LOCUS AF019386 1305 bp mRNA linear HUM 14-NOV-1997 DEFINITION Homo sapiens heparan sulfate 3-O-sulfotransferase-1 precursor (3OST1) mRNA, complete cds. ACCESSION AF019386 VERSION AF019386.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1305) AUTHORS Shworak,N.W., Liu,J., Fritze,L.M., Schwartz,J.J., Zhang,L., Logeart,D. and Rosenberg,R.D. TITLE Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase JOURNAL J. Biol. Chem. 272 (44), 28008-28019 (1997) PUBMED 9346953 REFERENCE 2 (bases 1 to 1305) AUTHORS Shworak,N.W., Liu,J., Fritze,L.M.S., Schwartz,J.J., Zhang,L., Logeart,D. and Rosenberg,R.D. TITLE Direct Submission JOURNAL Submitted (14-AUG-1997) Biology, MIT, 31 Ames Street, Cambridge, MA 02139, USA FEATURES Location/Qualifiers source 1..1305 /db_xref="H-InvDB:HIT000062479" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /note="isolated from lambda TriplEx Brain cDNA library from ClonTech" gene 1..1305 /gene="3OST1" 5'UTR 1..118 /gene="3OST1" CDS 119..1042 /gene="3OST1" /function="rate limiting enzyme for synthesis of anticoagulant heparan" /note="heparan sulfate sulfotransferase; 3-OST-1; interluminal Golgi resident protein (retension mechanism unknown)" /codon_start=1 /product="heparan sulfate 3-O-sulfotransferase-1 precursor" /protein_id="AAB84388.1" /translation="MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDG VAPNGSAQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGW YLSQMPFSWPHQLTVEKTPAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQV FYNHMQKHKPYPSIEEFLVRDGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGD RLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQ VDPKLLNKLHEYFHEPNKKFFELVGRTFDWH" sig_peptide 119..178 /gene="3OST1" mat_peptide 179..1039 /gene="3OST1" /product="heparan sulfate 3-O-sulfotransferase-1" regulatory 260..268 /regulatory_class="other" /gene="3OST1" /note="encodes potential N-linked site" misc_feature 278..1039 /gene="3OST1" /note="encodes presumptive sulfotransferase catalytic domain" regulatory 527..535 /regulatory_class="other" /gene="3OST1" /note="encodes potential N-linked site; this site probably not functional" regulatory 692..700 /regulatory_class="other" /gene="3OST1" /note="encodes potential N-linked site" regulatory 842..850 /regulatory_class="other" /gene="3OST1" /note="encodes potential N-linked site" regulatory 863..871 /regulatory_class="other" /gene="3OST1" /note="encodes potential N-linked site" misc_structure 873..911 /gene="3OST1" /note="encodes cystine-bridged peptide loop" 3'UTR 1043..1305 /gene="3OST1" regulatory 1277..1283 /regulatory_class="polyA_signal_sequence" /gene="3OST1" polyA_site 1305 /gene="3OST1" BASE COUNT 304 a 380 c 329 g 292 t ORIGIN 1 cgcggctcag taattgaagg cctgaaacgc ccatgtgcca ctgactagga ggcttccctg 61 ctgcggcact tcatgaccca gcggcgcgcg gcccagtgaa gccaccgtgg tgtccagcat 121 ggccgcgctg ctcctgggcg cggtgctgct ggtggcccag ccccagctag tgccttcccg 181 ccccgccgag ctaggccagc aggagcttct gcggaaagcg gggaccctcc aggatgacgt 241 ccgcgatggc gtggccccaa acggctctgc ccagcagttg ccgcagacca tcatcatcgg 301 cgtgcgcaag ggcggcacgc gcgcactgct ggagatgctc agcctgcacc ccgacgtggc 361 ggccgcggag aacgaggtcc acttcttcga ctgggaggag cattacagcc acggcttggg 421 ctggtacctc agccagatgc ccttctcctg gccacaccag ctcacagtgg agaagacccc 481 cgcgtatttc acgtcgccca aagtgcctga gcgagtctac agcatgaacc cgtccatccg 541 gctgctgctc atcctgcgag acccgtcgga gcgcgtgcta tctgactaca cccaagtgtt 601 ctacaaccac atgcagaagc acaagcccta cccgtccatc gaggagttcc tggtgcgcga 661 tggcaggctc aatgtggact acaaggccct caaccgcagc ctctaccacg tgcacatgca 721 gaactggctg cgctttttcc cgctgcgcca catccacatt gtggacggcg accgcctcat 781 cagggacccc ttccctgaga tccaaaaggt cgagaggttc ctaaagctgt cgccgcagat 841 caatgcttcg aacttctact ttaacaaaac caagggcttt tactgcctgc gggacagcgg 901 ccgggaccgc tgcttacatg agtccaaagg ccgggcgcac ccccaagtcg atcccaaact 961 actcaataaa ctgcacgaat attttcatga gccaaataag aagttcttcg agcttgttgg 1021 cagaacattt gactggcact gatttgcaat aagctaagct cagaaacttt cctactgtaa 1081 gttctggtgt acatctgagg ggaaaaagaa ttttaaaaaa gcatttaagg tataatttat 1141 ttgtaaaatc cataaagtac ttctgtacag tattagattc acaattgcca tatatactag 1201 ttatattttt ctacttgtta aatggagggc attttgtatt gtttttcatg gttgttaaca 1261 ttgtgtaata tgtctctata tgaaggaact aaactatttc actga //