LOCUS AF030409 4452 bp mRNA linear HUM 09-MAR-1998
DEFINITION Homo sapiens sodium-hydrogen exchanger 6 (NHE-6) mRNA, nuclear gene
encoding mitochondrial protein, complete cds.
ACCESSION AF030409
VERSION AF030409.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4452)
AUTHORS Numata,M., Petrecca,K., Lake,N. and Orlowski,J.
TITLE Identification of a mitochondrial Na+/H+ exchanger
JOURNAL J. Biol. Chem. 273 (12), 6951-6959 (1998)
PUBMED 9507001
REFERENCE 2 (bases 1 to 4452)
AUTHORS Numata,M. and Orlowski,J.
TITLE Direct Submission
JOURNAL Submitted (18-OCT-1997) Physiology, McGill University, 3655
Drummond St., Montreal, QC H3G 1Y6, Canada
COMMENT This mRNA sequence extends the sequence in the file with GenBank
Accession Number D87743.
FEATURES Location/Qualifiers
source 1..4452
/db_xref="H-InvDB:HIT000063030"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..4452
/gene="NHE-6"
CDS 36..2045
/gene="NHE-6"
/function="ion transporter"
/codon_start=1
/product="sodium-hydrogen exchanger 6"
/protein_id="AAC39643.1"
/translation="MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASD
GGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHET
GLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPII
FYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFT
DCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPA
GDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFF
LMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENF
IFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQH
MMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRV
GVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCG
PIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNS
SEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA"
BASE COUNT 1114 a 903 c 1008 g 1427 t
ORIGIN
1 cgccggtgag gtaggggcgg gaggcggggg gagacatggc tcggcgcggc tggcggcggg
61 cacccctccg ccgtggcgtc ggcagcagtc cccgagcccg caggctcatg cggccccttt
121 ggttgctcct cgcagtgggc gtctttgact gggcaggggc ttcggacggc ggcggcggag
181 aggctagagc catggacgag gagatcgtgt ccgagaagca agccgaggag agccaccggc
241 aggacagcgc caacctgctc atcttcatcc tgctgctcac cctcaccatt ctcacaatct
301 ggctcttcaa gcaccgccgg gcccgcttcc tgcacgaaac cggcctggct atgatttatg
361 gtcttttggt gggccttgtg cttcggtatg gcattcatgt tccgagtgat gtaaataatg
421 tgaccctgag ctgtgaagtg cagtcaagtc caactacctt actggttact tttgatccag
481 aagtattttt caacatatta cttcctccta tcatatttta tgcaggttat agcctgaaaa
541 ggagacattt ttttcgaaat cttgggtcta tcctagcata cgcttttctt ggaacagcaa
601 tttcttgttt cgttattggg tcaataatgt atggctgtgt aacgctgatg aaggtaacgg
661 gacaacttgc aggagatttt tactttacag attgcctact gtttggtgcc attgtatcag
721 caactgatcc agtgactgtt cttgctatat tccacgagct tcaagttgat gttgaactct
781 atgcacttct ttttggtgaa agtgtcctca atgatgctgt tgccatagtg ctgtcctcct
841 caatagtggc ataccagcca gctggagaca acagtcacac ctttgatgtc acagcgatgt
901 tcaagtctat tgggatcttc cttggaatct tcagtggatc ttttgcaatg ggtgctgcta
961 ctggagtggt gacagcttta gtgacaaagt tcaccaaatt acgggagttc cagttgttgg
1021 agacaggcct gttcttcttg atgtcctgga gtaccttcct cttggctgaa gcatggggct
1081 tcacaggtgt agttgcagta ttgttttgtg gcatcacaca agcacattat acgtataata
1141 atttgtccac ggagtctcag catagaacta aacagttgtt tgagcttctc aatttcttgg
1201 cagagaattt catcttctcc tacatggggc tgacactgtt caccttccag aaccatgtct
1261 ttaacccaac atttgtagta ggagcatttg ttgctatttt cttgggaaga gctgccaata
1321 tttacccctt gtccctctta cttaatttgg gtagaagaag taagattgga tcaaattttc
1381 aacacatgat gatgtttgct ggccttcgtg gtgcaatggc atttgccttg gccattcgag
1441 atactgccac ttatgcacgg caaatgatgt tcagcaccac gcttctgatt gtgtttttta
