LOCUS AF035152 4870 bp mRNA linear HUM 06-JUL-1998
DEFINITION Homo sapiens regulator of G-protein signalling 12 (RGS12) mRNA,
complete cds.
ACCESSION AF035152
VERSION AF035152.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4870)
AUTHORS Snow,B.E., Hall,R.A., Krumins,A.M., Brothers,G.M., Bouchard,D.,
Brothers,C.A., Chung,S., Mangion,J., Gilman,A.G., Lefkowitz,R.J.
and Siderovski,D.P.
TITLE GTPase activating specificity of RGS12 and binding specificity of
an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain
JOURNAL J. Biol. Chem. 273 (28), 17749-17755 (1998)
PUBMED 9651375
REFERENCE 2 (bases 1 to 4870)
AUTHORS Snow,B.E. and Siderovski,D.P.
TITLE Direct Submission
JOURNAL Submitted (19-NOV-1997) Quantitative Biology, Amgen Institute, 620
University Avenue, Suite 706, Toronto, ON M5G 2C1, Canada
FEATURES Location/Qualifiers
source 1..4870
/db_xref="H-InvDB:HIT000063202"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p16.3"
/tissue_type="brain"
gene 1..4870
/gene="RGS12"
CDS 55..4185
/gene="RGS12"
/note="regulator of G-alpha GTPase activity; regulator of
G-protein signalling 12"
/codon_start=1
/product="RGS12"
/protein_id="AAC39835.1"
/translation="MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVL
SCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGVLHMVIAEGVGRF
ESCSSDEEGGLYEGKGWLKPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASN
SEPLKLKQRSLSESAATRFDVGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDD
FALDASILNVAMIVGYLGSIELPSTSSNLESDSLQAIRGCMRRLRAEQKIHSLVTMKI
MHDCVQLSTDKAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALR
TSCHVFMVDPDLFNHKIHQGIARRFGFECTADPDTNGCLEFPASSLPVLQFISVLYRD
MGELIEGMRARAFLDGDADAHQNNSTSSNSDSGIGNFHQEEKSNRVLVVDLGGSSSRH
GPGGSAWDGVGGRGAQPWGAPWTGPFCPDPEGSPPFEAAHQTDRFWDLNKHLGPASPV
EVPPASLRSSVPPSKRGTVGAGCGFNQRWLPVHVLREWQCGHTSDQDSYTDSTDGWSS
INCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKREWSRKAFGMQSIFGPHRNVRKTKE
DKKGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITRSLDDLESATVSDGELTGADLKD
CVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEE
NILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLRAP
HPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHS
LGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKRE
HGDHADDALHANGGLCRRESQGSVSSAGSLDLSEACRTLAPEKDKATKHCCIHLPDGT
SCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLE
KRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLG
APISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSSRNHSATGEERTLGKS
NSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADD
QRGLLRKEDLVLPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQWE
PVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWKRQ
SQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTPQEVPGPSRPGTSRF"
BASE COUNT 1102 a 1341 c 1479 g 948 t
ORIGIN
1 atatggctcc aagggaacaa tgagacgtgc tcttggtctt ggaagctcat cagaatgttt
