa aagtagacct
      421 gatgaaggag tctatgtctg tgtagcaagg aattaccttg gagaggctgt gagccacaat
      481 gcatcgctgg aagtagccat acttcgggat gacttcagac aaaacccttc ggatgtcatg
      541 gttgcagtag gagagcctgc agtaatggaa tgccaacctc cacgaggcca tcctgagccc
      601 accatttcat ggaagaaaga tggctctcca ctggatgata aagatgaaag aataactata
      661 cgaggaggaa agctcatgat cacttacacc cgtaaaagtg acgctggcaa atatgtttgt
      721 gttggtacca atatggttgg ggaacgtgag agtgaagtag ccgagctgac tgtcttagag
      781 agaccatcat ttgtgaagag acccagtaac ttggcagtaa ctgtggatga cagtgcagaa
      841 tttaaatgtg aggcccgagg tgaccctgta cctacagtac gatggaggaa agatgatgga
      901 gagctgccca aatccagata tgaaatccga gatgatcata ccttgaaaat taggaaggtg
      961 acagctggtg acatgggttc atacacttgt gttgcagaaa atatggtggg caaagctgaa
     1021 gcatctgcta ctctgactgt tcaagaacct ccacattttg ttgtgaaacc ccgtgaccag
     1081 gttgttgctt tgggacggac tgtaactttt cagtgtgaag caaccggaaa tcctcaacca
     1141 gctattttct ggaggagaga agggagtcag aatctacttt tctcatatca accaccacag
     1201 tcatccagcc gattttcagt ctcccagact ggcgacctca caattactaa tgtccagcga
     1261 tctgatgttg gttattacat ctgccagact ttaaatgttg ctggaagcat catcacaaag
     1321 gcatatttgg aagttacaga tgtgattgca gatcggcctc ccccagttat tcgacaaggt
     1381 cctgtgaatc agactgtagc cgtggatggc actttcgtcc tcagctgtgt ggccacaggc
     1441 agtccagtgc ccaccattct gtggagaaag gatggagtcc tcgtttcaac ccaagactct
     1501 cgaatcaaac agttggagaa tggagtactg cagatccgat atgctaagct gggtgatact
     1561 ggtcggtaca cctgcattgc atcaaccccc agtggtgaag caacatggag tgcttacatt
     1621 gaagttcaag aatttggagt tccagttcag cctccaagac ctactgaccc aaatttaatc
     1681 cctagtgccc catcaaaacc tgaagtgaca gatgtcagca gaaatacagt cacattatcg
     1741 tggcaaccaa atttgaattc aggagcaact ccaacatctt atattataga agccttcagc
     1801 catgcatctg gtagcagctg gcagaccgta gcagagaatg tgaaaacaga aacatctgcc
     1861 attaaaggac tcaaacctaa tgcaatttac cttttccttg tgagggcagc taatgcatat
     1921 ggaattagtg atccaagcca aatatcagat ccagtgaaaa cacaagatgt cctaccaaca
     1981 agtcaggggg tggaccacaa gcaggtccag agagagctgg gaaatgctgt tctgcacctc
     2041 cacaacccca ccgtcctttc ttcctcttcc atcgaagtgc actggacagt agatcaacag
     2101 tctcagtata tacaaggata taaaattctc tatcggccat ctggagccaa ccacggagaa
     2161 tcagactggt tagtttttga agtgaggacg ccagccaaaa acagtgtggt aatccctgat
     2221 ctcagaaagg gagtcaacta tgaaattaag gctcgccctt tttttaatga atttcaagga
     2281 gcagatagtg aaatcaagtt tgccaaaacc ctggaagaag cacccagtgc cccaccccaa
     2341 ggtgtaactg tatccaagaa tgatggaaac ggaactgcaa ttctagttag ttggcagcca
     2401 cctccagaag acactcaaaa tggaatggtc caagagtata aggtttggtg tctgggcaat
     2461 gaaactcgat accacatcaa caaaacagtg gatggttcca ccttttccgt ggtcattccc
     2521 tttcttgttc ctggaatccg atacagtgtg gaagtggcag ccagcactgg ggctgggtct
     2581 ggggtaaaga gtgagcctca gttcatccag ctggatgccc atggaaaccc tgtgtcacct
     2641 gaggaccaag tcagcctcgc tcagcagatt tcagatgtgg tgaagcagcc ggccttcata
