LOCUS AF038007 3756 bp mRNA linear HUM 09-OCT-1998
DEFINITION Homo sapiens FIC1 mRNA, complete cds.
ACCESSION AF038007
VERSION AF038007.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3756)
AUTHORS Bull,L.N., van Eijk,M.J.T., Pawlikowska,L., DeYoung,J.A.,
Juijn,J.A., Liao,M., Klomp,L.W.J., Lomri,N., Berger,R.,
Scharschmidt,B.F., Knisley,A.S., Houwen,R.H.J. and Freimer,N.B.
TITLE A gene encoding a P-type ATPase mutated in two forms of hereditary
cholestasis
JOURNAL Nat. Genet. 18 (3), 219-224 (1998)
PUBMED 9500542
REFERENCE 2 (bases 1 to 3756)
AUTHORS Bull,L.N., van Eijk,M.J.T., Pawlikowska,L., DeYoung,J.A.,
Juijn,J.A., Liao,M., Klomp,L.W.J., Lomri,N., Berger,R.,
Scharschmidt,B.F., Knisley,A.S., Houwen,R.H.J. and Freimer,N.B.
TITLE Direct Submission
JOURNAL Submitted (10-DEC-1997) Psychiatry, UCSF, 401 Parnassus Ave., San
Francisco, CA 94143, USA
REFERENCE 3 (bases 1 to 3756)
AUTHORS Bull,L.N., van Eijk,M.J.T., Pawlikowska,L., DeYoung,J.A.,
Juijn,J.A., Liao,M., Klomp,L.W.J., Lomri,N., Berger,R.,
Scharschmidt,B.F., Knisley,A.S., Houwen,R.H.J. and Freimer,N.B.
TITLE Direct Submission
JOURNAL Submitted (18-SEP-1998) Psychiatry, UCSF, 401 Parnassus Ave., San
Francisco, CA 94143, USA
REMARK Sequence update by submitter
COMMENT On Sep 19, 1998 this sequence version replaced gi:2959703.
FEATURES Location/Qualifiers
source 1..3756
/db_xref="H-InvDB:HIT000063383"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q21"
CDS 1..3756
/function="P-type ATPase"
/codon_start=1
/product="FIC1"
/protein_id="AAC63461.1"
/translation="MSTERDSETTFDEDSQPNDEVVPYSDDETEDELDDQGSAVEPEQ
NRVNREAEENREPFRKECTWQVKANDRKYHEQPHFMNTKFLCIKESKYANNAIKTYKY
NAFTFIPMNLFEQFKRAANLYFLALLILQAVPQISTLAWYTTLVPLLVVLGVTAIKDL
VDDVARHKMDKEINNRTCEVIKDGRFKVAKWKEIQVGDVIRLKKNDFVPADILLLSSS
EPNSLCYVETAELDGETNLKFKMSLEITDQYLQREDTLATFDGFIECEEPNNRLDKFT
GTLFWRNTSFPLDADKILLRGCVIRNTDFCHGLVIFAGADTKIMKNSGKTRFKRTKID
YLMNYMVYTIFVVLILLSAGLAIGHAYWEAQVGNSSWYLYDGEDDTPSYRGFLIFWGY
IIVLNTMVPISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHY
IFSDKTGTLTQNIMTFKKCCINGQIYGDHRDASQHNHNKIEQVDFSWNTYADGKLAFY
DHYLIEQIQSGKEPEVRQFFFLLAVCHTVMVDRTDGQLNYQAASPDEGALVNAARNFG
FAFLARTQNTITISELGTERTYNVLAILDFNSDRKRMSIIVRTPEGNIKLYCKGADTV
IYERLHRMNPTKQETQDALDIFANETLRTLCLCYKEIEEKEFTEWNKKFMAASVASTN
RDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAE
NIGFACELLTEDTTICYGEDINSLLHARMENQRNRGGVYAKFAPPVQESFFPPGGNRA
LIITGSWLNEILLEKKTKRNKILKLKFPRTEEERRMRTQSKRRLEAKKEQRQKNFVDL
ACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQE
GMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFN
GYSAQTAYEDWFITLYNVLYTSLPVLLMGLLDQDVSDKLSLRFPGLYIVGQRDLLFNY
KRFFVSLLHGVLTSMILFFIPLGAYLQTVGQDGEAPSDYQSFAVTIASALVITVNFQI
GLDTSYWTFVNAFSIFGSIALYFGIMFDFHSAGIHVLFPSAFQFTGTASNALRQPYIW
LTIILTVAVCLLPVVAIRFLSMTIWPSESDKIQKHRKRLKAEEQWQRRQQVFRRGVST
RRSAYAFSHQRGYADLISSGRSIRKKRSPLDAIVADGTAEYRRTGDS"
BASE COUNT 1087 a 839 c 868 g 962 t
ORIGIN
1 atgagtacag aaagagactc agaaacgaca tttgacgagg attctcagcc taatgacgaa
61 gtggttccct acagtgatga tgaaacagaa gatgaacttg atgaccaggg gtctgctgtt
121 gaaccagaac aaaaccgagt caacagggaa gcagaggaga accgggagcc attcagaaaa
181 gaatgtacat ggcaagtcaa agcaaacgat cgcaagtacc acgaacaacc tcactttatg
241 aacacaaaat tcttgtgtat taaggagagt aaatatgcga ataatgcaat taaaacatac
301 aagtacaacg catttacctt tataccaatg aatctgtttg agcagtttaa gagagcagcc
361 aatttatatt tcctggctct tcttatctta caggcagttc ctcaaatctc taccctggct
421 tggtacacca cactagtgcc cctgcttgtg gtgctgggcg tcactgcaat caaagacctg
481 gtggacgatg tggctcgcca taaaatggat aaggaaatca acaataggac gtgtgaagtc
541 attaaggatg gcaggttcaa agttgctaag tggaaagaaa ttcaagttgg agacgtcatt
601 cgtctgaaaa aaaatgattt tgttccagct gacattctcc tgctgtctag ctctgagcct
661 aacagcctct gctatgtgga aacagcagaa ctggacggag aaaccaattt aaaatttaag
721 atgtcacttg aaatcacaga ccagtacctc caaagagaag atacattggc tacatttgat
781 ggttttattg aatgtgaaga acccaataac cgactagata agtttacagg aacactattt
841 tggagaaaca caagttttcc tttggatgct gataaaattt tgttacgtgg ctgtgtaatt
901 aggaacaccg atttctgcca cggcttagtc atttttgcag gtgctgacac taaaataatg
961 aagaatagtg ggaaaaccag atttaaaaga actaaaattg attacttgat gaactacatg
1021 gtttacacga tctttgttgt tcttattctg ctttctgctg gtcttgccat cggccatgct
1081 tattgggaag cacaggtggg caattcctct tggtacctct atgatggaga agacgataca
1141 ccctcctacc gtggattcct cattttctgg ggctatatca ttgttctcaa caccatggta
1201 cccatctctc tctatgtcag cgtggaagtg attcgtcttg gacagagtca cttcatcaac
1261 tgggacctgc aaatgtacta tgctgagaag gacacacccg caaaagctag aaccaccaca
1321 ctcaatgaac agctcgggca gatccattat atcttctctg ataagacggg gacactcaca
1381 caaaatatca tgacctttaa aaagtgctgt atcaacgggc agatatatgg ggaccatcgg
1441 gatgcctctc aacacaacca caacaaaata gagcaagttg attttagctg gaatacatat
1501 gctgatggga agcttgcatt ttatgaccac tatcttattg agcaaatcca gtcagggaaa
1561 gagccagaag tacgacagtt cttcttcttg ctcgcagttt gccacacagt catggtggat
1621 aggactgatg gtcagctcaa ctaccaggca gcctctcccg atgaaggtgc cctggtaaac
