LOCUS       AF022953                1242 bp    DNA     linear   HUM 30-OCT-1997
DEFINITION  Homo sapiens beta2-adrenergic receptor (ADRB2) gene, complete cds.
ACCESSION   AF022953
VERSION     AF022953.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1242)
  AUTHORS   Reihsaus,E., Innis,M., MacIntyre,N. and Liggett,S.B.
  TITLE     Mutations in the gene encoding for the beta 2-adrenergic receptor
            in normal and asthmatic subjects
  JOURNAL   Am. J. Respir. Cell Mol. Biol. 8 (3), 334-339 (1993)
   PUBMED   8383511
REFERENCE   2  (bases 1 to 1242)
  AUTHORS   Green,S.A., Cole,G., Jacinto,M., Innis,M. and Liggett,S.B.
  TITLE     A polymorphism of the human beta 2-adrenergic receptor within the
            fourth transmembrane domain alters ligand binding and functional
            properties of the receptor
  JOURNAL   J. Biol. Chem. 268 (31), 23116-23121 (1993)
   PUBMED   7901205
REFERENCE   3  (bases 1 to 1242)
  AUTHORS   Green,S.A., Turki,J., Innis,M. and Liggett,S.B.
  TITLE     Amino-terminal polymorphisms of the human beta 2-adrenergic
            receptor impart distinct agonist-promoted regulatory properties
  JOURNAL   Biochemistry 33 (32), 9414-9419 (1994)
   PUBMED   7915137
REFERENCE   4  (bases 1 to 1242)
  AUTHORS   Liggett,S.B. and Green,S.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-SEP-1997) Medicine, Univ of Cincinnati, 231 Bethesda
            Ave ML670564, Cincinnati, OH 45267-0564, USA
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
     gene            1..1242
                     /gene="ADRB2"
     CDS             1..1242
                     /gene="ADRB2"
                     /codon_start=1
                     /product="beta2-adrenergic receptor"
                     /protein_id="AAB82148.1"
                     /translation="MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWVVGMGIVMSLIV
                     LAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFG
                     NFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIV
                     SGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFV
                     YSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLG
                     IIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRI
                     AFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQG
                     TVPSDNIDSQGRNCSTNDSLL"
     variation       46
                     /gene="ADRB2"
                     /note="Arg16 to Gly polymorphism"
                     /replace="a"
BASE COUNT          275 a          331 c          326 g          310 t
ORIGIN      
        1 atggggcaac ccgggaacgg cagcgccttc ttgctggcac ccaatggaag ccatgcgccg
       61 gaccacgacg tcacgcagca aagggacgag gtgtgggtgg tgggcatggg catcgtcatg
      121 tctctcatcg tcctggccat cgtgtttggc aatgtgctgg tcatcacagc cattgccaag
      181 ttcgagcgtc tgcagacggt caccaactac ttcatcactt cactggcctg tgctgatctg
      241 gtcatgggcc tggcagtggt gccctttggg gccgcccata ttcttatgaa aatgtggact
      301 tttggcaact tctggtgcga gttttggact tccattgatg tgctgtgcgt cacggccagc
      361 attgagaccc tgtgcgtgat cgcagtggat cgctactttg ccattacttc acctttcaag
      421 taccagagcc tgctgaccaa gaataaggcc cgggtgatca ttctgatggt gtggattgtg
      481 tcaggcctta cctccttctt gcccattcag atgcactggt accgggccac ccaccaggaa
      541 gccatcaact gctatgccaa tgagacctgc tgtgacttct tcacgaacca agcctatgcc
      601 attgcctctt ccatcgtgtc cttctacgtt cccctggtga tcatggtctt cgtctactcc
      661 agggtctttc aggaggccaa aaggcagctc cagaagattg acaaatctga gggccgcttc
      721 catgtccaga accttagcca ggtggagcag gatgggcgga cggggcatgg actccgcaga
      781 tcttccaagt tctgcttgaa ggagcacaaa gccctcaaga cgttaggcat catcatgggc
      841 actttcaccc tctgctggct gcccttcttc atcgttaaca ttgtgcatgt gatccaggat
      901 aacctcatcc gtaaggaagt ttacatcctc ctaaattgga taggctatgt caattctggt
      961 ttcaatcccc ttatctactg ccggagccca gatttcagga ttgccttcca ggagcttctg
     1021 tgcctgcgca ggtcttcttt gaaggcctat gggaatggct actccagcaa cggcaacaca
     1081 ggggagcaga gtggatatca cgtggaacag gagaaagaaa ataaactgct gtgtgaagac
     1141 ctcccaggca cggaagactt tgtgggccat caaggtactg tgcctagcga taacattgat
     1201 tcacaaggga ggaattgtag tacaaatgac tcactgctgt aa
//