LOCUS AF019612 1759 bp mRNA linear HUM 09-JAN-1998
DEFINITION Homo sapiens S2P mRNA, complete cds.
ACCESSION AF019612
VERSION AF019612.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1759)
AUTHORS Rawson,R.B., Zelenski,N.G., Nijhawan,D., Ye,J., Sakai,J.,
Hasan,M.T., Chang,T.Y., Brown,M.S. and Goldstein,J.L.
TITLE Complementation cloning of S2P, a gene encoding a putative
metalloprotease required for intramembrane cleavage of SREBPs
JOURNAL Mol. Cell 1 (1), 47-57 (1997)
PUBMED 9659902
REFERENCE 2 (bases 1 to 1759)
AUTHORS Rawson,R.B., Zelenski,N.G., Nijhawan,D., Ye,J., Sakai,J.,
Hasan,M.T., Chang,T.Y., Brown,M.S. and Goldstein,J.L.
TITLE Direct Submission
JOURNAL Submitted (14-AUG-1997) Molecular Genetics, UT Southwestern Medical
Center, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
FEATURES Location/Qualifiers
source 1..1759
/db_xref="H-InvDB:HIT000062481"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/cell_line="HeLa"
CDS 100..1659
/codon_start=1
/product="S2P"
/protein_id="AAC51937.1"
/translation="MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLS
ISPFHIRWQTAVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTL
AQMMADSPSSYSSSSSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYF
FTAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQL
RIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVG
DLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTEC
CNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRTNKDCKKSSSSSFCIIPSLE
THTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVVVETFVKYLIS
LSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAAN
VTLGLWMVTAR"
BASE COUNT 410 a 399 c 380 g 570 t
ORIGIN
1 agcggatgct ggggctgtaa ggcgcgcgcg gtcagctgtt ggcggtgcag ggaggaggac
61 gccggggctc gccttccctc ctctgccgcc gctgccgcca tgattccggt gtcgctggtg
121 gtggtggtgg tgggtggctg gactgtcgtc tacctgaccg acttggtgct gaagtcatct
181 gtctatttta aacattctta tgaagactgg ctggaaaaca acggactgag catctcccct
241 ttccacataa gatggcaaac tgctgttttc aatcgtgcct tttacagttg gggacggcgg
301 aaagcaagga tgctttacca atggttcaat tttggaatgg tgtttggcgt aattgccatg
361 tttagctcat tttttctcct tggaaaaacg ctgatgcaga ctttggcaca aatgatggct
421 gactctccct cttcttattc ttcctcctct tcttcctctt cctcctcttc ttcctcttcc
481 tcttcttcat cttcttcctc ttcctcgctt cacaatgaac aggtgttaca agttgtggtt
541 cctggtataa atttacccgt caatcaactg acctatttct tcacggcagt tctcattagt
601 ggtgttgtac atgaaattgg acatgggata gcagctatta gggaacaagt tcgatttaat
661 ggctttggga tttttctctt cattatttat cctggagcat ttgttgatct gttcaccact
721 catttgcaac ttatatcgcc agtccagcag ctaaggatat tttgtgcagg tatctggcat
781 aattttgtcc ttgcactctt gggtatttta gctcttgttc tcctcccagt aattctcttg
841 ccattttact acactggagt tggggtgctc atcactgaag ttgctgagga ctctcctgcc
901 attggaccca gaggcctttt tgtgggagac cttgtcaccc atctacagga ttgtcctgtt
961 actaatgtgc aagattggaa tgaatgttta gataccatcg cctatgagcc ccaaattggt
1021 tactgtataa gtgcatcaac tttacagcag ttaagtttcc cagttagagc atacaaacga
1081 ctagatggtt caactgaatg ctgtaacaat cacagcctca cagatgtgtg cttttcctac
1141 agaaataatt ttaataagcg tttgcataca tgtcttcctg cccggaaagc agttgaagca
1201 actcaagttt gcagaaccaa taaagactgt aaaaaaagct caagttcaag tttctgtata
1261 ataccttctt tggaaactca cactcgctta ataaaagtaa aacacccacc tcagattgat
1321 atgttatacg taggacatcc tctgcatctt cactacacag tgagcatcac cagttttatc
1381 ccacgtttta actttctaag catagatctg ccagtggttg tggagacatt tgtcaagtac
1441 ctgatttccc tctcaggagc tctggctatt gttaatgcag taccctgctt tgctttggat
1501 ggacaatgga ttctaaactc tttcttggat gccaccctta cctcagtgat tggagacaat
1561 gatgtcaaag atctaatagg gtttttcatc ttgctgggtg gcagtgtact tttggctgcc
1621 aatgtgaccc tgggactctg gatggttaca gcacggtaat gtttgcactc atctgacaga
1681 atccctgagt tacagtatac agctatgtgg taatattcat tgccattgaa attcttactt
1741 ggtatgaaat ataaagtgt
//