LOCUS       AF039843                2135 bp    mRNA    linear   HUM 25-FEB-1998
DEFINITION  Homo sapiens Sprouty 2 (SPRY2) mRNA, complete cds.
ACCESSION   AF039843
VERSION     AF039843.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Hacohen,N., Kramer,S., Sutherland,D., Hiromi,Y. and Krasnow,M.A.
  TITLE     sprouty encodes a novel antagonist of FGF signaling that patterns
            apical branching of the Drosophila airways
  JOURNAL   Cell 92 (2), 253-263 (1998)
   PUBMED   9458049
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Hacohen,N., Kramer,S., Sutherland,D., Hiromi,Y. and Krasnow,M.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-DEC-1997) Biochemistry, Stanford University, Beckman
            Center 4th Floor, Stanford, CA 94305, USA
FEATURES             Location/Qualifiers
     source          1..2135
                     /db_xref="H-InvDB:HIT000063508"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="clone ID 40262 in Genbank EST database"
     gene            1..2135
                     /gene="SPRY2"
                     /note="sprouty 2"
     CDS             391..1338
                     /gene="SPRY2"
                     /note="h-Spry2; membrane-associated protein; similar to
                     Drosophila melanogaster spry, which inhibits FGF-induced
                     epithelial branching in Drosophila tracheal system"
                     /codon_start=1
                     /product="Sprouty 2"
                     /protein_id="AAC04258.1"
                     /translation="MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLD
                     QIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSS
                     ARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKP
                     GELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTC
                     VCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCL
                     KLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT"
     misc_feature    922..1267
                     /gene="SPRY2"
                     /note="encodes cysteine rich domain; highly conserved in
                     all Sprouty homologs"
BASE COUNT          583 a          474 c          488 g          590 t
ORIGIN      
        1 ggcacgaggg taaggccgtt ttcttttccc attcgctcat ctgccaggaa aagggacttg
       61 ccgttggcgc ttcggcctct tgttcattga gaaaaaagag gaaatactcc gcgtgcgctt
      121 gtagaagggg agtcgtctcc agctccgaac cccggagtgt tcatcagcgg ggaatctggc
      181 tccgaattct ctttttttct cccgccgatt gctcggaagt tggtctaaag cagaggttgg
      241 aaagaaagga aaaaagtttg catcgagact ggatttattt gcacatcgca gaaagaagag
      301 aatccaaggg agaggggttg gtgcaaagcc gcgatcacgg agttcagatg tgttctaagc
      361 ctgctggagt gaccacactt ccaagacctg atggaggcca gagctcagag tggcaacggg
      421 tcgcagccct tgctgcagac gccccgtgac ggtggcagac agcgtgggga gcccgacccc
      481 agagacgccc tcacccagca ggtacatgtc ttgtctctgg atcagatcag agccatccga
      541 aacaccaatg agtacacaga ggggcctact gtcgtcccaa gacctgggct caagcctgct
      601 cctcgcccct ccactcagca caaacacgag agactccacg gtctgcctga gcaccgccag
      661 cctcctaggc tccagcactc gcaggtccat tcttctgcac gagcccctct gtccagatcc
      721 ataagcacgg tcagctcagg gtcgcggagc agtacgagga caagtaccag cagcagctcc
      781 tctgaacaga gactgctagg atcatccttc tcctccgggc ctgttgctga tggcataatc
      841 cgggtgcaac ccaaatctga gctcaagcca ggtgagctta agccactgag caaggaagat
      901 ttgggcctgc acgcctacag gtgtgaggac tgtggcaagt gcaaatgtaa ggagtgcacc
      961 tacccaaggc ctctgccatc agactggatc tgcgacaagc agtgcctttg ctcggcccag
     1021 aacgtgattg actatgggac ttgtgtatgc tgtgtgaaag gtctcttcta tcactgttct
     1081 aatgatgatg aggacaactg tgctgacaac ccatgttctt gcagccagtc tcactgttgt
     1141 acacgatggt cagccatggg tgtcatgtcc ctctttttgc cttgtttatg gtgttacctt
     1201 ccagccaagg gttgccttaa attgtgccag gggtgttatg accgggttaa caggcctggt
     1261 tgccgctgta aaaactcaaa cacagtttgc tgcaaagttc ccactgtccc ccctaggaac
     1321 tttgaaaaac caacatagca tcattaatca ggaatattac agtaatgagg attttttctt
     1381 tcttttttta atacacatat gcaaccaact aaacagttat aatcttggca ctgttaatcg
     1441 aaagttggga tagtctttgc tgtttgcggt gaaatgcttt ttgtccatgt gccgttttaa
     1501 ctgatatgct tgttagaact cagctaatgg agctcaaagt atgagataca gaacttggtg
     1561 acccatgtat tgcataagct aaagcaacac agacactcct aggcaaagtt tttgtttgtg
     1621 aatagtactt gcaaaacttg taaattagca gatgactttt ttccattgtt ttctccagag
     1681 agaatgtgct atatttttgt atatacaata atatttgcaa ctgtgaaaaa caagttgtgc
     1741 catactacat ggcacagaca caaaatatta tactaatatg ttgtacattc ggaagaatgt
     1801 gaatcaatca gtatgttttt agattgtatt ttgccttaca gaaagccttt attgtaagac
     1861 tctgatttcc ctttggactt catgtatatt gtacagttac agtaaaattc aacctttatt
     1921 ttctaatttt ttcaacatat tgtttagtgt aaagaatatt tatttgaagt tttattattt
     1981 tataaaaaag aatatttatt ttaagaggca tcttacaaat tttgcccctt ttatgaggat
     2041 gtgatagttg ctgcaaatga ggggttacag atgcatatgt ccaatataaa atagaaaata
     2101 tattaacgtt tgaaattaaa aaaaaaaaaa aaaaa
//