LOCUS AF036892 6754 bp mRNA linear HUM 21-DEC-1997
DEFINITION Homo sapiens nuclear receptor coactivator (ACTR) mRNA, complete
cds.
ACCESSION AF036892
VERSION AF036892.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6754)
AUTHORS Chen,H., Lin,R.J., Schiltz,R.L., Chakravarti,D., Nash,A., Nagy,L.,
Privalsky,M.L., Nakatani,Y. and Evans,R.M.
TITLE Nuclear receptor coactivator ACTR is a novel histone
acetyltransferase and forms a multimeric activation complex with
P/CAF and CBP/p300
JOURNAL Cell 90 (3), 569-580 (1997)
PUBMED 9267036
REFERENCE 2 (bases 1 to 6754)
AUTHORS Chen,H. and Evans,R.M.
TITLE Direct Submission
JOURNAL Submitted (03-DEC-1997) Gene Expression Lab, The Salk Institute for
Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037,
USA
FEATURES Location/Qualifiers
source 1..6754
/db_xref="H-InvDB:HIT000063344"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="leukocyte"
gene 1..6754
/gene="ACTR"
CDS 184..4422
/gene="ACTR"
/function="histone acetyltransferase"
/function="transcriptional cofactor"
/note="activator for thyroid hormone and retinoid
receptors; member of the nuclear receptor coactivator
family which includes SRC-1, TIF2/GRIP1; similar to
p300/CBP interacting protein (p/CIP)"
/codon_start=1
/product="nuclear receptor coactivator"
/protein_id="AAB92368.1"
/translation="MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKY
IEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSS
TGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNI
LHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMR
QRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGK
VVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEVTSDGIFSPTAYL
NGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNP
VGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIA
SLTPGPGMQSPSSYQNNNYRLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFS
PVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNI
TQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLE
SKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSN
MHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPK
KKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTE
TSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLKSSQSVQ
SIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMGD
WGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPTLPLRSNSIPGARPVLQQ
QQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLLRNSLD
DLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPKQD
AFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMNQMNQQGNFPLQ
GMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTAGGAAVMRPM
MQPQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQ
QQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSSPP
NAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQFAHQGNPAVY
SMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC"
BASE COUNT 1955 a 1463 c 1511 g 1825 t
ORIGIN
1 gtcgacgtgg cggccggcgg cggctgcggg ctgagcggcg agtttccgat ttaaagctga
61 gctgcgagga aaatggcggc gggaggatca aaatacttgc tggatggtgg actcagagac
121 caataaaaat aaactgcttg aacatccttt gactggttag ccagttgctg atgtatattc
181 aagatgagtg gattaggaga aaacttggat ccactggcca gtgattcacg aaaacgcaaa
241 ttgccatgtg atactccagg acaaggtctt acctgcagtg gtgaaaaacg gagacgggag
301 caggaaagta aatatattga agaattggct gagctgatat ctgccaatct tagtgatatt
361 gacaatttca atgtcaaacc agataaatgt gcgattttaa aggaaacagt aagacagata
421 cgtcaaataa aagagcaagg aaaaactatt tccaatgatg atgatgttca aaaagccgat
481 gtatcttcta cagggcaggg agttattgat aaagactcct taggaccgct tttacttcag
541 gcattggatg gtttcctatt tgtggtgaat cgagacggaa acattgtatt tgtatcagaa
