LOCUS       AH006705                2772 bp    DNA     linear   HUM 06-APR-2016
DEFINITION  Homo sapiens chromosome 6 mu opioid receptor (OPRM1) gene, partial
            cds.
ACCESSION   AH006705 AF024515 AF024516 AF024517
VERSION     AH006705.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2772)
  AUTHORS   Wang,J.B., Johnson,P.S., Persico,A.M., Hawkins,A.L., Griffin,C.A.
            and Uhl,G.R.
  TITLE     Human mu opiate receptor. cDNA and genomic clones, pharmacologic
            characterization and chromosomal assignment
  JOURNAL   FEBS Lett. 338 (2), 217-222 (1994)
   PUBMED   7905839
REFERENCE   2  (bases 1 to 2772)
  AUTHORS   Bare,L.A., Mansson,E. and Yang,D.
  TITLE     Expression of two variants of the human mu opioid receptor mRNA in
            SK-N-SH cells and human brain
  JOURNAL   FEBS Lett. 354 (2), 213-216 (1994)
   PUBMED   7957926
REFERENCE   3  (bases 1 to 2772)
  AUTHORS   Bergen,A.W., Kokoszka,J., Peterson,R., Long,J.C., Virkkunen,M.,
            Linnoila,M. and Goldman,D.
  TITLE     Mu opioid receptor gene variants: lack of association with alcohol
            dependence
  JOURNAL   Mol. Psychiatry 2 (6), 490-494 (1997)
   PUBMED   9399694
REFERENCE   4  (bases 1 to 2772)
  AUTHORS   Bergen,A.W., Kokoszka,J. and Goldman,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-SEP-1997) Neurogenetics, NIAAA/NIH, 12501 Washington
            Avenue, Rockville, MD 20852, USA
COMMENT     On or before Apr 6, 2016 this sequence version replaced AF024515.1,
            AF024516.1, AF024517.1, AH006705.1.
FEATURES             Location/Qualifiers
     source          1..2772
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24-q25"
     gene            <1..>2772
                     /gene="OPRM1"
                     /note="mu opioid receptor locus"
     mRNA            <1..>305
                     /gene="OPRM1"
                     /product="mu opioid receptor"
     exon            <1..>305
                     /gene="OPRM1"
                     /number=1
     misc_feature    1..305
                     /gene="OPRM1"
                     /note="134 US Caucasian and North American Indian
                     chromosomes were directly sequenced at the OPRM1 locus,
                     5'UTR and Exon 1"
     5'UTR           <1..37
                     /gene="OPRM1"
     CDS             38..>305
                     /gene="OPRM1"
                     /note="G-protein linked 7 transmembrane protein"
                     /codon_start=1
                     /product="mu opioid receptor"
                     /protein_id="AAC51877.1"
                     /translation="MDSSAXPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDP
                     CGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNF"
     variation       137
                     /gene="OPRM1"
                     /note="results in a A6V (GCC->GTC) substitution, observed
                     in 2/134 chromosomes"
                     /replace="c"
     variation       155
                     /gene="OPRM1"
                     /note="results in a N40D (AAC->GAC) substitution observed
                     in 63/134 chromosomes. Asn40 is a phylogenetically
                     conserved asparagine in the sequence motif required for
                     N-glycosylation. This substitution observed in the cDNA
                     sequence of GenBank Accession Number U12569 [Bare et al.,
                     1994]"
                     /replace="g"
     misc_difference 188
                     /gene="OPRM1"
                     /note="GenBank Accession Number L25119"
                     /citation=[1]
                     /replace="a"
     misc_difference 220
                     /gene="OPRM1"
                     /note="GenBank Accession Number U12569"
