LOCUS AF017995 1891 bp mRNA linear HUM 30-OCT-1997 DEFINITION Homo sapiens 3-phosphoinositide dependent protein kinase-1 (PDK1) mRNA, complete cds. ACCESSION AF017995 VERSION AF017995.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1891) AUTHORS Alessi,D.R., James,S.R., Downes,C.P., Holmes,A.B., Gaffney,P.R., Reese,C.B. and Cohen,P. TITLE Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha JOURNAL Curr. Biol. 7 (4), 261-269 (1997) PUBMED 9094314 REFERENCE 2 (bases 1 to 1891) AUTHORS Alessi,D.R., Deak,M., Casamayor,A., Caudwell,F.B., Morrice,N., Norman,D.G., Gaffney,P., MacDougall,C.N., Reese,C.B., Harbison,D., Ashworth,A. and Bownes,M. TITLE 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase JOURNAL Curr. Biol. 7 (10), 776-789 (1997) PUBMED 9368760 REFERENCE 3 (bases 1 to 1891) AUTHORS Deak,M., Casamayor,A., Ashworth,A. and Alessi,D.R. TITLE Direct Submission JOURNAL Submitted (09-AUG-1997) MRC Protein Phosphorylation Unit. Dept. Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland (UK) FEATURES Location/Qualifiers source 1..1891 /db_xref="H-InvDB:HIT000062450" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="16" /map="16p13.3" /cell_line="MCF7" gene 1..1891 /gene="PDK1" CDS 81..1751 /gene="PDK1" /function="protein kinase" /note="Similar to the Drosophila protein kinase DSTPK61, encoded by GenBank Accession Number Y07908" /codon_start=1 /product="3-phosphoinositide dependent protein kinase-1" /protein_id="AAC51825.1" /translation="MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGG SRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLAREL ATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLS YAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMH IQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLV AGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYG PLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSS SSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQ FVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEA KNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ" BASE COUNT 475 a 509 c 502 g 405 t ORIGIN 1 ccgcttcggg gaggaggacg ctgaggaggc gccgagccgc gcagcgctgc gggggaggcg 61 cccgcgccga cgcggggccc atggccagga ccaccagcca gctgtatgac gccgtgccca 121 tccagtccag cgtggtgtta tgttcctgcc catccccatc aatggtgagg acccagactg 181 agtccagcac gccccctggc attcctggtg gcagcaggca gggccccgcc atggacggca 241 ctgcagccga gcctcggccc ggcgccggct ccctgcagca tgcccagcct ccgccgcagc 301 ctcggaagaa gcggcctgag gacttcaagt ttgggaaaat ccttggggaa ggctcttttt 361 ccacggttgt cctggctcga gaactggcaa cctccagaga atatgcgatt aaaattctgg 421 agaagcgaca tatcataaaa gagaacaagg tcccctatgt aaccagagag cgggatgtca 481 tgtcgcgcct ggatcacccc ttctttgtta agctttactt cacatttcag gacgacgaga 541 agctgtattt cggccttagt tatgccaaaa atggagaact acttaaatat attcgcaaaa 601 tcggttcatt cgatgagacc tgtacccgat tttacacggc tgagatcgtg tctgctttag 661 agtacttgca cggcaagggc atcattcaca gggaccttaa accggaaaac attttgttaa 721 atgaagatat gcacatccag atcacagatt ttggaacagc aaaagtctta tccccagaga 781 gcaaacaagc cagggccaac tcattcgtgg gaacagcgca gtacgtttct ccagagctgc 841 tcacggagaa gtccgcctgt aagagttcag acctttgggc tcttggatgc ataatatacc 901 agcttgtggc aggactccca ccattccgag ctggaaacga gtatcttata tttcagaaga 961 tcattaagtt ggaatatgac tttccagaaa aattcttccc taaggcaaga gacctcgtgg 1021 agaaactttt ggttttagat gccacaaagc ggttaggctg tgaggaaatg gaaggatacg 1081 gacctcttaa agcacacccg ttcttcgagt ccgtcacgtg ggagaacctg caccagcaga 1141 cgcctccgaa gctcaccgct tacctgccgg ctatgtcgga agacgacgag gactgctatg 1201 gcaattatga caatctcctg agccagtttg gctgcatgca ggtgtcttcg tcctcctcct 1261 cacactccct gtcagcctcc gacacgggcc tgccccagag gtcaggcagc aacatagagc 1321 agtacattca cgatctggac tcgaactcct ttgaactgga cttacagttt tccgaagatg 1381 agaagaggtt gttgttggag aagcaggctg gcggaaaccc ttggcaccag tttgtagaaa 1441 ataatttaat actaaagatg ggcccagtgg ataagcggaa gggtttattt gcaagacgac 1501 gacagctgtt gctcacagaa ggaccacatt tatattatgt ggatcctgtc aacaaagttc 1561 tgaaaggtga aattccttgg tcacaagaac ttcgaccaga ggccaagaat tttaaaactt 1621 tctttgtcca cacgcctaac aggacgtatt atctgatgga ccccagcggg aacgcacaca 1681 agtggtgcag gaagatccag gaggtttgga ggcagcgata ccagagccac ccggacgccg 1741 ctgtgcagtg acgtggcctg cggccgggct gcccttcgct gccaggacac ctgccccagc 1801 gcggcttggc cgccatccgg gacgcttcca gaccacctgc cagccatcac aaggggaacg 1861 cagaggcgga aaccttgcag catttttatt t //