LOCUS       AF019386                1305 bp    mRNA    linear   HUM 14-NOV-1997
DEFINITION  Homo sapiens heparan sulfate 3-O-sulfotransferase-1 precursor
            (3OST1) mRNA, complete cds.
ACCESSION   AF019386
VERSION     AF019386.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1305)
  AUTHORS   Shworak,N.W., Liu,J., Fritze,L.M., Schwartz,J.J., Zhang,L.,
            Logeart,D. and Rosenberg,R.D.
  TITLE     Molecular cloning and expression of mouse and human cDNAs encoding
            heparan sulfate D-glucosaminyl 3-O-sulfotransferase
  JOURNAL   J. Biol. Chem. 272 (44), 28008-28019 (1997)
   PUBMED   9346953
REFERENCE   2  (bases 1 to 1305)
  AUTHORS   Shworak,N.W., Liu,J., Fritze,L.M.S., Schwartz,J.J., Zhang,L.,
            Logeart,D. and Rosenberg,R.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-AUG-1997) Biology, MIT, 31 Ames Street, Cambridge, MA
            02139, USA
FEATURES             Location/Qualifiers
     source          1..1305
                     /db_xref="H-InvDB:HIT000062479"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /note="isolated from lambda TriplEx Brain cDNA library
                     from ClonTech"
     gene            1..1305
                     /gene="3OST1"
     5'UTR           1..118
                     /gene="3OST1"
     CDS             119..1042
                     /gene="3OST1"
                     /function="rate limiting enzyme for synthesis of
                     anticoagulant heparan"
                     /note="heparan sulfate sulfotransferase; 3-OST-1;
                     interluminal Golgi resident protein (retension mechanism
                     unknown)"
                     /codon_start=1
                     /product="heparan sulfate 3-O-sulfotransferase-1
                     precursor"
                     /protein_id="AAB84388.1"
                     /translation="MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDG
                     VAPNGSAQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGW
                     YLSQMPFSWPHQLTVEKTPAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQV
                     FYNHMQKHKPYPSIEEFLVRDGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGD
                     RLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQ
                     VDPKLLNKLHEYFHEPNKKFFELVGRTFDWH"
     sig_peptide     119..178
                     /gene="3OST1"
     mat_peptide     179..1039
                     /gene="3OST1"
                     /product="heparan sulfate 3-O-sulfotransferase-1"
     regulatory      260..268
                     /regulatory_class="other"
                     /gene="3OST1"
                     /note="encodes potential N-linked site"
     misc_feature    278..1039
                     /gene="3OST1"
                     /note="encodes presumptive sulfotransferase catalytic
                     domain"
     regulatory      527..535
                     /regulatory_class="other"
                     /gene="3OST1"
                     /note="encodes potential N-linked site; this site probably
                     not functional"
     regulatory      692..700
                     /regulatory_class="other"
                     /gene="3OST1"
                     /note="encodes potential N-linked site"
     regulatory      842..850
                     /regulatory_class="other"
                     /gene="3OST1"
                     /note="encodes potential N-linked site"
     regulatory      863..871
                     /regulatory_class="other"
                     /gene="3OST1"
                     /note="encodes potential N-linked site"
     misc_structure  873..911
                     /gene="3OST1"
                     /note="encodes cystine-bridged peptide loop"
     3'UTR           1043..1305
                     /gene="3OST1"
     regulatory      1277..1283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="3OST1"
     polyA_site      1305
                     /gene="3OST1"
BASE COUNT          304 a          380 c          329 g          292 t
ORIGIN      
        1 cgcggctcag taattgaagg cctgaaacgc ccatgtgcca ctgactagga ggcttccctg
       61 ctgcggcact tcatgaccca gcggcgcgcg gcccagtgaa gccaccgtgg tgtccagcat
      121 ggccgcgctg ctcctgggcg cggtgctgct ggtggcccag ccccagctag tgccttcccg
      181 ccccgccgag ctaggccagc aggagcttct gcggaaagcg gggaccctcc aggatgacgt
      241 ccgcgatggc gtggccccaa acggctctgc ccagcagttg ccgcagacca tcatcatcgg
      301 cgtgcgcaag ggcggcacgc gcgcactgct ggagatgctc agcctgcacc ccgacgtggc
      361 ggccgcggag aacgaggtcc acttcttcga ctgggaggag cattacagcc acggcttggg
      421 ctggtacctc agccagatgc ccttctcctg gccacaccag ctcacagtgg agaagacccc
      481 cgcgtatttc acgtcgccca aagtgcctga gcgagtctac agcatgaacc cgtccatccg
      541 gctgctgctc atcctgcgag acccgtcgga gcgcgtgcta tctgactaca cccaagtgtt
      601 ctacaaccac atgcagaagc acaagcccta cccgtccatc gaggagttcc tggtgcgcga
      661 tggcaggctc aatgtggact acaaggccct caaccgcagc ctctaccacg tgcacatgca
      721 gaactggctg cgctttttcc cgctgcgcca catccacatt gtggacggcg accgcctcat
      781 cagggacccc ttccctgaga tccaaaaggt cgagaggttc ctaaagctgt cgccgcagat
      841 caatgcttcg aacttctact ttaacaaaac caagggcttt tactgcctgc gggacagcgg
      901 ccgggaccgc tgcttacatg agtccaaagg ccgggcgcac ccccaagtcg atcccaaact
      961 actcaataaa ctgcacgaat attttcatga gccaaataag aagttcttcg agcttgttgg
     1021 cagaacattt gactggcact gatttgcaat aagctaagct cagaaacttt cctactgtaa
     1081 gttctggtgt acatctgagg ggaaaaagaa ttttaaaaaa gcatttaagg tataatttat
     1141 ttgtaaaatc cataaagtac ttctgtacag tattagattc acaattgcca tatatactag
     1201 ttatattttt ctacttgtta aatggagggc attttgtatt gtttttcatg gttgttaaca
     1261 ttgtgtaata tgtctctata tgaaggaact aaactatttc actga
//