LOCUS AF033861 4142 bp mRNA linear HUM 08-FEB-1999
DEFINITION Homo sapiens type III adenylyl cyclase (AC-III) mRNA, complete cds.
ACCESSION AF033861
VERSION AF033861.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4142)
AUTHORS Yang,B., He,B., Abdel-Halim,S.M., Tibell,A., Brendel,M.D.,
Bretzel,R.G., Efendic,S. and Hillert,J.
TITLE Molecular cloning of a full-length cDNA for human type 3 adenylyl
cyclase and its expression in human islets
JOURNAL Biochem. Biophys. Res. Commun. 254 (3), 548-551 (1999)
PUBMED 9920776
REFERENCE 2 (bases 1 to 4142)
AUTHORS Yang,B., He,B., Abdel-Halim,S.M., Efendic,S. and Hillert,J.
TITLE Direct Submission
JOURNAL Submitted (11-NOV-1997) The Department of Neurology and The
Department of Molecular Medicine, Karolinska Institute, Stockholm
141 86 Huddinge, Sweden
FEATURES Location/Qualifiers
source 1..4142
/db_xref="H-InvDB:HIT000063133"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p24-22"
gene 1..4142
/gene="AC-III"
CDS 148..3582
/gene="AC-III"
/function="catalyzes the formation of cAMP"
/note="expressed in fetal brain; adenylyl cyclases (AC)
are membrane associated enzymes which catalyze the
formation of the secondary messenger cyclic adenosine
monophosphate (cAMP); AC activity in various tissues is
regulated by peptide hormones, neurotransmitters,
prostaglandins, adenosine and Ca2+"
/codon_start=1
/product="type III adenylyl cyclase"
/protein_id="AAD13403.1"
/translation="MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSG
SCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSS
DKLAPLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFA
RAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELK
GMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQE
NLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSA
CSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGL
AMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGI
PGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGL
NGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRR
LRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRY
SVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAI
FPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAG
METEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPV
FDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYF
SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEEL
YSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVIT
KIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNI
NNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEE
TQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS"
BASE COUNT 865 a 1228 c 1177 g 872 t
ORIGIN
1 gctggaggtg gcctcccctc cgccccagac aagaagaggc cctcagccct cccccggtct
61 cagagagccc tgagaggagg cccagtccag agctcttcct ccgttcccag tccacttctc
121 tagggccagt agcagacacc agccagtatg ccgaggaacc agggcttctc cgagcccgaa
181 tactcggccg agtactcagc cgagtactcc gtcagcctgc cctccgaccc tgaccgcggg
241 gtgggccgga cccatgaaat ctcggtccgg aactcgggct cctgcctgtg cctgcctcgc
301 ttcatgcggc tgactttcgt gccggagtcc ttggagaacc tctaccagac ctacttcaaa
361 aggcagcgcc acgagaccct gctggtgctg gtggtctttg cagccctctt tgactgctac
421 gtggtggtca tgtgtgctgt ggtcttctcc agcgacaagc tggctcccct cgccgtggct
481 ggaattggac tggtgttgga catcatcctc ttcgtgctct gcaaaaaggg gctgctcccg
541 gaccgggtca cccgcagagt gctgccctac gtgctgtggc tgctcataac cgcccagatc
601 ttctcctacc tgggcctgaa cttcgcgcgt gcccacgcgg ctagtgacac ggtgggctgg
661 caggtcttct ttgtcttctc cttcttcatc acgctgcccc tcagcctcag ccccatcgtg
721 atcatctccg tggtctcctg tgtggtgcac acgttggtcc tgggggtcac cgtggcccag
781 cagcagcagg aggagctcaa ggggatgcag ctgctgcggg agatcctggc caacgtcttc
841 ctctacctgt gcgccatcgc tgtgggcatc atgtcctact acatggctga ccgcaagcac
901 cgcaaggcct tcctggaggc ccgccagtcg ctggaggtga agatgaacct ggaagagcag
