LOCUS       AF035555                 967 bp    mRNA    linear   HUM 26-AUG-2013
DEFINITION  Homo sapiens 17beta-hydroxysteroid dehydrogenase type 10/short
            chain L-3-hydroxyacyl-CoA dehydrogenase (HSD17B10/SCHAD) mRNA,
            complete cds.
ACCESSION   AF035555
VERSION     AF035555.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 967)
  AUTHORS   He,X.Y., Schulz,H. and Yang,S.Y.
  TITLE     A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical
            to an amyloid beta-peptide-binding protein involved in Alzheimer's
            disease
  JOURNAL   J. Biol. Chem. 273 (17), 10741-10746 (1998)
   PUBMED   9553139
REFERENCE   2  (bases 1 to 967)
  AUTHORS   He,X.Y., Merz,G., Mehta,P., Schulz,H. and Yang,S.Y.
  TITLE     Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is
            a single-domain multifunctional enzyme. Characterization of a novel
            17beta-hydroxysteroid dehydrogenase
  JOURNAL   J. Biol. Chem. 274 (21), 15014-15019 (1999)
   PUBMED   10329704
REFERENCE   3  (bases 1 to 967)
  AUTHORS   Yang,S.Y. and He,X.Y.
  TITLE     Role of type 10 17beta-hydroxysteroid dehydrogenase in the
            pathogenesis of Alzheimer's disease
  JOURNAL   Adv. Exp. Med. Biol. 487, 101-110 (2001)
   PUBMED   11403151
REFERENCE   4  (bases 1 to 967)
  AUTHORS   He,X.Y., Merz,G., Yang,Y.Z., Mehta,P., Schulz,H. and Yang,S.Y.
  TITLE     Characterization and localization of human type10
            17beta-hydroxysteroid dehydrogenase
  JOURNAL   Eur. J. Biochem. 268 (18), 4899-4907 (2001)
   PUBMED   11559359
REFERENCE   5  (bases 1 to 967)
  AUTHORS   Yang,S.Y., Dobkin,C., He,X.Y. and Brown,W.T.
  TITLE     Transcription start sites and epigenetic analysis of the HSD17B10
            proximal promoter
  JOURNAL   BMC Biochem. 14 (1), 17 (2013)
   PUBMED   23834306
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 967)
  AUTHORS   Yang,S.-Y., Schulz,H. and He,X.-Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-1997) Pharmacology, Institute for Basic Research
            in Developmental Disabilities, 1050 Forest Hill Road, Staten
            Island, NY 10314, USA
REFERENCE   7  (bases 1 to 967)
  AUTHORS   Yang,S.-Y. and He,X.-Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-AUG-2013) NYS Institute for Basic Research in
            Developmental Disabilities, 1050 Forest Hill Road, Staten Island,
            NY 10314, USA
  REMARK    Sequence update by submitter
COMMENT     On Aug 26, 2013 this sequence version replaced AF035555.1.
FEATURES             Location/Qualifiers
     source          1..967
                     /db_xref="H-InvDB:HIT000063271"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
                     /cell_type="neuron"
                     /tissue_type="brain"
     gene            1..967
                     /gene="HSD17B10/SCHAD"
     CDS             37..822
                     /gene="HSD17B10/SCHAD"
                     /EC_number="1.1.1.35"
                     /function="catalyzes fatty acid and steroid metabolism"
                     /note="single-domain multifunctional enzyme; can bind to
                     amyloid beta-peptides"
                     /codon_start=1
                     /product="17beta-hydroxysteroid dehydrogenase type
                     10/short chain L-3-hydroxyacyl-CoA dehydrogenase"
                     /protein_id="AAC15902.1"
                     /translation="MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPN
                     SGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYN
                     LKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFE
                     GQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLA
                     SQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP"
BASE COUNT          205 a          271 c          288 g          203 t
ORIGIN      
        1 gcccccatcc cctcccgtgg agtggccggc gacaagatgg cagcagcgtg tcggagcgtg
       61 aagggcctgg tggcggtaat aaccggagga gcctcgggcc tgggcctggc cacggcggag
      121 cgacttgtgg ggcagggagc ctctgctgtg cttctggacc tgcccaactc gggtggggag
      181 gcccaagcca agaagttagg aaacaactgc gttttcgccc cagccgacgt gacctctgag
      241 aaggatgtgc aaacagctct ggctctagca aaaggaaagt ttggccgtgt ggatgtagct
      301 gtcaactgtg caggcatcgc ggtggctagc aagacgtaca acttaaagaa gggccagacc
      361 cataccttgg aagacttcca gcgagttctt gatgtgaatc tcatgggcac cttcaatgtg
      421 atccgcctgg tggctggtga gatgggccag aatgaaccag accagggagg ccaacgtggg
      481 gtcatcatca acactgccag tgtggctgcc ttcgagggtc aggttggaca agctgcatac
      541 tctgcttcca aggggggaat agtgggcatg acactgccca ttgctcggga tctggctccc
      601 ataggtatcc gggtgatgac cattgcccca ggtctgtttg gcaccccact gctgaccagc
      661 ctcccagaga aagtgtgcaa cttcttggcc agccaagtgc ccttccctag ccgactgggt
      721 gaccctgctg agtatgctca cctcgtacag gccatcatcg agaacccatt cctcaatgga
      781 gaggtcatcc ggctggatgg ggccattcgt atgcagcctt gaagggagaa ggcagagaaa
      841 acacacgctc ctctgccctt cctttccctg gggtactact ctccagtctt gggaggaagc
      901 ccagtagcca ttttgtaact gcctaccagt cgccctctgt gcctaataaa gtctcttttt
      961 ctcacag
//