LOCUS AF025304 3949 bp mRNA linear HUM 29-NOV-2000
DEFINITION Homo sapiens protein-tyrosine kinase EPHB2v (EPHB2) mRNA, complete
cds.
ACCESSION AF025304
VERSION AF025304.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3949)
AUTHORS Ikegaki,N., Tang,X.X., Liu,X.G., Biegel,J.A., Allen,C.,
Yoshioka,A., Sulman,E.P., Brodeur,G.M. and Pleasure,D.E.
TITLE Molecular characterization and chromosomal localization of DRT
(EPHT3): a developmentally regulated human protein-tyrosine kinase
gene of the EPH family
JOURNAL Hum. Mol. Genet. 4 (11), 2033-2045 (1995)
PUBMED 8589679
REFERENCE 2 (bases 1 to 3949)
AUTHORS Tang,X.X., Pleasure,D.E., Brodeur,G.M. and Ikegaki,N.
TITLE A variant transcript encoding an isoform of the human protein
tyrosine kinase EPHB2 is generated by alternative splicing and
alternative use of polyadenylation signals
JOURNAL Oncogene 17 (4), 521-526 (1998)
PUBMED 9696046
REFERENCE 3 (bases 1 to 3949)
AUTHORS Ikegaki,N. and Tang,X.X.
TITLE Direct Submission
JOURNAL Submitted (15-SEP-1997) Oncology, The Children's Hospital of
Philadelphia, 324 South 34th Street, Philadelphia, PA 19104, USA
FEATURES Location/Qualifiers
source 1..3949
/db_xref="H-InvDB:HIT000062752"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.1"
gene 1..3949
/gene="EPHB2"
CDS 26..3193
/gene="EPHB2"
/note="alternative splicing variant of EPHB2 (DRT)"
/codon_start=1
/product="protein-tyrosine kinase EPHB2v"
/protein_id="AAB94602.1"
/translation="MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWE
EVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPS
VPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKIN
TEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTS
LVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGT
FKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISS
VNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPR
IYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVD
SITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQV
RARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCN
RRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIE
QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNV
IHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM
NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAI
QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALH
QLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTS
FNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQ
VMRAQMNQIQSVEGQPLARRPRATGRTKRCQPRDVTKKTCNSNDGKKKGMGKKKTDPG
RGREIQGIFFKEDSHKESNDCSCGG"
BASE COUNT 934 a 1142 c 1105 g 768 t
ORIGIN
1 gaattccgcc ccgggaagcg cagccatggc tctgcggagg ctgggggccg cgctgctgct
61 gctgccgctg ctcgccgccg tggaagaaac gctaatggac tccactacag cgactgctga
121 gctgggctgg atggtgcatc ctccatcagg gtgggaagag gtgagtggct acgatgagaa
181 catgaacacg atccgcacgt accaggtgtg caacgtgttt gagtcaagcc agaacaactg
241 gctacggacc aagtttatcc ggcgccgtgg cgcccaccgc atccacgtgg agatgaagtt
301 ttcggtgcgt gactgcagca gcatccccag cgtgcctggc tcctgcaagg agaccttcaa
361 cctctattac tatgaggctg actttgactc ggccaccaag accttcccca actggatgga
421 gaatccatgg gtgaaggtgg ataccattgc agccgacgag agcttctccc aggtggacct
481 gggtggccgc gtcatgaaaa tcaacaccga ggtgcggagc ttcggacctg tgtcccgcag
541 cggcttctac ctggccttcc aggactatgg cggctgcatg tccctcatcg ccgtgcgtgt
601 cttctaccgc aagtgccccc gcatcatcca gaatggcgcc atcttccagg aaaccctgtc
661 gggggctgag agcacatcgc tggtggctgc ccggggcagc tgcatcgcca atgcggaaga
721 ggtggatgta cccatcaagc tctactgtaa cggggacggc gagtggctgg tgcccatcgg
781 gcgctgcatg tgcaaagcag gcttcgaggc cgttgagaat ggcaccgtct gccgaggttg
841 tccatctggg actttcaagg ccaaccaagg ggatgaggcc tgtacccact gtcccatcaa
