LOCUS AF031647 1556 bp mRNA linear HUM 20-APR-1998
DEFINITION Homo sapiens JAB1-containing signalosome subunit 3 (SGN3) mRNA,
complete cds.
ACCESSION AF031647
VERSION AF031647.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1556)
AUTHORS Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
TITLE A novel protein complex involved in signal transduction possessing
similarities to 26S proteasome subunits
JOURNAL FASEB J. 12 (6), 469-478 (1998)
PUBMED 9535219
REFERENCE 2 (bases 1 to 1556)
AUTHORS Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
TITLE Direct Submission
JOURNAL Submitted (29-OCT-1997) Biochemistry, Humboldt University Berlin
(Charite), Monbijoustrasse 2, Berlin 10117, Germany
FEATURES Location/Qualifiers
source 1..1556
/db_xref="H-InvDB:HIT000063074"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="HeLa"
gene 1..1556
/gene="SGN3"
CDS 83..1294
/gene="SGN3"
/function="part of a complex, JAB-1 containing signalosome
(SGN), that phosphorylates cJun, Ikappa-Balpha and p105"
/note="Sgn3 is a 45.7 kDa component of a 450 kDa complex
with kinase activity; JAB1-containing signalosome (SGN)
complex is similar to the plant COP9 particle but
different from the I kappa B kinase (IKK) signalsome"
/codon_start=1
/product="JAB1-containing signalosome subunit 3"
/protein_id="AAC14197.1"
/translation="MTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFV
KFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIG
ILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKH
FLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKV
QQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVK
QCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQK
DGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQE
DDSGNKPSSYS"
BASE COUNT 472 a 325 c 335 g 424 t
ORIGIN
1 ggaattccgg cacgagggaa aacatggcgt ctgcctggag cagttcgtga acagtgtccg
61 acagctctca gctcaagggc aaatgacaca gctttgtgaa ctgatcaaca agagtgggga
121 actccttgcg aagaacttat cccatctgga cactgtgctc ggggctctgg atgtacaaga
181 acactccttg ggcgtccttg ctgttttgtt tgtgaagttt tctatgccca gtgttcctga
241 cttcgaaacg ctattctcac aggttcagct cttcatcagc acttgtaatg gggagcacat
301 tcgatatgca acagacactt ttgctgggct ttgccatcag ctaacaaatg cacttgtgga
361 aagaaaacag cccctgcgag gaattggcat ccttaagcaa gccatagaca agatgcagat
421 gaatacaaac cagctgacct caatacatgc tgatctctgc cagctttgtt tgctagcaaa
481 atgctttaag cctgcccttc catatcttga cgtggatatg atggatatct gtaaagagaa
541 tggagcctat gatgcaaaac actttttatg ttactattat tatggaggga tgatctatac
601 tgggctgaag aactttgaaa gagctctcta cttttatgaa caggctataa ctactcctgc
661 catggcggtc agtcatatca tgttggaatc atataaaaag tatattttag tgtctttgat
721 attacttggc aaagtacaac agctaccaaa atatacatct caaattgtgg gtagattcat
781 taagcctctt agcaatgcat accacgagtt agcacaagtg tattcaacca acaacccctc
841 agaactccga aacctggtga ataagcacag tgaaaccttc actcgcgata acaacatggg
901 gctggtgaag caatgcttgt catctcttta taagaagaat attcagaggc taacaaagac
961 ctttttaact ctatcattac aagatatggc aagtcgtgtg cagttgtctg gacctcagga
1021 ggcagagaaa tacgttctgc acatgataga agatggtgag atttttgcaa gtattaacca
1081 gaaggacggt atggtcagtt tccatgataa ccctgaaaaa tataataacc cagccatgct
1141 tcataacatt gatcaggaga tgctgaagtg cattgagctg gatgagcggc tgaaagccat
1201 ggaccaggag atcacagtga accctcagtt tgtacaaaag agtatgggct cacaagaaga
1261 tgattcagga aacaaaccat ccagttattc ttgaaactaa catccatcct gagctaaaca
1321 agagaaacta ccatcttggc cagtgacaag tgttcggagg gcagcagaga ggaccaagcc
1381 tgtgtcacct ggagactaaa aaattaagtt ttgttttgac atcttcagtc ctgtgtgctt
1441 tcagaaaacc attttctctg caaagaaagg aaacagattt gcaaacttta aagtctgtcg
1501 tggatttatt tatcctcaga ttattgttac tgcattaaat ctaccttttt gcttta
//