1681 gctgccagga actttggctt tgccttcctc gccaggaccc agaacaccat caccatcagt
1741 gaactgggca ctgaaaggac ttacaatgtt cttgccattt tggacttcaa cagtgaccgg
1801 aagcgaatgt ctatcattgt aagaacccca gaaggcaata tcaagcttta ctgtaaaggt
1861 gctgacactg ttatttatga acggttacat cgaatgaatc ctactaagca agaaacacag
1921 gatgccctgg atatctttgc aaatgaaact cttagaaccc tatgcctttg ctacaaggaa
1981 attgaagaaa aagaatttac agaatggaat aaaaagttta tggctgccag tgtggcctcc
2041 accaaccggg acgaagctct ggataaagta tatgaggaga ttgaaaaaga cttaattctc
2101 ctgggagcta cagctattga agacaagcta caggatggag ttccagaaac catttcaaaa
2161 cttgcaaaag ctgacattaa gatctgggtg cttactggag acaaaaagga aactgctgaa
2221 aatataggat ttgcttgtga acttctgact gaagacacca ccatctgcta tggggaggat
2281 attaattctc ttcttcatgc aaggatggaa aaccagagga atagaggtgg cgtctacgca
2341 aagtttgcac ctcctgtgca ggaatctttt tttccacccg gtggaaaccg tgccttaatc
2401 atcactggtt cttggttgaa tgaaattctt ctcgagaaaa agaccaagag aaataagatt
2461 ctgaagctga agttcccaag aacagaagaa gaaagacgga tgcggaccca aagtaaaagg
2521 aggctagaag ctaagaaaga gcagcggcag aaaaactttg tggacctggc ctgcgagtgc
2581 agcgcagtca tctgctgccg cgtcaccccc aagcagaagg ccatggtggt ggacctggtg
2641 aagaggtaca agaaagccat cacgctggcc atcggagatg gggccaatga cgtgaacatg
2701 atcaaaactg cccacattgg cgttggaata agtggacaag aaggaatgca agctgtcatg
2761 tcgagtgact attcctttgc tcagttccga tatctgcaga ggctactgct ggtgcatggc
2821 cgatggtctt acataaggat gtgcaagttc ctacgatact tcttttacaa aaactttgcc
2881 tttactttgg ttcatttctg gtactccttc ttcaatggct actctgcgca gactgcatac
2941 gaggattggt tcatcaccct ctacaacgtg ctgtacacca gcctgcccgt gctcctcatg
3001 gggctgctcg accaggatgt gagtgacaaa ctgagcctcc gattccctgg gttatacata
3061 gtgggacaaa gagacttact attcaactat aagagattct ttgtaagctt gttgcatggg
3121 gtcctaacat cgatgatcct cttcttcata cctcttggag cttatctgca aaccgtaggg
3181 caggatggag aggcaccttc cgactaccag tcttttgccg tcaccattgc ctctgctctt
3241 gtaataacag tcaatttcca gattggcttg gatacttctt attggacttt tgtgaatgct
3301 ttttcaattt ttggaagcat tgcactttat tttggcatca tgtttgactt tcatagtgct
3361 ggaatacatg ttctctttcc atctgcattt caatttacag gcacagcttc aaacgctctg
3421 agacagccat acatttggtt aactatcatc ctgactgttg ctgtgtgctt actacccgtc
3481 gttgccattc gattcctgtc aatgaccatc tggccatcag aaagtgataa gatccagaag
3541 catcgcaagc ggttgaaggc ggaggagcag tggcagcgac ggcagcaggt gttccgccgg
3601 ggcgtgtcaa cgcggcgctc ggcctacgcc ttctcgcacc agcggggcta cgcggacctc
3661 atctcctccg ggcgcagcat ccgcaagaag cgctcgccgc ttgatgccat cgtggcggat
3721 ggcaccgcgg agtacaggcg caccggggac agctga
//