LOCUS       AF023477                3328 bp    mRNA    linear   HUM 21-FEB-2001
DEFINITION  Homo sapiens meltrin-S (ADAM12) mRNA, complete cds, alternatively
            spliced.
ACCESSION   AF023477
VERSION     AF023477.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3328)
  AUTHORS   Gilpin,B.J., Loechel,F., Mattei,M.G., Engvall,E., Albrechtsen,R.
            and Wewer,U.M.
  TITLE     A novel, secreted form of human ADAM 12 (meltrin alpha) provokes
            myogenesis in vivo
  JOURNAL   J. Biol. Chem. 273 (1), 157-166 (1998)
   PUBMED   9417060
REFERENCE   2  (bases 1 to 3328)
  AUTHORS   Gilpin,B.J., Loechel,F., Mattei,M.G., Engvall,E., Albrechtsen,R.
            and Wewer,U.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-SEP-1997) Institute of Molecular Pathology,
            University of Copenhagen, Frederik V's Vej 11, Copenhagen 2100,
            Denmark
REFERENCE   3  (bases 1 to 3328)
  AUTHORS   Gilpin,B.J., Loechel,F., Mattei,M.G., Engvall,E., Albrechtsen,R.
            and Wewer,U.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-FEB-2001) Institute of Molecular Pathology,
            University of Copenhagen, Frederik V's Vej 11, Copenhagen 2100,
            Denmark
  REMARK    Sequence update by submitter
COMMENT     On Feb 21, 2001 this sequence version replaced AF023477.1.
FEATURES             Location/Qualifiers
     source          1..3328
                     /db_xref="H-InvDB:HIT000062716"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26 between D10S216 and D10S575"
                     /tissue_type="placenta"
                     /clone_lib="Clontech #HL50416"
     gene            1..3328
                     /gene="ADAM12"
     CDS             307..2523
                     /gene="ADAM12"
                     /note="ADAM 12-S; N-terminal portion of this protein is
                     identical to ADAM 12-L sequence encoded by GenBank
                     Accession Number AF023476; rare splice variant"
                     /codon_start=1
                     /product="meltrin-S"
                     /protein_id="AAC08703.2"
                     /translation="MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVS
                     ASVRSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQD
                     GTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSA
                     TNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVEL
                     VIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVS
                     QDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIV
                     MDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF
                     SSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRC
                     CNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYL
                     HDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVS
                     KSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGD
                     DMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHW
                     APPFCDKFGFGGSTDSGPIRQAEARQEAAESNRERGQGQEPVGSQEHASTASLTLI"
     misc_feature    691..924
                     /gene="ADAM12"
                     /note="Region: pro-domain"
     misc_feature    925..1554
                     /gene="ADAM12"
                     /note="Region: metalloprotease domain"
     misc_feature    1555..1842
                     /gene="ADAM12"
                     /note="Region: disintegrin domain"
     misc_feature    1843..2427
                     /gene="ADAM12"
                     /note="Region: cysteine rich domain"
     variation       646..654
                     /gene="ADAM12"
                     /replace=""
     3'UTR           2524..3328
                     /gene="ADAM12"
BASE COUNT          856 a          854 c          943 g          675 t
ORIGIN      
        1 cactaacgct cttcctagtc cccgggccaa ctcggacagt ttgctcattt attgcaacgg
       61 tcaaggctgg cttgtgccag aacggcgcgc gcgcgacgca cgcacacaca cggggggaaa