901 cagccggacc acttctgaag gggccaccaa ctgtgtctgc cgcaatggct actacagagc
961 agacctggac cccctggaca tgccctgcac aaccatcccc tccgcgcccc aggctgtgat
1021 ttccagtgtc aatgagacct ccctcatgct ggagtggacc cctccccgcg actccggagg
1081 ccgagaggac ctcgtctaca acatcatctg caagagctgt ggctcgggcc ggggtgcctg
1141 cacccgctgc ggggacaatg tacagtacgc accacgccag ctaggcctga ccgagccacg
1201 catttacatc agtgacctgc tggcccacac ccagtacacc ttcgagatcc aggctgtgaa
1261 cggcgttact gaccagagcc ccttctcgcc tcagttcgcc tctgtgaaca tcaccaccaa
1321 ccaggcagct ccatcggcag tgtccatcat gcatcaggtg agccgcaccg tggacagcat
1381 taccctgtcg tggtcccagc cagaccagcc caatggcgtg atcctggact atgagctgca
1441 gtactatgag aaggagctca gtgagtacaa cgccacagcc ataaaaagcc ccaccaacac
1501 ggtcaccgtg cagggcctca aagccggcgc catctatgtc ttccaggtgc gggcacgcac
1561 cgtggcaggc tacgggcgct acagcggcaa gatgtacttc cagaccatga cagaagccga
1621 gtaccagaca agcatccagg agaagttgcc actcatcatc ggctcctcgg ccgctggcct
1681 ggtcttcctc attgctgtgg ttgtcatcgc catcgtgtgt aacagacggg ggtttgagcg
1741 tgctgactcg gagtacacgg acaagctgca acactacacc agtggccaca tgaccccagg
1801 catgaagatc tacatcgatc ctttcaccta cgaggacccc aacgaggcag tgcgggagtt
1861 tgccaaggaa attgacatct cctgtgtcaa aattgagcag gtgatcggag caggggagtt
1921 tggcgaggtc tgcagtggcc acctgaagct gccaggcaag agagagatct ttgtggccat
1981 caagacgctc aagtcgggct acacggagaa gcagcgccgg gacttcctga gcgaagcctc
2041 catcatgggc cagttcgacc atcccaacgt catccacctg gagggtgtcg tgaccaagag
2101 cacacctgtg atgatcatca ccgagttcat ggagaatggc tccctggact cctttctccg
2161 gcaaaacgat gggcagttca cagtcatcca gctggtgggc atgcttcggg gcatcgcagc
2221 tggcatgaag tacctggcag acatgaacta tgttcaccgt gacctggctg cccgcaacat
2281 cctcgtcaac agcaacctgg tctgcaaggt gtcggacttt gggctctcac gctttctaga
2341 ggacgatacc tcagacccca cctacaccag tgccctgggc ggaaagatcc ccatccgctg
2401 gacagccccg gaagccatcc agtaccggaa gttcacctcg gccagtgatg tgtggagcta
2461 cggcattgtc atgtgggagg tgatgtccta tggggagcgg ccctactggg acatgaccaa
2521 ccaggatgta atcaatgcca ttgagcagga ctatcggctg ccaccgccca tggactgccc
2581 gagcgccctg caccaactca tgctggactg ttggcagaag gaccgcaacc accggcccaa
2641 gttcggccaa attgtcaaca cgctagacaa gatgatccgc aatcccaaca gcctcaaagc
2701 catggcgccc ctctcctctg gcatcaacct gccgctgctg gaccgcacga tccccgacta
2761 caccagcttt aacacggtgg acgagtggct ggaggccatc aagatggggc agtacaagga
2821 gagcttcgcc aatgccggct tcacctcctt tgacgtcgtg tctcagatga tgatggagga
2881 cattctccgg gttggggtca ctttggctgg ccaccagaaa aaaatcctga acagtatcca
2941 ggtgatgcgg gcgcagatga accagattca gtctgtggag ggccagccac tcgccaggag
3001 gccacgggcc acgggaagaa ccaagcggtg ccagccacga gacgtcacca agaaaacatg
3061 caactcaaac gacggaaaaa aaaagggaat gggaaaaaag aaaacagatc ctgggagggg
3121 gcgggaaata caaggaatat tttttaaaga ggattctcat aaggaaagca atgactgttc
3181 ttgcggggga taaaaaaggg cttgggagat tcatgcgatg tgtccaatcg gagacaaaag
3241 cagtttctct ccaactccct ctgggaaggt gacctggcca gagccaagaa acactttcag
3301 aaaaacaaat gtgaagggga gagacagggg ccacccttgg ctcctgtccc tgctgctcct
3361 ctaggcctca ctcaacaacc aagcgcctgg aggacgggac agatggacag acagccaccc
3421 tgagaacccc tctgggaaaa tctattcctg ccaccactgg gcaaacagaa gaatttttct
3481 gtctttggag agtattttag aaactccaat gaaagacact gtttctcctg ttggctcaca
3541 gggctgaaag gggcttttgt cctcctgggt cagggagaac gcggggaccc cagaaaggtc
3601 agccttcctg aggatgggca acccccaggt ctgcagctcc aggtacatat cacgcgcaca
3661 gcctggcagc ctggccctcc tggtgcccac tcccgccagc ccctgcctcg aggactgata
3721 ctgcagtgac tgccgtcagc tccgactgcc gctgagaagg gttgatcctg catctgggtt
3781 tgtttacagc aattcctgga ctcgggggta ttttggtcac agggtggttt tggtttaggg
3841 ggtttgtttg ttgggttgtt ttttgttttt tggttttttt taatgacaat gaagtgacac
3901 tttgacattt ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//