LOCUS AF023476 5062 bp mRNA linear HUM 21-FEB-2001
DEFINITION Homo sapiens meltrin-L precursor (ADAM12) mRNA, complete cds,
alternatively spliced.
ACCESSION AF023476
VERSION AF023476.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5062)
AUTHORS Gilpin,B.J., Loechel,F., Mattei,M.G., Engvall,E., Albrechtsen,R.
and Wewer,U.M.
TITLE A novel, secreted form of human ADAM 12 (meltrin alpha) provokes
myogenesis in vivo
JOURNAL J. Biol. Chem. 273 (1), 157-166 (1998)
PUBMED 9417060
REFERENCE 2 (bases 1 to 5062)
AUTHORS Gilpin,B.J., Loechel,F., Mattei,M.G., Engvall,E., Albrechtsen,R.
and Wewer,U.M.
TITLE Direct Submission
JOURNAL Submitted (06-SEP-1997) Institute of Molecular Pathology,
University of Copenhagen, Frederik V's Vej 11, Copenhagen 2100,
Denmark
REFERENCE 3 (bases 1 to 5062)
AUTHORS Gilpin,B.J., Loechel,F., Mattei,M.G., Engvall,E., Albrechtsen,R.
and Wewer,U.M.
TITLE Direct Submission
JOURNAL Submitted (21-FEB-2001) Institute of Molecular Pathology,
University of Copenhagen, Frederik V's Vej 11, Copenhagen 2100,
Denmark
REMARK Sequence update by submitter
COMMENT On Feb 21, 2001 this sequence version replaced AF023476.1.
FEATURES Location/Qualifiers
source 1..5062
/db_xref="H-InvDB:HIT000062715"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q26 between D10S216 and D10S575"
/tissue_type="placenta"
/clone_lib="Clontech #HL50416"
gene <1..5062
/gene="ADAM12"
5'UTR <1..306
/gene="ADAM12"
CDS 307..3036
/gene="ADAM12"
/note="ADAM 12-L; N-terminal portion of this protein is
identical to ADAM 12-S sequence, encoded by GenBank
Accession Number AF023477; rare splice variant"
/codon_start=1
/product="meltrin-L precursor"
/protein_id="AAC08702.2"
/translation="MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVS
ASVRSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQD
GTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSA
TNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVEL
VIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVS
QDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIV
MDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF
SSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRC
CNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYL
HDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVS
KSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGD
DMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHW
APPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFT
NKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNV
DISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQK
PLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTAYIK"
sig_peptide 307..390
/gene="ADAM12"
mat_peptide 391..3033
/gene="ADAM12"
/product="meltrin-L"
misc_feature 391..924
/gene="ADAM12"
/note="Region: pro-domain"
misc_feature 925..1554
/gene="ADAM12"
/note="Region: metalloprotease domain"
misc_feature 1555..1842
/gene="ADAM12"
/note="Region: disintegrin domain"
misc_feature 1843..2427
/gene="ADAM12"
/note="Region: cysteine rich domain"
misc_feature 2326..2490
/gene="ADAM12"
/note="Region: transmembrane domain"
misc_feature 2488..3033
/gene="ADAM12"
/note="Region: cytoplasmic tail"
