LOCUS AF035121 5830 bp mRNA linear HUM 02-DEC-1997
DEFINITION Homo sapiens KDR/flk-1 protein mRNA, complete cds.
ACCESSION AF035121
VERSION AF035121.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5830)
AUTHORS Yin,L.Y., Wu,Y. and Patterson,C.
TITLE Full length human KDR/flk-1 sequence
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 5830)
AUTHORS Yin,L.Y., Wu,Y. and Patterson,C.
TITLE Direct Submission
JOURNAL Submitted (19-NOV-1997) Sealy Center for Molecular Cardiology,
University of Texas Medical Branch, 301 University Boulevard,
Galveston, TX 77555-1064, USA
FEATURES Location/Qualifiers
source 1..5830
/db_xref="H-InvDB:HIT000063201"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 304..4374
/note="similar to H. sapiens vascular endothelial growth
factor (VEGF) receptor-2, Swiss-Prot Accession Number
P35968"
/codon_start=1
/product="KDR/flk-1 protein"
/protein_id="AAB88005.1"
/translation="MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIK
ANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYK
CFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVS
LCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVV
VGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRD
LKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGS
GMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERD
TGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAI
PPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIE
GKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQES
VSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDI
LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGE
SIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQAC
SVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELK
TGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGI
DKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMV
IVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSS
ASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLA
ARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDV
WSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGE
PSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEE
EEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGM
VLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYS
SEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV"
BASE COUNT 1594 a 1301 c 1441 g 1494 t
ORIGIN
1 actgagtccc gggaccccgg gagagcggtc agtgtgtggt cgctgcgttt cctctgcctg
61 cgccgggcat cacttgcgcg ccgcagaaag tccgtctggc agcctggata tcctctccta
121 ccggcacccg cagacgcccc tgcagccgcc ggtcggcgcc cgggctccct agccctgtgc
181 gctcaactgt cctgcgctgc ggggtgccgc gagttccacc tccgcgcctc cttctctaga
241 caggcgctgg gagaaagaac cggctcccga gttctgggca tttcgcccgg ctcgaggtgc
301 aggatgcaga gcaaggtgct gctggccgtc gccctgtggc tctgcgtgga gacccgggcc
361 gcctctgtgg gtttgcctag tgtttctctt gatctgccca ggctcagcat acaaaaagac
421 atacttacaa ttaaggctaa tacaactctt caaattactt gcaggggaca gagggacttg
481 gactggcttt ggcccaataa tcagagtggc agtgagcaaa gggtggaggt gactgagtgc
541 agcgatggcc tcttctgtaa gacactcaca attccaaaag tgatcggaaa tgacactgga
