LOCUS AF039196 5709 bp mRNA linear HUM 15-APR-2002
DEFINITION Homo sapiens putative single zinc finger transcription factor
protein (hairless) mRNA, complete cds.
ACCESSION AF039196
VERSION AF039196.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5709)
AUTHORS Ahmad,W., ul Haque,M.F., Brancolini,V., Tsou,H.C., ul Haque,S.,
Lam,H., Aita,V.M., Owen,J., deBlaquiere,M., Frank,J.,
Cserhalmi-Friedman,P.B., Leask,A., McGrath,J.A., Peacocke,M.,
Ahmad,M., Ott,J. and Christiano,A.M.
TITLE Alopecia universalis associated with a mutation in the human
hairless gene
JOURNAL Science 279 (5351), 720-724 (1998)
PUBMED 9445480
REFERENCE 2 (bases 1 to 5709)
AUTHORS Ahmad,W., Zlotogorski,A., Panteleyev,A.A., Lam,H., Ahmad,M., ul
Haque,M.F., Abdallah,H.M., Dragan,L. and Christiano,A.M.
TITLE Genomic organization of the human hairless gene (HR) and
identification of a mutation underlying congenital atrichia in an
Arab Palestinian family
JOURNAL Genomics 56 (2), 141-148 (1999)
PUBMED 10051399
REFERENCE 3 (bases 1 to 5709)
AUTHORS Christiano,A.M.
TITLE Direct Submission
JOURNAL Submitted (18-DEC-1997) Dermatology, Columbia University, 630 West
168th Street VC-1526, New York, NY 10032, USA
REFERENCE 4 (bases 1 to 5709)
AUTHORS Christiano,A.M.
TITLE Direct Submission
JOURNAL Submitted (18-AUG-1998) Dermatology, Columbia University, 630 West
168th Street VC-1526, New York, NY 10032, USA
REMARK Sequence update by submitter
REFERENCE 5 (bases 1 to 5709)
AUTHORS Christiano,A.M.
TITLE Direct Submission
JOURNAL Submitted (11-JUN-1999) Dermatology, Columbia University, 630 West
168th Street VC-1526, New York, NY 10032, USA
REMARK Sequence update by submitter
REFERENCE 6 (bases 1 to 5709)
AUTHORS Christiano,A.M.
TITLE Direct Submission
JOURNAL Submitted (15-APR-2002) Dermatology, Columbia University, 630 West
168th Street VC-1526, New York, NY 10032, USA
REMARK Sequence update by submitter
COMMENT On Apr 15, 2002 this sequence version replaced AF039196.2.
FEATURES Location/Qualifiers
source 1..5709
/db_xref="H-InvDB:HIT000063471"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p12"
gene 1..5709
/gene="hairless"
CDS 1485..5054
/gene="hairless"
/note="restricted expression in the brain and skin"
/codon_start=1
/product="putative single zinc finger transcription factor
protein"
/protein_id="AAC32258.3"
/translation="MESTPSFLKGTPTWEKTAPENGIVRQEPGSPPRDGLHHGPLCLG
EPAPFWRGVLSTPDSWLPPGFPQGPKDMLPLVEGEGPQNGERKVNWLGSKEGLRWKEA
MLTHPLAFCGPACPPRCGPLMPEHSGGHLKSDPVAFRPWHCPFLLETKILERAPFWVP
TCLPPYLVSGLPPEHPCDWPLTPHPWVYSGGQPKVPSAFSLGSKGFYYKDPSIPRLAK
EPLAAAEPGLFGLNSGGHLQRAGEAERPSLHQRDGEMGAGRQQNPCPLFLGQPDTVPW
