LOCUS AF040709 5482 bp mRNA linear HUM 05-NOV-1998
DEFINITION Homo sapiens putative tumor suppressor gene 26 protein alpha 2
delta calcium channel subunit mRNA, complete cds.
ACCESSION AF040709
VERSION AF040709.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5482)
AUTHORS Sekido,Y., Duh,F.-M., Latif,F., Ding,J., Lin,J., Mathis,M. and
Minna,J.D.
TITLE Gene 26, a new candidate human tumor suppressor gene located in the
3p21.3 small cell lung cancer homozygous deletion region homologous
to a voltage gated calcium channel alpha 2/ delta subunit
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 5482)
AUTHORS Minna,J.D.
TITLE Direct Submission
JOURNAL Submitted (02-JAN-1998) Hamon Center for Therapeutic Oncology
Research, University of Texas Southwestern Medical Center, 5323
Harry Hines Blvd., Dallas, TX 75235-8593, USA
REFERENCE 3 (bases 1 to 5482)
AUTHORS Minna,J.D.
TITLE Direct Submission
JOURNAL Submitted (05-OCT-1998) Hamon Center for Therapeutic Oncology
Research, University of Texas Southwestern Medical Center, 5323
Harry Hines Blvd., Dallas, TX 75235-8593, USA
REMARK Amino acid sequence updated by submitter
FEATURES Location/Qualifiers
source 1..5482
/db_xref="H-InvDB:HIT000063622"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.3"
/note="small cell lung cancer homozygous deletion region"
CDS 181..3618
/note="similar to a voltage gated calcium channel alpha
2/delta subunit"
/codon_start=1
/product="putative tumor suppressor gene 26 protein alpha
2 delta calcium channel subunit"
/protein_id="AAC70914.1"
/translation="MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRPTSGPPRPL
WLLLPLLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNR
NLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIV
YYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGS
TVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDV
RRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNE
KAQPVSCFTHLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRANC
NKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYF
EIPSIGAIRINTQEYLDVLGRPMVLAGKEAKQVQWTNVYEDALGLGLVVTGTLPVFNL
TQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKP
QTTNFREPVTLDFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYIDEVTRN
YTWVPIRSTNYSLGLVLPPYSTFYLQANLSDQILQVKYFEFLLPSSFESEGHVFIAPR
EYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWRD
QDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNHGYVFKPPH
QDALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRT
HQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDAN
LMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAW
SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVNASYNAIIDCGN
CSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHCPADGPEQCELVQRPRYRR
GPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQVLVHASRRL"
BASE COUNT 1209 a 1685 c 1502 g 1086 t
ORIGIN
1 cgggcagcgc agcccgcaga ggcgctgcgg cccgtgcagc cccggaggcc cctcgcggag
61 aaggcggcgg cggaggagag gccgagttac cgcccgccgc ccgcgccccc ccaaccccgc
121 cgccgccgcc gccgccgcca ctgccccccc tccccgcggc gccgcatctt gaatggaaac
181 atggcggtgc cggctcggac ctgcggcgcc tctcggcccg gcccagcgcg gactgcgcgc
