LOCUS AF034611 11344 bp mRNA linear HUM 03-DEC-1998
DEFINITION Homo sapiens intrinsic factor-B12 receptor precursor, mRNA,
complete cds.
ACCESSION AF034611
VERSION AF034611.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 11344)
AUTHORS Birn,H., Verroust,P.J., Nexo,E., Hager,H., Jacobsen,C.,
Christensen,E.I. and Moestrup,S.K.
TITLE Characterization of an epithelial approximately 460-kDa protein
that facilitates endocytosis of intrinsic factor-vitamin B12 and
binds receptor-associated protein
JOURNAL J. Biol. Chem. 272 (42), 26497-26504 (1997)
PUBMED 9334227
REFERENCE 2 (bases 1 to 11344)
AUTHORS Kozyraki,R., Kristiansen,M., Silahtaroglu,A., Hansen,C.,
Jacobsen,C., Tommerup,N., Verroust,P.J. and Moestrup,S.K.
TITLE The human intrinsic factor-vitamin B12 receptor, cubilin: molecular
characterization and chromosomal mapping of the gene to 10p within
the autosomal recessive megaloblastic anemia (MGA1) region
JOURNAL Blood 91 (10), 3593-3600 (1998)
PUBMED 9572993
REFERENCE 3 (bases 1 to 11344)
AUTHORS Moestrup,S.K., Kristiansen,M., Kozyraki,R., Tommerup,N. and
Verroust,P.J.
TITLE Direct Submission
JOURNAL Submitted (14-NOV-1997) Medical Biochemistry, University of Aarhus,
Ole Worms Alle, Aarhus 8000 C, Denmark
REFERENCE 4 (bases 1 to 11344)
AUTHORS Moestrup,S.K., Kristiansen,M., Kozyraki,R., Tommerup,N. and
Verroust,P.J.
TITLE Direct Submission
JOURNAL Submitted (02-JUN-1998) Medical Biochemistry, University of Aarhus,
Ole Worms Alle, Aarhus 8000 C, Denmark
REMARK Sequence update by submitter
REFERENCE 5 (bases 1 to 11344)
AUTHORS Moestrup,S.K., Aminoff,M., Kristiansen,M., Carter,J.E.,
Kozyraki,R., Verroust,P.J. and Krahe,R.
TITLE Direct Submission
JOURNAL Submitted (25-NOV-1998) Medical Biochemistry, University of Aarhus,
Ole Worms Alle, Aarhus 8000 C, Denmark
REMARK Sequence update by submitter
COMMENT On Nov 30, 1998 this sequence version replaced gi:3172328.
FEATURES Location/Qualifiers
source 1..11344
/db_xref="H-InvDB:HIT000063148"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10p12"
CDS 27..10898
/note="membrane receptor protein; cubilin"
/codon_start=1
/product="intrinsic factor-B12 receptor precursor"
/protein_id="AAC82612.1"
/translation="MMNMSLPFLWSLLTLLIFAEVNGERGELELQRQKRSINLQQPRM
ATERGNLVFLTGSAQNIEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSAIGL
PQNISSQIYQLNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGNCLNLHDSFFCICPP
QWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCE
GGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMSSPNSPACTLDRDECSFQPGPCST
LVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQ
ACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGC
VQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDG
VDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEM
GKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYF
HLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSP
DLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARI
HFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQ
PQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCGNGTISHIKSITNSVWIRF
KIDASVEKASFRAVYQVACGDELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILL
NFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSS
STENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHL
MFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDL
AYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAV
HFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSD
QIDTRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFE
LEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTD
EGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNY
TFLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRR
EKGFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDF
DVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSI
NGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRYHRVLLNF
TDFDLEPQDSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNR
GFRAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFE
LERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGG
FHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIISSPGNRLQLSFISFQ
LEDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTG
FQATFMKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIE
EIQNCYYDKLRIYDGPSIHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLL
EWFAVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST
VELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFT
SDSSVTRAGFNASFHKSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAV
HFEQPFQIPNGDSSCNQGDYLVLRNGPDIYSPPLGPPGGNGHFCGSHASSTLFTSDNQ
MFVQFISDHSNEGQGFKIKYEAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCI
WILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQW
SSGEVMYLRFRSDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCE
WHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNILGRYCGNTIPDSIDTS
SNTAVVRFVTDGSVTASGFRLRFESSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEW
RITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKS
SGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRN
LNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKP
TLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVITSPNYPNAYDSL
THCSWLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPR
TIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPHWPQNFPEN
SRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNV
APGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQYDNNM
NCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDE
MPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPN
DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRP
PNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSN
GMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAG
TFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNIS
SPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSR
FQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRS
PGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLL
GKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTS
PGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSS
GPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTWDS"
sig_peptide 27..98
/note="putative"
