LOCUS AF020202 6330 bp mRNA linear HUM 10-JUN-1998
DEFINITION Homo sapiens Munc13 mRNA, complete cds.
ACCESSION AF020202
VERSION AF020202.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6330)
AUTHORS Song,Y., Ailenberg,M. and Silverman,M.
TITLE Cloning of a novel gene in the human kidney homologous to rat
munc13s: its potential role in diabetic nephropathy
JOURNAL Kidney Int. 53 (6), 1689-1695 (1998)
PUBMED 9607201
REFERENCE 2 (bases 1 to 6330)
AUTHORS Song,Y. and Silverman,M.
TITLE Direct Submission
JOURNAL Submitted (19-AUG-1997) Clinical Science Division, University of
Toronto, 1 Kings College Circle, Medical Science Bldg. Rm. 7207,
Toronto, ON M5S 1A8, Canada
FEATURES Location/Qualifiers
source 1..6330
/db_xref="H-InvDB:HIT000062507_02"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="mesangial cells (primary culture)"
/tissue_type="kidney"
CDS 225..5000
/note="contains C2 domains; similar to R. norvegicus
Munc13-2 encoded by GenBank Accession Number U24071"
/codon_start=1
/product="Munc13"
/protein_id="AAC19406.1"
/translation="MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPS
WEQDFMFEISRLDLGLSVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAE
TLMKDDEICGTRNPTPHKILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQ
EESQRKPLPTAAAQCSFEDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPV
PVRSPQQLLLQGSSRDSCNDSMQSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSE
LDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEM
KEDATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPD
DGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTS
LKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRC
SECGVKCHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIF
EVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPY
VTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLK
RESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYH
VQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESI
YQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKER
FVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPP
RASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSIRNLDFWPKLI
TLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKS
ADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGAL
ERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIG
KVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSL
KEPQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQDA
DSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQ
LIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
EKSPDLQSLRYALSLYTQTTDTLIKRFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTG
EHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNET
FHLLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKI
HMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS"
BASE COUNT 1688 a 1543 c 1682 g 1417 t
ORIGIN
1 agtcccagcc tgccggccgg tactcaccgc tacccggagt tcgctcagac ggtgagattt
61 ggggcgggtc cgaggcagcg gcgggacgta cctgcgaccg ggaccatgag gagctgccag
121 acccgtgggg ccggtaacga gagcagtcgc ggcacctgct gagaggaaag agggagcggt
181 cccgcgcggc tggggcgcgg cagaggcttg cccgatcctc ggccatgtca ctgctctgcg
241 tgcgcgttaa aagggccaaa ttccagggtt caccagataa atttaacaca tatgtgaccc
301 tgaaagtaca gaatgtgaag agcacaactg tagcagttcg tggtgatcag ccttcctggg
361 aacaggattt catgtttgag attagtcgcc tggacctggg tctaagtgtg gaggtatgga
421 acaaaggact gatctgggac accatggtgg ggactgtgtg gattgcgctg aagactattc
481 gtcagtcgga tgaggaaggg cctggggaat ggtccacatt agaggcagag acgttaatga