61 agagctgggg aggcctccaa acgcccattg cctgggccgt cgcccccaag ggtgcggagt
121 gtggaggttg cccgggggag ggccggctac ggattcacgc tttcgggaca ggcaccctgt
181 gtgctcagct gcgtcatgag agggagccct gcggatttcg tgggcctccg agctggagac
241 cagatacttg ctgtcaatga aatcaacgtg aaaaaagcat ctcatgaaga tgtagtgaaa
301 ttaattggga agtgctctgg tgtccttcac atggtgattg ctgaaggcgt cggccgcttc
361 gaatcctgtt ccagtgatga agaaggggga ctctatgaag gaaaaggctg gctgaagccc
421 aagctggatt ctaaagcact aggtataaac agagcagagc gagtcgtgga ggaaatgcag
481 tctggtggaa ttttcaatat gatttttgaa aacccgagcc tttgtgcgag caattcagag
541 cccttgaaat tgaaacaaag atccctttcg gagtcggccg caactcgatt tgatgttgga
601 catgaaagta taaataatcc aaatcccaac atgctttcta aggaggaaat atcaaaagtt
661 attcatgatg attcggtttt cagcattgga ctagaaagtc atgacgattt tgcattggat
721 gcaagtattt taaacgtggc gatgatcgtg ggctacttag gctccattga gcttccttcc
781 acgagctcca acctggagtc cgacagcttg caagccatcc gcggctgcat gcggcgcctg
841 cgggcagagc agaaaatcca ctcgctggtg accatgaaga tcatgcacga ctgtgtgcag
901 ctgagcactg acaaggctgg agtcgtggcc gagtacccgg ccgagaagct ggccttcagc
961 gccgtgtgcc cggacgaccg gcgatttttc gggttggtta ccatgcagac gaatgacgac
1021 gggagcctgg cccaggagga ggagggcgcc ctgcggactt cctgccacgt gttcatggtg
1081 gacccagact tgtttaatca caagatccac caaggcattg ctcggcggtt tgggtttgag
1141 tgcacggccg acccagacac caatggctgt ctggaattcc cggcgtcctc cctccccgtc
1201 ctgcagttca tctctgtcct gtaccgagac atgggtgagc tgattgaggg catgcgggcc
1261 cgcgcctttc tggacgggga cgccgatgcc caccagaaca acagcaccag cagcaacagt
1321 gacagcggca ttgggaactt ccaccaggag gagaagagca accgggtcct tgtggtggac
1381 ctgggtggga gctcgagcag acacggcccc ggaggcagcg cgtgggacgg tgtgggtggg
1441 aggggtgccc agccctgggg tgctccctgg actgggccct tctgtccgga ccccgaaggg
1501 agccccccat ttgaggccgc tcatcagact gacaggttct gggacctaaa caagcaccta
1561 gggccagcct ctcctgtgga ggtgccccca gcttccttga ggagctcagt ccccccttcc
1621 aagaggggca ccgtgggtgc tggctgtggt ttcaaccagc gctggctccc ggtccacgtg
1681 ctccgggagt ggcagtgcgg acacaccagc gaccaggact cttacacaga ttccaccgat
1741 ggctggtcca gcatcaactg cggcacactg ccccctccta tgagcaagat ccccgcagac
1801 cgctacaggg tggagggcag cttcgcgcag cccccgctga atgccccgaa gagggagtgg
1861 tccaggaagg cctttggaat gcaaagcatt tttggtcccc atcgaaatgt tcgaaagact
1921 aaggaagata aaaagggctc aaaatttggg cggggaactg gactcactca gccttctcaa
1981 cgcacgtctg ctcggagatc atttgggaga tccaagagat tcagtatcac tcgctccctt
2041 gatgatcttg agtctgcaac tgtgtctgat ggcgagttga cgggcgccga cctgaaggac
2101 tgcgtcagca acaacagcct gagcagcaat gccagcctcc ccagcgtgca gagctgccgg
2161 cgcctgcgtg agaggagggt cgccagctgg gccgtgtcct ttgagcgcct gctgcaggac
2221 cccgtcggtg tccgctactt ctctgatttt ctaaggaaag aattcagtga agaaaacatt
2281 ttattctggc aggcctgtga atattttaat catgttcctg cacatgacaa aaaggagctt
2341 tcctacaggg cccgggagat tttcagtaag tttctctgca gcaaagccac caccccggtc
2401 aacatcgaca gccaggccca gctagcagac gacgtcctcc gcgcacctca cccagacatg