241 ccctggcccg gctgcggccc ccaccctggc cccggcaccc ggcgcccgac gtccgggccc
301 ccgcgcccgc tgtggctgct gctgccgctt ctaccgctgc tcgccgcccc cggcgcctct
361 gcctacagct tcccccagca gcacacgatg cagcactggg cccggcgtct ggagcaggag
421 gtcgacggcg tgatgcggat ttttggaggc gtccagcagc tccgtgagat ttacaaggac
481 aaccggaacc tgttcgaggt acaggagaat gagcctcaga agttggtgga gaaggtggca
541 ggggacattg agagccttct ggacaggaag gtgcaggccc tgaagagact ggctgatgct
601 gcagagaact tccagaaagc acaccgctgg caggacaaca tcaaggagga agacatcgtg
661 tactatgacg ccaaggctga cgctgagctg gacgaccctg agagtgagga tgtggaaagg
721 gggtctaagg ccagcaccct aaggctggac ttcatcgagg acccaaactt caagaacaag
781 gtcaactatt catacgcggc tgtacagatc cctacggaca tctacaaagg ctccactgtc
841 atcctcaatg agctcaactg gacagaggcc ctggagaatg tgttcatgga aaaccgcaga
901 caagacccca cactgctgtg gcaggtcttc ggcagcgcca caggagtcac tcgctactac
961 ccggccaccc cgtggcgagc ccccaagaag atcgacctgt acgatgtccg aaggagaccc
1021 tggtatatcc agggggcctc gtcacccaaa gacatggtca tcatcgtgga tgtgagtggc
1081 agtgtgagcg gcctgaccct gaagctgatg aagacatctg tctgcgagat gctggacacg
1141 ctgtctgatg atgactatgt gaatgtggcc tcgttcaacg agaaggcaca gcctgtgtca
1201 tgcttcacac acctggtgca ggccaatgtg cgcaacaaga aggtgttcaa ggaagctgtg
1261 cagggcatgg tggccaaggg caccacaggc tacaaggccg gctttgagta tgcctttgac
1321 cagctgcaga actccaacat cactcgggcc aactgcaaca agatgatcat gatgttcacg
1381 gatggtggtg aggaccgcgt gcaggacgtc tttgagaagt acaattggcc aaaccggacg
1441 gtgcgcgtgt ttactttctc cgtggggcag cataactatg acgtcacacc gctgcagtgg
1501 atggcctgtg ccaacaaagg ctactatttt gagatccctt ccatcggagc catccgcatc
1561 aacacacagg aatatctaga tgtgttgggc aggcccatgg tgctggcagg caaggaggcc
1621 aagcaggttc agtggaccaa cgtgtatgag gatgcactgg gactggggtt ggtggtaaca
1681 gggaccctcc ctgttttcaa cctgacacag gatggccctg gggaaaagaa gaaccagctg
1741 atcctgggcg tgatgggcat tgacgtggct ctgaatgaca tcaagaggct gacccccaac
1801 tacacgcttg gagccaacgg ctatgtgttt gccattgacc tgaacggcta cgtgttgctg
1861 caccccaatc tcaagcccca gaccaccaac ttccgggagc ctgtgactct ggacttcctg
1921 gatgcggagc tagaggatga gaacaaggaa gagatccgtc ggagcatgat tgatggcaac
1981 aagggccaca agcagatcag aacgttggtc aagtccctgg atgagaggta catagatgag
2041 gtgacacgga actacacctg ggtgcctata aggagcacta actacagcct ggggctggtg
2101 ctcccaccct acagcacctt ctacctccaa gccaatctca gtgaccagat cctgcaggtc
2161 aagtattttg agttcctgct ccccagcagc tttgagtctg aaggacacgt tttcattgct
2221 cccagagagt actgcaagga cctgaatgcc tcagacaaca acaccgagtt cctgaaaaac
2281 tttattgagc tcatggagaa agtgactcca gactccaagc agtgcaacaa cttccttctg
2341 cacaacctga tcttggacac gggcatcacg cagcagctgg tagagcgtgt gtggagggac
2401 caggatctca acacgtacag cctactggcc gtgttcgctg ccacagacgg tggcatcacc
2461 cgagtcttcc ccaacaaggc agctgaggac tggacagaga accctgagcc cttcaatgcc
2521 agcttctacc gccgcagcct ggataaccac ggttatgtct tcaagccccc acaccaggat
2581 gccctgttaa ggccgctgga gctggagaat gacactgtgg gcatcctcgt cagcacagct
2641 gtggagctca gcctaggcag gcgcacactg aggccagcag tggtgggcgt caagctggac
2701 ctagaggctt gggctgagaa gttcaaggtg ctagccagca accgtaccca ccaagaccag
2761 cctcagaagt gcggccccaa cagccactgt gagatggact gcgaggttaa caatgaggac
2821 ttactctgtg tcctcattga tgatggagga ttcctggtgc tgtcaaacca gaaccatcag