541 aagacgatga gatctgtgga actagaaacc caactcctca taaaattttg cttgatacaa
601 gatttgagtt gccttttgat atcccagagg aggaagccag atattggacc tacaaatggg
661 agcaaatcaa tgccttggga gctgacaatg agtattctag tcaagaagaa agccagagga
721 agccattgcc cactgctgcc gcccagtgtt cttttgaaga ccctgatagt gccgtcgatg
781 accgagatag tgactatcgc agtgagacca gcaacagctt cccacctcct taccatacag
841 cttcccagcc caacgcttct gtgcaccagt tccctgtgcc ggtgcgatcg ccacagcagc
901 tgctacttca aggcagttcc cgggactctt gtaatgactc tatgcaaagt tatgaccttg
961 attatccaga gcggcgggct atcagcccca ccagcagcag taggtatggc tcctcctgta
1021 atgtgagtca aggaagctct cagctaagtg aactagacca gtatcacgaa caagatgacg
1081 accatcggga gacggactcg attcattctt gccacagctc tcacagcctg tccagagatg
1141 gccaagcagg ttttggagaa caagagaaac ccttggaggt gacaggtcaa gcagagaagg
1201 aggcagcatg tgaacccaag gagatgaaag aagatgccac aacccaccct cccccagatc
1261 tggtgctgca aaaagaccac ttcctaggtc cccaggagag ttttcctgag gagaatgcat
1321 cttcaccatt tacccaagcc agagcacatt ggatccgagc agttaccaag gttcgactcc
1381 agctgcagga gattccagat gatggtgacc cctctctgcc tcagtggctc ccggaagggc
1441 cagccggagg gctctatggc attgacagca tgccagattt acgcagaaag aagccactgc
1501 cacttgtcag tgatctgtca ctggtccagt ctcggaaggc aggaatcact tctgcaatgg
1561 ctacacgcac ttctcttaag gacgaagagc tgaaatccca cgtgtataag aaaaccctgc
1621 aggccttaat ctaccccatt tcgtgcacca ctcctcataa ctttgaggtc tggacggcca
1681 ctaccccaac ctactgctat gagtgtgaag gcctgctctg gggcattgcc cggcagggca
1741 tgcgctgcag cgaatgtgga gtcaagtgcc atgagaagtg ccaggatctg ctcaatgctg
1801 actgcctgca gcgggctgca gaaaagagct gtaaacatgg agctgaggac cggacccaga
1861 acattatcat ggccatgaag gaccgcatga agatccgaga gcgaaataag ccagagatct
1921 ttgaagttat ccgggacgtc ttcacagtga acaaagctgc ccatgtgcag cagatgaaaa
1981 cagtgaagca gagtgtactg gatggcacct ccaagtggtc agccaagatc accattactg
2041 tggtgtgtgc ccagggccta caagccaagg acaaaacagg atccagtgac ccttacgtga
2101 ctgtgcaagt cagcaaaact aagaagcgta ccaagaccat ttttggaaac ttgaatcctg
2161 tttgggagga gaagttccat tttgagtgcc acaactcctc tgaccgcatt aaggtgcgtg
2221 tatgggatga ggatgatgac atcaagtcaa gagtaaagca acgcctaaag cgagagtctg
2281 atgatttcct tggccaaacc atcattgagg ttcggaccct aagtggcgag atggacgtct
2341 ggtacaactt ggagaagagg acagacaaat cagccgtctc aggggctatc cgactacaaa
2401 tcagtgtgga gatcaagggg gaggagaaag tagccccata ccacgtgcag tatacatgtc
2461 tccatgagaa tcttttccat tacctcacag acattcaggg cagtggagga gtccgcatcc
2521 ctgaagctcg aggagacgat gcctggaagg tgtactttga tgagacagcc caagaaattg
2581 tggatgaatt tgccatgcgt tatggcattg agtccatata tcaggccatg acgcactttg
2641 catgtttatc atccaagtac atgtgtcctg gtgtgccagc agtgatgagc accttactgg
2701 ccaacatcaa cgcctactat gcccacacaa ctgcctctac caatgtctct gcatctgatc
2761 gctttgcagc ctccaacttt gggaaagaga gatttgtaaa actgctggac cagctacaca
2821 actcactgag gatcgacctc tctacataca ggaataattt ccctgctggg agtcctgaac
2881 ggcttcagga cttaaaatcc acagtggatt tgctgaccag cattactttc ttcagaatga
2941 aggtacaaga actgcaaagc cctccaagag ccagccaggt ggtaaaggat tgtgtgaagg
3001 cctgtttgaa ctccacatat gaatatatct tcaacaactg ccacgactta tacagccgcc
3061 agtaccagct gaagcaggag ctacctccag aggaacaagg gcccagcatt cggaacctgg
3121 atttctggcc caagctcatc acactcatcg tgtcaatcat agaggaagat aagaattcct
3181 acacacctgt tctgaaccag tttcctcagg agttgaatgt gggaaaagtc agcgcagaag
3241 tgatgtggca tttgtttgcc caagacatga aatatgcatt ggaggagcat gagaaagacc
3301 acctgtgtaa aagtgctgac tacatgaacc tgcacttcaa ggtgaagtgg ctccacaatg
3361 aatacgtgcg ggatctgcct gtcctccagg ggcaggtgcc tgagtaccca gcgtggtttg
