LOCUS AF026947 1331 bp mRNA linear HUM 02-JUL-1998
DEFINITION Homo sapiens aflatoxin aldehyde reductase AFAR mRNA, complete cds.
ACCESSION AF026947
VERSION AF026947.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1331)
AUTHORS Ireland,L.S., Harrison,D.J., Neal,G.E. and Hayes,J.D.
TITLE Molecular cloning, expression and catalytic activity of a human
AKR7 member of the aldo-keto reductase superfamily: evidence that
the major 2-carboxybenzaldehyde reductase from human liver is a
homologue of rat aflatoxin B1-aldehyde reductase
JOURNAL Biochem. J. 332 (Pt 1), 21-34 (1998)
PUBMED 9576847
REFERENCE 2 (bases 1 to 1331)
AUTHORS Ireland,L.S. and Hayes,J.D.
TITLE Direct Submission
JOURNAL Submitted (26-SEP-1997) Biomedical Research Centre, University of
Dundee, Level 5, Ninewells Hospital and Medical School, Dundee DD1
9SY, Scotland
FEATURES Location/Qualifiers
source 1..1331
/db_xref="H-InvDB:HIT000062860"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="liver"
CDS 78..1070
/note="2-carboxybenzaldehyde reductase; member of
aldo-keto reductase AKR7 family"
/codon_start=1
/product="aflatoxin aldehyde reductase AFAR"
/protein_id="AAC52104.1"
/translation="MSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDT
AFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQ
CPQVDLFYLHTPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNG
WILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQP
VGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQL
QGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR"
BASE COUNT 252 a 416 c 393 g 270 t
ORIGIN
1 ccgcgtctcg cgtagtctcc cgcgccgccg tccactgcgc gcttcgctct ccgccgcccg
61 aggcccgcgc gctcgccatg tcccggccac cgccaccgcg ggtcgcctcg gtgctgggca
121 ccatggagat ggggcgccgc atggacgcgc ccgccagcgc cgcggccgtg cgcgcctttc
181 tggagcgcgg ccacaccgaa ctggacacgg ccttcatgta cagcgacggc cagtccgaga
241 ccatcctggg cggcctgggg ctcgggctgg gcggtggcga ctgcagagtg aaaattgcca
301 ccaaggccaa cccttgggat ggaaaatcac taaagcctga cagtgtccgg tcccagctgg
361 agacgtcatt gaagaggctg cagtgtcccc aagtggacct cttctaccta cacacacctg
421 accacggcac cccggtggaa gagacgctgc atgcctgcca gcggctgcac caggagggca
481 agttcgtgga gcttggcctc tccaactatg ctagctggga agtggccgag atctgtaccc
541 tctgcaagag caatggctgg atcctgccca ctgtgtacca gggcatgtac aacgccacca
601 cccggcaggt ggaaacggag ctcttcccct gcctcaggca ctttggactg aggttctatg
661 cctacaaccc tctggctggg ggcctgctga ctggcaagta caagtatgag gacaaggacg
721 ggaaacagcc tgtgggccgc ttctttggga atagctgggc tgagacctac aggaatcgct
781 tctggaagga gcaccacttc gaggccattg cgttggtgga gaaggccctg caggccgcat
841 atggcgccag cgcccccagt gtgacctcgg ctgccctccg gtggatgtac caccactcac
901 agctgcaggg tgcccacggg gacgcggtca tcctgggcat gtccagcctg gagcagctgg
961 agcagaactt ggcagcaaca gaggaagggc ccctggagcc ggctgtcgtg gatgccttta
1021 atcaagcctg gcatttggtt gctcacgaat gtcccaacta cttccgctag gcccatcatg
1081 gctcaggctg cccaaggctt ttctgtcacc tcttttgttc tctcacactg accagtcttg
1141 gccttaagct gacttagaag ggtttttctg aattgtctag atccatgcat tatttttcta
1201 gcttcctgcc ttgctcccta ttcactttac actgtgaaag gtggggggtg agtcccactt
1261 gagcgcttcc tgttgaataa agcaggcact tgacctggct gtagcctagg tcttgagtga
1321 accccaaaaa a
//