TSWPACPPGLVHTLGNVWAGPGDGNLGYQLGPPATPRCPSPEPPVTQRGCCSSYPPTK
GGDLGPCGKCQEGLEGGASGASEPSEEVNKASGPRACPPSHHTKLKKTWLTRHSEQFE
CPRGCPEVEERPVARLRALKRAGSPEVQGAMGSPAPKRPPDPFPGTAEQGAGGWQEVR
DTSIGNKDVDSGQHDEQKGPQDGQASLQDPGLQDIPCLALPAKLAQCQSCAQAAGEGG
GHACHSQQVRRSPLGGELQQEEDTATNSSSEEGPGSGPDSRLSTGLAKHLLSGLGDRL
CRLLRREREALAWAQREGQGPAVTEDSPGIPRCCSRCHHGLFNTHWRCPRCSHRLCVA
CGRVAGTGRAREKAGFQEQSAEECTQEAGHAACSLMLTQFVSSQALAELSTAMHQVWV
KFDIRGHCPCQADARVWAPGDAGQQKESTQKTPPTPQPSCNGDTHRTKSIKEETPDSA
ETPAEDRAGRGPLPCPSLCELLASTAVKLCLGHERIHMAFAPVTPALPSDDRITNILD
SIIAQVVERKIQEKALGPGLRAGPGLRKGLGLPLSPVRPRLPPPGALLWLQEPQPCPR
RGFHLFQEHWRQGQPVLVSGIQRTLQGNLWGTEALGALGGQVQALSPLGPPQPSSLGS
TTFWEGFSWPELRPKSDEGSVLLLHRALGDEDTSRVENLAASLPLPEYCALHGKLNLA
SYLPPGLALRPLEPQLWAAYGVSPHRGHLGTKNLCVEVADLVSILVHADTPLPAWHRA
QKDFLSGLDGEGLWSPGSQVSTVWHVFRAQDAQRIRRFLQMVCPAGAGALEPGAPGSC
YLDAGLRRRLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTVSVTQHFLSPETS
ALSAQLCHQGPSLPPDCHLLYAQMDWAVFQAVKVAVGTLQEAK"
BASE COUNT 1015 a 1950 c 1826 g 918 t
ORIGIN
1 tctcccggga gccactcccc tgggcgcctc tccagcccct gggctggaag caccagcaac
61 cctggggatg gggcagaccc tcacagcccg gggtctggag ccggtgtcgg agctcacatg
121 ggcccatgac ctctccagac atttggcaaa atcaaggccc ttagaccagg gacagaccca
181 agcccaggcc ctcccagagg tcataggacg caaccctttg tgcccttggg ctatggaaga
241 ggtttgggaa cggctttggg gtggaagatg gccaaaggag cagcttggcc aggtgaggat
301 gaggcagggc agacacaggc cagtggggcg tgccatgtgc cacagatgga gaggaccagg
361 agccagtggc ccggcaggca cagcccggtt ggcgtgggcc agagcgccca tcactgaccc
421 gtgagaactc gactgcccct gccagctctg gcactgcccc ctcccagccg ccccgcccta
481 gcaccctggg gggcaccccg cccaaccgtg gcctggtccg gcccctcccg ccctttgctc
541 cagttcccgg gcttggcacc tatagtgggg gtgccgcccg cctgccaggc tccggggccg
601 ggcccacggg agggtggggc ggctgggaag ctggcacgct gccccggggg agcctctgtc
661 ggcaggcgcc cgggtgccgc gggggggagg gggaacaaag ggctcattct ccccgtgcgc
721 agccggtggc atcgccgggg cgttggcgga agcccccggg gcccgggagg gggccggccc
781 aggcgcggcc gccgaatcac gggctcctgt ttcccgcagg gtgctggagg aggaaaccgg
841 cggagcagct tccccactct cagttgcgcg tctggcgatg gcgatcagag gtcgtgctgc
901 gctctccgcc gcgctctacc tccattagcc gcgctgcgcg gtgctgcgcc ctcgccggtg
961 cctctctcct gggtcccagg atcggccccc accatccagg cacgaccccc ttccccggcc
1021 cctcggcctt tcccccaact cggccatctc cgacccgggg cgcgtgttcc ccccggcccg
1081 gcgccttctc tccctccggg ggcacccgct ccctagcccc ggcccggccc tccccgcggc
1141 gcagcacgga gtctcggcgt cccatggcgc aacctacggc ctcggcccag aagctggtgc
1201 ggccgatccg cgccgtgtgc cgcatcctgc agatcccgga gtccgacccc tccaacctgc
1261 ggccctagag cgcccccgcc gccccggggg aaggagagcg cgagcgcgct gagcagacag
1321 agcgggagaa cgcgtcctcg cccgccggcc gggaggcccc ggagctggcc catggggagc