2461 ttcaaggagc agcagctgca gatcttcaat ctcatgaagt ttgatagcta cactcgcttt
2521 ctgaagtccc cgctgtacca ggaatgcatc ctggcggaag tggagggccg tgcactcccg
2581 gactcgcagc aggtccccag cagcccggct tccaagcaca gcctcggttc agaccactcc
2641 agtgtgtcca cgccaaaaaa gttaagtgga aaatcaaaat ccggccgatc cctgaatgaa
2701 gagctggggg atgaggacag cgagaagaag cggaaaggcg cgtttttctc gtggtcgcgg
2761 accaggagca ccgggaggtc ccagaaaaag agggagcacg gggaccacgc agacgacgcc
2821 ctgcatgcca atggaggcct gtgtcgccga gagtcgcagg gctctgtgtc ctctgcgggg
2881 agcctggacc tgtcggaggc ctgcaggact ttggcacccg agaaggacaa ggccaccaag
2941 cactgctgca ttcatctccc ggatgggaca tcctgcgtgg tggctgtcaa ggcgggcttc
3001 tccatcaaag acatcctgtc cggactctgt gagcggcatg gcatcaacgg ggcggccgcg
3061 gacctcttcc tggtgggcgg ggacaagcct ctggtgctgc accaagacag tagcatcttg
3121 gagtcaaggg acctgcgcct agaaaagcgc accttgtttc ggctggatct tgttccgatt
3181 aaccggtcag tgggactcaa ggccaagccc accaagcccg tcacggaggt gctgcggccc
3241 gtggtggcca gatacggcct ggacctcagt ggcctgctgg tgaggctgag tggagagaag
3301 gagcccctgg accttggcgc ccctatatcg agtctggacg gacagcgggt tgtcttggag
3361 gagaaggatc cttccagagg aaaggcatcc gcagataaac agaaaggtgt gccagtgaaa
3421 cagaacacag ctgtaaattc cagctccaga aaccactcgg ctacgggaga ggaaagaaca
3481 ctaggcaagt ctaattctat taaaataaaa ggagaaaatg gaaaaaatgc tagggatccc
3541 cggctttcaa agagagaaga atctattgca aagattggga aaaaaaaata tcagaaaatt
3601 aatttggacg aagcagagga gttttttgag cttatttcca aagctcagag caacagagca
3661 gatgaccaac gtgggctgct aaggaaggaa gacctggtgt tgccagagtt cctccgttta
3721 cctcctggtt ccacagaact caccctcccc actccagctg ctgtggccaa gggctttagc
3781 aagagaagcg ccacaggcaa cggccgggag agcgcctccc agcctggcga gcagtgggag
3841 ccagtccagg agagcagcga cagtccgtcc accagcccgg gctcagcctc cagcccccct
3901 ggacctcctg ggacgacccc ccccgggcag aagtctccca gcgggccctt ctgcactccc
3961 cagtcccccg tctccctcgc gcaggagggc accgcccaga tctggaagag gcagtctcag
4021 gaagtggagg ccgggggcat ccagacggtg gaggatgagc acgtggccga gctgaccctg
4081 atgggggagg gggacatcag cagccccaac agcaccttgc tgccgccgcc ctccaccccc
4141 caggaagtgc caggaccttc cagaccaggt acctccaggt tctgatccct ccaccttggc
4201 cccgtaagcg tggtctgctc agcttccagt cagaaaggac agtgggcccc cggctgccac
4261 tgtttgctgg tggtctccgt gaccccctcc tcacctgctg gttgggggct tccttggccc
4321 tcttggaaag gaggggctcg tgtggcccca ggccagtgtc tgtcaggatg gtccccccga
4381 ggcgctctgg gcaggcatcc tggtgtcctg agaggctctt gcaggaatga tacgtggcag
4441 tgcctgcagc gaggtctggg aacaccctgg gtgaggcctg ggggtttccg aaaatggagg
4501 cattcctttc caaatctgga cagcgatcgt ttttagtgtt tctgtctcaa gactggaaaa
4561 caatagcatt tgtcttgagt gaggaagtga agcccgctgt gttcatagca ggagagggct
4621 cccagacaca ggcccgtcct cggaagagcc ttgagagtgc agctcggacc caccggcggc
4681 ccccgtagca ggtggtgtgg gtgctcggga gtggaggtga cgtcagcagc gctctctgac
4741 cgcgggtgtc acgggcattt ctcaaaggaa gcaggggatt cagtgagtgt gaaggtgaac
4801 aggatggcct ggcagcaggg atgtttccgt gagccacaaa taccagaaac tgaggcgagg
4861 ctcccagcag
//