LOCUS AH006705 2772 bp DNA linear HUM 06-APR-2016 DEFINITION Homo sapiens chromosome 6 mu opioid receptor (OPRM1) gene, partial cds. ACCESSION AH006705 AF024515 AF024516 AF024517 VERSION AH006705.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2772) AUTHORS Wang,J.B., Johnson,P.S., Persico,A.M., Hawkins,A.L., Griffin,C.A. and Uhl,G.R. TITLE Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment JOURNAL FEBS Lett. 338 (2), 217-222 (1994) PUBMED 7905839 REFERENCE 2 (bases 1 to 2772) AUTHORS Bare,L.A., Mansson,E. and Yang,D. TITLE Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain JOURNAL FEBS Lett. 354 (2), 213-216 (1994) PUBMED 7957926 REFERENCE 3 (bases 1 to 2772) AUTHORS Bergen,A.W., Kokoszka,J., Peterson,R., Long,J.C., Virkkunen,M., Linnoila,M. and Goldman,D. TITLE Mu opioid receptor gene variants: lack of association with alcohol dependence JOURNAL Mol. Psychiatry 2 (6), 490-494 (1997) PUBMED 9399694 REFERENCE 4 (bases 1 to 2772) AUTHORS Bergen,A.W., Kokoszka,J. and Goldman,D. TITLE Direct Submission JOURNAL Submitted (11-SEP-1997) Neurogenetics, NIAAA/NIH, 12501 Washington Avenue, Rockville, MD 20852, USA COMMENT On or before Apr 6, 2016 this sequence version replaced AF024515.1, AF024516.1, AF024517.1, AH006705.1. FEATURES Location/Qualifiers source 1..2772 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="6" /map="6q24-q25" gene <1..>2772 /gene="OPRM1" /note="mu opioid receptor locus" mRNA <1..>305 /gene="OPRM1" /product="mu opioid receptor" exon <1..>305 /gene="OPRM1" /number=1 misc_feature 1..305 /gene="OPRM1" /note="134 US Caucasian and North American Indian chromosomes were directly sequenced at the OPRM1 locus, 5'UTR and Exon 1" 5'UTR <1..37 /gene="OPRM1" CDS 38..>305 /gene="OPRM1" /note="G-protein linked 7 transmembrane protein" /codon_start=1 /product="mu opioid receptor" /protein_id="AAC51877.1" /translation="MDSSAXPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDP CGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNF" variation 137 /gene="OPRM1" /note="results in a A6V (GCC->GTC) substitution, observed in 2/134 chromosomes" /replace="c" variation 155 /gene="OPRM1" /note="results in a N40D (AAC->GAC) substitution observed in 63/134 chromosomes. Asn40 is a phylogenetically conserved asparagine in the sequence motif required for N-glycosylation. This substitution observed in the cDNA sequence of GenBank Accession Number U12569 [Bare et al., 1994]" /replace="g" misc_difference 188 /gene="OPRM1" /note="GenBank Accession Number L25119" /citation=[1] /replace="a" misc_difference 220 /gene="OPRM1" /note="GenBank Accession Number U12569" /citation=[2] /replace="a" gap 306..405 /estimated_length=unknown mRNA join(<406..745,1519..>2003) /gene="OPRM1" /product="mu opioid receptor" CDS join(<406..745,1519..>2003) /gene="OPRM1" /note="G-protein linked 7 transmembrane protein" /codon_start=1 /product="mu opioid receptor" /protein_id="AAC51878.1" /translation="KTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIV ISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP VMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRL KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVS WHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHP" misc_feature 406..2003 /gene="OPRM1" /note="30 US Caucasian and North American Indian chromosomes were directly sequenced at the OPRM1 locus, exon 2, IVS 2 and exon 3" exon <406..745 /gene="OPRM1" /number=2 variation 542 /gene="OPRM1" /note="observed in 1/30 chromosomes corresponding to a S145C (TCC->TGC) substitution" /replace="g" misc_difference 724 /gene="OPRM1" /note="GenBank Accession Number U12569" /citation=[2] /replace="a" intron 746..1518 /gene="OPRM1" /number=2 variation 1436 /gene="OPRM1" /note="observed in 12/30 chromosomes" /replace="g" exon 1519..>2003 /gene="OPRM1" /number=3 misc_difference 1574 /gene="OPRM1" /note="GenBank Accession Number L25119" /citation=[1] /replace="c" misc_difference 1575 /gene="OPRM1" /note="GenBank Accession Number L25119" /citation=[1] /replace="g" gap 2004..2103 /estimated_length=unknown mRNA <2104..