                     /citation=[2]
                     /replace="a"
     gap             306..405
                     /estimated_length=unknown
     mRNA            join(<406..745,1519..>2003)
                     /gene="OPRM1"
                     /product="mu opioid receptor"
     CDS             join(<406..745,1519..>2003)
                     /gene="OPRM1"
                     /note="G-protein linked 7 transmembrane protein"
                     /codon_start=1
                     /product="mu opioid receptor"
                     /protein_id="AAC51878.1"
                     /translation="KTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIV
                     ISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP
                     VMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRL
                     KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVS
                     WHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHP"
     misc_feature    406..2003
                     /gene="OPRM1"
                     /note="30 US Caucasian and North American Indian
                     chromosomes were directly sequenced at the OPRM1 locus,
                     exon 2, IVS 2 and exon 3"
     exon            <406..745
                     /gene="OPRM1"
                     /number=2
     variation       542
                     /gene="OPRM1"
                     /note="observed in 1/30 chromosomes corresponding to a
                     S145C (TCC->TGC) substitution"
                     /replace="g"
     misc_difference 724
                     /gene="OPRM1"
                     /note="GenBank Accession Number U12569"
                     /citation=[2]
                     /replace="a"
     intron          746..1518
                     /gene="OPRM1"
                     /number=2
     variation       1436
                     /gene="OPRM1"
                     /note="observed in 12/30 chromosomes"
                     /replace="g"
     exon            1519..>2003
                     /gene="OPRM1"
                     /number=3
     misc_difference 1574
                     /gene="OPRM1"
                     /note="GenBank Accession Number L25119"
                     /citation=[1]
                     /replace="c"
     misc_difference 1575
                     /gene="OPRM1"
                     /note="GenBank Accession Number L25119"
                     /citation=[1]
                     /replace="g"
     gap             2004..2103
                     /estimated_length=unknown
     mRNA            <2104..>2772
                     /gene="OPRM1"
                     /product="mu opioid receptor"
     3'UTR           <2104..>2772
                     /gene="OPRM1"
     misc_feature    2104..2772
                     /gene="OPRM1"
                     /note="30 US Caucasian and North American Indian
                     chromosomes were directly sequenced at the OPRM1 locus,
                     3'UTR"
     misc_difference 2159
                     /gene="OPRM1"
                     /note="GenBank Accession Number L25119"
                     /citation=[1]
                     /replace="a"
     misc_difference 2501
                     /gene="OPRM1"
                     /note="GenBank Accession Number L25119"
                     /citation=[1]
                     /replace=""
     misc_difference 2546
                     /gene="OPRM1"
                     /note="GenBank Accession Number L25119"
                     /citation=[1]
                     /replace="a"
     misc_difference 2616
                     /gene="OPRM1"
                     /note="GenBank Accession Number L25119"
                     /citation=[1]
                     /replace=""
     misc_difference 2697
                     /gene="OPRM1"