961 agccagcagc aggagaacct catgctttcc atcctgccca agcacgtggc tgacgagatg
1021 ctgaaagaca tgaagaaaga cgagagccag aaggaccagc agcagttcaa caccatgtac
1081 atgtaccgtc acgagaacgt cagcatcctc tttgccgaca tcgtgggctt tacccagctg
1141 tcttctgcct gcagtgccca ggagcttgtg aagctgctca acgagctctt tgcccgcttt
1201 gacaagctgg cagctaaata ccaccagctg cggattaaga tcctgggcga ctgctactac
1261 tgcatctgcg gcttgcctga ctaccgggag gaccacgccg tctgctccat cctcatgggg
1321 ctggccatgg tggaggccat ctcgtatgtg cgggagaaga ccaagactgg ggtggacatg
1381 cgtgtggggg tgcacacggg caccgtgctg gggggcgtcc tgggccagaa gcgctggcag
1441 tacgacgtgt ggtcgactga tgtcactgta gccaacaaga tggaggccgg cggcatccct
1501 gggcgcgtgc acatctccca gagcaccatg gactgcctga aaggggagtt tgatgtggag
1561 ccaggcgatg ggggcagccg ctgtgattac ctagaagaga agggtattga aacctacctc
1621 atcattgcct ccaagccaga ggtgaagaaa acagccaccc agaatggcct caatggctcg
1681 gccctgccca atggagcacc agcttcctca aagtccagct cccctgccct cattgagacc
1741 aaggagccca acgggagtgc ccacagcagt gggtccacgt cggagaagcc cgaggagcag
1801 gatgcccagg ccgacaaccc ctcattcccc aacccacgcc ggaggctgcg cctgcaggac
1861 ctggctgacc gagtggtgga tgcctctgaa gatgagcacg agctcaacca gctgctcaac
1921 gaggccctgc ttgagcgaga gtccgcccaa gtagtaaaga agagaaacac cttcctcttg
1981 tccatgcggt tcatggaccc cgagatggaa acccgctact cggtggagaa ggagaagcag
2041 agtggggctg ccttcagctg ctcctgcgtc gtcctgctct gcacggccct ggtcgagata
2101 ctcatcgacc cctggctaat gacaaactat gtgaccttca tggtggggga gattctgctc
2161 ctcatcctga ccatctgctc cctggctgcc atctttcccc gggcctttcc taagaagctt
2221 gtggccttct caacttggat tgaccggacc cgctgggcca ggaacacctg ggccatgctc
2281 gccatcttca tcctggtgat ggcaaatgtc gtggacatgc tcagctgtct ccagtactac
2341 acgggaccca gcaatgcaac ggcagggatg gagacggagg gcagctgcct ggagaacccc
2401 aagtattaca actatgtggc cgtgctgtcc ctcatcgcca ccatcatgct ggtgcaggtc
2461 agccacatgg tgaagctcac gctcatgctg ctcgtcgcag gcgccgtggc caccatcaac
2521 ctctatgcct ggcgtcccgt ctttgatgaa tacgaccaca agcgttttcg ggagcacgac
2581 ttacctatgg tggccttaga gcagatgcaa ggattcaacc ctgggctcaa tggcactgac
2641 aggctgcccc tggtgccttc caagtactct atgacggtga tggtgttcct catgatgctc
2701 agcttctact acttctcccg ccacgtagaa aaactggcac ggacactttt cttgtggaag
2761 attgaggtcc acgaccagaa ggaacgtgtc tatgagatgc gacgctggaa cgaggccttg
2821 gtcaccaaca tgttgcctga gcacgtggca cgccatttcc tggggtccaa gaagagagat
2881 gaggagctgt atagccagac gtatgatgag attggagtca tgtttgcctc cctgcccaac
2941 tttgctgact tctacacaga ggagagcatc aacaatggtg gtattgagtg tctgcgtttc
3001 ctcaatgaaa tcatctcaga ttttgactct ctcctggaca atcccaagtt ccgggtgatc
3061 accaagatca aaaccattgg cagcacgtat atggcggctt caggagtcac ccccgatgtc
3121 aacaccaatg gctttgccag ctccaacaag gaagacaagt ccgagagaga gcgctggcag
3181 cacctggctg acctggccga cttcgcgctg gccatgaagg atacgctcac caacatcaac
3241 aaccagtcct tcaataactt catgctgcgc ataggcatga acaaaggcgg ggttctggct
3301 ggggtcatcg gagcccggaa accacactac gacatctggg gcaatacagt caatgtagcc
3361 agcaggatgg agtccacggg ggtcatgggc aacattcagg tggtagaaga aacccaagtc
3421 atcctccgag agtacggctt ccgctttgtg aggcgaggcc ccatctttgt gaaggggaag
3481 ggggagctgc tgaccttctt cttgaagggg cgggataagc tagccacctt ccccaatggc
3541 ccctctgtca cactgcccca ccaggtggtg gacaactcct gaatggcctc gagcctgaaa
3601 cagtccaaac cggaagggag aatttatttt ttgaaactga aggaagtccc gaccttcctg
3661 gattgaagtg cacactcatg gactttaggt ttagaaacct cctcagcctt catttgttcg
3721 tggatgtgtg agctctgagg gtggccctgc tattcctctg cgtgcctgta gtgtccccag
3781 cataggggtc ttaggcatag ggctgaacag tccttccaga gccctcgttc caatccctgc
3841 cgtccttgcc cctgaggggc cctgaccact gtgagcagga gggtggcaga gctgggacaa
3901 agctgccttt gccgctgggc tttccgggac tgtggaggga gcacaggcgg ggaagctcca
3961 cttcagacag ggcttggtgg ggcaggacat ggctcccatt ttgaagggag gtctccatgt
4021 ggtccgagtg aggtgagacg gccctcgtcc tggtgttcct gatcatcttg aaaggttctt
4081 ctggaactcc tgtcccctta gtcatgagaa cagaaagtgc aatatttcct ttcacctggc
4141 cc
//