>2772 /gene="OPRM1" /product="mu opioid receptor" 3'UTR <2104..>2772 /gene="OPRM1" misc_feature 2104..2772 /gene="OPRM1" /note="30 US Caucasian and North American Indian chromosomes were directly sequenced at the OPRM1 locus, 3'UTR" misc_difference 2159 /gene="OPRM1" /note="GenBank Accession Number L25119" /citation=[1] /replace="a" misc_difference 2501 /gene="OPRM1" /note="GenBank Accession Number L25119" /citation=[1] /replace="" misc_difference 2546 /gene="OPRM1" /note="GenBank Accession Number L25119" /citation=[1] /replace="a" misc_difference 2616 /gene="OPRM1" /note="GenBank Accession Number L25119" /citation=[1] /replace="" misc_difference 2697 /gene="OPRM1" /note="GenBank Accession Number L25119" /citation=[1] /replace="n" misc_difference 2725 /gene="OPRM1" /note="GenBank Accession Number L25119" /citation=[1] /replace="n" BASE COUNT 733 a 600 c 492 g 746 t ORIGIN 1 tacctcgcac agcggtgccc gcccggccgt cagtaccatg gacagcagcg ctgyccccac 61 gaacgccagc aattgcactg atgccttggc gtactcaagt tgctccccag cacccagccc 121 cggttcctgg gtcaacttgt cccacttaga tggcaacctg tccgacccat gcggtccgaa 181 ccgcaccgac ctgggcggga gagacagcct gtgccctccg accggcagtc cctccatgat 241 cacggccatc acgatcatgg ccctctactc catcgtgtgc gtggtggggc tcttcggaaa 301 cttccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnaagac tgccaccaac 421 atctacattt tcaaccttgc tctggcagat gccttagcca ccagtaccct gcccttccag 481 agtgtgaatt acctaatggg aacatggcca tttggaacca tcctttgcaa gatagtgatc 541 tccatagatt actataacat gttcaccagc atattcaccc tctgcaccat gagtgttgat 601 cgatacattg cagtctgcca ccctgtcaag gccttagatt tccgtactcc ccgaaatgcc 661 aaaattatca atgtctgcaa ctggatcctc tcttcagcca ttggtcttcc tgtaatgttc 721 atggctacaa caaaatacag gcaaggtgag tgatgttacc agcctgaggg aaggagggtt 781 cacagcctga tatgttggtg atgtcataag caaagcagta tttatggagt gccccattgt 841 cttagtcaca ttgtaatttt aattattctt cctagcaaaa aaagcctttg aatacttaaa 901 aataggaatt ttcctcataa ttttaggcct attaaatcct ttaaagagaa tgtaatctat 961 ttatttctga tttctctgta tttacttcat aaaaatggtg tgtaaattag tacatagctc 1021 tcccaagagt aattggagct taaacccaaa gagtattaca ctgaggcttg tttaaaatta 1081 tcaagtggct gactacatgg caaatgtatc tttctacacc taatatcaga atattgaaca 1141 atccatcaaa aaatgaagtg aaaacatcca ttacctggag ccgcctagag actttggaca 1201 attattacat tttttatatc aatatagacc tcatggagga tctagctcat gttgagaggt 1261 tcatttttgt tccctgaacg aaagcttaat gtgatcgaag tggactgcaa aatgggaaat 1321 ttagaaaaaa acaaaaaaca ttagaagtaa aactttcttt gaaaagtaac aaacaactga 1381 gtttcttcca caatttcttt atagccttaa gttagctctg gtcaaggcta aaaatcaatg 1441 agcaaaatgg cagtattaac accttatgac ataattaaat gttgctgcta atttttcctt 1501 taaattcctt tcttctaggt tccatagatt gtacactaac attctctcat ccaacctggt 1561 actgggaaaa cctgctgaag atctgtgttt tcatcttcgc cttcattatg ccagtgctca 1621 tcattaccgt gtgctatgga ctgatgatct tgcgcctcaa gagtgtccgc atgctctctg 1681 gctccaaaga aaaggacagg aatcttcgaa ggatcaccag gatggtgctg gtggtggtgg 1741 ctgtgttcat cgtctgctgg actcccattc acatttacgt catcattaaa gccttggtta 1801 caatcccaga aactacgttc cagactgttt cttggcactt ctgcattgct ctaggttaca 1861 caaacagctg cctcaaccca gtcctttatg catttctgga tgaaaacttc aaacgatgct 1921 tcagagagtt ctgtatccca acctcttcca acattgagca acaaaactcc actcgaattc 1981 gtcagaacac tagagaccac cccnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2101 nnngaagcag gttgcttcaa gaatgtgtag gaggctctaa ttctctagga aagtgcctgc 2161 ttttaggtca tccaacctct ttcctctctg gccactctgc tctgcacatt agagggacag 2221 ccaaaagtaa gtggagcatt tggaaggaaa ggaatatacc acaccgagga gtccagtttg 2281 tgcaagacac ccagtggaac caaaacccat cgtggtatgt gaattgaagt catcataaaa 2341 ggtgaccctt ctgtctgtaa gattttattt tcaagcaaat atttatgacc tcaacaaaga 2401 agaaccatct tttgttaagt tcaccgtagt aacacataaa gtaaatgcta cctctgatca 2461 aagcaccttg aatggaaggt ccgagtcttt ttagtgtttt gcaagggaat gaatccatta 2521 ttctatttta gacttttaac ttcaccttaa aattagcatc tggctaaggc atcattttca 2581 cctccatttc ttggttttgt attgtttaaa aaaataacat ctctttcatc tagctccata 2641 attgcaaggg aagagattag catgaaaggt aatctgaaac acagtcatgt gtcagctgta 2701 gaaaggttga ttctcatgca ctgcaaatac ttccaaagag tcatcatggg ggatttttca 2761 ttcttaggct tt //