      121 cttttttaaa aatgaaaggc tagaagagct cagcggcggc gcgggccgtg cgcgagggct
      181 ccggagctga ctcgccgagg caggaaatcc ctccggtcgc gacgcccggc cccgctcggc
      241 gcccgcgtgg gatggtgcag cgctcgccgc cgggcccgag agctgctgca ctgaaggccg
      301 gcgacgatgg cagcgcgccc gctgcccgtg tcccccgccc gcgccctcct gctcgccctg
      361 gccggtgctc tgctcgcgcc ctgcgaggcc cgaggggtga gcttatggaa ccaaggaaga
      421 gctgatgaag ttgtcagtgc ctctgttcgg agtggggacc tctggatccc agtgaagagc
      481 ttcgactcca agaatcatcc agaagtgctg aatattcgac tacaacggga aagcaaagaa
      541 ctgatcataa atctggaaag aaatgaaggt ctcattgcca gcagtttcac ggaaacccac
      601 tatctgcaag acggtactga tgtctccctc gctcgaaatt acacggtaat tctgggtcac
      661 tgttactacc atggacatgt acggggatat tctgattcag cagtcagtct cagcacgtgt
      721 tctggtctca ggggacttat tgtgtttgaa aatgaaagct atgtcttaga accaatgaaa
      781 agtgcaacca acagatacaa actcttccca gcgaagaagc tgaaaagcgt ccggggatca
      841 tgtggatcac atcacaacac accaaacctc gctgcaaaga atgtgtttcc accaccctct
      901 cagacatggg caagaaggca taaaagagag accctcaagg caactaagta tgtggagctg
      961 gtgatcgtgg cagacaaccg agagtttcag aggcaaggaa aagatctgga aaaagttaag
     1021 cagcgattaa tagagattgc taatcacgtt gacaagtttt acagaccact gaacattcgg
     1081 atcgtgttgg taggcgtgga agtgtggaat gacatggaca aatgctctgt aagtcaggac
     1141 ccattcacca gcctccatga atttctggac tggaggaaga tgaagcttct acctcgcaaa
     1201 tcccatgaca atgcgcagct tgtcagtggg gtttatttcc aagggaccac catcggcatg
     1261 gccccaatca tgagcatgtg cacggcagac cagtctgggg gaattgtcat ggaccattca
     1321 gacaatcccc ttggtgcagc cgtgaccctg gcacatgagc tgggccacaa tttcgggatg
     1381 aatcatgaca cactggacag gggctgtagc tgtcaaatgg cggttgagaa aggaggctgc
     1441 atcatgaacg cttccaccgg gtacccattt cccatggtgt tcagcagttg cagcaggaag
     1501 gacttggaga ccagcctgga gaaaggaatg ggggtgtgcc tgtttaacct gccggaagtc
     1561 agggagtctt tcgggggcca gaagtgtggg aacagatttg tggaagaagg agaggagtgt
     1621 gactgtgggg agccagagga atgtatgaat cgctgctgca atgccaccac ctgtaccctg
     1681 aagccggacg ctgtgtgcgc acatgggctg tgctgtgaag actgccagct gaagcctgca
     1741 ggaacagcgt gcagggactc cagcaactcc tgtgacctcc cagagttctg cacaggggcc
     1801 agccctcact gcccagccaa cgtgtacctg cacgatgggc actcatgtca ggatgtggac
     1861 ggctactgct acaatggcat ctgccagact cacgagcagc agtgtgtcac actctgggga
     1921 ccaggtgcta aacctgcccc tgggatctgc tttgagagag tcaattctgc aggtgatcct
     1981 tatggcaact gtggcaaagt ctcgaagagt tcctttgcca aatgcgagat gagagatgct
     2041 aaatgtggaa aaatccagtg tcaaggaggt gccagccggc cagtcattgg taccaatgcc
     2101 gtttccatag aaacaaacat ccccctgcag caaggaggcc ggattctgtg ccgggggacc
     2161 cacgtgtact tgggcgatga catgccggac ccagggcttg tgcttgcagg cacaaagtgt
     2221 gcagatggaa aaatctgcct gaatcgtcaa tgtcaaaata ttagtgtctt tggggttcac
     2281 gagtgtgcaa tgcagtgcca cggcagaggg gtgtgcaaca acaggaagaa ctgccactgc
     2341 gaggcccact gggcacctcc cttctgtgac aagtttggct ttggaggaag cacagacagc
     2401 ggccccatcc ggcaagcaga agcaaggcag gaagctgcag agtccaacag ggagcgcggc
     2461 cagggccagg agcccgtggg atcgcaggag catgcgtcta ctgcctcact gacactcatc
     2521 tgagccctcc catgacatgg agaccgtgac cagtgctgct gcagaggagg tcacgcgtcc
     2581 ccaaggcctc ctgtgactgg cagcattgac tctgtggctt tgccatcgtt tccatgacaa
     2641 cagacacaac acagttctcg gggctcagga ggggaagtcc agcctaccag gcaggtctgc
     2701 agaaacagtg caaggaaggg cagcgacttc ctggttgagc ttctgctaaa acatggacat
     2761 gcttcagtgc tgctcctgag agagtagcag gttaccactc tggcaggccc cagccctgca
     2821 gcaaggagga agaggactca aaagtctggc ctttcactga gcctccacag cagtggggga
     2881 gaagcaaggg ttgggcccag tgtccccttt ccccagtgac acctccgcct tggcagccct
     2941 gatgactggt ctctggctgc aacttaatgc tctgatatgg cttttagcat ttattatatg
     3001 aaaatagcag ggttttagtt tttaatttat cagagaccct gccacccatt ccatctccat
     3061 ccaagcaaac tgaatggcat tgaaacaaac tggagaagaa ggtaggagaa agggcggtga
     3121 actctggctc tttgctgtgg acatgcgtga ccagcagtac tcaggtttga gggtttgcag
     3181 aaagccaggg aacccacaga gtcaccaacc cttcatttaa caagtaagaa tgttaaaaag
     3241 tgaaaacaat gtaagagcct aactccatcc cccgtggcca ttactgcata aaaatagagt
     3301 gcattttgaa ataaaaaaaa aaaaaaaa
//