mat_peptide 99..10895
/product="intrinsic factor-B12 receptor"
misc_feature 120..131
/note="encodes recognition sequence for furin-mediated
cleavage"
misc_feature 423..536
/note="encodes EGF repeat"
misc_feature 537..665
/note="encodes EGF repeat"
misc_feature 666..815
/note="encodes EGF repeat"
misc_feature 816..944
/note="encodes EGF repeat"
misc_feature 945..1076
/note="encodes EGF repeat"
misc_feature 1077..1221
/note="encodes EGF repeat"
misc_feature 1222..1322
/note="encodes EGF repeat"
misc_feature 1323..1436
/note="encodes EGF repeat"
misc_feature 1446..1793
/note="encodes CUB domain"
misc_feature 1794..2147
/note="encodes CUB domain"
misc_feature 2148..2474
/note="encodes CUB domain"
misc_feature 2475..2819
/note="encodes CUB domain"
misc_feature 2820..3167
/note="encodes CUB domain"
misc_feature 3168..3518
/note="encodes CUB domain"
misc_feature 3519..3857
/note="encodes CUB domain"
misc_feature 3858..4196
/note="encodes CUB domain"
misc_feature 4197..4553
/note="encodes CUB domain"
misc_feature 4554..4883
/note="encodes CUB domain"
misc_feature 4884..5237
/note="encodes CUB domain"
misc_feature 5238..5582
/note="encodes CUB domain"
misc_feature 5583..5957
/note="encodes CUB domain"
misc_feature 5958..6299
/note="encodes CUB domain"
misc_feature 6300..6674
/note="encodes CUB domain"
misc_feature 6675..7031
/note="encodes CUB domain"
misc_feature 7032..7379
/note="encodes CUB domain"
misc_feature 7380..7733
/note="encodes CUB domain"
misc_feature 7734..8090
/note="encodes CUB domain"
misc_feature 8091..8438
/note="encodes CUB domain"
misc_feature 8439..8783
/note="encodes CUB domain"
misc_feature 8784..9134
/note="encodes CUB domain"
misc_feature 9135..9494
/note="encodes CUB domain"
misc_feature 9495..9857
/note="encodes CUB domain"
misc_feature 9858..10208
/note="encodes CUB domain"
misc_feature 10209..10556
/note="encodes CUB domain"
misc_feature 10557..10895
/note="encodes CUB domain"
BASE COUNT 2960 a 2752 c 2567 g 3061 t
ORIGIN
1 ctcttacctg ccaacctggg aggttgatga tgaacatgtc tttacctttt ctttggagtt
61 tgcttacctt attaatattt gctgaagtaa atggcgaacg tggagaactt gagctgcaga
121 gacaaaaaag aagcatcaat ctccaacagc ctcgaatggc tacagagaga ggaaatttgg
181 tgtttcttac ggggtctgct caaaacattg agtttagaac cggatccctg ggaaaaatta
241 aattaaatga tgaagatctc agtgagtgtt tacatcagat ccagaaaaac aaagaagata
301 ttatagagtt aaaagggagc gcaattggtc tgcctcaaaa tatatctagt caaatctatc
361 agcttaattc caagctggtg gatcttgaga gaaaattcca aggcttgcag cagactgttg
421 acaaaaaggt ttgcagcagc aatccttgcc agaatggtgg gaactgcctc aatctgcatg
481 attccttttt ttgtatctgt cccccacagt ggaagggtcc tctctgctca gctgatgtta
541 acgaatgtga gatttactca ggaacaccct tgagctgcca gaatggaggc acatgtgtta
601 atacaatggg aagttacagt tgtcactgcc cacctgagac gtacggaccc cagtgtgcat
661 ccaaatatga cgactgtgaa gggggttctg tggcacgctg tgtccatggc atctgtgagg
721 atttaatgcg agagcaagct ggagagccca agtacagctg cgtctgtgat gctgggtgga
781 tgtcttcacc caacagccct gcctgcacgc tggacagaga cgagtgcagc ttccagcccg
841 ggccttgctc cacacttgtg cagtgtttca acactcaagg ctctttctac tgtggggcct
901 gtccaacagg ctggcaaggc aatggatata tttgcgaaga tatcaatgaa tgtgagataa
