LOCUS AF025794 3259 bp mRNA linear HUM 26-MAR-1998
DEFINITION Homo sapiens methionine synthase reductase (MTRR) mRNA, complete
cds.
ACCESSION AF025794
VERSION AF025794.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3259)
AUTHORS Leclerc,D., Wilson,A., Dumas,R., Gafuick,C., Song,D., Watkins,D.,
Heng,H.H.Q., Rommens,J.M., Scherer,S.W., Rosenblatt,D.S. and
Gravel,R.A.
TITLE Cloning and mapping of a cDNA for methionine synthase reductase, a
flavoprotein defective in patients with homocystinuria
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (6), 3059-3064 (1998)
PUBMED 9501215
REFERENCE 2 (bases 1 to 3259)
AUTHORS Leclerc,D.
TITLE Direct Submission
JOURNAL Submitted (19-SEP-1997) Human Genetics, McGill University -
Montreal Children's Hospital Research Institute, 4060 Ste-Catherine
West, Montreal, Que H3Z 2Z3, Canada
REFERENCE 3 (bases 1 to 3259)
AUTHORS Leclerc,D.
TITLE Direct Submission
JOURNAL Submitted (12-NOV-1997) Human Genetics, McGill University -
Montreal Children's Hospital Research Institute, 4060 Ste-Catherine
West, Montreal, Que H3Z 2Z3, Canada
REMARK Sequence update by submitter
FEATURES Location/Qualifiers
source 1..3259
/db_xref="H-InvDB:HIT000062784"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5p15.2-p15.3"
gene 1..3259
/gene="MTRR"
CDS 80..2176
/gene="MTRR"
/note="B12 vitamin; cblE complementation group"
/codon_start=1
/product="methionine synthase reductase"
/protein_id="AAC39667.1"
/translation="MRRFLLLYATQQGQAKAIAEEMCEQAVVHGFSADLHCISESDKY
DLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYT
YFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQ
EEISGALPVASPASLRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSN
VVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQV
PISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLE
DKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYT
SDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQP
RPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHAS
HEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQH
PDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKY
VQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKT
LATLKEEKRYLQDIWS"
BASE COUNT 944 a 695 c 674 g 946 t
ORIGIN
1 caaggttggt ggaagtcgcg ttgtgcaggt tcgtgcccgg ctggcgcggc gtggtttcac
61 tgttacatgc cttgaagtga tgaggaggtt tctgttacta tatgctacac agcagggaca
121 ggcaaaggcc atcgcagaag aaatgtgtga gcaagctgtg gtacatggat tttctgcaga
181 tcttcactgt attagtgaat ccgataagta tgacctaaaa accgaaacag ctcctcttgt
241 tgttgtggtt tctaccacgg gcaccggaga cccacccgac acagcccgca agtttgttaa
301 ggaaatacag aaccaaacac tgccggttga tttctttgct cacctgcggt atgggttact
361 gggtctcggt gattcagaat acacctactt ttgcaatggg gggaagataa ttgataaacg
421 acttcaagag cttggagccc ggcatttcta tgacactgga catgcagatg actgtgtagg
481 tttagaactt gtggttgagc cgtggattgc tggactctgg ccagccctca gaaagcattt
541 taggtcaagc agaggacaag aggagataag tggcgcactc ccggtggcat cacctgcatc
601 cttgaggaca gaccttgtga agtcagagct gctacacatt gaatctcaag tcgagcttct
661 gagattcgat gattcaggaa gaaaggattc tgaggttttg aagcaaaatg cagtgaacag