2881 tgggaccagg tgggcaggtt cttcagtgag gtggatgcca acctgatgct ggcactctac
2941 aataactcct tctacacccg caaggagtcc tatgactatc aggcagcctg tgcccctcag
3001 ccccctggca acctgggtgc tgcaccccgg ggtgtctttg tgcccaccgt tgcagatttc
3061 cttaacctgg cctggtggac ctctgctgcc gcctggtccc tgttccagca gcttctctac
3121 ggcctcatct accacagctg gttccaagca gaccccgcgg aggccgaggg gagccccgag
3181 acgcgcgaga gcagctgcgt catgaaacag acccagtact acttcggctc ggtaaacgcc
3241 tcctacaacg ccatcatcga ctgcggaaac tgctccaggc tgttccacgc gcagagactg
3301 accaacacca atcttctctt tgtggtggcc gagaagccgc tgtgcagcca gtgcgaggct
3361 ggccggctgc tgcagaagga gacgcactgc ccagcggacg gcccggagca gtgtgagcta
3421 gtgcagagac cgcgataccg gagaggcccg cacatctgct tcgactacaa cgcgacagaa
3481 gatacctcag actgtggccg cggggcctcc ttcccgccgt cgctgggcgt cctggtctcc
3541 ctgcaactgc tgctcctcct gggcctgccg ccccggccgc agcctcaagt cctcgtccac
3601 gcctctcgcc gcctctgagc accctgcccc accccacctc cactcccacc tcacccggcc
3661 tcttcgcctt tcccaccctc ctgccccaca ctccccgcct tagagcctcg tccctccctc
3721 actgaaggac ctgagctggc caggccctga gagtctggtc tgcgccttgg gatggggagt
3781 cccaaagcgg gacgccgcag gtgtttggca cccaaatcac atctcacctc cgaactgttc
3841 aagtgtcccc agacccttct tgcctgctgg gctcccccca gtgggatggg acagggaggc
3901 cacacgcact ggtgccaaaa ccaggcctct gctgccgccc ttcctggagg ctgcctatgt
3961 tgggggggac cctgcctcag ctgacccggc ctctctgccc cacccaagcc caaacttggt
4021 ttctgtgaga atagtggagg aaggtgagat ggccagtttg aagcctgtgc ctcccagctt
4081 aaatcctagc aggagagagg ctctggggca gcccccatgg gctcctgccc ctttcaggcc
4141 tacagccaca tccccaagcc caccaggtgt caggatagtc acagtgatac cagttcagac
4201 actaccccat atacacctgg aacattgagg atggaaactg gactcacatt cgacataccc
4261 cactgggcac acgcacaaac acacacacta tggggtgggg tgggtgtagg ggcttacaaa
4321 gccttacaca gggcgagggg ttggtgggag ggttggcacc tgcacactcc atctcctgct
4381 caccacctgc ctctaatctg agctgcagcc tggctggtcc tcccatttct aaagctgaat
4441 gtcaaacagt gccaaatgct ggggcagggg gtgaagaacc ctctgtccca cccctagcca
4501 ccagtgtcct ccaagtgccc cctcacctct ccaggtgctc attgtaacca tttctcacta
4561 gtgtcaggcc cccagtggga ccacatgcca ctgcctgcac ctttcggcag aggaaccccc
4621 accagacatc accctttgcc ttagcagggg tgactttgtc tctcctggct gggccatcct
4681 tccgccaatc tggcccttac acactcaggc ctgtgcccac tccctatctc cttcccaccc
4741 ctacacacac actccctgct tgcaggaggc caaactgtcc ctcccttgct gaacacacac
4801 acacacacac acacacaggt ggggactggg cacagctctt cacaccattc attctggtca
4861 tttcccccaa aggcatccca gcctgggggc cagtggggaa ctgagggcaa ggggatatag
4921 tgatggggct cagatggact gggaggaggg ggagggtgat gcattaatta atggcttcgt
4981 taattaatgt catgttgctt gtcgctttct cagtgtgtgt gtgtggtcca tgcccactgc
5041 tggtgccagg gtgggtgtcc atgtgcaccc ggcctggatg ccagctgtgt ccttcggggg
5101 cgtgcgtgta actgtagtgt agtcaggtgc tcaatggaga atataaacat atacagaaaa
5161 atatatattt taagtttaaa aaacagaaaa acagacaaaa caatccccat caggtagctg
5221 tctaaccccc agctgggtct aatccttctc attacccacc cgacctggct gcccctcacc
5281 ttgggctggg ggactggggg gccatttcct tttctctgcc ctttttttgt tgttctattt
5341 tgtacagaca agttggaaaa acaacagcga caaaaaagtc aagaaacttt gtaaaatatc
5401 gtgtgtgtga ttccttgtaa aatattttca aatggtttat tacagaagat cagttattaa
5461 ataatgttca tattttcact tc
//