LOCUS AF035586 2570 bp mRNA linear HUM 10-APR-2003
DEFINITION Homo sapiens X-ray repair cross-complementing protein 3 (XRCC3)
mRNA, complete cds.
ACCESSION AF035586
VERSION AF035586.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2570)
AUTHORS Liu,N., Lamerdin,J.E., Tebbs,R.S., Schild,D., Tucker,J.D.,
Shen,M.R., Brookman,K.W., Siciliano,M.J., Walter,C.A., Fan,W.,
Narayana,L.S., Zhou,Z.Q., Adamson,A.W., Sorensen,K.J., Chen,D.J.,
Jones,N.J. and Thompson,L.H.
TITLE XRCC2 and XRCC3, new human Rad51-family members, promote chromosome
stability and protect against DNA cross-links and other damages
JOURNAL Mol. Cell 1 (6), 783-793 (1998)
PUBMED 9660962
REFERENCE 2 (bases 1 to 2570)
AUTHORS Liu,N., Lamerdin,J.E., Tebbs,R.S., Schild,D., Tucker,J.D., Shen,R.,
Brookman,K.W., Siciliano,M.J., Walter,C.A., Fan,W., Narayana,L.S.,
Zhou,Z.-Q., Adamson,A.W., Sorenson,K.J., Chen,D.J., Jones,N.J. and
Thompson,L.H.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-1997) Biology and Biotechnology Research Program,
Lawrence Livermore National Laboratory, 7000 East Ave, Livermore,
CA 94550, USA
FEATURES Location/Qualifiers
source 1..2570
/db_xref="H-InvDB:HIT000063273"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q32.3"
/cell_line="HeLa"
/note="HeLa cell cDNA (from Legerski expression library)
recovered from CHO irs1SF cells by ability to restore
resistance to cisplatin and EMS"
gene 1..2570
/gene="XRCC3"
CDS 309..1349
/gene="XRCC3"
/note="DNA repair protein; Xrcc3"
/codon_start=1
/product="X-ray repair cross-complementing protein 3"
/protein_id="AAC05368.1"
/translation="MDLDLLDLNPRIIAAIKKAKLKSVKEVLHFSGPDLKRLTNLSSP
EVWHLLRTASLHLRGSSILTALQLHQQKERFPTQHQRLSLGCPVLDALLRGGLPLDGI
TELAGRSSAGKTQLALQLCLAVQFPRQHGGLEAGAVYICTEDAFPHKRLQQLMAQQPR
LRTDVPGELLQKLRFGSQIFIEHVADVDTLLECVNKKVPVLLSRGMARLVVIDSVAAP
FRCEFDSQASAPRARHLQSLGATLRELSSAFQSPVLCINQVTEAMEEQGAAHGPLGFW
DERVSPALGITWANQLLVRLLADRLREEEAALGCPARTLRVLSAPHLPPSSCSYTISA
EGVRGTPGTQSH"
regulatory 2510..2515
/regulatory_class="polyA_signal_sequence"
/gene="XRCC3"
BASE COUNT 519 a 819 c 766 g 466 t
ORIGIN
1 agagggccca ggaggagcct caggagccgg actgccgttg gccaaccgag tccccaggga
61 gacacttaag ggaaattaaa ctgcagagtg caagagatgc ctcagtcaag tcagccaaaa
121 acacgcgggt catccccaag ccccagagag tgacagagcc ccgatgacac ggacacctcg
181 gctgctgtca cttccctggt tcgggcctcc cacaggcttt gaattgaagg cgagtgcctc
241 agaatttgca tccattgttc tgtctttcct gggaagttat tcatcctggt ggccagccca
301 ccgacaaaat ggatttggat ctactggacc tgaatcccag aattattgct gcaattaaga
361 aagccaaact gaaatcggta aaggaggttt tacacttttc tggaccagac ttgaagagac