     2701 gcaggtattg gagcagcctg ttggatcatc ctcatggtct tcagcatctg gctttatcga
     2761 caccgcaaga agagaaacgg acttactagt acctacgcgg gtatcagaaa agtcccgtct
     2821 tttaccttca caccaacagt aacttaccag agaggaggcg aagctgtcag cagtggaggg
     2881 aggcctggac ttctcaacat cagtgaacct gccgcgcagc catggctggc agacacgtgg
     2941 cctaatactg gcaacaacca caatgactgc tccatcagct gctgcacggc aggcaatgga
     3001 aacagcgaca gcaacctcac tacctacagt cgcccagctg attgtatagc aaattataac
     3061 aaccaactgg ataacaaaca aacaaatctg atgctccctg agtcaactgt ttatggtgat
     3121 gtggacctta gtaacaaaat caatgagatg aaaaccttca atagcccaaa tctgaaggat
     3181 gggcgttttg tcaatccatc agggcagcct actccttacg ccaccactca gctcatccag
     3241 tcaaacctca gcaacaacat gaacaatggc agcggggact ctggcgagaa gcactggaaa
     3301 ccactgggac agcagaaaca agaagtggca ccagttcagt acaacatcgt ggagcaaaac
     3361 aagctgaaca aagattatcg agcaaatgac acagttcctc caactatccc atacaaccaa
     3421 tcatacgacc agaacacagg aggatcctac aacagctcag accggggcag tagtacatct
     3481 gggagtcagg ggcacaagaa aggggcaaga acacccaagg taccaaaaca gggtggcatg
     3541 aactgggcag acctgcttcc tcctccccca gcacatcctc ctccacacag caatagcgaa
     3601 gagtacaaca tttctgtaga tgaaagctat gaccaagaaa tgccatgtcc cgtgccacca
     3661 gcaaggatgt atttgcaaca agatgaatta gaagaggagg aagatgaacg aggccccact
     3721 ccccctgttc ggggagcagc ttcttctcca gctgccgtgt cctatagcca tcagtccact
     3781 gccactctga ctccctcccc acaggaagaa ctccagccca tgttacagga ttgtccagag
     3841 gagactggcc acatgcagca ccagcccgac aggagacggc agcctgtgag tcctcctcca
     3901 ccaccacggc cgatctcccc tccacatacc tatggctaca tttcaggacc cctggtctca
     3961 gatatggata cggatgcgcc agaagaggaa gaagacgaag ccgacatgga ggtagccaag
     4021 atgcaaacca gaaggctttt gttacgtggg cttgagcaga cacctgcctc cagtgttggg
     4081 gacctggaga gctctgtcac ggggtccatg atcaacggct ggggctcagc ctcagaggag
     4141 gacaacattt ccagcggacg ctccagtgtt agttcttcgg acggctcctt tttcactgat
     4201 gctgactttg cccaggcagt cgcagcagcg gcagagtatg ctggtctgaa agtagcacga
     4261 cggcaaatgc aggatgctgc tggccgtcga cattttcatg cgtctcagtg ccctaggccc
     4321 acaagtcccg tgtctacaga cagcaacatg agtgccgccg taatgcagaa aaccagacca
     4381 gccaagaaac tgaaacacca gccaggacat ctgcgcagag aaacctacac agatgatctt
     4441 ccaccacctc ctgtgccgcc acctgctata aagtcaccta ctgcccaatc caagacacag
     4501 ctggaagtac gacctgtagt ggtgccaaaa ctcccttcta tggatgcaag aacagacaga
     4561 tcatcagaca gaaaaggaag cagttacaag gggagagaag tgttggatgg aagacaggtt
     4621 gttgacatgc gaacaaatcc aggtgatccc agagaagcac aggaacagca aaatgacggg
     4681 aaaggacgtg gaaacaaggc agcaaaacga gaccttccac cagcaaagac tcatctcatc
     4741 caagaggata ttctacctta ttgtagacct acttttccaa catcaaataa tcccagagat
     4801 cccagttcct caagctcaat gtcatcaaga ggatcaggaa gcagacaaag agaacaagca
     4861 aatgtaggtc gaagaaatat tgcagaaatg caggtacttg gaggatatga aagaggagaa
     4921 gataataatg aagaattaga ggaaactgaa agctga
//