LOCUS AF020340 1951 bp mRNA linear HUM 05-JAN-1998
DEFINITION Homo sapiens soluble guanylate cyclase beta-1 subunit (GC-S-beta-1)
mRNA, alternatively spliced, complete cds.
ACCESSION AF020340
VERSION AF020340.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1062 to 1587)
AUTHORS Chhajlani,V., Frandberg,P.A., Ahlner,J., Axelsson,K.L. and
Wikberg,J.E.
TITLE Heterogeneity in human soluble guanylate cyclase due to alternative
splicing
JOURNAL FEBS Lett. 290 (1-2), 157-158 (1991)
PUBMED 1680753
REFERENCE 2 (bases 1 to 1951)
AUTHORS Gansemans,Y., Brouckaert,P. and Fiers,W.
TITLE Alternatively spliced human soluble guanylate cyclase small subunit
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 1951)
AUTHORS Gansemans,Y., Brouckaert,P. and Fiers,W.
TITLE Direct Submission
JOURNAL Submitted (20-AUG-1997) Department of Molecular Biology, Flanders
Interuniversity Institute of Biotechnology (V.I.B.), University of
Ghent, K. L. Ledeganckstraat, 35, Ghent 9000, Belgium
FEATURES Location/Qualifiers
source 1..1951
/db_xref="H-InvDB:HIT000062511"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="kidney"
/dev_stage="fetal"
gene 1..1951
/gene="GC-S-beta-1"
CDS 52..1812
/gene="GC-S-beta-1"
/note="alternatively spliced; truncated by 33 amino acids"
/codon_start=1
/product="soluble guanylate cyclase beta-1 subunit"
/protein_id="AAB94877.1"
/translation="MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYD
DSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLD
ALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGT
EIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFP
FHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVF
VLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLT
RRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDT
GIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVS
GLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYC
LFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPM
QVWFLSRKNTGTEETKQDDD"
BASE COUNT 582 a 414 c 448 g 507 t
ORIGIN
1 cggccgtacc tctgcgtggg ggctgcctcc ccggctcccg gtgcagacac catgtacgga
61 tttgtgaatc acgccctgga gttgctggtg atccgcaatt acggccccga ggtgtgggaa
121 gacatcaaaa aagaggcaca gttagatgaa gaaggacagt ttcttgtcag aataatatat
181 gatgactcca aaacttatga tttggttgct gctgcaagca aagtcctcaa tctcaatgct
241 ggagaaatcc tccaaatgtt tgggaagatg tttttcgtct tttgccaaga atctggttat
301 gatacaatct tgcgtgtcct gggctctaat gtcagagaat ttctacagaa ccttgatgct
361 ctgcacgacc accttgctac catctaccca ggaatgcgtg caccttcctt taggtgcact
421 gatgcagaaa agggcaaagg actcattttg cactactact cagagagaga aggacttcag
481 gatattgtca ttggaatcat caaaacagtg gcacaacaaa tccatggcac tgaaatagac
541 atgaaggtta ttcagcaaag aaatgaagaa tgtgatcata ctcaattttt aattgaagaa
601 aaagagtcaa aagaagagga tttttatgaa gatcttgaca gatttgaaga aaatggtacc
661 caggaatcac gcatcagccc atatacattc tgcaaagctt ttccttttca tataatattt
721 gaccgggacc tagtggtcac tcagtgtggc aatgctatat acagagttct cccccagctc
781 cagcctggga attgcagcct tctgtctgtc ttctcgctgg ttcgtcctca tattgatatt
841 agtttccatg ggatcctttc tcacatcaat actgtttttg tattgagaag caaggaagga
901 ttgttggatg tggagaaatt agaatgtgag gatgaactga ctgggactga gatcagctgc
961 ttacgtctca agggtcaaat gatctactta cctgaagcag atagcatact ttttctatgt
1021 tcaccaagtg tcatgaacct ggacgatttg acaaggagag ggctgtatct aagtgacatc
1081 cctctgcatg atgccacgcg cgatcttgtt cttttgggag aacaatttag agaggaatac
1141 aaactcaccc aagaactgga aatcctcact gacaggctac agctcacgtt aagagccctg
1201 gaagatgaaa agaaaaagac agacactggc attgtgggct tcaatgcttt ctgtagcaag
1261 catgcatctg gagaaggagc catgaagatc gtcaacctcc tcaacgacct ctacaccaga
1321 tttgacacac tgactgattc ccggaaaaac ccatttgttt ataaggtgga gactgttggt
1381 gacaagtata tgacagtgag tggtttacca gagccatgca ttcaccatgc acgatccatc
1441 tgccacctgg ccttggacat gatggaaatt gctggccagg ttcaagtaga tggtgaatct
1501 gttcagataa caatagggat acacactgga gaggtagtta caggtgtcat aggacagcgg
1561 atgcctcgat actgtctttt tgggaatact gtcaacctca caagccgaac agaaaccaca
1621 ggagaaaagg gaaaaataaa tgtgtctgaa tatacataca gatgtcttat gtctccagaa
1681 aattcagatc cacaattcca cttggagcac agaggcccag tgtccatgaa gggcaaaaaa
1741 gaaccaatgc aagtttggtt tctatccaga aaaaatacag gaacagagga aacaaagcag
1801 gatgatgact gaatcttgga ttatggggtg aagaggagta cagactaggt tccagttttc
1861 tcctaacacg tgccaagccc aggagcagtt cttccctatg gatacagatt ttcttttgtc
1921 cttgtccatt accccaagac tttcttctag a
//