LOCUS       AF036905                1060 bp    mRNA    linear   HUM 06-MAR-1998
DEFINITION  Homo sapiens linker for activation of T cells (LAT) mRNA, complete
            cds.
ACCESSION   AF036905
VERSION     AF036905.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1060)
  AUTHORS   Zhang,W., Sloan-Lancaster,J., Kitchen,J., Trible,R.P. and
            Samelson,L.E.
  TITLE     LAT: the ZAP-70 tyrosine kinase substrate that links T cell
            receptor to cellular activation
  JOURNAL   Cell 92 (1), 83-92 (1998)
   PUBMED   9489702
REFERENCE   2  (bases 1 to 1060)
  AUTHORS   Zhang,W., Sloan-Lancaster,J., Kitchen,J., Trible,R.P. and
            Samelson,L.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-DEC-1997) Cell Biology and Metabolism Branch,
            National Institute of Child Health and Development, National
            Institute of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
COMMENT     LAT is a highly tyrosine phosphorylated protein, previously
            described as p36-38, and it associates with many signaling
            molecules, such as Grb2, PLC-gamma1, PI-3 kinase, cbl, Vav, and
            SLP-76, either directly or indirectly upon T cell activation. It is
            a potential type III transmembrane protein.
FEATURES             Location/Qualifiers
     source          1..1060
                     /db_xref="H-InvDB:HIT000063347"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="Jurkat T cells"
     gene            1..1060
                     /gene="LAT"
                     /note="linker for activation of T cells"
     CDS             58..759
                     /gene="LAT"
                     /note="tyrosine kinase substrate"
                     /codon_start=1
                     /product="LAT"
                     /protein_id="AAC39636.1"
                     /translation="MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSL
                     YPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSD
                     GANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRD
                     SAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEV
                     EEEGAPDYENLQELN"
BASE COUNT          227 a          331 c          301 g          201 t
ORIGIN      
        1 gactctgccc ttgaggggcc taggggtgca gccagcctgc tccgagctcc cctgcagatg
       61 gaggaggcca tcctggtccc ctgcgtgctg gggctcctgc tgctgcccat cctggccatg
      121 ttgatggcac tgtgtgtgca ctgccacaga ctgccaggct cctacgacag cacatcctca
      181 gatagtttgt atccaagggg catccagttc aaacggcctc acacggttgc cccctggcca
      241 cctgcctacc cacctgtcac ctcctaccca cccctgagcc agccagacct gctccccatc
      301 ccaagatccc cgcagcccct tgggggctcc caccggacgc catcttcccg gcgggattct
      361 gatggtgcca acagtgtggc gagctacgag aacgaggaac cagcctgtga ggatgcagat
      421 gaggatgagg acgactatca caacccaggc tacctggtgg tgcttcctga cagcaccccg
      481 gccactagca ctgctgcccc atcagctcct gcactcagca cccctggcat ccgagacagt
      541 gccttctcca tggagtccat tgatgattac gtgaacgttc cggagagcgg ggagagcgca
      601 gaagcgtctc tggatggcag ccgggagtat gtgaatgtgt cccaggaact gcatcctgga
      661 gcggctaaga ctgagcctgc cgccctgagt tcccaggagg cagaggaagt ggaggaagag
      721 ggggctccag attacgagaa tctgcaggag ctgaactgag ggcctgtgga ggccgagtct
      781 gtcctggaac caggcttgcc tgggacggct gagctgggca gctggaagtg gctctggggt
      841 cctcacatgg cgtcctgccc ttgctccagc ctgacaacag cctgagaaat ccccccgtaa
      901 cttattatca ctttggggtt cggcctgtgt cccccgaacg ctctgcacct tctgacgcag
      961 cctgagaatg acctgccctg gccccagccc tactctgtgt aatagaataa aggcctgcgt
     1021 gtgtctgtgg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//