961 ataatggcgg ctgttctgtg gctccacccg ttgagtgtgt gaatacacct gggtcttccc
1021 actgccaggc ctgtccacca gggtaccagg gtgacggaag agtgtgcaca ctcacagaca
1081 tctgctcagt cagtaatgga ggctgccacc cagatgcctc atgctcctca actctaggtt
1141 ccttacctct ctgcacgtgt ctcccgggtt atactggaaa tggttatggg ccaaatggat
1201 gtgtgcagct cagtaatatt tgcctaagtc acccctgtct aaatggacaa tgcatcgaca
1261 ctgtctctgg ttatttttgt aagtgtgact caggttggac aggtgtcaac tgtacagaaa
1321 acatcaatga gtgtttgagc aacccctgtt tgaatggagg aacttgtgtt gatggcgttg
1381 attctttcag ttgtgaatgc acacgtctct ggactggagc tctctgtcag gttcctcagc
1441 aagtttgtgg agagtccctc tcaggaataa atggaagctt cagctacagg agcccggatg
1501 ttggttatgt tcatgatgtt aactgcttct gggttatcaa aactgaaatg ggaaaggtcc
1561 tgcgtatcac tttcactttt ttccggttag aatccatgga caactgtcca cacgagtttc
1621 ttcaggttta tgatggagat tcctcttctg cttttcaact tggaagattt tgtggctcca
1681 gcctccctca tgaactcctc agcagtgaca atgctctcta ttttcatctc tattctgaac
1741 atttaagaaa tgggagaggc tttacagtaa gatgggaaac acagcaacca gagtgtggag
1801 gtatcctgac tggtccttac ggttctatta agtctccggg gtatcctgga aactatcccc
1861 caggaagaga ttgtgtctgg attgttgtaa ctagtcctga cctcctggta acatttactt
1921 ttgggacctt gagcctcgag caccatgatg actgcaacaa agattacctt gagattcgag
1981 atggtccttt gtatcaggac ccccttcttg ggaagttctg caccactttc tctgtcccac
2041 cgctccagac tactggcccc tttgccagaa ttcacttcca ttcagactcc cagattagtg
2101 accaaggctt ccatatcacc tacttaacat caccttcgga tctgcgttgt ggtgggaact
2161 acacggaccc agagggtgaa ctcttcttgc ctgagttgtc tgggcctttc actcacacca
2221 ggcaatgcgt ctatatgatg aagcagcccc agggagaaca aatacaaatc aacttcaccc
2281 acgtggagct gcaatgccag agtgacagtt ctcagaatta cattgaggtt cgagatggtg
2341 aaaccttact tggaaaagtc tgtggcaacg gaaccatctc tcacattaaa tccattacta
2401 atagtgtctg gatcaggttt aaaatagatg cttctgttga aaaagctagt ttcagagctg
2461 tttatcaagt cgcttgcggg gatgaattaa ctggagaagg ggtcattcgc tcgccttttt
2521 ttcctaacgt gtatcctgga gaaagaacct gtaggtggac catccaccag ccccaaagcc
2581 aagtcattct cctcaacttc actgtctttg aaattggaag ttctgcccac tgtgaaacag
2641 attatgttga gattggtagc agttccattt tgggttctcc tgaaaataaa aagtattgcg
2701 gtacagacat accttcattt ataacatctg tgtacaattt tctttatgtc acattcgtga
2761 aaagttcttc tactgaaaac catggtttca tggctaagtt cagtgctgag gatttggcat
2821 gtggagaaat tcttacagaa tcaacaggga ccattcaaag tcctggccat ccaaatgtct
2881 acccccacgg tatcaactgt acttggcata tattagtcca acctaatcac ctgattcatt
2941 taatgttcga aacatttcat ctggagtttc attacaattg cacaaacgac tacttggaag
3001 tttatgacac cgactctgag acatcccttg gaagatactg tggaaagtcg atcccgccat
3061 ctctcacaag cagtggtaac tcattgatgc tggtgtttgt gactgactcc gacctcgctt
3121 atgaaggctt cttaataaac tatgaagcaa tcagtgcagc aacagcatgt ttgcaagact
3181 acacagatga tttggggaca ttcacttctc caaacttccc caataattat cccaacaact
3241 gggaatgcat ttatcggatc acagtgagaa ctggccaact gattgcagtg cacttcacaa
3301 acttctcctt ggaggaagcc attggaaact attatacaga ttttctggaa atcagagatg
3361 gaggctatga aaaatcacca ttgctgggaa tattctatgg ctcaaatcta cccccaacaa
3421 tcatctctca tagtaacaaa ctatggttaa aatttaagag tgaccaaata gacacaaggt
3481 ctggattctc agcttactgg gatgggtcat caacaggttg cgggggtaat ctcaccactt