1381 aggcgcccgg tgccggccac gacgaccgcc accgcccgcg ccgcgaccgg ccggtgaagc
1441 ccagggaccc ccctctggga gagccccatg agggcaggag agtgatggag agtacgccca
1501 gcttcctgaa gggcacccca acctgggaga agacggcccc agagaacggc atcgtgagac
1561 aggagcccgg cagcccgcct cgagatggac tgcaccatgg gccgctgtgc ctgggagagc
1621 ctgctccctt ttggaggggc gtcctgagca ccccagactc ctggcttccc cctggcttcc
1681 cccagggccc caaggacatg ctcccacttg tggagggcga gggcccccag aatggggaga
1741 ggaaggtcaa ctggctgggc agcaaagagg gactgcgctg gaaggaggcc atgcttaccc
1801 atccgctggc attctgcggg ccagcgtgcc cacctcgctg tggccccctg atgcctgagc
1861 atagtggtgg ccatctcaag agtgaccctg tggccttccg gccctggcac tgccctttcc
1921 ttctggagac caagatcctg gagcgagctc ccttctgggt gcccacctgc ttgccaccct
1981 acctagtgtc tggcctgccc ccagagcatc catgtgactg gcccctgacc ccgcacccct
2041 gggtatactc cgggggccag cccaaagtgc cctctgcctt cagcttaggc agcaagggct
2101 tttactacaa ggatccgagc attcccaggt tggcaaagga gcccttggca gctgcggaac
2161 ctgggttgtt tggcttaaac tctggtgggc acctgcagag agccggggag gccgaacgcc
2221 cttcactgca ccagagggat ggagagatgg gagctggccg gcagcagaat ccttgcccgc
2281 tcttcctggg gcagccagac actgtgccct ggacctcctg gcccgcttgt cccccaggcc
2341 ttgttcatac tcttggcaac gtctgggctg ggccaggcga tgggaacctt gggtaccagc
2401 tggggccacc agcaacacca aggtgcccct ctcctgagcc gcctgtcacc cagcggggct
2461 gctgttcatc ctacccaccc actaaaggtg gggatcttgg cccttgtggg aagtgccagg
2521 agggcctgga ggggggtgcc agtggagcca gcgaacccag cgaggaagtg aacaaggcct
2581 ctggccccag ggcctgtccc cccagccacc acaccaagct gaagaagaca tggctcacac
2641 ggcactcgga gcagtttgaa tgtccacgcg gctgccctga ggtcgaggag aggccggttg
2701 ctcggctccg ggccctcaaa agggcaggca gccccgaggt ccagggagca atgggcagtc
2761 cagcccccaa gcggccaccg gaccctttcc caggcactgc agaacagggg gctgggggtt
2821 ggcaggaggt gcgggacaca tcgataggga acaaggatgt ggactcggga cagcatgatg
2881 agcagaaagg accccaagat ggccaggcca gtctccagga cccgggactt caggacatac
2941 catgcctggc tctccctgca aaactggctc aatgccaaag ttgtgcccag gcagctggag
3001 agggaggagg gcacgcctgc cactctcagc aagtgcggag atcgcctctg ggaggggagc
3061 tgcagcagga ggaagacaca gccaccaact ccagctctga ggaaggccca gggtccggcc
3121 ctgacagccg gctcagcaca ggcctcgcca agcacctgct cagtggtttg ggggaccgac
3181 tgtgccgcct gctgcggagg gagcgggagg ccctggcttg ggcccagcgg gaaggccaag
3241 ggccagccgt gacagaggac agcccaggca ttccacgctg ctgcagccgt tgccaccatg
3301 gactcttcaa cacccactgg cgatgtcccc gctgcagcca ccggctgtgt gtggcctgtg
3361 gtcgtgtggc aggcactggg cgggccaggg agaaagcagg ctttcaggag cagtccgcgg
3421 aggagtgcac gcaggaggcc gggcacgctg cctgttccct gatgctgacc cagtttgtct
3481 ccagccaggc tttggcagag ctgagcactg caatgcacca ggtctgggtc aagtttgata