601 gcctacaagt gcttctaccg ggaaactgac ttggcctcgg tcatttatgt ctatgttcaa
661 gattacagat ctccatttat tgcttctgtt agtgaccaac atggagtcgt gtacattact
721 gagaacaaaa acaaaactgt ggtgattcca tgtctcgggt ccatttcaaa tctcaacgtg
781 tcactttgtg caagataccc agaaaagaga tttgttcctg atggtaacag aatttcctgg
841 gacagcaaga agggctttac tattcccagc tacatgatca gctatgctgg catggtcttc
901 tgtgaagcaa aaattaatga tgaaagttac cagtctatta tgtacatagt tgtcgttgta
961 gggtatagga tttatgatgt ggttctgagt ccgtctcatg gaattgaact atctgttgga
1021 gaaaagcttg tcttaaattg tacagcaaga actgaactaa atgtggggat tgacttcaac
1081 tgggaatacc cttcttcgaa gcatcagcat aagaaacttg taaaccgaga cctaaaaacc
1141 cagtctggga gtgagatgaa gaaatttttg agcaccttaa ctatagatgg tgtaacccgg
1201 agtgaccaag gattgtacac ctgtgcagca tccagtgggc tgatgaccaa gaagaacagc
1261 acatttgtca gggtccatga aaaacctttt gttgcttttg gaagtggcat ggaatctctg
1321 gtggaagcca cggtggggga gcgtgtcaga atccctgcga agtaccttgg ttacccaccc
1381 ccagaaataa aatggtataa aaatggaata ccccttgagt ccaatcacac aattaaagcg
1441 gggcatgtac tgacgattat ggaagtgagt gaaagagaca caggaaatta cactgtcatc
1501 cttaccaatc ccatttcaaa ggagaagcag agccatgtgg tctctctggt tgtgtatgtc
1561 ccaccccaga ttggtgagaa atctctaatc tctcctgtgg attcctacca gtacggcacc
1621 actcaaacgc tgacatgtac ggtctatgcc attcctcccc cgcatcacat ccactggtat
1681 tggcagttgg aggaagagtg cgccaacgag cccagccaag ctgtctcagt gacaaaccca
1741 tacccttgtg aagaatggag aagtgtggag gacttccagg gaggaaataa aattgaagtt
1801 aataaaaatc aatttgctct aattgaagga aaaaacaaaa ctgtaagtac ccttgttatc
1861 caagcggcaa atgtgtcagc tttgtacaaa tgtgaagcgg tcaacaaagt cgggagagga
1921 gagagggtga tctccttcca cgtgaccagg ggtcctgaaa ttactttgca acctgacatg
1981 cagcccactg agcaggagag cgtgtctttg tggtgcactg cagacagatc tacgtttgag
2041 aacctcacat ggtacaagct tggcccacag cctctgccaa tccatgtggg agagttgccc
2101 acacctgttt gcaagaactt ggatactctt tggaaattga atgccaccat gttctctaat
2161 agcacaaatg acattttgat catggagctt aagaatgcat ccttgcagga ccaaggagac
2221 tatgtctgcc ttgctcaaga caggaagacc aagaaaagac attgcgtggt caggcagctc
2281 acagtcctag agcgtgtggc acccacgatc acaggaaacc tggagaatca gacgacaagt
2341 attggggaaa gcatcgaagt ctcatgcacg gcatctggga atccccctcc acagatcatg
2401 tggtttaaag ataatgagac ccttgtagaa gactcaggca ttgtattgaa ggatgggaac
2461 cggaacctca ctatccgcag agtgaggaag gaggacgaag gcctctacac ctgccaggca
2521 tgcagtgttc ttggctgtgc aaaagtggag gcatttttca taatagaagg tgcccaggaa
2581 aagacgaact tggaaatcat tattctagta ggcacggcgg tgattgccat gttcttctgg
2641 ctacttcttg tcatcatcct acggaccgtt aagcgggcca atggagggga actgaagaca
2701 ggctacttgt ccatcgtcat ggatccagat gaactcccat tggatgaaca ttgtgaacga
2761 ctgccttatg atgccagcaa atgggaattc cccagagacc ggctgaagct aggtaagcct
2821 cttggccgtg gtgcctttgg ccaagtgatt gaagcagatg cctttggaat tgacaagaca
2881 gcaacttgca ggacagtagc agtcaaaatg ttgaaagaag gagcaacaca cagtgagcat
2941 cgagctctca tgtctgaact caagatcctc attcatattg gtcaccatct caatgtggtc
3001 aaccttctag gtgcctgtac caagccagga gggccactca tggtgattgt ggaattctgc
3061 aaatttggaa acctgtccac ttacctgagg agcaagagaa atgaatttgt cccctacaag
3121 accaaagggg cacgattccg tcaagggaaa gactacgttg gagcaatccc tgtggatctg
3181 aaacggcgct tggacagcat caccagtagc cagagctcag ccagctctgg atttgtggag
