LOCUS       AF017995                1891 bp    mRNA    linear   HUM 30-OCT-1997
DEFINITION  Homo sapiens 3-phosphoinositide dependent protein kinase-1 (PDK1)
            mRNA, complete cds.
ACCESSION   AF017995
VERSION     AF017995.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1891)
  AUTHORS   Alessi,D.R., James,S.R., Downes,C.P., Holmes,A.B., Gaffney,P.R.,
            Reese,C.B. and Cohen,P.
  TITLE     Characterization of a 3-phosphoinositide-dependent protein kinase
            which phosphorylates and activates protein kinase Balpha
  JOURNAL   Curr. Biol. 7 (4), 261-269 (1997)
   PUBMED   9094314
REFERENCE   2  (bases 1 to 1891)
  AUTHORS   Alessi,D.R., Deak,M., Casamayor,A., Caudwell,F.B., Morrice,N.,
            Norman,D.G., Gaffney,P., MacDougall,C.N., Reese,C.B., Harbison,D.,
            Ashworth,A. and Bownes,M.
  TITLE     3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural
            and functional homology with the Drosophila DSTPK61 kinase
  JOURNAL   Curr. Biol. 7 (10), 776-789 (1997)
   PUBMED   9368760
REFERENCE   3  (bases 1 to 1891)
  AUTHORS   Deak,M., Casamayor,A., Ashworth,A. and Alessi,D.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-AUG-1997) MRC Protein Phosphorylation Unit. Dept.
            Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland (UK)
FEATURES             Location/Qualifiers
     source          1..1891
                     /db_xref="H-InvDB:HIT000062450"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
                     /cell_line="MCF7"
     gene            1..1891
                     /gene="PDK1"
     CDS             81..1751
                     /gene="PDK1"
                     /function="protein kinase"
                     /note="Similar to the Drosophila protein kinase DSTPK61,
                     encoded by GenBank Accession Number Y07908"
                     /codon_start=1
                     /product="3-phosphoinositide dependent protein kinase-1"
                     /protein_id="AAC51825.1"
                     /translation="MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGG
                     SRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLAREL
                     ATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLS
                     YAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMH
                     IQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLV
                     AGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYG
                     PLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSS
                     SSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQ
                     FVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEA
                     KNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ"
BASE COUNT          475 a          509 c          502 g          405 t
ORIGIN      
        1 ccgcttcggg gaggaggacg ctgaggaggc gccgagccgc gcagcgctgc gggggaggcg
       61 cccgcgccga cgcggggccc atggccagga ccaccagcca gctgtatgac gccgtgccca
      121 tccagtccag cgtggtgtta tgttcctgcc catccccatc aatggtgagg acccagactg
      181 agtccagcac gccccctggc attcctggtg gcagcaggca gggccccgcc atggacggca
      241 ctgcagccga gcctcggccc ggcgccggct ccctgcagca tgcccagcct ccgccgcagc
      301 ctcggaagaa gcggcctgag gacttcaagt ttgggaaaat ccttggggaa ggctcttttt
      361 ccacggttgt cctggctcga gaactggcaa cctccagaga atatgcgatt aaaattctgg
      421 agaagcgaca tatcataaaa gagaacaagg tcccctatgt aaccagagag cgggatgtca
      481 tgtcgcgcct ggatcacccc ttctttgtta agctttactt cacatttcag gacgacgaga
      541 agctgtattt cggccttagt tatgccaaaa atggagaact acttaaatat attcgcaaaa
      601 tcggttcatt cgatgagacc tgtacccgat tttacacggc tgagatcgtg tctgctttag
      661 agtacttgca cggcaagggc atcattcaca gggaccttaa accggaaaac attttgttaa
      721 atgaagatat gcacatccag atcacagatt ttggaacagc aaaagtctta tccccagaga
      781 gcaaacaagc cagggccaac tcattcgtgg gaacagcgca gtacgtttct ccagagctgc
      841 tcacggagaa gtccgcctgt aagagttcag acctttgggc tcttggatgc ataatatacc
      901 agcttgtggc aggactccca ccattccgag ctggaaacga gtatcttata tttcagaaga
      961 tcattaagtt ggaatatgac tttccagaaa aattcttccc taaggcaaga gacctcgtgg
     1021 agaaactttt ggttttagat gccacaaagc ggttaggctg tgaggaaatg gaaggatacg
     1081 gacctcttaa agcacacccg ttcttcgagt ccgtcacgtg ggagaacctg caccagcaga
     1141 cgcctccgaa gctcaccgct tacctgccgg ctatgtcgga agacgacgag gactgctatg
     1201 gcaattatga caatctcctg agccagtttg gctgcatgca ggtgtcttcg tcctcctcct
     1261 cacactccct gtcagcctcc gacacgggcc tgccccagag gtcaggcagc aacatagagc
     1321 agtacattca cgatctggac tcgaactcct ttgaactgga cttacagttt tccgaagatg
     1381 agaagaggtt gttgttggag aagcaggctg gcggaaaccc ttggcaccag tttgtagaaa
     1441 ataatttaat actaaagatg ggcccagtgg ataagcggaa gggtttattt gcaagacgac
     1501 gacagctgtt gctcacagaa ggaccacatt tatattatgt ggatcctgtc aacaaagttc
     1561 tgaaaggtga aattccttgg tcacaagaac ttcgaccaga ggccaagaat tttaaaactt
     1621 tctttgtcca cacgcctaac aggacgtatt atctgatgga ccccagcggg aacgcacaca
     1681 agtggtgcag gaagatccag gaggtttgga ggcagcgata ccagagccac ccggacgccg
     1741 ctgtgcagtg acgtggcctg cggccgggct gcccttcgct gccaggacac ctgccccagc
     1801 gcggcttggc cgccatccgg gacgcttcca gaccacctgc cagccatcac aaggggaacg
     1861 cagaggcgga aaccttgcag catttttatt t
//