3541 caagcggtac gttcatatct cccaactacc cgatgcccta ttaccacagc tctgaatgct
3601 actggtggtt gaaatctagc cacggcagcg catttgaact ggaattcaaa gactttcact
3661 tggagcatca tccaaactgc actttagatt acctggctgt atatgatggc ccaagtagca
3721 actctcatct gctaactcag ctttgtgggg atgagaaacc ccctcttatt cgttctagtg
3781 gagacagcat gtttataaaa ctgaggacag atgaaggtca gcaaggacgt ggcttcaagg
3841 ctgaataccg gcagacatgt gagaatgtgg taatagtcaa tcaaacctat ggcatcttag
3901 agagtatagg gtatccgaat ccttattctg aaaatcagca ttgcaactgg accatccggg
3961 caacaacagg caacactgtg aactacacat ttttagcatt tgacttggaa catcacataa
4021 actgctccac agattattta gagctctatg atggaccacg gcagatggga cgctactgtg
4081 gagtagacct gccccctcca gggagtacta caagctccaa gcttcaagtg ctgctcctta
4141 cagatggggt tggccgccgt gagaaaggat ttcagatgca gtggtttgtt tacggttgtg
4201 gtggagagct gtctggggcc acaggctcct tcagcagccc cgggttcccc aacaggtatc
4261 caccaaacaa ggagtgtatc tggtacatta ggacggaccc cgggagtagc attcagctca
4321 ccatccatga cttcgatgtg gagtatcatt caaggtgcaa ctttgatgtc ttggagatct
4381 atggaggccc cgatttccac tctcccagaa tagcccaact gtgtacccag agatcacctg
4441 agaaccccat gcaggtctcc agcactggaa atgagctagc aattcgattc aagaccgact
4501 tgtccataaa tgggagaggc ttcaatgcgt catggcaagc agtcactgga ggttgtggtg
4561 ggattttcca ggctcccagt ggagagattc attctccaaa ttaccccagt ccttatagga
4621 gcaacacaga ctgttcttgg gtcattcggg ttgacagata tcatcgtgtt ctcttgaact
4681 tcactgactt tgatcttgaa ccacaagact cttgtattat ggcatacgat ggcttaagct
4741 ccacaatgtc ccgccttgcc aggacgtgtg gaagggagca gctggctaac cccatcgtct
4801 cctcaggaaa cagcctcttc ttgagatttc agtctggccc ttccagacag aacagaggct
4861 tccgagctca attcaggcaa gcctgcggag gccacatcct caccagctca tttgatactg
4921 tttcctctcc acggttccct gccaattatc caaacaatca gaactgcagc tggatcattc
4981 aagcgcaacc tccattaaat catatcaccc tctcttttac ccactttgaa cttgaaagaa
5041 gcacaacgtg tgcacgtgac tttgtagaaa ttttggatgg cggccacgaa gacgcgcccc
5101 tccgaggccg ttactgtggc accgacatgc cccatcctat cacatccttc agcagcgccc
5161 tgacgctgag attcgtctct gattctagca tcagtgctgg gggtttccac accacggtca
5221 ccgcatcagt gtcggcttgt ggtggaacgt tctacatggc tgaaggcatc ttcaacagcc
5281 ctggctaccc agacatttat ccccctaatg tggaatgtgt ctggaacatc atcagttccc
5341 ctggcaaccg gctccagctg tcttttatat ctttccagtt ggaagactct caggactgca
5401 gcagagattt tgtggagatc cgtgaaggaa atgccacggg tcacttggtg ggacgatact
5461 gtggaaactc cttccctctc aattattctt ccatcgttgg acataccctg tgggtcagat
5521 ttatctcaga tggttctggc agcggcacgg gcttccaggc cacatttatg aagatatttg
5581 gcaatgataa tattgtggga actcatggga aagtcgcctc tcctttctgg cctgaaaact
5641 acccacataa ctccaattac caatggacag taaatgtgaa tgcatctcac gttgtccatg
5701 gtagaatctt ggagatggac atagaagaaa tacaaaactg ctattatgac aaattaagga
5761 tctatgatgg gcctagcatt cacgcccgcc taattggagc ttactgtggt acccagactg
5821 aatctttcag ctccactgga aattctttga catttcattt ttactccgac tcttcaatct
5881 cggggaaggg attccttctg gagtggtttg cagtggatgc acctgatggt gttttaccta
5941 ccattgctcc aggtgcttgt ggtggcttcc tgaggacggg agatgcaccc gtgtttctct
6001 tctccccggg ctggcctgac agttacagta atagagtgga ctgtacgtgg ctcatccagg
6061 ctcccgactc taccgtggaa ctcaacattc tttccctgga cattgaatct caccgaacgt
6121 gtgcctatga tagccttgtg atacgagatg gagataataa cttggcccag cagctagcag
6181 ttctctgtgg cagagagatc cctgggccca tccggtctac tggagagtac atgttcatcc
6241 gcttcacctc ggactccagt gtaaccaggg caggcttcaa tgcatccttt cacaagagct
6301 gcggtggata tttgcatgca gacagaggga tcatcacgtc ccccaagtat ccagagactt
6361 acccatccaa cctcaactgt tcttggcacg tcctggtcca aagtggcctg accattgctg
6421 tccattttga acagcctttc cagattccaa atggagattc ttcttgcaac cagggggatt
6481 acttggtgct aagaaatggt cctgatatct attctccacc cttgggaccc cctggaggaa
6541 atggtcattt ttgtggcagt catgcttcat caactctgtt cacctcggat aatcaaatgt
6601 ttgttcagtt tatttctgat cacagtaatg aagggcaagg atttaaaatc aaatatgagg
6661 caaagagttt agcctgtggg ggcaacgtct acatccatga tgctgattct gctgggtatg
6721 tgacctcccc caaccaccct cataattatc ccccgcacgc tgattgcatt tggatcttag
6781 cggctccacc ggaaacacgc atacagctgc aatttgaaga tcgattcgat attgaagtaa
6841 cacccaactg tacttccaac taccttgagt tgcgggatgg agtggattcg gatgcaccaa
6901 tactttccaa attttgtggg acatctttgc ccagcagtca gtggtcctca ggagaggtta
6961 tgtatttgag atttcgatct gacaacagcc ccacacatgt gggattcaag gccaagtatt
7021 ctatagctca gtgtggggga agagtaccag ggcaaagtgg tgttgttgaa agcattggac
7081 atccaacact tccatacaga gacaacttat tctgtgagtg gcatctccag gggctctctg
7141 gacactatct caccatctct tttgaagact ttaaccttca gaattcttct ggctgtgaaa
7201 aagacttcgt ggagatctgg gacaatcata cctctggaaa catcttgggc agatactgtg
7261 gaaacaccat tcctgacagc atagacactt ctagcaatac tgctgtggtc aggtttgtca
7321 cagacggctc tgtgactgcc tcaggattca gactgcgatt tgaatccagt atggaagagt
7381 gtggtgggga tcttcagggc tctattggaa catttacttc tcccaactac ccgaacccaa
7441 atcctcatgg ccggatctgc gagtggagaa tcactgcccc ggagggaagg cggatcaccc
7501 taatgtttaa caacctgagg ctggccacgc atccgtcctg caacaatgag catgtgatag
7561 tattcaatgg cattagaagt aactcacccc agctagagaa actgtgtagt agtgtgaatg
7621 taagcaatga gattaaatct tcaggaaaca caatgaaagt catttttttc acggatggat
7681 ccaggccata tggcggcttc actgcttcct atacctccag tgaagatgca gtgtgtggtg
7741 ggtctcttcc aaatactcct gaaggaaact ttacttctcc tggctatgac ggagtcagga
7801 attactcaag aaacctgaac tgcgaatgga ctctcagcaa tccaaatcag ggaaattcat
7861 ccatttccat tcactttgaa gatttttacc tagaaagtca ccaagactgt caatttgatg
7921 tcctcgagtt tcgagtgggt gatgctgatg ggcccctgat gtggagactt tgtggtcctt
7981 caaagcctac attgccattg gttatacctt attctcaggt atggattcac tttgtcacca
8041 acgaacgtgt agaacacatt ggattccatg caaagtattc ctttacagat tgtggcggaa
8101 tacagatagg tgacagtgga gtgatcacaa gccccaacta tccaaatgct tatgacagcc
8161 tgacccactg ctcttggctg ttggaggccc cacaagggca caccatcact ctcacattta
8221 gtgactttga tattgaaccc catacaactt gtgcttggga ctctgtcact gtcaggaatg
8281 gtgggtcccc tgaatcaccc atcataggac aatactgtgg aaattcaaac cccaggacaa
8341 tacagtcagg ttccaatcag ctggtcgtga cttttaactc agaccattca ttgcaaggtg
8401 gtggatttta tgctacgtgg aacacacaaa ctttaggttg tggtggaata tttcattctg
8461 ataatggtac aatcagatcc cctcactggc ctcagaattt tcccgaaaac agcagatgtt
8521 cctggacggc cattactcac aaaagtaaac acttggagat cagctttgac aacaacttcc
8581 taatccccag cggtgatgga caatgtcaga atagcttcgt gaaggtgtgg gcaggaactg
8641 aggaggtgga caaagccctg ctagccactg gctgtgggaa cgtggctccg ggtcccgtta
8701 tcacaccaag taacacattc actgccgtct tccagtctca ggaggcacca gctcagggct
