LOCUS AF035555 967 bp mRNA linear HUM 26-AUG-2013 DEFINITION Homo sapiens 17beta-hydroxysteroid dehydrogenase type 10/short chain L-3-hydroxyacyl-CoA dehydrogenase (HSD17B10/SCHAD) mRNA, complete cds. ACCESSION AF035555 VERSION AF035555.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 967) AUTHORS He,X.Y., Schulz,H. and Yang,S.Y. TITLE A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease JOURNAL J. Biol. Chem. 273 (17), 10741-10746 (1998) PUBMED 9553139 REFERENCE 2 (bases 1 to 967) AUTHORS He,X.Y., Merz,G., Mehta,P., Schulz,H. and Yang,S.Y. TITLE Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase JOURNAL J. Biol. Chem. 274 (21), 15014-15019 (1999) PUBMED 10329704 REFERENCE 3 (bases 1 to 967) AUTHORS Yang,S.Y. and He,X.Y. TITLE Role of type 10 17beta-hydroxysteroid dehydrogenase in the pathogenesis of Alzheimer's disease JOURNAL Adv. Exp. Med. Biol. 487, 101-110 (2001) PUBMED 11403151 REFERENCE 4 (bases 1 to 967) AUTHORS He,X.Y., Merz,G., Yang,Y.Z., Mehta,P., Schulz,H. and Yang,S.Y. TITLE Characterization and localization of human type10 17beta-hydroxysteroid dehydrogenase JOURNAL Eur. J. Biochem. 268 (18), 4899-4907 (2001) PUBMED 11559359 REFERENCE 5 (bases 1 to 967) AUTHORS Yang,S.Y., Dobkin,C., He,X.Y. and Brown,W.T. TITLE Transcription start sites and epigenetic analysis of the HSD17B10 proximal promoter JOURNAL BMC Biochem. 14 (1), 17 (2013) PUBMED 23834306 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 967) AUTHORS Yang,S.-Y., Schulz,H. and He,X.-Y. TITLE Direct Submission JOURNAL Submitted (21-NOV-1997) Pharmacology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA REFERENCE 7 (bases 1 to 967) AUTHORS Yang,S.-Y. and He,X.-Y. TITLE Direct Submission JOURNAL Submitted (26-AUG-2013) NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA REMARK Sequence update by submitter COMMENT On Aug 26, 2013 this sequence version replaced AF035555.1. FEATURES Location/Qualifiers source 1..967 /db_xref="H-InvDB:HIT000063271" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="X" /map="Xp11.21" /cell_type="neuron" /tissue_type="brain" gene 1..967 /gene="HSD17B10/SCHAD" CDS 37..822 /gene="HSD17B10/SCHAD" /EC_number="1.1.1.35" /function="catalyzes fatty acid and steroid metabolism" /note="single-domain multifunctional enzyme; can bind to amyloid beta-peptides" /codon_start=1 /product="17beta-hydroxysteroid dehydrogenase type 10/short chain L-3-hydroxyacyl-CoA dehydrogenase" /protein_id="AAC15902.1" /translation="MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPN SGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYN LKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFE GQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLA SQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP" BASE COUNT 205 a 271 c 288 g 203 t ORIGIN 1 gcccccatcc cctcccgtgg agtggccggc gacaagatgg cagcagcgtg tcggagcgtg 61 aagggcctgg tggcggtaat aaccggagga gcctcgggcc tgggcctggc cacggcggag 121 cgacttgtgg ggcagggagc ctctgctgtg cttctggacc tgcccaactc gggtggggag 181 gcccaagcca agaagttagg aaacaactgc gttttcgccc cagccgacgt gacctctgag 241 aaggatgtgc aaacagctct ggctctagca aaaggaaagt ttggccgtgt ggatgtagct 301 gtcaactgtg caggcatcgc ggtggctagc aagacgtaca acttaaagaa gggccagacc 361 cataccttgg aagacttcca gcgagttctt gatgtgaatc tcatgggcac cttcaatgtg 421 atccgcctgg tggctggtga gatgggccag aatgaaccag accagggagg ccaacgtggg 481 gtcatcatca acactgccag tgtggctgcc ttcgagggtc aggttggaca agctgcatac 541 tctgcttcca aggggggaat agtgggcatg acactgccca ttgctcggga tctggctccc 601 ataggtatcc gggtgatgac cattgcccca ggtctgtttg gcaccccact gctgaccagc 661 ctcccagaga aagtgtgcaa cttcttggcc agccaagtgc ccttccctag ccgactgggt 721 gaccctgctg agtatgctca cctcgtacag gccatcatcg agaacccatt cctcaatgga 781 gaggtcatcc ggctggatgg ggccattcgt atgcagcctt gaagggagaa ggcagagaaa 841 acacacgctc ctctgccctt cctttccctg gggtactact ctccagtctt gggaggaagc 901 ccagtagcca ttttgtaact gcctaccagt cgccctctgt gcctaataaa gtctcttttt 961 ctcacag //