421 tgaccaacct ctccagcccc gaggtctggc acttgctgag aacggcctcc ttacacttgc
481 ggggaagcag catccttaca gcactgcagc tgcaccagca gaaggagcgg ttccccacgc
541 agcaccagcg cctgagcctg ggctgcccgg tgctggacgc gctgctccgc ggtggcctgc
601 ccctggacgg catcactgag ctggccggac gcagctcggc agggaagacc cagctggcgc
661 tgcagctctg cctggctgtg cagttcccgc ggcagcacgg aggcctggag gctggagccg
721 tctacatctg cacggaagac gccttcccgc acaagcgcct gcagcagctc atggcccagc
781 agccgcggct gcgcactgac gttccaggag agctgcttca gaagctccga tttggcagcc
841 agatcttcat cgagcacgtg gccgatgtgg acaccttgtt ggagtgtgtg aataagaagg
901 tccccgtact gctgtctcgg ggcatggctc gcctggtggt catcgactcg gtggcagccc
961 cattccgctg tgaatttgac agccaggcct ccgcccccag ggccaggcat ctgcagtccc
1021 tgggggccac gctgcgtgag ctgagcagtg ccttccagag ccctgtgctg tgcatcaacc
1081 aggtgacaga ggccatggag gagcagggcg cagcacacgg gccgctgggg ttctgggacg
1141 aacgtgtttc cccagccctt ggcataacct gggctaacca gctcctggtg agactgctgg
1201 ctgaccggct ccgcgaggaa gaggctgccc tcggctgccc agcccggacc ctgcgggtgc
1261 tctctgcccc ccacctgccc ccctcctcct gttcctacac gatcagtgcc gaaggggtgc
1321 gagggacacc tgggacccag tcccactgac acggtggcgg ctgcacaaca gccctgcctg
1381 agaagccccg acacacgggg ctcgggcctt taaaacgcgt ctgcctgggc cgtggcacag
1441 ctgggagcct ggttcagaca cagctcttcc agggcagcgg ctccactttc tcatccgaag
1501 atggtggcca cagactgacc cccatctgag ctggggggat gttctgcctc tccctgggtc
1561 tggggacagg cccgcttgct gggtacctgg tccccactgc tgagctggcc cttggggaga
1621 ggtgattctc agggctggag cctggggtgt cctacagtga ctccctggga gccgcctgct
1681 tcttctctcc atatggaagc ccaactgggg ttgcgtctga ggcctgcccc ctgggctggg
1741 gcctcagacc ccctcagcct tgggaccgtg cccacgaggg tcttccctcc tgcacacagg
1801 gcagtcctta ctcccccacc actcaggcca cagtggggct gcaggcaggc ggctcctcct
1861 cacccacctc tgggtccttg gctcccgggg gccccacctc ggcacacact gtgccccaca
1921 aaacttcagt gtggtacaag gtggagaaag catatcccac caacctccag tgtcagggtc
1981 caggagagcc tgggggtggg gggactgcct tgtctctagt agtgtggcct gtgccagcac
2041 cacagccggt cagaggagcg caggcagcgc agggctggca cgtgacaggc tcgtcagcca
2101 cctgggaaca cagttctggg caaagaggat ccgaggttga gaggaaggag ggtcccggtg
2161 tatcctggcc ctgggggtct gggcgtccag ctcagccctg gcctggctgg gtggtattct
2221 ggtagggata tggcaggact cctggcaggg ccacctgcag gaccctgtcc tgcagtccca
2281 cactgtgcag acccagtccc acactgtggc caggccttac atctggctgg aaagcagagc
2341 ctcctgggaa cacatctggc tgcacaggct gaaatatcca cccagcaggc agagtggcgt
2401 ggcctcccca tgggcacagt ggtgaccccc ttgattccca ccgtacaacc ccctccaccc
2461 cccactcagt gcctccacat gctgcctggc acagaccagg cctttgacaa ataaatgttc
2521 aatggatgca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//