3421 agcagttcgt gctacaatgg ctggatgaga atgaggatgt atccctggaa ttcctgcgtg
3481 gggccctgga acgagataag aaggatggat tccagcagac atcagagcat gcactctttt
3541 cctgctctgt ggtggatgtc ttcacacaac tcaatcagag ctttgagatc atccggaagc
3601 tggaatgccc agaccccagc atccttgccc actacatgag gaggtttgct aagaccatcg
3661 ggaaggtgct gatgcagtat gcagacatct tgtcaaagga cttcccagcc tattgcacaa
3721 aggagaaact gccctgcatc ctgatgaaca acgtgcagca actgagggtc cagctggaga
3781 aaatgtttga ggccatggga ggcaaggagc tggaccttga agctgcagac agtctgaagg
3841 agccgcaggt gaaactgaat acggttctgg atgagctcag catggtgttt ggaaacagtt
3901 tccaggtacg gattgatgag tgtgttcgac aaatggccga catcctgggc caggttcggg
3961 gcacagggaa tgcatctcca gacgccaggg cctcagcggc tcaggatgca gatagcgtac
4021 tccggcctct catggacttc ctggatggca acctcaccct ctttgccact gtgtgtgaga
4081 agacggttct gaagcgtgta ctgaaggagc tctggcgcgt ggtgatgaac acaatggaga
4141 ggatgattgt tctgccccca ctcactgacc agacgggcac ccagctgatc ttcactgctg
4201 ccaaggagct gagccatctt tccaaactca aggatcacat ggtacgagag gaaacacgga
4261 atctcactcc aaagcagtgt gcagtccttg acctcgccct ggacaccatc aagcaatact
4321 tccatgcagg aggcaatggg ctgaagaaaa ccttcctgga gaagagccca gatctgcagt
4381 ctctacgcta tgccctgtct ctgtacacac agactactga cactctcatc aagaggtttg
4441 tgcgctcgca gaccacccaa gggtctggtg tggacgatcc tgtgggagaa gtctctattc
4501 aggtggactt gtttacacac cctggtactg gggagcacaa ggtcacagtg aaagtggtgg
4561 ctgccaatga cctcaagtgg cagacagcgg gtatgttccg gcctttcgtg gaggtgacta
4621 tggttggccc acaccaaagt gataagaaga ggaagttcac aaccaaatcc aaaagcaaca
4681 actgggcccc caagtacaat gagacattcc acttactcct gggaaatgag gaggggcccg
4741 agtcctatga gttgcagata tgcgtgaagg attactgctt tgcccgggaa gatcgcgtgc
4801 tagggctggc tgtgatgcct ctgagggatg tcacagccaa gggcagctgt gcctgctggt
4861 gccccttggg ccggaagatc catatggatg agacaggcct gaccattctc cggattttat
4921 ctcagaggag caatgacgag gtggcccgag aatttgtgaa actcaaatca gagtctcgtt
4981 ccacggagga ggggagctga agaggttcga ctcctgtgcc aatcaggcag cagcaatttc
5041 acaaatcagg gccagtggga gttagctgtg taaccggctt agggtctttg cagtcaagag
5101 gctgacccct tcagttaaag atatttaagg aaaaatttgg ggtggtgata atatggcttt
5161 tcacagaaag ggtcatgaag ccctggccca acaggactgt ggtactaggg gctgggatgt
5221 ggggttacca catggagaga ttttccatta agagagaagg acaaacattt ctgagagtgt
5281 cagccattct tggtagacac ctctccactc ctcatcccac ctctacccat ctccatgcca
5341 caccttatcc agttagacac atacatacca atcattagaa gaacaagttt agaaggtgtg
5401 gaacttgtgc ctggctggct gggtagtcag ctgagcctgt tgctgagccc ggtggtctgg
5461 attggagtat ggccagggca ggagtacaca gaatagaatt tagactgtcc cttgagtaga
5521 atccactgat tttctgtggc tccagtgaga acaaggcttt gaaactgaac aagataactt
5581 ctagaaatga actgtactaa tccctttccc cagattgtat catgagtaga atcaggttca
5641 cgtggtgctt caaagccctg agaagaatat ttctttggac cccaggcact aggggccacc
5701 tgcctgggag tctccctgcc tcactcctct aggcagggga gtgatgcttc aggacgtgac
5761 aggctgttct aacatgtgtc tacctgaggg ctagttgaag gatccaggag tattttcttc
5821 ttgggtgggc ctgaacaaaa gccaaaaatt gtagaaacca gtctagaaaa agtcctgctc
5881 atctgtggcc actgccttct agccgtcctc caccttgcag aaagaatcta gcctttggtc
5941 tctctctctc tcatcggggt catttgctat tcccctctga tattcaaccc tatagaagga
6001 gcctggactc tgatccctct gtacaggctg gatggaaggg gccctccaca cttcctggga
6061 ggtcagagac aaactgtttc agagagtcag atggacttcc caagacttgt tgagagatgt
6121 gacatggttc ttggatttcc tctgtagcag cctcctggac ttcctgagga ctcgacattg
6181 tccacagatg tactggccat tacatgaaac aagaaaccaa gcatctttgc tgttgttaat
6241 tattatatgt gccattgtta caggagatta taggctagtc tgtaataaat tatcttatag
6301 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//