3241 gagaagtccc tcagtgatgt agaagaagag gaagctcctg aagatctgta taaggacttc
3301 ctgaccttgg agcatctcat ctgttacagc ttccaagtgg ctaagggcat ggagttcttg
3361 gcatcgcgaa agtgtatcca cagggacctg gcggcacgaa atatcctctt atcggagaag
3421 aacgtggtta aaatctgtga ctttggcttg gcccgggata tttataaaga tccagattat
3481 gtcagaaaag gagatgctcg cctccctttg aaatggatgg ccccagaaac aatttttgac
3541 agagtgtaca caatccagag tgacgtctgg tcttttggtg ttttgctgtg ggaaatattt
3601 tccttaggtg cttctccata tcctggggta aagattgatg aagaattttg taggcgattg
3661 aaagaaggaa ctagaatgag ggcccctgat tatactacac cagaaatgta ccagaccatg
3721 ctggactgct ggcacgggga gcccagtcag agacccacgt tttcagagtt ggtggaacat
3781 ttgggaaatc tcttgcaagc taatgctcag caggatggca aagactacat tgttcttccg
3841 atatcagaga ctttgagcat ggaagaggat tctggactct ctctgcctac ctcacctgtt
3901 tcctgtatgg aggaggagga agtatgtgac cccaaattcc attatgacaa cacagcagga
3961 atcagtcagt atctgcagaa cagtaagcga aagagccggc ctgtgagtgt aaaaacattt
4021 gaagatatcc cgttagaaga accagaagta aaagtaatcc cagatgacaa ccagacggac
4081 agtggtatgg ttcttgcctc agaagagctg aaaactttgg aagacagaac caaattatct
4141 ccatcttttg gtggaatggt gcccagcaaa agcagggagt ctgtggcatc tgaaggctca
4201 aaccagacaa gcggctacca gtccggatat cactccgatg acacagacac caccgtgtac
4261 tccagtgagg aagcagaact tttaaagctg atagagattg gagtgcaaac cggtagcaca
4321 gcccagattc tccagcctga ctcggggacc acactgagct ctcctcctgt ttaaaaggaa
4381 gcatccacac cccaactccc ggacatcaca tgagaggtct gctcagattt tgaagtgttg
4441 ttctttccac cagcaggaag tagccgcatt tgattttcat ttcgacaaca gaaaaaggac
4501 ctcggactgc agggagccag tcttctaggc atatcctgga agaggcttgt gacccaagaa
4561 tgtgtctgtg tcttctccca gtgttgacct gatcctcttt tttcattcat ttaaaaagca
4621 ttatcatgcc cctgctgcgg gtctcaccat gggtttagaa caaagagctt caagcaatgg
4681 ccccatcctc aaagaagtag cagtacctgg ggagctgaca cttctgtaaa actagaagat
4741 aaaccaggca acgtaagtgt tcgaggtgtt gaagatggga aggatttgca gggctgagtc
4801 tatccaagag gctttgttta ggacgtgggt cccaagccaa gccttaagtg tggaattcgg
4861 attgatagaa aggaagacta acgttacctt gctttggaga gtactggagc ctgcaaatgc
4921 attgtgtttg ctctggtgga ggtgggcatg gggtctgttc tgaaatgtaa agggttcaga
4981 cggggtttct ggttttagaa ggttgcgtgt tcttcgagtt gggctaaagt agagttcgtt
5041 gtgctgtttc tgactcctaa tgagagttcc ttccagaccg ttagctgtct ccttgccaag
5101 ccccaggaag aaaatgatgc agctctggct ccttgtctcc caggctgatc ctttattcag
5161 aataccacaa agaaaggaca ttcagctcaa ggctccctgc cgtgttgaag agttctgact
5221 gcacaaacca gcttctggtt tcttctggaa tgaataccct catatctgtc ctgatgtgat
5281 atgtctgaga ctgaatgcgg gaggttcaat gtgaagctgt gtgtggtgtc aaagtttcag
5341 gaaggatttt acccttttgt tcttccccct gtccccaacc cactctcacc ccgcaaccca
5401 tcagtatttt agttatttgg cctctactcc agtaaacctg attgggtttg ttcactctct
5461 gaatgattat tagccagact tcaaaattat tttatagccc aaattataac atctattgta
5521 ttatttagac ttttaacata tagagctatt tctactgatt tttgcccttg ttctgtcctt
5581 tttttcaaaa aagaaaatgt gttttttgtt tggtaccata gtgtgaaatg ctgggaacaa
5641 tgactataag acatgctatg gcacatatat ttatagtctg tttatgtaga aacaaatgta
5701 atatattaaa gccttatata taatgaactt tgtactattc acattttgta tcagtattat
5761 gtagcataac aaaggtcata atgctttcag caattgatgt cattttatta aagaacattg
5821 aaaaacttga
//