LOCUS AF039400 3311 bp mRNA linear HUM 14-DEC-1998
DEFINITION Homo sapiens calcium-dependent chloride channel-1 (hCLCA1) mRNA,
complete cds.
ACCESSION AF039400
VERSION AF039400.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3311)
AUTHORS Gruber,A.D., Elble,R.C., Ji,H.L., Schreur,K.D., Fuller,C.M. and
Pauli,B.U.
TITLE Genomic cloning, molecular characterization, and functional
analysis of human CLCA1, the first human member of the family of
Ca2+-activated Cl- channel proteins
JOURNAL Genomics 54 (2), 200-214 (1998)
PUBMED 9828122
REFERENCE 2 (bases 1 to 3311)
AUTHORS Gruber,A.D., Elble,R. and Pauli,B.U.
TITLE Direct Submission
JOURNAL Submitted (19-DEC-1997) Pathology, College of Veterinary Medicine,
Cornell University, Ithaca, NY 14853, USA
FEATURES Location/Qualifiers
source 1..3311
/db_xref="H-InvDB:HIT000063479"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p22-p31"
/tissue_type="small intestine"
gene 1..3311
/gene="hCLCA1"
CDS 352..3096
/gene="hCLCA1"
/note="transmembrane glycoprotein"
/codon_start=1
/product="calcium-dependent chloride channel-1"
/protein_id="AAC95428.1"
/translation="MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVP
EDETLIQQIKDMVTQASLYLFEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNA
DVLVAESTPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGKAFVHEWAH
LRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGL
YEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVI
RDSEDFKKTTPMTTQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFL
LQTVELGSWVGMVTFDSAAHVQSELIQINSGSDRDTLAKRLPAAASGGTSICSGLRSA
FTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSK
MTGGLQTYASDQVQNNGLIDAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIV
DSTVGKDTLFLITWTTQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVGTWKY
SLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRA
SVTALIESVNGKTVTLELLDNGAGADATKDDGVYSRYFTTYDTNGRYSVKVRALGGVN
AARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVAS
DVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILD
LRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDLFIAIQAVDKVDLKSEI
SNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILKIMWKWIGELQLSIA
"
BASE COUNT 1028 a 692 c 742 g 849 t
ORIGIN
1 tgctaatgct tttggtacaa atggatgtgg aatataattg aatattttct tgtttaaggg
61 gagcatgaag aggtgttgag gttatgtcaa gcatctggca cagctgaagg cagatggaaa
121 tatttacaag tacgcaattt gagactaaga tattgttatc attctcctat tgaagacaag
181 agcaatagta aaacacatca ggtcaggggg ttaaagacct gtgataaacc acttccgata
241 agttggaaac gtgtgtctat attttcatat ctgtatatat ataatggtaa agaaagacac
301 cttcgtaacc cgcattttcc aaagagagga atcacaggga gatgtacagc aatggggcca
361 tttaagagtt ctgtgttcat cttgattctt caccttctag aaggggccct gagtaattca
421 ctcattcagc tgaacaacaa tggctatgaa ggcattgtcg ttgcaatcga ccccaatgtg
481 ccagaagatg aaacactcat tcaacaaata aaggacatgg tgacccaggc atctctgtat
541 ctgtttgaag ctacaggaaa gcgattttat ttcaaaaatg ttgccatttt gattcctgaa
601 acatggaaga caaaggctga ctatgtgaga ccaaaacttg agacctacaa aaatgctgat
661 gttctggttg ctgagtctac tcctccaggt aatgatgaac cctacactga gcagatgggc
