LOCUS AF038935 1490 bp mRNA linear ROD 28-DEC-1997
DEFINITION Mus musculus presenilin 2 mRNA, complete cds.
ACCESSION AF038935
VERSION AF038935.1
KEYWORDS .
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 1490)
AUTHORS Sahara,N., Mori,H. and Shirasawa,T.
TITLE Molecular cloning of mouse presenilin 2 gene
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1490)
AUTHORS Sahara,N., Mori,H. and Shirasawa,T.
TITLE Direct Submission
JOURNAL Submitted (16-DEC-1997) Molecular Biology, Tokyo Institute of
Psychiatry, 2-1-8 Kami-Kitazawa, Setagaya-ku, Tokyo 156, Japan
FEATURES Location/Qualifiers
source 1..1490
/organism="Mus musculus"
/mol_type="mRNA"
/strain="NIH SwissMus"
/db_xref="taxon:10090"
CDS 19..1362
/note="causal gene for familial Alzheimer's disease"
/codon_start=1
/product="presenilin 2"
/protein_id="AAB92660.1"
/translation="MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGEST
AQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVV
VATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLY
KYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVC
IHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRM
LVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEDSYDSFGEPS
YPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFI
AILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI"
BASE COUNT 315 a 418 c 416 g 341 t
ORIGIN
1 gaattcaagc agcagaccat gctcgcattc atggcctctg acagcgagga agaggtgtgt
61 gatgagcgga cgtccttgat gtcagccgag agccccacat ctcgctcctg ccaggaaggc
121 aggccaggcc cggaggatgg agagagcact gcccagtgga ggacccagga gagcgaagaa
181 gactgtgaag aggacccgga ccgctacgca tgcagtgggg ctcctgggcg accgtcgggc
241 ctggaggaag agctgaccct gaagtatggg gcgaagcatg tgatcatgct attcgtgcct
301 gtcacgctgt gtatgatcgt ggtggtggcc actatcaagt ctgtgcgttt ctacactgag
361 aagaacgggc agctcatcta cacgcccttc acggaggaca cgccctcggt gggccagcgg
421 ctcctcaact ctgtgctgaa caccctcatc atgatcagcg tcattgtagt catgaccatc
481 tttctcgtgg tactctacaa gtatcgatgc tacaagttca tccatggctg gctgatcatg
541 tcctccctga tgctcctctt cttgttcacc tacatctacc tcggggaagt gctcaagacc
601 tacaatgtgg ccatggacta tcccacactc ttcctggctg tctggaactt cggggcagtg
661 ggcatggtgt gcatccactg gaaggggcct ctggtgctgc agcaggctta tcttattgtg
721 atcagcgcac tcatggccct ggtgttcatc aagtacctgc cggagtggtc tgcctgggtc
781 atcttgggtg ccatctctgt gtacgatctc gtggccgtgc tgtgccccaa agggccactg
841 aggatgctgg tggaaactgc ccaggagaga aatgagccca tatttcctgc cctgatatac
901 tcatctgcca tggtgtggac ggtgggcatg gcaaagctgg acccctcctc tcaaggagcg
961 ctgcagctcc cctatgaccc agagatggaa gactcgtacg acagttttgg agaaccctca
1021 taccctgaag ccttcgaagc ccccctgcct ggctacccag gggaggagct ggaggaggag
1081 gaggaaaggg gcgtgaagct cggcctggga gacttcatct tctacagcgt cctggtgggc
1141 aaggctgcag ccactggcaa cggagactgg aacactacgc tggcctgttt tatcgccatc
1201 ctcattggct tgtgtctcac cctcctgctg cttgctgtgt tcaagaaggc tctgcccgcc
1261 ctccccatct ccatcacctt tggactcatc ttctacttct ccacagacaa cctggtgcgc
1321 cctttcatgg acactctggc ctcccaccag ctctacatct gacaggagcc aggcggaggc
1381 tccgagagct atgggggcgt cactggatgc aggtgtatag ttttacactc tagtgccata
1441 tattttttaa agaaattttc tttccttaca aaagaagaag aagaaaaaaa
//