LOCUS       AF036329                4498 bp    DNA     linear   HUM 19-FEB-1998
DEFINITION  Homo sapiens gonadotropin-releasing hormone precursor, second form
            (GnRH-II) gene, complete cds.
ACCESSION   AF036329
VERSION     AF036329.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4498)
  AUTHORS   White,R.B., Eisen,J.A., Kasten,T.L. and Fernald,R.D.
  TITLE     Second gene for gonadotropin-releasing hormone in humans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (1), 305-309 (1998)
   PUBMED   9419371
REFERENCE   2  (bases 1 to 4498)
  AUTHORS   White,R.B., Kasten,T.L. and Fernald,R.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-DEC-1997) Neuroscience, Stanford University, Jordan
            Hall, Bldg 420, Stanford, CA 94305-2130, USA
FEATURES             Location/Qualifiers
     source          1..4498
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
                     /clone_lib="PAC library from Genome Systems (St. Louis,
                     MO, USA) constructed by Pieter Dejong"
                     /note="PAC clone location: plate 184, well B21"
     gene            1312..3431
                     /gene="GnRH-II"
     mRNA            join(1312..1355,2098..2258,2369..2526,3372..3431)
                     /gene="GnRH-II"
     exon            1312..1355
                     /gene="GnRH-II"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /number=1
     exon            2098..2258
                     /gene="GnRH-II"
                     /number=2
     CDS             join(2105..2258,2369..2526,3372..3422)
                     /gene="GnRH-II"
                     /note="GnRH-II precursor; gonadoliberin, second form;
                     LHRH, second form; similar to chicken GnRH-II"
                     /codon_start=1
                     /product="gonadotropin-releasing hormone precursor, second
                     form"
                     /protein_id="AAC02980.1"
                     /translation="MASSRRGLLLLLLLTAHLGPSEAQHWSHGWYPGGKRALSSAQDP
                     QNALRPPGRALDTAAGSPVQTAHGLPSDALAPLDDSMPWEGRTTAQWSLHRKRHLART
                     LLTAAREPRPAPPSSNKV"
     sig_peptide     2105..2173
                     /gene="GnRH-II"
     mat_peptide     2174..2203
                     /gene="GnRH-II"
                     /product="gonadotropin-releasing hormone, second form"
     misc_feature    2204..2212
                     /gene="GnRH-II"
                     /note="cleavage site"
     mat_peptide     join(2213..2258,2369..2526,3372..3419)
                     /gene="GnRH-II"
                     /product="gonadotropin-releasing hormone associated
                     peptide, second form"
                     /note="GnRH-II-associated peptide"
     exon            2369..2526
                     /gene="GnRH-II"
                     /number=3
     exon            3372..3431
                     /gene="GnRH-II"
                     /number=4
     regulatory      3411..3416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GnRH-II"
BASE COUNT          949 a         1309 c         1400 g          840 t
ORIGIN      
        1 aagcttggct ctggtttaga ttttccagga aaagccggaa tcaaattaca gaataaataa
       61 aggcaaccat ccccctttta aaggtacacc agccttggtg catctttgaa gaaagcattc
      121 tgtaaacccc aaccagaact aaactagtac gtcgaactca gattcatttt cactaaacca
      181 caagcaaatg tttccctaaa aatcacccag ttaacaaagt ccgcatattt aagccaaaac
      241 aatttaactg aacaaatggg ccacacgttg atttccggtc cctgctaata agtcagtctg
      301 gaagttcaca ggtgtgccca tcctgccttg gctgctgaag tccaggtgtc tagggctgac
      361 tgatgcccat tatgcctccc ctcccccatc tttgtcacag gatttgacgc accagctctc
      421 caaatgaccc tggccctccc atttgctgtt cagcccaagt gcggagattg gctatgaacc
      481 ctgtaaacag gcctctgacc cccagaggct gatggctggc caaggaaagc tgagctgctg
      541 acgcagactg ggaagcaaga gcccacttcc agcagcccag gctagctgtg tccaaatcca
      601 tgactgggga ggggttagag ccttgaggga caaaattatt ctacctacct agggagactg
      661 cactggccca acagctgggc cccatctcat gggcccgctt cttcgccagg agagaagcca
      721 ctccggggta ggtactgccc cacccaaacc cagccatctg gagtgaccca gccctggttc
      781 ccaggtgtgt ggatgtgaat tgtcccaccc aacccactct acagtgagca aacggaagcc
      841 ctctgggaga gtggtcacag cctcccctgt acctttgaac agcctgccag gctccctact
      901 cttaggcttc cactgtccac cagggaaagc cctgagctgg gagttgggga gcccccaggc
      961 attgcccctg cccaggacac aattctcttt tgggatcagg gaaggctgtg agggctttct
