LOCUS AF027208 3794 bp mRNA linear HUM 24-DEC-1997
DEFINITION Homo sapiens AC133 antigen mRNA, complete cds.
ACCESSION AF027208
VERSION AF027208.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3794)
AUTHORS Yin,A.H., Miraglia,S., Zanjani,E.D., Almeida-Porada,G., Ogawa,M.,
Leary,A.G., Olweus,J., Kearney,J. and Buck,D.W.
TITLE AC133, a novel marker for human hematopoietic stem and progenitor
cells
JOURNAL Blood 90 (12), 5002-5012 (1997)
PUBMED 9389720
REFERENCE 2 (bases 1 to 3794)
AUTHORS Miraglia,S., Godfrey,W., Yin,A.H., Atkins,K., Warnke,R.,
Holden,J.T., Bray,R.A., Waller,E.K. and Buck,D.W.
TITLE A novel five-transmembrane hematopoietic stem cell antigen:
isolation, characterization, and molecular cloning
JOURNAL Blood 90 (12), 5013-5021 (1997)
PUBMED 9389721
REFERENCE 3 (bases 1 to 3794)
AUTHORS Miraglia,S.J., Godfrey,W.R., Yin,A.H. and Buck,D.W.
TITLE Direct Submission
JOURNAL Submitted (28-SEP-1997) AmCell Corporation, 1190 Bordeaux Dr.,
Sunnyvale, CA 94089, USA
FEATURES Location/Qualifiers
source 1..3794
/db_xref="H-InvDB:HIT000062880"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="CD34+ stem cells"
/tissue_type="fetal liver; WERI RB-1 retinoblastoma"
CDS 38..2635
/note="5-transmembrane cell surface receptor"
/codon_start=1
/product="AC133 antigen"
/protein_id="AAB92514.1"
/translation="MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQ
DSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKI
VYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAI
SLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQ
YNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNST
LKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQ
LPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSD
IDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVI
FYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFG
ANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKN
RGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAAC
GIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQ
QRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETK
KYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGI
GKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHN
PVMTSPSQH"
BASE COUNT 1118 a 765 c 813 g 1098 t
ORIGIN
1 ccaagttcta cctcatgttt ggaggatctt gctagctatg gccctcgtac tcggctccct
61 gttgctgctg gggctgtgcg ggaactcctt ttcaggaggg cagccttcat ccacagatgc
121 tcctaaggct tggaattatg aattgcctgc aacaaattat gagacccaag actcccataa
181 agctggaccc attggcattc tctttgaact agtgcatatc tttctctatg tggtacagcc
241 gcgtgatttc ccagaagata ctttgagaaa attcttacag aaggcatatg aatccaaaat
301 tgattatgac aagccagaaa ctgtaatctt aggtctaaag attgtctact atgaagcagg
361 gattattcta tgctgtgtcc tggggctgct gtttattatt ctgatgcctc tggtggggta
421 tttcttttgt atgtgtcgtt gctgtaacaa atgtggtgga gaaatgcacc agcgacagaa
481 ggaaaatggg cccttcctga ggaaatgctt tgcaatctcc ctgttggtga tttgtataat
541 aataagcatt ggcatcttct atggttttgt ggcaaatcac caggtaagaa cccggatcaa
601 aaggagtcgg aaactggcag atagcaattt caaggacttg cgaactctct tgaatgaaac
661 tccagagcaa atcaaatata tattggccca gtacaacact accaaggaca aggcgttcac
721 agatctgaac agtatcaatt cagtgctagg aggcggaatt cttgaccgac tgagacccaa
781 catcatccct gttcttgatg agattaagtc catggcaaca gcgatcaagg agaccaaaga
841 ggcgttggag aacatgaaca gcaccttgaa gagcttgcac caacaaagta cacagcttag
901 cagcagtctg accagcgtga aaactagcct gcggtcatct ctcaatgacc ctctgtgctt