8761 tctccgcgtc ctttgttagc cgatgtggaa gtaatttcac tggcccttca ggttacatca
8821 tttctccaaa ttacccaaaa caatatgaca acaacatgaa ttgcacctat gtcatagagg
8881 ctaatcctct gtcagtggtc ctcttgactt ttgtgtcctt ccacttagaa gctcgttccg
8941 ctgtgacggg aagctgtgtc aacgatggcg tgcacattat cagaggttac agcgtcatgt
9001 ccaccccatt tgctactgtg tgtggggatg agatgccagc tcccctcacc atcgctgggc
9061 cggttctgct taacttctac tccaacgagc aaatcacaga cttcggattc aagttttcct
9121 ataggataat ctcctgtggt ggtgtgttca atttctcttc tggaatcatc acaagtcctg
9181 cctattcata cgcagactac ccaaatgata tgcactgtct gtataccatc accgttagtg
9241 acgacaaggt gatcgagctc aagttcagtg attttgatgt ggttccctcc acctcctgct
9301 cccatgacta cctggcaatt tacgatggtg ccaataccag cgatcccctt cttggcaaat
9361 tctgcggttc caagcgccca ccaaatgtga agagcagcaa taatagtatg ctcctggtgt
9421 tcaagacaga ttcatttcag acagcaaaag gctggaagat gtctttccgg cagacattgg
9481 ggcctcagca aggatgtggt ggttatctga caggctcgaa taataccttt gcctctcctg
9541 attctgattc gaatggaatg tatgacaaga atttaaactg tgtatggatc ataattgcac
9601 ctgtaaacaa agtaattcac ctcaccttca atacatttgc tctggaggca gcaagtacta
9661 ggcaaagatg cctttatgat tatgtaaagt tatatgatgg ggatagtgaa aatgcgaact
9721 tggctggaac gttttgtggt tccacagtac ctgctccttt tatctcttct ggtaacttcc
9781 ttacggttca attcatcagt gacttaacat tagagaggga aggatttaat gctacataca
9841 ccatcatgga catgccttgt ggtggaacgt acaatgcaac ttggacccca caaaatattt
9901 catcacccaa ttcatcagac ccagatgtcc cattttccat ctgtacttgg gtcattgatt
9961 cccctccgca tcagcaggtc aagataactg tgtgggcatt acagctgacc tcgcaagact
10021 gcacgcagaa ttacttacag cttcaggact caccgcaggg tcacggaaat tcaagatttc
10081 agttctgtgg cagaaatgct tcggctgtgc cagtgtttta ttcttctatg agtactgcaa
10141 tggtcatttt caaatctgga gttgtaaaca gaaactctag aatgagtttc acctatcaga
10201 ttgcagattg caacagagac tatcacaagg catttggcaa cctgagaagc cctggatggc
10261 cagataacta cgacaatgac aaggattgca ccgttactct cacagccccc cagaaccaca
10321 ccatttccct cttttttcat tcacttggca tcgagaactc agttgaatgc agaaacgatt
10381 tcttggaggt gagaaatgga agtaacagca attcaccatt actgggcaag tactgtggaa
10441 ctctgctgcc aaaccctgtc ttctctcaaa ataatgaact atacctacga tttaagagtg
10501 atagtgtaac ttctgatcgt ggatatgaaa tcatctggac ttcatcaccc tctggatgtg
10561 gtggaactct ttatggagac agaggctcat tcaccagccc cggctatcca ggcacatacc
10621 caaacaacac gtactgcgag tgggtccttg ttgctcctgc tggaaggctt gtcaccatca
10681 acttctactt catcagcatt gacgatccag gagactgtgt ccagaactat ctcacactct
10741 atgatgggcc caacgccagc tctccatcct ctggaccata ctgcggaggc gacaccagca
10801 tagctccctt cgtggcttcc tcaaatcagg tcttcataaa atttcatgct gattatgcac
10861 ggcgtccatc cgcattccga ttaacttggg acagctaagt gggtaacaac tcgtgttcac
10921 tcagcacttt ccctctgcag cacgctggac agcactctgc catcctgata catgacccct
10981 gctgatgcca cagagaataa gctgaacttg tatggttttt caccaaacca tggatagaat
11041 caatatttgt aggccaggcg tggtggctca cccccctgta ttctcagcac tttgggaggc
11101 cgaggcaggt tgatcacctg aggtcaggag tttgagacta gcctggccag catggtgaaa
11161 cctcatccct ctaacaatat aataattagc caggcgtggt ggtgggtgcc tgtaattcca
11221 gccactcgag aagctgaggc aggagaattg cttgaaccca ggaggcagag gttgcagtga
11281 gctaagatca caccactaca ctccagcctg ggcgandddg taagactcca tctcaaaaaa
11341 aaaa
//