     1021 aggtctcaag atcaggagct tgaagatgca gcctgggaag tgggaaggtg agaccaggac
     1081 ataggccagc ctaaagcaag agtcctgggc ctgaaggctc ctgggaaggt ggtggggagg
     1141 gagcatgtgt cggtggcctc agggcagcag ctgcctggtg aatgttcatg gactggatgc
     1201 tctgggaagc gggttgggtg gtgagcttct ctcttcccct ctgaagacgt cactggagtc
     1261 tgggggtgga gctgcctggt ctataaatcc tggggccatc aggctggggt cctgcagctg
     1321 cctgaaggag ccatctcatc cacagctctt ccttggtgag tggggagcct tccctaaggg
     1381 ctaggacacc tgaaccaatt ttcatcctgg gcgtatggtg tgctgctcct cttccccatt
     1441 cccaggtgcc tccacccctg aaccatgcca gagaagtccc cttttcctct cctctcccca
     1501 acagctctac catctattct tgtgcttgtt gcccctggca tgggagggat aaggggtaga
     1561 agcacttgcc cccatcaata ccactcatcc attccacatc cccaactact atggaagaga
     1621 tacagcaggc cacggagaaa agggcagaag gcctgcaact ctggttccct agcactggtg
     1681 ctccaaacac gcctacattg agaactcccc tgaccatcca tctatcctcc catccattgg
     1741 cctgaattca ggtctctgtt cccctccaac tttcttccac ttctggaaac tccttgaagg
     1801 aaagatggat ggacctggac aagtgggagg gccctcagag ctggcaaggc aggtagcctc
     1861 tgtgccccag gctcagggag aaggctcgtc ccctggagca tcatcccctg ctgggccagg
     1921 atcccccagg atctggaccc ctgtatgctt gggatgagga gcggtggcag agagggaagg
     1981 gcataaggag ataccaaagc tgcccctgag atgccagttt tccaaagtgg ccctggagga
     2041 agtaggggga tgtgggggtg aggtaagtct ccttgaatgc tgtaccctgt ccattagagc
     2101 agccatggcc agctccaggc gaggcctcct gctcctgctg ctgctgactg cccaccttgg
     2161 accctcagag gctcagcact ggtcccatgg ctggtaccct ggaggaaagc gagccctcag
     2221 ctcagcccag gatccccaga atgcccttag gcccccaggt gggtgtctcc cagcctcatg
     2281 gggaggaaga aagtgatggc cgggggctcc cccaccctcc tggagcctga ggtcggggta
     2341 gggaggacag catcagttcc cttctaagga agggccctgg acactgcagc aggcagccca
     2401 gtccagactg cccatggcct cccaagtgat gccctggctc ccctggacga cagcatgccc
     2461 tgggagggca ggaccacggc ccagtggtcc cttcacagga agcgacacct ggcacggaca
     2521 ctgctggtga gtagggtgag aggtccccag catcaagacc agccactggt catcagaggc
     2581 cattgtggct tagggttggg tgctgggagg gtggggagaa tgaaacacca ctgagatgcc
     2641 ccctgccaca gcacccccag ccatttctca gtgcccctac tgcacacagc agggtgctgt
     2701 ctgctatcct tcctatttcc caggaggatt ctagacaatt tacaaagcac ttgggttaaa
     2761 gaccaaagtc actagtagac tagaaggaga taattgttct ataagacagt ggtggccatg
     2821 ggatcccaca ggcatcctga caagccaatg actgtcttga ggtggacaga ccccaggcca
     2881 gtggaaagag gtgagggatg caacctcact cagacaacag ggccaagagg accaggtggt
     2941 gactgacatg tgcactagga acatctcagg gactgcagag ctccccaaga ccatagcaga
     3001 agacaggcgt ggggaaatgg tttgctactg ttttgcaaat caaacattta cagtgcatca
     3061 ggagagcccg gtaactaaag aagaaagtgg ttagttccta tgaggcaaag tcttaccgcc
     3121 tgatttgtgt gtatgtgctg aggtttctat gcgtcaggct tgtttagggt ggacaagagg
     3181 gcatgcccaa gggagctgga gatccccaca ctagctggat cctcaggctt ctacgggagg
     3241 cggggggcgt cctgctgtgg gaggccacat ggggactggg ggggacgaga ggggagagaa
     3301 ccaggaagat ggcagctcgg cggttacgag accagtgtcc tgagacatga ccgccacctc
     3361 tccctccgca gaccgcagcc cgagagcccc gccccgcccc gccatcctcc aataaagtgt
     3421 gaggttctcc gaagctgttg cgtcgagttc tgtccttcgt cccctccctg tcttccccgc
     3481 tgagaccctt ccctgcgtgg gggctggagg gacgcgggtc cggccccgcg ggcgggagta
     3541 actaagggat ggccccgggc cctggcggga aggccgggcc agagcctggg ggcgggatgc
     3601 ggacgtccgc agggtcgccg cttcggttcc agaggccaca cggccgggcg gggcgtgagg
     3661 gacagcccga ggactacagg tcccaaggtt ccccgcgccg cttccggggc acggtggcgt
     3721 cccggcaccg cggccgcagt gaggagactc ggccatgcta cgcgcgctga gccgcctggg
     3781 cgcggggacc ccgtgcaggc cccgggcccc tctggtgctg ccagcgcgcg gccgcaagac
     3841 ccgccacgac ccgctggcca aatccaagat cgagcgagtg aacatgccgc ccgcggtgga
     3901 ccctgcggag ttcttcgtgc tgatggagcg ttaccagcac taccgccaga ccgtgcgcgc
     3961 cctcaggtgt gcggccgggg ggaggtggcc gcccgcgcgc gctggtgacg gtgggagtgg
     4021 gcggagaggg tgctgattcc tggcgcgtct gcacccagga tggagttcgt gtccgaggtg
     4081 cagaggaagg tgcacgaggc ccgagccggg gttctggcgg agcgcaaggc cctgaaggac
     4141 gccgccgagc accgcgagct gatggcctgg aaccaggcgg agaaccggcg gctgcacgag
     4201 ctgcggtgcg tggggcggga ggcggggcgg ggcggcgcgg cctggccggc ctgggagaag
     4261 cccgggcccc gctcagcctc ggccctttga ccctcacagg atagcgaggc tgcggcagga
     4321 ggagcgggag caggagcagc ggcaggcgtt ggagcaggcc cgcaaggccg aagaggtgca
     4381 ggcctgggcg cagcgcaagg agcgggaagt gctgcagctg caggtgggca acgtttccgg
     4441 agggtgggac tccagcgggg acgcggcttg cggggcactg gaattagata tcaagctt
//