3541 tccgggggca ctgcccctgc caagctgatg cccgggtatg ggcccccggg gatgcaggcc
3601 agcagaagga atcaacacag aaaacgcccc caactccaca accttcctgc aatggcgaca
3661 cccacaggac caagagcatc aaagaggaga cccccgattc cgctgagacc ccagcagagg
3721 accgtgctgg ccgagggccc ctgccttgtc cttctctctg cgaactgctg gcttctaccg
3781 cggtcaaact ctgcttgggc catgagcgaa tacacatggc cttcgccccc gtcactccgg
3841 ccctgcccag tgatgaccgc atcaccaaca tcctggacag cattatcgca caggtggtgg
3901 aacggaagat ccaggagaaa gccctggggc cggggcttcg agctggcccg ggtctgcgca
3961 agggcctggg cctgcccctc tctccagtgc ggccccggct gcctccccca ggggctttgc
4021 tgtggctgca ggagccccag ccttgccctc ggcgtggctt ccacctcttc caggagcact
4081 ggaggcaggg ccagcctgtg ttggtgtcag ggatccaaag gacattgcag ggcaacctgt
4141 gggggacaga agctcttggg gcacttggag gccaggtgca ggcgctgagc cccctcggac
4201 ctccccagcc cagcagcctg ggcagcacaa cattctggga gggcttctcc tggcctgagc
4261 ttcgcccaaa gtcagacgag ggctctgtcc tcctgctgca ccgagctttg ggggatgagg
4321 acaccagcag ggtggagaac ctagctgcca gtctgccact tccggagtac tgcgccctcc
4381 atggaaaact caacctggct tcctacctcc caccgggcct tgccctgcgt ccactggagc
4441 cccagctctg ggcagcctat ggtgtgagcc cgcaccgggg acacctgggg accaagaacc
4501 tctgtgtgga ggtggccgac ctggtcagca tcctggtgca tgccgacaca ccactgcctg
4561 cctggcaccg ggcacagaaa gacttccttt caggcctgga cggggagggg ctctggtctc
4621 cgggcagcca ggtcagcact gtgtggcacg tgttccgggc acaggacgcc cagcgcatcc
4681 gccgctttct ccagatggtg tgcccggccg gggcaggcgc cctggagcct ggcgccccag
4741 gcagctgcta cctggatgca gggctgcggc ggcgcctgcg ggaggagtgg ggcgtgagct
4801 gctggaccct gctccaggcc cccggagagg ccgtgctggt gcctgcaggg gctccccacc
4861 aggtgcaggg cctggtgagc acagtcagcg tcactcagca cttcctctcc cctgagacct
4921 ctgccctctc tgctcagctc tgccaccagg gacccagcct tccccctgac tgccacctgc
4981 tttatgccca gatggactgg gctgtgttcc aagcagtgaa ggtggccgtg gggacattac
5041 aggaggccaa atagagggat gctaggtgtc tgggatcggg gtggggacag gtagaccagg
5101 tgctcagccc aggcacaact tcagcagggg atggcgctag gggacttggg gatttctggt
5161 caaccccaca agcaccactc tgggcacaag cagggcactc tgttcccctc ccccttaagc
5221 caacaaccac agtgccacca agctcacacc tgtccttctc aggctggcat ctcccccacc
5281 ctgtgcccct tttcatggta ccaggcccgc actgggggca attgacttcc tccaatcccc
5341 actcctccga gacccaggag acaaacagcc cttccttggg gaaacttggg aatcattctg
5401 gcttaaacaa cacctcctcc tgctgctcac tcccgctgag cccactctac tgccccagct
5461 ccgtttctac caccgcatcc tcactgggct cactgcaggc atgctgaaca aggggcctcc
5521 aaccttctgc cctcctgcca aaagatctgg ggagtgtgag gagagggtgg catcaggagc
5581 tgctcaggct tggcggaggg agcggcatgg gcgatgtcac tcatgccctt cccggtccgc
5641 ccgcttccct ccttcatgat ttccattaaa gtctgttgtt ttgaaaaaaa aaaaaaaaaa
5701 aaaaaaaaa
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