721 aactgtggag agaagggtga aaggatccac ctcactcctg atttcattgc aggaaaaaag
781 ttagctgaat atggaccaca aggtaaggca tttgtccatg agtgggctca tctacgatgg
841 ggagtatttg acgagtacaa taatgatgag aaattctact tatccaatgg aagaatacaa
901 gcagtaagat gttcagcagg tattactggt acaaatgtag taaagaagtg tcagggaggc
961 agctgttaca ccaaaagatg cacattcaat aaagttacag gactctatga aaaaggatgt
1021 gagtttgttc tccaatcccg ccagacggag aaggcttcta taatgtttgc acaacatgtt
1081 gattctatag ttgaattctg tacagaacaa aaccacaaca aagaagctcc aaacaagcaa
1141 aatcaaaaat gcaatctccg aagcacatgg gaagtgatcc gtgattctga ggactttaag
1201 aaaaccactc ctatgacaac acagccacca aatcccacct tctcattgct gcagattgga
1261 caaagaattg tgtgtttagt ccttgacaaa tctggaagca tggcgactgg taaccgcctc
1321 aatcgactga atcaagcagg ccagcttttc ctgctgcaga cagttgagct ggggtcctgg
1381 gttgggatgg tgacatttga cagtgctgcc catgtacaaa gtgaactcat acagataaac
1441 agtggcagtg acagggacac actcgccaaa agattacctg cagcagcttc aggagggacg
1501 tccatctgca gcgggcttcg atcggcattt actgtgatta ggaagaaata tccaactgat
1561 ggatctgaaa ttgtgctgct gacggatggg gaagacaaca ctataagtgg gtgctttaac
1621 gaggtcaaac aaagtggtgc catcatccac acagtcgctt tggggccctc tgcagctcaa
1681 gaactagagg agctgtccaa aatgacagga ggtttacaga catatgcttc agatcaagtt
1741 cagaacaatg gcctcattga tgcttttggg gccctttcat caggaaatgg agctgtctct
1801 cagcgctcca tccagcttga gagtaaggga ttaaccctcc agaacagcca gtggatgaat
1861 ggcacagtga tcgtggacag caccgtggga aaggacactt tgtttcttat cacctggaca
1921 acgcagcctc cccaaatcct tctctgggat cccagtggac agaagcaagg tggctttgta
1981 gtggacaaaa acaccaaaat ggcctacctc caaatcccag gcattgctaa ggttggcact
2041 tggaaataca gtctgcaagc aagctcacaa accttgaccc tgactgtcac gtcccgtgcg
2101 tccaatgcta ccctgcctcc aattacagtg acttccaaaa cgaacaagga caccagcaaa
2161 ttccccagcc ctctggtagt ttatgcaaat attcgccaag gagcctcccc aattctcagg
2221 gccagtgtca cagccctgat tgaatcagtg aatggaaaaa cagttacctt ggaactactg
2281 gataatggag caggtgctga tgctactaag gatgacggtg tctactcaag gtatttcaca
2341 acttatgaca cgaatggtag atacagtgta aaagtgcggg ctctgggagg agttaacgca
2401 gccagacgga gagtgatacc ccagcagagt ggagcactgt acatacctgg ctggattgag
2461 aatgatgaaa tacaatggaa tccaccaaga cctgaaatta ataaggatga tgttcaacac
2521 aagcaagtgt gtttcagcag aacatcctcg ggaggctcat ttgtggcttc tgatgtccca
2581 aatgctccca tacctgatct cttcccacct ggccaaatca ccgacctgaa ggcggaaatt
2641 cacgggggca gtctcattaa tctgacttgg acagctcctg gggatgatta tgaccatgga
2701 acagctcaca agtatatcat tcgaataagt acaagtattc ttgatctcag agacaagttc
2761 aatgaatctc ttcaagtgaa tactactgct ctcatcccaa aggaagccaa ctctgaggaa
2821 gtctttttgt ttaaaccaga aaacattact tttgaaaatg gcacagatct tttcattgct
2881 attcaggctg ttgataaggt cgatctgaaa tcagaaatat ccaacattgc acgagtatct
2941 ttgtttattc ctccacagac tccgccagag acacctagtc ctgatgaaac gtctgctcct
3001 tgtcctaata ttcatatcaa cagcaccatt cctggcattc acattttaaa aattatgtgg
3061 aagtggatag gagaactgca gctgtcaata gcctagggct gaatttttgt cagataaata
3121 aaataaatca ttcatccttt ttttgattat aaaattttct aaaatgtatt ttagacttcc
3181 tgtagggggc gatatactaa atgtatatag tacatttata ctaaatgtat tcctgtaggg
3241 ggcgatatac taaatgtatt ttagacttcc tgtagggggc gataaaataa aatgctaaac
3301 aactgggtaa a
//