721 caaccaatcc aatgttgtaa ttgaagactt tgagtcctca cttacccgtt cggtaccccc
781 actctcacaa gcctctctga atattcctgg tttaccccca gaatatttac aggtacatct
841 gcaggagtct cttggccagg aggaaagcca agtatctgtg acttcagcag atccagtttt
901 tcaagtgcca atttcaaagg cagttcaact tactacgaat gatgccataa aaaccactct
961 gctggtagaa ttggacattt caaatacaga cttttcctat cagcctggag atgccttcag
1021 cgtgatctgc cctaacagtg attctgaggt acaaagccta ctccaaagac tgcagcttga
1081 agataaaaga gagcactgcg tccttttgaa aataaaggca gacacaaaga agaaaggagc
1141 taccttaccc cagcatatac ctgcgggatg ttctctccag ttcattttta cctggtgtct
1201 tgaaatccga gcaattccta aaaaggcatt tttgcgagcc cttgtggact ataccagtga
1261 cagtgctgaa aagcgcaggc tacaggagct gtgcagtaaa caaggggcag ccgattatag
1321 ccgctttgta cgagatgcct gtgcctgctt gttggatctc ctcctcgctt tcccttcttg
1381 ccagccacca ctcagtctcc tgctcgaaca tcttcctaaa cttcaaccca gaccatattc
1441 gtgtgcaagc tcaagtttat ttcacccagg aaagctccat tttgtcttca acattgtgga
1501 atttctgtct actgccacaa cagaggttct gcggaaggga gtatgtacag gctggctggc
1561 cttgttggtt gcttcagttc ttcagccaaa catacatgca tcccatgaag acagcgggaa
1621 agccctggct cctaagatat ccatctctcc tcgaacaaca aattctttcc acttaccaga
1681 tgacccctca atccccatca taatggtggg tccaggaacc ggcatagccc cgtttattgg
1741 gttcctacaa catagagaga aactccaaga acaacaccca gatggaaatt ttggagcaat
1801 gtggttgttt tttggctgca ggcataagga tagggattat ctattcagaa aagagctcag
1861 acatttcctt aagcatggga tcttaactca tctaaaggtt tccttctcaa gagatgctcc
1921 tgttggggag gaggaagccc cagcaaagta tgtacaagac aacatccagc ttcatggcca
1981 gcaggtggcg agaatcctcc tccaggagaa cggccatatt tatgtgtgtg gagatgcaaa
2041 gaatatggcc aaggatgtac atgatgccct tgtgcaaata ataagcaaag aggttggagt
2101 tgaaaaacta gaagcaatga aaaccctggc cactttaaaa gaagaaaaac gctaccttca
2161 ggatatttgg tcataaaacc agaaattaaa gaaagaggat taagcttttt tgactgaaag
2221 tactaaaagt cagctttact agtgccaaac ctttaaattt tcaaaagaaa attttctttc
2281 aacatttctt gaaggacatg gagtggagat tggatcattt aacaatataa caaaacttcc
2341 tgatttgatt ttacgtatct tctatctacg cccttcctgt gcctgtgact ctccccaaat
2401 tgccctgttg ccttgagctc ttctgagcta aaggcagcct tcagtcccta tcagcgcctc
2461 ctttacttcc cagagaactt cacagagact ctgtccttcc atgcaaaggc ttcctgaaat
2521 aggggagact gactgagtag ctcattcttg tgacttacag tgccaacatt taaaaaagta
2581 tgaaaatgat ttatttttat atgatgtata cccataaaga atgctcatat taatgtactt
2641 aaattacaca tgtagagcat atctgttata tgtttatgta actatcaaat ggttatttgt
2701 tactaaagct atatttctga taaaaaatat tttaggataa ttgcctacag agggatttat
2761 ttttatgatg ctgggaaata tgaaatgtat tttaaaattt cactctgggc atatggattt
2821 atctatcacc attacttttt tttaagtcac aatttcagaa ttttgggaca tttgcattca
2881 atttacaggt accagtacgt acatatttta atagaaagat acaacctttt tattttcact
2941 ccttttattt ctgctgcttg gcacattttt gagttttccc acattatttg tctccatgat
3001 accactcaag cagtgtgctg gacctaaaat actgacttta gttagtatcc ttggattttt
3061 agattcccca gtgtctaatt ccctgttata atttgcacaa acaaaacaaa atgttatgat
3121 aatctttctc cactgttcta atatatattg tatttttatt tgatagcttg ggatttaaaa
3181 catctctgtt gaaggctttt gatccttttg agaaataaag atctgaaaga aatggcataa
3241 tcttaaaaaa aaaaaaaaa
//