variation 646..654
/gene="ADAM12"
/replace=""
3'UTR 3037..5062
/gene="ADAM12"
regulatory 4929..4934
/regulatory_class="polyA_signal_sequence"
/gene="ADAM12"
regulatory 5024..5029
/regulatory_class="polyA_signal_sequence"
/gene="ADAM12"
polyA_site 5044
/gene="ADAM12"
BASE COUNT 1341 a 1262 c 1252 g 1207 t
ORIGIN
1 cactaacgct cttcctagtc cccgggccaa ctcggacagt ttgctcattt attgcaacgg
61 tcaaggctgg cttgtgccag aacggcgcgc gcgcgacgca cgcacacaca cggggggaaa
121 cttttttaaa aatgaaaggc tagaagagct cagcggcggc gcgggccgtg cgcgagggct
181 ccggagctga ctcgccgagg caggaaatcc ctccggtcgc gacgcccggc cccgctcggc
241 gcccgcgtgg gatggtgcag cgctcgccgc cgggcccgag agctgctgca ctgaaggccg
301 gcgacgatgg cagcgcgccc gctgcccgtg tcccccgccc gcgccctcct gctcgccctg
361 gccggtgctc tgctcgcgcc ctgcgaggcc cgaggggtga gcttatggaa ccaaggaaga
421 gctgatgaag ttgtcagtgc ctctgttcgg agtggggacc tctggatccc agtgaagagc
481 ttcgactcca agaatcatcc agaagtgctg aatattcgac tacaacggga aagcaaagaa
541 ctgatcataa atctggaaag aaatgaaggt ctcattgcca gcagtttcac ggaaacccac
601 tatctgcaag acggtactga tgtctccctc gctcgaaatt acacggtaat tctgggtcac
661 tgttactacc atggacatgt acggggatat tctgattcag cagtcagtct cagcacgtgt
721 tctggtctca ggggacttat tgtgtttgaa aatgaaagct atgtcttaga accaatgaaa
781 agtgcaacca acagatacaa actcttccca gcgaagaagc tgaaaagcgt ccggggatca
841 tgtggatcac atcacaacac accaaacctc gctgcaaaga atgtgtttcc accaccctct
901 cagacatggg caagaaggca taaaagagag accctcaagg caactaagta tgtggagctg
961 gtgatcgtgg cagacaaccg agagtttcag aggcaaggaa aagatctgga aaaagttaag
1021 cagcgattaa tagagattgc taatcacgtt gacaagtttt acagaccact gaacattcgg
1081 atcgtgttgg taggcgtgga agtgtggaat gacatggaca aatgctctgt aagtcaggac
1141 ccattcacca gcctccatga atttctggac tggaggaaga tgaagcttct acctcgcaaa
1201 tcccatgaca atgcgcagct tgtcagtggg gtttatttcc aagggaccac catcggcatg
1261 gccccaatca tgagcatgtg cacggcagac cagtctgggg gaattgtcat ggaccattca
1321 gacaatcccc ttggtgcagc cgtgaccctg gcacatgagc tgggccacaa tttcgggatg
1381 aatcatgaca cactggacag gggctgtagc tgtcaaatgg cggttgagaa aggaggctgc
1441 atcatgaacg cttccaccgg gtacccattt cccatggtgt tcagcagttg cagcaggaag
1501 gacttggaga ccagcctgga gaaaggaatg ggggtgtgcc tgtttaacct gccggaagtc
1561 agggagtctt tcgggggcca gaagtgtggg aacagatttg tggaagaagg agaggagtgt
1621 gactgtgggg agccagagga atgtatgaat cgctgctgca atgccaccac ctgtaccctg
1681 aagccggacg ctgtgtgcgc acatgggctg tgctgtgaag actgccagct gaagcctgca
1741 ggaacagcgt gcagggactc cagcaactcc tgtgacctcc cagagttctg cacaggggcc
1801 agccctcact gcccagccaa cgtgtacctg cacgatgggc actcatgtca ggatgtggac
1861 ggctactgct acaatggcat ctgccagact cacgagcagc agtgtgtcac actctgggga
1921 ccaggtgcta aacctgcccc tgggatctgc tttgagagag tcaattctgc aggtgatcct
1981 tatggcaact gtggcaaagt ctcgaagagt tcctttgcca aatgcgagat gagagatgct
2041 aaatgtggaa aaatccagtg tcaaggaggt gccagccggc cagtcattgg taccaatgcc
2101 gtttccatag aaacaaacat ccccctgcag caaggaggcc ggattctgtg ccgggggacc
2161 cacgtgtact tgggcgatga catgccggac ccagggcttg tgcttgcagg cacaaagtgt
2221 gcagatggaa aaatctgcct gaatcgtcaa tgtcaaaata ttagtgtctt tggggttcac
2281 gagtgtgcaa tgcagtgcca cggcagaggg gtgtgcaaca acaggaagaa ctgccactgc
2341 gaggcccact gggcacctcc cttctgtgac aagtttggct ttggaggaag cacagacagc