601 aatgtcacac aatacctgca atataagcaa gaggacctgg ttaacacaag tgtttacaat
661 atcttacatg aagaagacag aaaggatttt cttaagaatt taccaaaatc tacagttaat
721 ggagtttcct ggacaaatga gacccaaaga caaaaaagcc atacatttaa ttgccgtatg
781 ttgatgaaaa caccacatga tattctggaa gacataaacg ccagtcctga aatgcgccag
841 agatatgaaa caatgcagtg ctttgccctg tctcagccac gagctatgat ggaggaaggg
901 gaagatttgc aatcttgtat gatctgtgtg gcacgccgca ttactacagg agaaagaaca
961 tttccatcaa accctgagag ctttattacc agacatgatc tttcaggaaa ggttgtcaat
1021 atagatacaa attcactgag atcctccatg aggcctggct ttgaagatat aatccgaagg
1081 tgtattcaga gattttttag tctaaatgat gggcagtcat ggtcccagaa acgtcactat
1141 caagaagtta ccagtgatgg gatattttcc ccaacagctt atcttaatgg ccatgcagaa
1201 accccagtat atcgattctc gttggctgat ggaactatag tgactgcaca gacaaaaagc
1261 aaactcttcc gaaatcctgt aacaaatgat cgacatggct ttgtctcaac ccacttcctt
1321 cagagagaac agaatggata tagaccaaac ccaaatcctg ttggacaagg gattagacca
1381 cctatggctg gatgcaacag ttcggtaggc ggcatgagta tgtcgccaaa ccaaggctta
1441 cagatgccga gcagcagggc ctatggcttg gcagacccta gcaccacagg gcagatgagt
1501 ggagctaggt atgggggttc cagtaacata gcttcattga cccctgggcc aggcatgcaa
1561 tcaccatctt cctaccagaa caacaactat aggctcaaca tgagtagccc cccacatggg
1621 agtcctggtc ttgccccaaa ccagcagaat atcatgattt ctcctcgtaa tcgtgggagt
1681 ccaaagatag cctcacatca gttttctcct gttgcaggtg tgcactctcc catggcatct
1741 tctggcaata ctgggaacca cagcttttcc agcagctctc tcagtgccct gcaagccatc
1801 agtgaaggtg tggggacttc ccttttatct actctgtcat caccaggccc caaattggat
1861 aactctccca atatgaatat tacccaacca agtaaagtaa gcaatcagga ttccaagagt
1921 cctctgggct tttattgcga ccaaaatcca gtggagagtt caatgtgtca gtcaaatagc
1981 agagatcacc tcagtgacaa agaaagtaag gagagcagtg ttgagggggc agagaatcaa
2041 aggggtcctt tggaaagcaa aggtcataaa aaattactgc agttacttac ctgttcttct
2101 gatgaccggg gtcattcctc cttgaccaac tcccccctag attcaagttg taaagaatct
2161 tctgttagtg tcaccagccc ctctggagtc tcctcctcta catctggagg agtatcctct
2221 acatccaata tgcatgggtc actgttacaa gagaagcacc ggattttgca caagttgctg
2281 cagaatggga attcaccagc tgaggtagcc aagattactg cagaagccac tgggaaagac
2341 accagcagta taacttcttg tggggacgga aatgttgtca agcaggagca gctaagtcct
2401 aagaagaagg agaataatgc acttcttaga tacctgctgg acagggatga tcctagtgat
2461 gcactctcta aagaactaca gccccaagtg gaaggagtgg ataataaaat gagtcagtgc
2521 accagctcca ccattcctag ctcaagtcaa gagaaagacc ctaaaattaa gacagagaca
2581 agtgaagagg gatctggaga cttggataat ctagatgcta ttcttggtga tctgactagt
2641 tctgactttt acaataattc catatcctca aatggtagtc atctggggac taagcaacag
2701 gtgtttcaag gaactaattc tctgggtttg aaaagttcac agtctgtgca gtctattcgt
2761 cctccatata accgagcagt gtctctggat agccctgttt ctgttggctc aagtcctcca
2821 gtaaaaaata tcagtgcttt ccccatgtta ccaaagcaac ccatgttggg tgggaatcca
2881 agaatgatgg atagtcagga aaattatggc tcaagtatgg gagactgggg cttaccaaac
2941 tcaaaggccg gcagaatgga acctatgaat tcaaactcca tgggaagacc aggaggagat
3001 tataatactt ctttacccag acctgcactg ggtggctcta ttcccacatt gcctcttcgg
3061 tctaatagca taccaggtgc gagaccagta ttgcaacagc agcagcagat gcttcaaatg
3121 aggcctggtg aaatccccat gggaatgggg gctaatccct atggccaagc agcagcatct
3181 aaccaactgg gttcctggcc cgatggcatg ttgtccatgg aacaagtttc tcatggcact
3241 caaaataggc ctcttcttag gaattccctg gatgatcttg ttgggccacc ttccaacctg
3301 gaaggccaga gtgacgaaag agcattattg gaccagctgc acactcttct cagcaacaca
3361 gatgccacag gcctggaaga aattgacaga gctttgggca ttcctgaact tgtcaatcag
3421 ggacaggcat tagagcccaa acaggatgct ttccaaggcc aagaagcagc agtaatgatg
3481 gatcagaagg caggattata tggacagaca tacccagcac aggggcctcc aatgcaagga
3541 ggctttcatc ttcagggaca atcaccatct tttaactcta tgatgaatca gatgaaccag
3601 caaggcaatt ttcctctcca aggaatgcac ccacgagcca acatcatgag accccggaca
3661 aacaccccca agcaacttag aatgcagctt cagcagaggc tgcagggcca gcagtttttg
