LOCUS       AF035685                4153 bp    mRNA    linear   HUM 24-JUL-2016
DEFINITION  Homo sapiens voltage-gated sodium channel, subtype III (SCN3A)
            mRNA, alternatively spliced neonatal isoform, partial cds.
ACCESSION   AF035685
VERSION     AF035685.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4153)
  AUTHORS   Lu,C.M. and Brown,G.B.
  TITLE     Isolation of a human-brain sodium-channel gene encoding two
            isoforms of the subtype III alpha-subunit
  JOURNAL   J. Mol. Neurosci. 10 (1), 67-70 (1998)
   PUBMED   9589372
REFERENCE   2  (bases 1 to 4153)
  AUTHORS   Lu,C.-M. and Brown,G.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-NOV-1997) Psychiatry and Behavioral Neurobiology,
            University of Alabama at Birmingham, 1720 7th Ave. South, Sparks
            Ctr., Room 1075, Birmingham, AL 35294-0017, USA
FEATURES             Location/Qualifiers
     source          1..4153
                     /db_xref="H-InvDB:HIT000063281"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24-q31"
                     /sex="female"
                     /tissue_type="cerebral cortex of brain"
                     /dev_stage="15-yr-old"
                     /note="from a Caucasian individual; Marathon-Ready cDNA
                     from Clontech, catalog #7420-1"
     gene            1..>4153
                     /gene="SCN3A"
     CDS             55..>4153
                     /gene="SCN3A"
                     /note="neonatal isoform generated from alternative
                     splicing"
                     /codon_start=1
                     /product="voltage-gated sodium channel, subtype III"
                     /protein_id="AAC29514.1"
                     /translation="MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDND
                     DENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRF
                     SATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYT
                     FTGIYTFESLIKILVRGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTF
                     RVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK
                     CLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDNIGDDSHFYVLDGQKDP
                     LLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLT
                     LRAAGKTYTIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLE
                     QLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQ
                     REHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSL
                     FSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSETRRDSLFEPHRHGERRNSN
                     GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWY
                     RFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFS
                     SVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGL
                     SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG
                     KSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIV
                     FMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNK
                     MRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKALNYLRDGNGTTSGVGTGSS
                     VEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATS
                     SSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNL
                     RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL
                     EMLLKWVAYGFQTYFTNAWCRLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP
                     LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT
                     GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVVS"
     misc_feature    657..748
                     /gene="SCN3A"
                     /note="location of neonatal isoform specific exon"
BASE COUNT         1218 a          795 c          969 g         1171 t
ORIGIN      
        1 taaggtaatt cgtatgcaag aagctacacg taattaaatg tgcaggatga aaagatggca
       61 caggcactgt tggtaccccc aggacctgaa agcttccgcc tttttactag agaatctctt
      121 gctgctatcg aaaaacgtgc tgcagaagag aaagccaaga agcccaaaaa ggaacaagat
      181 aatgatgatg agaacaaacc aaagccaaat agtgacttgg aagctggaaa gaaccttcca
      241 tttatttatg gagacattcc tccagagatg gtgtcagagc ccctggagga cctggatccc
      301 tactatatca ataagaaaac ttttatagta atgaataaag gaaaggcaat tttccgattc
      361 agtgccacct ctgccttgta tattttaact ccactaaacc ctgttaggaa aattgctatc
      421 aagattttgg tacattcttt attcagcatg cttatcatgt gcactatttt gaccaactgt
      481 gtatttatga ccttgagcaa ccctcctgac tggacaaaga atgtagagta cacattcact