2401 ggccccatcc ggcaagcaga taaccaaggt ttaaccatag gaattctggt gaccatcctg
2461 tgtcttcttg ctgccggatt tgtggtttat ctcaaaagga agaccttgat acgactgctg
2521 tttacaaata agaagaccac cattgaaaaa ctaaggtgtg tgcgcccttc ccggccaccc
2581 cgtggcttcc aaccctgtca ggctcacctc ggccaccttg gaaaaggcct gatgaggaag
2641 ccgccagatt cctacccacc gaaggacaat cccaggagat tgctgcagtg tcagaatgtt
2701 gacatcagca gacccctcaa cggcctgaat gtccctcagc cccagtcaac tcagcgagtg
2761 cttcctcccc tccaccgggc cccacgtgca cctagcgtcc ctgccagacc cctgccagcc
2821 aagcctgcac ttaggcaggc ccaggggacc tgtaagccaa acccccctca gaagcctctg
2881 cctgcagatc ctctggccag aacaactcgg ctcactcatg ccttggccag gaccccagga
2941 caatgggaga ctgggctccg cctggcaccc ctcagacctg ctccacaata tccacaccaa
3001 gtgcccagat ccacccacac cgcctatatt aagtgagaag ccgacacctt ttttcaacag
3061 tgaagacaga agtttgcact atctttcagc tccagttgga gttttttgta ccaactttta
3121 ggattttttt taatgtttaa aacatcatta ctataagaac tttgagctac tgccgtcagt
3181 gctgtgctgt gctatggtgc tctgtctact tgcacaggta cttgtaaatt attaatttat
3241 gcagaatgtt gattacagtg cagtgcgctg tagtaggcat ttttaccatc actgagtttt
3301 ccatggcagg aaggcttgtt gtgcttttag tattttagtg aacttgaaat atcctgcttg
3361 atgggattct ggacaggatg tgtttgcttt ctgatcaagg ccttattgga aagcagtccc
3421 ccaactaccc ccagctgtgc ttatggtacc agatgcagct caagagatcc caagtagaat
3481 ctcagttgat tttctggatt ccccatctca ggccagagcc aaggggcttc aggtccaggc
3541 tgtgtttggc tttcagggag gccctgtgcc ccttgacaac tggcaggcag gctcccaggg
3601 acacctggga gaaatctggc ttctggccag gaagctttgg tgagaacctg ggttgcagac
3661 aggaatctta aggtgtagcc acaccaggat agagactgga acactagaca agccagaact
3721 tgaccctgag ctgaccagcc gtgagcatgt ttggaagggg tctgtagtgt cactcaaggc
3781 ggtgcttgat agaaatgcca agcacttctt tttctcgctg tcctttctag agcactgcca
3841 ccagtaggtt atttagcttg ggaaaggtgg tgtttctgta agaaacctac tgcccaggca
3901 ctgcaaaccg ccacctccct atactgcttg gagctgagca aatcaccaca aactgtaata
3961 caatgatcct gtattcagac agatgaggac tttccatggg accacaacta ttttcagatg
4021 tgaaccatta accagatcta gtcaatcaag tctgtttact gcaaggttca acttattaac
4081 aattaggcag actctttatg cttgcaaaaa ctacaaccaa tggaatgtga tgttcatggg
4141 tatagttcat gtctgctatc attattcgta gatattggac aaagaacctt ctctatgggg
4201 catcctcttt ttccaacttg gctgcaggaa tctttaaaag atgcttttaa cagagtctga
4261 acctatttct taaacacttg caacctacct gttgagcatc acagaatgtg ataaggaaat
4321 caacttgctt atcaacttcc taaatattat gagatgtggc ttgggcagca tccccttgaa
4381 ctcttcactc ttcaaatgcc tgactaggga gccatgtttc acaaggtctt taaagtgact
4441 aatggcatga gaaatacaaa aatactcaga taaggtaaaa tgccatgatg cctctgtctt
4501 ctggactggt tttcacatta gaagacaatt gacaacagtt acataattca ctctgagtgt
4561 tttatgagaa agccttcttt tggggtcaac agttttccta tgctttgaaa cagaaaaata
4621 tgtaccaaga atcttggttt gccttccaga aaacaaaact gcatttcact ttcccggtgt
4681 tccccactgt atctaggcaa catagtattc atgactatgg ataaactaaa cacgtgacac
4741 aaacacacac aaaagggaac ccagctctaa tacattccaa ctcgtatagc atgcatctgt
4801 ttattctata gttattaagt tctttaaaat gtaaagccat gctggaaaat aatactgctg
4861 agatacatac agaattactg taactgatta cacttggtaa ttgtactaaa gccaaacata
4921 tatatactat taaaaaggtt tacagaattt tatggtgcat tacgtgggca ttgtcttttt
4981 agatgcccaa atccttagat ctggcatgtt agcccttcct ccaattataa gaggatatga
5041 accaaaaaaa aaaaaaaaaa aa
//