LOCUS AF036905 1060 bp mRNA linear HUM 06-MAR-1998 DEFINITION Homo sapiens linker for activation of T cells (LAT) mRNA, complete cds. ACCESSION AF036905 VERSION AF036905.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1060) AUTHORS Zhang,W., Sloan-Lancaster,J., Kitchen,J., Trible,R.P. and Samelson,L.E. TITLE LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation JOURNAL Cell 92 (1), 83-92 (1998) PUBMED 9489702 REFERENCE 2 (bases 1 to 1060) AUTHORS Zhang,W., Sloan-Lancaster,J., Kitchen,J., Trible,R.P. and Samelson,L.E. TITLE Direct Submission JOURNAL Submitted (05-DEC-1997) Cell Biology and Metabolism Branch, National Institute of Child Health and Development, National Institute of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA COMMENT LAT is a highly tyrosine phosphorylated protein, previously described as p36-38, and it associates with many signaling molecules, such as Grb2, PLC-gamma1, PI-3 kinase, cbl, Vav, and SLP-76, either directly or indirectly upon T cell activation. It is a potential type III transmembrane protein. FEATURES Location/Qualifiers source 1..1060 /db_xref="H-InvDB:HIT000063347" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /cell_line="Jurkat T cells" gene 1..1060 /gene="LAT" /note="linker for activation of T cells" CDS 58..759 /gene="LAT" /note="tyrosine kinase substrate" /codon_start=1 /product="LAT" /protein_id="AAC39636.1" /translation="MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSL YPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSD GANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRD SAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEV EEEGAPDYENLQELN" BASE COUNT 227 a 331 c 301 g 201 t ORIGIN 1 gactctgccc ttgaggggcc taggggtgca gccagcctgc tccgagctcc cctgcagatg 61 gaggaggcca tcctggtccc ctgcgtgctg gggctcctgc tgctgcccat cctggccatg 121 ttgatggcac tgtgtgtgca ctgccacaga ctgccaggct cctacgacag cacatcctca 181 gatagtttgt atccaagggg catccagttc aaacggcctc acacggttgc cccctggcca 241 cctgcctacc cacctgtcac ctcctaccca cccctgagcc agccagacct gctccccatc 301 ccaagatccc cgcagcccct tgggggctcc caccggacgc catcttcccg gcgggattct 361 gatggtgcca acagtgtggc gagctacgag aacgaggaac cagcctgtga ggatgcagat 421 gaggatgagg acgactatca caacccaggc tacctggtgg tgcttcctga cagcaccccg 481 gccactagca ctgctgcccc atcagctcct gcactcagca cccctggcat ccgagacagt 541 gccttctcca tggagtccat tgatgattac gtgaacgttc cggagagcgg ggagagcgca 601 gaagcgtctc tggatggcag ccgggagtat gtgaatgtgt cccaggaact gcatcctgga 661 gcggctaaga ctgagcctgc cgccctgagt tcccaggagg cagaggaagt ggaggaagag 721 ggggctccag attacgagaa tctgcaggag ctgaactgag ggcctgtgga ggccgagtct 781 gtcctggaac caggcttgcc tgggacggct gagctgggca gctggaagtg gctctggggt 841 cctcacatgg cgtcctgccc ttgctccagc ctgacaacag cctgagaaat ccccccgtaa 901 cttattatca ctttggggtt cggcctgtgt cccccgaacg ctctgcacct tctgacgcag 961 cctgagaatg acctgccctg gccccagccc tactctgtgt aatagaataa aggcctgcgt 1021 gtgtctgtgg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa //