LOCUS AF036144 5147 bp mRNA linear HUM 17-OCT-2000
DEFINITION Homo sapiens meningioma-expressed antigen 5 (MEA5) mRNA, complete
cds.
ACCESSION AF036144 AF036145 AH007262
VERSION AF036144.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5147)
AUTHORS Heckel,D., Comtesse,N., Brass,N., Blin,N., Zang,K.D. and Meese,E.
TITLE Novel immunogenic antigen homologous to hyaluronidase in meningioma
JOURNAL Hum. Mol. Genet. 7 (12), 1859-1872 (1998)
PUBMED 9811929
REFERENCE 2 (bases 1 to 5147)
AUTHORS Heckel,D., Comtesse,N., Brass,N. and Meese,E.
TITLE Direct Submission
JOURNAL Submitted (24-NOV-1997) Institute of Human Genetics, University of
Saarland Medical School, Kirrbergerstrasse, Homburg, Saarland
66421, Germany
REFERENCE 3 (bases 1 to 5147)
AUTHORS Heckel,D., Comtesse,N., Brass,N. and Meese,E.
TITLE Direct Submission
JOURNAL Submitted (17-OCT-2000) Institute of Human Genetics, University of
Saarland Medical School, Kirrbergerstrasse, Homburg, Saarland
66421, Germany
REMARK Sequence update by submitter
COMMENT On or before Oct 17, 2000 this sequence version replaced
AH007262.1, AF036145.1, AF036144.1.
FEATURES Location/Qualifiers
source 1..5147
/db_xref="H-InvDB:HIT000063324"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q24.1-q24.3"
/tissue_type="meningioma"
gene 1..5147
/gene="MEA5"
CDS 396..3146
/gene="MEA5"
/note="hyaluronidase homolog; similar to product encoded
by Caenorhabiditis elegans gene deposited under GenBank
Accession Number U28742"
/codon_start=1
/product="meningioma-expressed antigen 5"
/protein_id="AAD05385.2"
/translation="MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAG
AGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYK
HRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQ
VSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTE
YCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPV
IWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKS
NMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFG
VPHQYSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTT
LTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAE
SKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFY
LPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGM
FTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFR
GGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGV
GLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWI
PFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSV
AKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGR
SL"
regulatory 5131..5136
/regulatory_class="polyA_signal_sequence"
/gene="MEA5"
BASE COUNT 1442 a 969 c 1294 g 1442 t
ORIGIN
1 aggcagcagc agagggagag ctcggggctt ggaggggaaa cagcggaaga cctaagatta
61 tcgggagggc agcagaggca gagaacgagg acaggaccct tggccgtctt cttccaggga
121 acgagaggtc acagcctcgc tctccgctta tgcttctggc gccccagctt aaagccgagg
181 ctgcggctga caaagggctc gcgccggtgc cgccgccctt ctcatccggg cattcgggtc
241 cctgcgagaa ggagggggaa ggacagaggg ggaggggaag gagccggagg ggcgcacact
301 tggagctgaa gccctctcca gggctccggg ccggtgcccc aacggacaga ggtcgaggag
361 gacccgcaga ggtggcagcg gccgggggca ggaggatggt gcagaaggag agtcaagcga
421 cgttggagga gcgggagagc gagctcagct ccaaccctgc cgcctctgcg ggggcatcgc
481 tggagccgcc ggcagctccg gcacccggag aagacaaccc cgccggggct gggggagcgg
541 cggtggccgg ggctgcagga ggggctcggc ggttcctctg cggtgtggtg gaaggatttt
601 atggaagacc ttgggttatg gaacagagaa aagaactctt tagaaggctc cagaaatggg
661 aattaaatac atacttgtat gccccaaaag atgactacaa acataggatg ttttggcgag
721 agatgtattc agtggaggaa gctgagcaac ttatgactct catctctgct gcacgagaat
781 atgagataga gttcatctat gcgatctcac ctggattgga tatcactttt tctaacccca
841 aggaagtatc cacattgaaa cgtaaattgg accaggtttc tcagtttggg tgcagatcat
901 ttgctttgct ttttgatgat atagaccata atatgtgtgc agcagacaaa gaggtattca
961 gttcttttgc tcatgcccaa gtctccatca caaatgaaat ctatcagtac ctaggagagc
1021 cagaaacttt cctcttctgt cccacagaat actgtggcac tttctgttat ccaaatgtgt
1081 ctcagtctcc atatttaagg actgtgggtg aaaagcttct acctggaatt gaagtgcttt
1141 ggacaggtcc caaagttgtt tctaaagaaa ttccagtaga gtccatcgaa gaggtttcta
1201 agattattaa gagagctcca gtaatctggg ataacattca tgctaatgat tatgatcaga
1261 agagactgtt tctgggcccg tacaaaggaa gatccacaga actcatccca cggttaaaag
1321 gagtcctcac taatccaaat tgtgaatttg aagccaacta cgttgctatc cacacccttg
1381 ccacctggta caaatcaaac atgaatggag tgagaaaaga tgtagtgatg actgacagtg
1441 aagatagtac tgtgtccatc cagataaaat tagaaaatga aggcagtgat gaagatattg
1501 aaactgatgt actctatagt ccacagatgg ctctaaagct agcattaaca gaatggttgc
1561 aagagtttgg tgtgcctcat caatacagca gtaggcaagt tgcacacagt ggagctaaag
1621 caagtgtagt tgatgggact cctttagttg cagcaccctc tttaaatgcc acaaccgtag
1681 taacaacagt ttatcaggag cccattatga gccagggagc agccttgagt ggtgagccta
1741 ctactctgac caaggaagaa gaaaagaaac agcctgatga agaacccatg gacatggtgg
1801 tggaaaaaca agaagaaacg gaccacaaga atgacaatca aatactgagt gaaattgttg
1861 aagcgaaaat ggcagaggaa ttgaaaccaa tggacactga taaagagagc atagctgaat
1921 caaaatcccc agagatgtcc atgcaagaag attgtattag tgacattgcc cccatgcaaa
1981 ctgatgaaca gacaaacaag gagcagtttg tgccaggtcc aaatgaaaag cctttgtaca
2041 ctgcggaacc agtgaccctg gaggatttgc agttacttgc tgatctattc taccttcctt
2101 acgagcatgg acccaaagga gcacagatgt tacgggaatt tcaatggctt cgagcaaata
2161 gtagtgttgt cagtgtcaat tgcaaaggaa aagactctga aaaaattgaa gaatggcggt
2221 cacgagcagc caagtttgaa gagatgtgtg gactagtgat gggaatgttc actcggctct
2281 ccaattgtgc caacaggaca attctttatg acatgtactc ctatgtttgg gatatcaaga
2341 gtataatgtc tatggtgaag tcttttgtac agtggttagg gtgtcgtagt cattcttcag
2401 cacaattctt aattggagac caagaaccct gggcctttag aggtggtcta gcaggagagt
2461 tccagcgttt gctgccaatt gatggggcaa atgatctctt ttttcagcca cctccactga
2521 ctcctacctc caaagtttat actatcagac cttattttcc taaggatgag gcatccgtgt
2581 acaagatttg cagagaaatg tatgacgatg gagtgggttt accctttcaa agtcagcctg
2641 atcttattgg agacaagtta gtaggagggc tgctttccct cagcctggat tactgctttg