      541 ggaatctata cctttgagtc acttataaaa atcttggtaa gagggttttg cttagaagat
      601 tttacgtttc ttcgtgatcc atggaactgg ctggatttca gtgtcattgt gatggcgtat
      661 gtaacagaat ttgtaagcct aggcaatgtt tcagcccttc gaactttcag agtcttgaga
      721 gctctgaaaa ctatttctgt aattccaggt ttaaagacca ttgtgggggc cctgatccag
      781 tcggtaaaga agctttctga tgtgatgatc ctgactgtgt tctgtctgag cgtgtttgct
      841 ctcattgggc tgcagctgtt catgggcaat ctgaggaata aatgtttgca gtggccccca
      901 agcgattctg cttttgaaac caacaccact tcctacttta atggcacaat ggattcaaat
      961 gggacatttg ttaatgtaac aatgagcaca tttaactgga aggataacat tggagatgac
     1021 agtcactttt atgttttgga tgggcaaaaa gaccctttac tctgtggaaa tggttcagat
     1081 gcaggccagt gtccagaagg atacatctgt gtgaaggctg gtcgaaaccc caactatggc
     1141 tacacaagct ttgacacctt tagctgggct ttcctgtctc tatttcgact catgactcaa
     1201 gactactggg aaaatcttta ccagttgaca ttacgtgctg ctgggaaaac atacacgata
     1261 ttttttgtcc tggtcatttt cttgggctca ttttatttgg tgaatttgat cctggctgtg
     1321 gtggccatgg cctatgagga gcagaatcag gccaccttgg aagaagcaga acaaaaagag
     1381 gccgaatttc agcagatgct cgaacagctt aaaaagcaac aggaagaagc tcaggcagtt
     1441 gcggcagcat cagctgcttc aagagatttc agtggaatag gtgggttagg agagctgttg
     1501 gaaagttctt cagaagcatc aaagttgagt tccaaaagtg ctaaagaatg gaggaaccga
     1561 aggaagaaaa gaagacagag agagcacctt gaaggaaaca acaaaggaga gagagacagc
     1621 tttcccaaat ccgaatctga agacagcgtc aaaagaagca gcttcctttt ctccatggat
     1681 ggaaacagac tgaccagtga caaaaaattc tgctcccctc atcagtctct cttgagtatc
     1741 cgtggctccc tgttttcccc aagacgcaat agcaaaacaa gcattttcag tttcagaggt
     1801 cgggcaaagg atgttggatc tgaaaatgac tttgctgatg atgaacacag cacatttgaa
     1861 gacagcgaaa cgaggagaga ctcactgttt gagccgcaca gacatggaga gcgacgcaac
     1921 agtaacggca ccaccacaga aacggaggtc agaaagagaa ggttaagttc ttaccagatt
     1981 tcaatggaga tgctggagga ttcttctgga aggcaaagag ccgtgagcat agccagcatt
     2041 ctgaccaaca caatggaaga acttgaagaa tctagacaga aatgtccgcc atgctggtat
     2101 agatttgcca atgtgttctt gatctgggac tgctgtgatg catggttaaa agtaaaacat
     2161 cttgtgaatt taattgttat ggatccattt gttgatcttg ccatcactat ttgcattgtc
     2221 ttaaataccc tctttatggc catggagcac taccccatga ctgagcaatt cagtagtgtg
     2281 ttgactgtag gaaacctggt ctttactggg attttcacag cagaaatggt tctcaagatc
     2341 attgccatgg atccttatta ctatttccaa gaaggctgga atatctttga tggaattatt
     2401 gtcagcctca gtttaatgga gcttggtctg tcaaatgtgg agggattgtc tgtactgcga
     2461 tcattcagac tgcttagagt tttcaagttg gcaaaatcct ggcccacact aaatatgcta
     2521 attaagatca ttggcaattc tgtgggggct ctaggaaacc tcaccttggt gttggccatc
     2581 atcgtcttca tttttgctgt ggtcggcatg cagctctttg gtaagagcta caaagaatgt
     2641 gtctgcaaga tcaatgatga ctgtacgctc ccacggtggc acatgaacga cttcttccac
     2701 tccttcctga ttgtgttccg cgtgctgtgt ggagagtgga tagagaccat gtgggactgt
     2761 atggaggtcg ctggccaaac catgtgcctt attgttttca tgttggtcat ggtcattgga
     2821 aaccttgtgg ttctgaacct ctttctggcc ttattgttga gttcatttag ctcagacaac
     2881 cttgctgcta ctgatgatga caatgaaatg aataatctgc agattgcagt aggaagaatg
     2941 caaaagggaa ttgattatgt gaaaaataag atgcgggagt gtttccaaaa agcctttttt
     3001 agaaagccaa aagttataga aatccatgaa ggcaataaga tagacagctg catgtccaat
     3061 aatactggaa ttgaaataag caaagcgctt aattatctta gagatgggaa tggaaccacc
     3121 agtggtgtag gtactggaag cagtgttgaa aaatacgtaa tcgatgaaaa tgattatatg
     3181 tcattcataa acaaccccag cctcaccgtc acagtgccaa ttgctgttgg agagtctgac
     3241 tttgaaaact taaatactga agagttcagc agtgagtcag aactagaaga aagcaaagag
     3301 aaattaaatg caaccagctc atctgaagga agcacagttg atgttgttct accccgagaa
     3361 ggtgaacaag ctgaaactga acccgaagaa gaccttaaac cggaagcttg ttttactgaa
     3421 ggatgtatta aaaagtttcc attctgtcaa gtaagtacag aagaaggcaa agggaagatc
     3481 tggtggaatc ttcgaaaaac ctgctacagt attgttgagc acaactggtt tgagactttc
     3541 attgtgttca tgatccttct cagtagtggt gcattggcct ttgaagatat atacattgaa
     3601 cagcgaaaga ctatcaaaac catgctagaa tatgctgaca aagtctttac ctatatattc
     3661 attctggaaa tgcttctcaa atgggttgct tatggatttc aaacatattt cactaatgcc
     3721 tggtgccggc tagatttctt gatcgttgat gtttctttgg ttagcctggt agccaatgct
     3781 cttggctact cagaactcgg tgccatcaaa tcattacgga cattaagagc tttaagacct
     3841 ctaagagcct tatcccggtt tgaaggcatg agggtggttg tgaatgctct tgttggagca
     3901 attccctcta tcatgaatgt gctgttggtc tgtctcatct tctggttgat ctttagcatc
     3961 atgggtgtga atttgtttgc tggcaagttc taccactgtg ttaacatgac aacgggtaac
     4021 atgtttgaca ttagtgatgt taacaatttg agtgactgtc aggctcttgg caagcaagct
     4081 cggtggaaaa acgtgaaagt aaactttgat aatgttggcg ctggctatct tgcactgctt
     4141 caagtggtaa gtg
//