961 ggtgcatcca tcaagtgaaa cctgcaacag catcagattg tctctaagcc agctgaatag
1021 caaccctgaa ctgaggcagc ttccacccgt ggatgcagaa cttgacaacg ttaataacgt
1081 tcttaggaca gatttggatg gcctggtcca acagggctat caatccctta atgatatacc
1141 tgacagagta caacgccaaa ccacgactgt cgtagcaggt atcaaaaggg tcttgaattc
1201 cattggttca gatatcgaca atgtaactca gcgtcttcct attcaggata tactctcagc
1261 attctctgtt tatgttaata acactgaaag ttacatccac agaaatttac ctacattgga
1321 agagtatgat tcatactggt ggctgggtgg cctggtcatc tgctctctgc tgaccctcat
1381 cgtgattttt tactacctgg gcttactgtg tggcgtgtgc ggctatgaca ggcatgccac
1441 cccgaccacc cgaggctgtg tctccaacac cggaggcgtc ttcctcatgg ttggagttgg
1501 attaagtttc ctcttttgct ggatattgat gatcattgtg gttcttacct ttgtctttgg
1561 tgcaaatgtg gaaaaactga tctgtgaacc ttacacgagc aaggaattat tccgggtttt
1621 ggatacaccc tacttactaa atgaagactg ggaatactat ctctctggga agctatttaa
1681 taaatcaaaa atgaagctca cttttgaaca agtttacagt gactgcaaaa aaaatagagg
1741 cacttacggc actcttcacc tgcagaacag cttcaatatc agtgaacatc tcaacattaa
1801 tgagcatact ggaagcataa gcagtgaatt ggaaagtctg aaggtaaatc ttaatatctt
1861 tctgttgggt gcagcaggaa gaaaaaacct tcaggatttt gctgcttgtg gaatagacag
1921 aatgaattat gacagctact tggctcagac tggtaaatcc cccgcaggag tgaatctttt
1981 atcatttgca tatgatctag aagcaaaagc aaacagtttg cccccaggaa atttgaggaa
2041 ctccctgaaa agagatgcac aaactattaa aacaattcac cagcaacgag tccttcctat
2101 agaacaatca ctgagcactc tataccaaag cgtcaagata cttcaacgca cagggaatgg
2161 attgttggag agagtaacta ggattctagc ttctctggat tttgctcaga acttcatcac
2221 aaacaatact tcctctgtta ttattgagga aactaagaag tatgggagaa caataatagg
2281 atattttgaa cattatctgc agtggatcga gttctctatc agtgagaaag tggcatcgtg
2341 caaacctgtg gccaccgctc tagatactgc tgttgatgtc tttctgtgta gctacattat
2401 cgaccccttg aatttgtttt ggtttggcat aggaaaagct actgtatttt tacttccggc
2461 tctaattttt gcggtaaaac tggctaagta ctatcgtcga atggattcgg aggacgtgta
2521 cgatgatgtt gaaactatac ccatgaaaaa tatggaaaat ggtaataatg gttatcataa
2581 agatcatgta tatggtattc acaatcctgt tatgacaagc ccatcacaac attgatagct
2641 gatgttgaaa ctgcttgagc atcaggatac tcaaagtgga aaggatcaca gatttttggt
2701 agtttctggg tctacaagga ctttccaaat ccaggagcaa cgccagtggc aacgtagtga
2761 ctcaggcggg caccaaggca acggcaccat tggtctctgg gtagtgcttt aagaatgaac
2821 acaatcacgt tatagtccat ggtccatcac tattcaagga tgactccctc ccttcctgtc
2881 tatttttgtt ttttactttt ttacactgag tttctattta gacactacaa catatggggt
2941 gtttgttccc attggatgca tttctatcaa aactctatca aatgtgatgg ctagattcta
3001 acatattgcc atgtgtggag tgtgctgaac acacaccagt ttacaggaaa gatgcatttt
3061 gtgtacagta aacggtgtat ataccttttg ttaccacaga gttttttaaa caaatgagta
3121 ttataggact ttcttctaaa tgagctaaat aagtcaccat tgacttcttg gtgctgttga
3181 aaataatcca ttttcactaa aagtgtgtga aacctacagc atattcttca cgcagagatt
3241 ttcatctatt atactttatc aaagattggc catgttccac ttggaaatgg catgcaaaag
3301 ccatcataga gaaacctgcg taactccatc tgacaaattc aaaagagaga gagagatctt
3361 gagagagaaa tgctgttcgt tcaaaagtgg agttgtttta acagatgcca attacggtgt
3421 acagtttaac agagttttct gttgcattag gataaacatt aattggagtg cagctaacat
3481 gagtatcatc agactagtat caagtgttct aaaatgaaat atgagaagat cctgtcacaa
3541 ttcttagatc tggtgtccag catggatgaa acctttgagt ttggtcccta aatttgcatg
3601 aaagcacaag gtaaatattc atttgcttca ggagtttcat gttggatctg tcattatcaa
3661 aagtgatcag caatgaagaa ctggtcggac aaaatttaac gttgatgtaa tggaattcca
3721 gatgtaggca ttccccccag gtcttttcat gtgcagattg cagttctgat tcatttgaat
3781 aaaaaggaac ttgg
//