3721 aatcagagcc gacaggcact tgaattgaaa atggaaaacc ctactgctgg tggtgctgcg
3781 gtgatgaggc ctatgatgca gccccagcag ggttttctta atgctcaaat ggtcgcccaa
3841 cgcagcagag agctgctaag tcatcacttc cgacaacaga gggtggctat gatgatgcag
3901 cagcagcaac agcagcagca gcagcagcag cagcagcaac agcaacagca acagcaacag
3961 cagcaacagc agcaaaccca ggccttcagc ccacctccta atgtgactgc ttcccccagc
4021 atggatgggc ttttggcagg acccacaatg ccacaagctc ctccgcaaca gtttccatat
4081 caaccaaatt atggaatggg acaacaacca gatccagcct ttggtcgagt gtctagtcct
4141 cccaatgcaa tgatgtcgtc aagaatgggt ccctcccaga atcccatgat gcaacacccg
4201 caggctgcat ccatctatca gtcctcagaa atgaagggct ggccatcagg aaatttggcc
4261 aggaacagct ccttttccca gcagcagttt gcccaccagg ggaatcctgc agtgtatagt
4321 atggtgcaca tgaatggcag cagtggtcac atgggacaga tgaacatgaa ccccatgccc
4381 atgtctggca tgcctatggg tcctgatcag aaatactgct gacatctctg caccaggacc
4441 tcttaaggaa accactgtac aaatgacact gcactaggat tattgggaag gaatcattgt
4501 tccaggcatc catcttggaa gaaaggacca gctttgagct ccatcaaggg tattttaagt
4561 gatgtcattt gagcaggact ggattttaag ccgaagggca atatctacgt gtttttcccc
4621 cctccttctg ctgtgtatca tggtgttcaa aacagaaatg ttttttggca ttccacctcc
4681 tagggatata attctggaga catggagtgt tactgatcat aaaacttttg tgtcactttt
4741 ttctgccttg ctagccaaaa tctcttaaat acacgtaggt gggccagaga acattggaag
4801 aatcaagaga gattagaata tctggtttct ctagttgcag tattggacaa agagcatagt
4861 cccagccttc aggtgtagta gttctgtgtt gaccctttgt ccagtggaat tggtgattct
4921 gaattgtcct ttactaatgg tgttgagttg ctctgtccct attatttgcc ctaggctttc
4981 tcctaatgaa ggttttcatt tgccattcat gtcctgtaat acttcacctc caggaactgt
5041 catggatgtc caaatggctt tgcagaaagg aaatgagatg acagtattta atcgcagcag
5101 tagcaaactt ttcacatgct aatgtgcagc tgagtgcact ttatttaaaa agaatggata
5161 aatgcaatat tcttgaggtc ttgagggaat agtgaaacac attcctggtt tttgcctaca
5221 cttacgtgtt agacaagaac tatgattttt ttttttaaag tactggtgtc accctttgcc
5281 tatatggtag agcaataatg ctttttaaaa ataaacttct gaaaacccaa ggccaggtac
5341 tgcattctga atcagaatct cgcagtgttt ctgtgaatag atttttttgt aaatatgacc
5401 tttaagatat tgtattatgt aaaatatgta tatacctttt tttgtaggtc acaacaactc
5461 atttttacag agtttgtgaa gctaaatatt taacattgtt gatttcagta agctgtgtgg
5521 tgaggctacc agtggaagag acatcccttg acttttgtgg cctgggggag gggtagtgca
5581 ccacagcttt tccttcccca ccccccagcc ttagatgcct cgctcttttc aatctcttaa
5641 tctaaatgct ttttaaagag attatttgtt tagatgtagg cattttaatt ttttaaaaat
5701 tcctctacca gaactaagca ctttgttaat ttggggggaa agaatagata tggggaaata
5761 aacttaaaaa aaaatcagga atttaaaaaa aacgagcaat ttgaagagaa tcttttggat
5821 tttaagcagt ccgaaataat agcaattcat gggctgtgtg tgtgtgtgta tgtgtgtgtg
5881 tgtgtgtgta tgtttaatta tgttaccttt tcatcccctt taggagcgtt ttcagatttt
5941 ggttcgtaag acctgaatcc catattgaga tctcgagtag aatccttggt gtggtttctg
6001 gtgtctgctc agctgtcccc tcattctact aatgtgatgc tttcattatg tccctgtgga
6061 ttagaatagt gtcagttatt tcttaagtaa ctcagtaccc agaacagcca gttttactgt
6121 gattcagagc cacagtctaa ctgagcacct tttaaacccc tccctcttct gccccctacc
6181 acttttctgc tgttgcctct ctttgacacc tgttttagtc agttgggagg aagggaaaaa
6241 tcaagtttaa ttccctttat ctgggttaat tcatttggtt caaatagttg acggaattgg
6301 gtttctgaat gtctgtgaat ttcagaggtc tctgctagcc ttggtatcat tttctagcaa
6361 taactgagag ccagttaatt ttaagaattt cacacattta gccaatcttt ctagatgtct
6421 ctgaaggtaa gatcatttaa tatctttgat atgcttacga gtaagtgaat cctgattatt
6481 tccagaccca ccaccagagt ggatcttatt ttcaaagcag tatagacaat tatgagtttg
6541 ccctctttcc cctaccaagt tcaaaatata tctaagaaag attgtaaatc cgaaaacttc
6601 cattgtagtg gcctgtgctt ttcagatagt atactctcct gtttggagac agaggaagaa
6661 ccaggtcagt ctgtctcttt ttcagctcaa ttgtatctga cccttcttta agttatgtgt
6721 gtggggagaa atagaatggt gctcttatgt cgac
//