                     /note="GenBank Accession Number L25119"
                     /citation=[1]
                     /replace="n"
     misc_difference 2725
                     /gene="OPRM1"
                     /note="GenBank Accession Number L25119"
                     /citation=[1]
                     /replace="n"
BASE COUNT          733 a          600 c          492 g          746 t
ORIGIN      
        1 tacctcgcac agcggtgccc gcccggccgt cagtaccatg gacagcagcg ctgyccccac
       61 gaacgccagc aattgcactg atgccttggc gtactcaagt tgctccccag cacccagccc
      121 cggttcctgg gtcaacttgt cccacttaga tggcaacctg tccgacccat gcggtccgaa
      181 ccgcaccgac ctgggcggga gagacagcct gtgccctccg accggcagtc cctccatgat
      241 cacggccatc acgatcatgg ccctctactc catcgtgtgc gtggtggggc tcttcggaaa
      301 cttccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnaagac tgccaccaac
      421 atctacattt tcaaccttgc tctggcagat gccttagcca ccagtaccct gcccttccag
      481 agtgtgaatt acctaatggg aacatggcca tttggaacca tcctttgcaa gatagtgatc
      541 tccatagatt actataacat gttcaccagc atattcaccc tctgcaccat gagtgttgat
      601 cgatacattg cagtctgcca ccctgtcaag gccttagatt tccgtactcc ccgaaatgcc
      661 aaaattatca atgtctgcaa ctggatcctc tcttcagcca ttggtcttcc tgtaatgttc
      721 atggctacaa caaaatacag gcaaggtgag tgatgttacc agcctgaggg aaggagggtt
      781 cacagcctga tatgttggtg atgtcataag caaagcagta tttatggagt gccccattgt
      841 cttagtcaca ttgtaatttt aattattctt cctagcaaaa aaagcctttg aatacttaaa
      901 aataggaatt ttcctcataa ttttaggcct attaaatcct ttaaagagaa tgtaatctat
      961 ttatttctga tttctctgta tttacttcat aaaaatggtg tgtaaattag tacatagctc
     1021 tcccaagagt aattggagct taaacccaaa gagtattaca ctgaggcttg tttaaaatta
     1081 tcaagtggct gactacatgg caaatgtatc tttctacacc taatatcaga atattgaaca
     1141 atccatcaaa aaatgaagtg aaaacatcca ttacctggag ccgcctagag actttggaca
     1201 attattacat tttttatatc aatatagacc tcatggagga tctagctcat gttgagaggt
     1261 tcatttttgt tccctgaacg aaagcttaat gtgatcgaag tggactgcaa aatgggaaat
     1321 ttagaaaaaa acaaaaaaca ttagaagtaa aactttcttt gaaaagtaac aaacaactga
     1381 gtttcttcca caatttcttt atagccttaa gttagctctg gtcaaggcta aaaatcaatg
     1441 agcaaaatgg cagtattaac accttatgac ataattaaat gttgctgcta atttttcctt
     1501 taaattcctt tcttctaggt tccatagatt gtacactaac attctctcat ccaacctggt
     1561 actgggaaaa cctgctgaag atctgtgttt tcatcttcgc cttcattatg ccagtgctca
     1621 tcattaccgt gtgctatgga ctgatgatct tgcgcctcaa gagtgtccgc atgctctctg
     1681 gctccaaaga aaaggacagg aatcttcgaa ggatcaccag gatggtgctg gtggtggtgg
     1741 ctgtgttcat cgtctgctgg actcccattc acatttacgt catcattaaa gccttggtta
     1801 caatcccaga aactacgttc cagactgttt cttggcactt ctgcattgct ctaggttaca
     1861 caaacagctg cctcaaccca gtcctttatg catttctgga tgaaaacttc aaacgatgct
     1921 tcagagagtt ctgtatccca acctcttcca acattgagca acaaaactcc actcgaattc
     1981 gtcagaacac tagagaccac cccnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2101 nnngaagcag gttgcttcaa gaatgtgtag gaggctctaa ttctctagga aagtgcctgc
     2161 ttttaggtca tccaacctct ttcctctctg gccactctgc tctgcacatt agagggacag
     2221 ccaaaagtaa gtggagcatt tggaaggaaa ggaatatacc acaccgagga gtccagtttg
     2281 tgcaagacac ccagtggaac caaaacccat cgtggtatgt gaattgaagt catcataaaa
     2341 ggtgaccctt ctgtctgtaa gattttattt tcaagcaaat atttatgacc tcaacaaaga
     2401 agaaccatct tttgttaagt tcaccgtagt aacacataaa gtaaatgcta cctctgatca
     2461 aagcaccttg aatggaaggt ccgagtcttt ttagtgtttt gcaagggaat gaatccatta
     2521 ttctatttta gacttttaac ttcaccttaa aattagcatc tggctaaggc atcattttca
     2581 cctccatttc ttggttttgt attgtttaaa aaaataacat ctctttcatc tagctccata
     2641 attgcaaggg aagagattag catgaaaggt aatctgaaac acagtcatgt gtcagctgta
     2701 gaaaggttga ttctcatgca ctgcaaatac ttccaaagag tcatcatggg ggatttttca
     2761 ttcttaggct tt
//