1501 ccgtgtgggt atttggtggt ggcaccactg caatgctgtc atgcttgcat atcagggttg
1561 gtgttgattc agaccaagaa cacttgggtg ttcctgaaaa tgaaaggaga actaccaaag
1621 cagagagtgc ttggcttttc cggatgtggt acaactttga tcataactat ctgaagcctc
1681 tgctgaccca cagcgggcct ccgctgacaa caacactccc tgcctgctgt ggacccatcg
1741 ccaggtgcct caccagcccc caggcttacg aaaaccagga acagttgaaa gatgatgatt
1801 ctgatcttat tctcaatgat ggtgacatca gtttgacata tggagattct actgtgaaca
1861 ctgaaccggc cacatccagc gccccaagga gatttatggg aaacagttct gaagatgcct
1921 tggatcggga gcttgcattt ggggaccatg aactggtcat tcgaggaaca cgcctggttc
1981 ttccaatgga tgattctgaa cccccgctaa atttgttaga taatacgaga catggtccag
2041 cctaagctta ctaatactca cttagtgatt tgtaaaattt gcacatgtga ttgtgaagaa
2101 atttgtacta cctaaaagtc ccagtgcatg tctctgaatg tgtaagctat ataaatgcta
2161 tttatatggc atagaaagaa tataaatatc ctgtacacgg cagattgtga acaaactata
2221 ttcctttaag ttttcctggt tgcactctgt agactggatc tgttttagga agttactttc
2281 acagtgatgt tgtgtgttct gttagtttta tgtctcagtt aaagtgtaaa aagtgacgga
2341 ttttctcttt cttaaactta cctgacactt aaccagagta ccagttctcg tgatgtgaat
2401 taattttttt gtgtgctagg ggagggagag tgaggaggga gtgttatttc cttgggaacc
2461 tagggaggag aggttccttt gttgggaaac ttttgttgat agctgctgcc tttgtcctga
2521 tcgttttctt tcccttttct ctggtggcct gttgtggtgc aacgagctga tggcatttga
2581 tcttgcccca ttcaggttgg ggagtgaagt gtggggaccc ttttcccccg cttgctgtga
2641 aagcacagat tcattgacta cagtacactg ttgttcagaa aagaaggctg caaatgactt
2701 ctgagacttt atgtcttttc ttccagacca agaccgtaga aggagtcaca tctagccggc
2761 ttagccaaag tacaggtgta tatagttcag ggcacttgat ttagatttgg aggggctggg
2821 gtgggcagag agcaagaggc gagtaaagag aatggtggtt tcagagatct ctcttcccaa
2881 atgtgtaaat attctatacc agataagttt aaataagaaa tttaattgct gcttaatttt
2941 tgattatgta ctttatctgt atagcaggct ttgtcgtcag aagtttttat atcgatttaa
3001 attgctgctc tttagcagcc aaacaggagc aaaatgtaaa atttttgaac ttactgtgtc
3061 taatcatcat ttgttagtct gtagttaatg tcaacagtta atttatgaac ccacgatcgt
3121 tccacactgc accaaagtca gtcataagag aaatcgaata ttctggagca ctgattgcag
3181 cagggtggct cctttgtgtg cagcaggtgt agtagtcttc attttcatgg tacgttttaa
3241 tattaattac ctaagctgcc atgcattttt tttttacagt tctcaaggaa gagcacagaa
3301 caatttctca tttcatattt ggagtatgaa agtagattct attttgtaat gctgataata
3361 cctaaagatg cattgaatgc ttggaagaat gctttttgat gttgattttg acctgttcat
3421 gattcagaag aaaaacaaac ttttttggat tttttttccc tcaggtctga gtagcattgc
3481 cttaaatctt atccagttag aacattgatt tatttacatg atgttcagat tttccagtga
3541 aaaataccct tctgaacaaa acatgtactt actctccgaa aggcatctat ctgtgctatt
3601 gcaaacactc cttgagattt taggggaatt ctaatgttgt accctttcgt ggcagctttg
3661 actgttggca tagccatttg ttatgtagtg gtagcgactt tcctgctatg caggaatccc
3721 tcccatgacg tgtatgtttt acatgatgtg tgcctcttca cgcagtaaat agtttcttgt
3781 taatgtatgt ttgaggagtt tgaacgtcag tgtcacttac ccacaaagtt attcaagttg
3841 taaaaggtta taaataattt aacaactacc ttttttattc tgtcgggtta ctgacctcac
3901 tttatgtaaa tacttcgcat gacaaattca gtaactcgtc tatttcagca tgcataagac
3961 ttttcactag ggaaactgat aaagcttgag tcaactaaat ctgccttcat actttatcaa
4021 ggggaaccaa gcctgctgtg cttacatcag catctggaag actttcctct cctctaatct
4081 gtgtacacat ctccaagcaa ggaagaaaaa acaaactctg ctcagacgcc tatgaaacac
4141 ctgaatgaac tttgatgaag tacagtctga gttaccatca tgcacaagta gaactgctct
4201 tggacttgtt ttcctgttgt ttgtggaacc tacgcgtttg aatggcttga acgttgcatc
4261 ttttaaagtt attttttaag gtttcttggc atttatccta gttgtccgtg tttggcaatg
4321 tgctgttaaa gtaatagact tttaatcttt atgtattttt tgttttctct ggagtacttg
4381 gacagatgtt atagtggttt cttttaggaa aatctgtcat taaaaaagtt atagccttgc
4441 aaataaccac tc
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