2701 tcctagaaga tgaagatggc atatgtggtt atgccttggg cactgtagat gtgaccccct
2761 ttattaaaaa atgtaaaatt tcctggatcc ccttcatgca ggagaagtat accaagccaa
2821 atggtgacaa ggaactctct gaggctgaga aaataatgtt gagtttccat gaagaacagg
2881 aagtactgcc agaaactttc cttgctaatt tcccttctct gataaagatg gacattcaca
2941 aaaaagtaac tgacccaagt gtggccaaaa gcatgatggc ttgcctcctg tcttcactga
3001 aggctaatgg ctcccgggga gctttctgtg aagtgagacc agatgataaa agaattctgg
3061 aattttacag caagttagga tgttttgaaa ttgcaaaaat ggaaggattt ccaaaggatg
3121 tggttatact tggtcggagc ctgtgacatt tgttgacact gtgaactgtc caaaagtctc
3181 ttaactgcac cttgtgaatg gtagttgagg tcttcataca gttcagcctc tagaatggta
3241 acaaatcagc caattggatt cgaaacaaag aagactatgt aaaactcacc catcacactt
3301 tgagactact cactggttgg aagaatatag tattgcagca aatcctgtat gaaagagaga
3361 tgtgggcttc ctttttgagt cttgtgttag gtgctgagac cttttacatg ggcttataca
3421 gggagagagt cttcaataaa tgtagtcagc actattttct gcatccagtg tggttgcgtt
3481 tctcacctga gagtaatcaa gataacatct gtcatcttcc ttggtttatt gagtgaaatg
3541 cctctcagtc ttaggggaca tggcagagat gaaagaaaga aagagtgggt ttcagaagtg
3601 tcagggtgga gtgattccaa gtgggatggt tgtggcatta gtttaagctg aataaataat
3661 ttcaatttgg ggcagttatt ctgctttttg taaagccgtg gccaattgtc tcctgtaatg
3721 actgttggtt caggcatgtt gtactttgta gggacaaatg tgcatttgtt tgtggcaaaa
3781 gcctacaatt gacaaacttg taaatttctt tgtatataaa ctagctgtaa cctgactatc
3841 ctttgtgttt actgtttttg taaatttttt tcctctataa atgaaagggt gttggttcag
3901 aatggcactt tgaataatgt aaaccagtga aaagtggatt ttctttactt ttgtctttgg
3961 gtttggggtt gtttttgttc tttttgaagt tttattattt ttaaagtgcc tcccacctag
4021 gcgtaggcca tgaccatttg gggtacgaga gcctaatttt gtaggactta atctgttgaa
4081 aagtgcagtt acttctggaa attaacctca atattaggtc agcatgtgaa atgttggatt
4141 tgacatgtca ggtagggttc agggactgat tggtcccatt tgccctcagg tcagttgttt
4201 aatctcaaga cctgttacta ctgattttat taaatcagag tctttaattc ttgcatgttt
4261 gtatctaatt tctgaacgaa tgagcacact ttaaccagtt atttacagtt acctttttcc
4321 tttaaccgga ttgtgaaagc ttcatgtatt ttaatttaga ttctgtgttt ttaagggttc
4381 tgagcatgaa gctggcagat agtcggcagg actcattttt tcatcatggc tggctgattt
4441 ctccatagat tgataacagt attttgttat cttgcttctc tgtagttttg catcagctgt
4501 ttaactttga gctgagtgag gggagagggg taaagagaaa gaaacttaag ttttctttca
4561 cagaactcca ccattgtggg ctttgagaga gccctaaagc attgtaccta gtggtaccta
4621 gtgacttcca accaaagcct ttgagtatgc actaaatagg tgagaagaaa ggagagaagg
4681 tttttaggtt agaaaccttt aaccgataga aggatatggt atgttgtaaa gctggaacca
4741 agtttgcatt tttgagggct tgagatgaag ggaagactct taccagatag taagacagct
4801 gagttttcct cagttttctc gtcttaacac tagtggacaa ttctagcatt ttgtttggag
4861 gatttcagag ttaacctcat ggaattcagg attttttagc aagtttgctt ttggttttat
4921 cttggctttt agtaatcatg ttggctggtc tggtcacagg tgactgtgaa acagatgccc
4981 ctggtcttgc tttcatcact ctaggatcat gaagtgctat gctatttcct ggttatgaat
5041 attaaggttg gaattacatt tttattgatt gtttggatca gagctcagtt cctgtagaaa
5101 acgaactgta aaagaccatg caagaggcaa aataaaactt gaagtgg
//