LOCUS       AH005616               10526 bp    DNA     linear   HUM 10-JUN-2016
DEFINITION  Homo sapiens aldehyde oxidase (AOX1) gene, complete cds.
ACCESSION   AH005616 AF009441-AF009474 AF017060
VERSION     AH005616.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10526)
  AUTHORS   Wright,R.M., Weigel,L.K., Varella-Garcia,M., Vaitaitis,G. and
            Repine,J.E.
  TITLE     Molecular cloning, refined chromosomal mapping and structural
            analysis of the human gene encoding aldehyde oxidase (AOX1), a
            candidate for the ALS2 gene
  JOURNAL   Redox Rep. 3 (3), 135-144 (1997)
   PUBMED   27406959
REFERENCE   2  (bases 1 to 10526)
  AUTHORS   Wright,R.M., Weigel,L.K., Varella-Garcia,M., Vaitaitis,G. and
            Repine,J.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-1997) Department of Medicine, University of
            Colorado HSC., Webb-Waring Institute for Biomedical Research, 4200
            East 9th Avenue, Campus Box C322, Denver, CO 80262, USA
COMMENT     On or before Jun 10, 2016 this sequence version replaced
            AF009441.1, AF009442.1, AF009443.1, AF009444.1, AF009445.1,
            AF009446.1, AF009447.1, AF009448.1, AF009449.1, AF009450.1,
            AF009451.1, AF009452.1, AF009453.1, AF009454.1, AF009455.1,
            AF009456.1, AF009457.1, AF009458.1, AF009459.1, AF009460.1,
            AF009461.1, AF009462.1, AF009463.1, AF009464.1, AF009465.1,
            AF009466.1, AF009467.1, AF009468.1, AF009469.1, AF009470.1,
            AF009471.1, AF009472.1, AF009473.1, AF009474.1, AF017060.1,
            AH005616.1.
FEATURES             Location/Qualifiers
     source          1..10526
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
     gene            1..10526
                     /gene="AOX1"
     mRNA            join(1..343,497..554,715..811,972..1080,1241..1367,
                     1528..1589,1754..1843,2005..2085,2248..2392,2553..2645,
                     2805..2956,3117..3210,3372..3481,3634..3818,3974..4136,
                     4296..4388,4549..4718,4879..5005,5161..5283,5444..5540,
                     5694..5818,5979..6112,6272..6359,6520..6606,6764..6955,
                     7115..7342,7503..7598,7759..7887,8048..8122,8276..8328,
                     8488..8602,8763..8828,8989..9177,9338..9505,9666..10526)
                     /gene="AOX1"
                     /product="aldehyde oxidase"
     exon            1..343
                     /gene="AOX1"
                     /number=1
     CDS             join(299..343,497..554,715..811,972..1080,1241..1367,
                     1528..1589,1754..1843,2005..2085,2248..2392,2553..2645,
                     2805..2956,3117..3210,3372..3481,3634..3818,3974..4136,
                     4296..4388,4549..4718,4879..5005,5161..5283,5444..5540,
                     5694..5818,5979..6112,6272..6359,6520..6606,6764..6955,
                     7115..7342,7503..7598,7759..7887,8048..8122,8276..8328,
                     8488..8602,8763..8828,8989..9177,9338..9505,9666..9716)
                     /gene="AOX1"
                     /codon_start=1
                     /product="aldehyde oxidase"
                     /protein_id="AAB83966.1"
                     /translation="MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTPYGC
                     GGGGCGACTVMISRYNPITKRIRHHPANACLIPICSLYGAAVTTVEGIGSTHTRIHPV
                     QERIAKCHGTQCGFCTPGMVMSIYPLLRNHPEPTLDQLTDALGGNLCRCHGYRPIIDA
                     CKTFCKTSGCCQSKENGVCCLDQGINGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIF
                     PPELMIMADKQSQRTRVFGSERMMWFSPVTLKELLEFKFKYPQAPVIMGNTSVGPEVK
                     FKGVFHPGYNSPDRIEEPECCKPCIYGLTLGAGLSLAQVKDILADVVQKLPEEKTQMY
                     HALLKHLGTLAGSQIRNMASLGGHIISRHPDSDLNPILAVGNCTLNLLSKEGKRQIPL
                     NEQFLSKCPNADLKPQEILVSVNIPISRKWEFVSAFRQAQRQENALAIVNSGMRVFFG
                     EGDGIIRELCISYGGVGPATICAKNSCQKLIGRHWNEQMLDIACRLILNELSLLGSAP
                     GGKVEFKRTLIISFLFKFYLEVSQILKKMDPVHYPSLADKYESALEDLHSKHHCSTLK
                     YQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYCDDMPLVDQELFLTFVTSSRAHAKI
                     VSNDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAEKFLATDKVFCVGQLVCAVLADS
                     EVQAKRAAKRVKIVYQDLEPLILTIEESIQHNSSFKPERKLEYGNVDEAFKVVDQILE
                     GEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVASTLKLPANKVMC
                     HVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGEDMLITGGRHPYLGKYK
                     AGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKFPNLRCRGWACRTNL
                     PSNTAFRGFGFPQAVLITESCITEVAAKCGLSPEKVRIINMYKEIDQTPYKQEINAKN
                     LIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLASRAAGQAAALV
                     HIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETVPNANISGG
                     SVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVGYFRGYE
                     SDMNWEKGEGQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAIDIGQI
                     EGAFIQGMGLYTIEELNYSPQGILHTRGPDQYKIPAICDMPTELHIALLPPSQNSNTL
                     YSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMACEDKFT
                     KMIPRDEPGSYVPWNVPI"
     intron          344..>373
                     /gene="AOX1"
                     /note="intron is approximately 7000 bp long"
                     /number=1
     gap             374..473
                     /estimated_length=unknown
     intron          <474..496
                     /gene="AOX1"
                     /note="intron is approximately 7000 bp long"
                     /number=1
     exon            497..554
                     /gene="AOX1"
                     /number=2
     intron          555..>584
                     /gene="AOX1"
                     /note="intron is approximately 2200 bp long"
                     /number=2
     gap             585..684
                     /estimated_length=unknown
     intron          <685..714
                     /gene="AOX1"
                     /note="intron is approximately 2200 bp long"
                     /number=2
     exon            715..811
                     /gene="AOX1"
                     /number=3
     intron          812..>841
                     /gene="AOX1"
                     /note="intron is approximately 2000 bp long"
                     /number=3
     gap             842..941
                     /estimated_length=unknown
     intron          <942..971
                     /gene="AOX1"
                     /note="intron is approximately 2000 bp long"
                     /number=3
     exon            972..1080
                     /gene="AOX1"
                     /number=4
     intron          1081..>1110
                     /gene="AOX1"
                     /note="intron is approximately 1900 bp long"
                     /number=4
     gap             1111..1210
                     /estimated_length=unknown
     intron          <1211..1240
                     /gene="AOX1"
                     /note="intron is approximately 1900 bp long"
                     /number=4
     exon            1241..1367
                     /gene="AOX1"
                     /number=5
     intron          1368..>1397
                     /gene="AOX1"
                     /note="intron is approximately 2600 bp long"
                     /number=5
     gap             1398..1497
                     /estimated_length=unknown
     intron          <1498..1527
                     /gene="AOX1"
                     /note="intron is approximately 2600 bp long"
                     /number=5
     exon            1528..1589
                     /gene="AOX1"
                     /number=6
     intron          1590..>1623
                     /gene="AOX1"
                     /note="intron is approximately 900 bp long"
                     /number=6
     gap             1624..1723
                     /estimated_length=unknown
     intron          <1724..1753
                     /gene="AOX1"
                     /note="intron is approximately 900 bp long"
                     /number=6
     exon            1754..1843
                     /gene="AOX1"
                     /number=7
     intron          1844..>1873
                     /gene="AOX1"
                     /note="intron is approximately 700 bp long"
                     /number=7
     gap             1874..1973
                     /estimated_length=unknown
     intron          <1974..2004
                     /gene="AOX1"
                     /note="intron is approximately 700 bp long"
                     /number=7
     exon            2005..2085
                     /gene="AOX1"
                     /number=8
     intron          2086..>2115
                     /gene="AOX1"
                     /note="intron is approximately 650 bp long"
                     /number=8
     gap             2116..2215
                     /estimated_length=unknown
     intron          <2216..2247
                     /gene="AOX1"
                     /note="intron is approximately 650 bp long"
                     /number=8
     exon            2248..2392
                     /gene="AOX1"
                     /number=9
     intron          2393..>2422
                     /gene="AOX1"
                     /note="intron is approximately 600 bp long"
                     /number=9
     gap             2423..2522
                     /estimated_length=unknown
     intron          <2523..2552
                     /gene="AOX1"
                     /note="intron is approximately 600 bp long"
                     /number=9
     exon            2553..2645
                     /gene="AOX1"
                     /number=10
     intron          2646..>2675
                     /gene="AOX1"
                     /note="intron is approximately 3500 bp long"
                     /number=10
     gap             2676..2775
                     /estimated_length=unknown
     intron          <2776..2804
                     /gene="AOX1"
                     /note="intron is approximately 3500 bp long"
                     /number=10
     exon            2805..2956
                     /gene="AOX1"
                     /number=11
     intron          2957..>2986
                     /gene="AOX1"
                     /note="intron is approximately 160 bp long"
                     /number=11
     gap             2987..3086
                     /estimated_length=unknown
     intron          <3087..3116
                     /gene="AOX1"
                     /note="intron is approximately 160 bp long"
                     /number=11
     exon            3117..3210
                     /gene="AOX1"
                     /number=12
     intron          3211..>3241
                     /gene="AOX1"
                     /note="intron is approximately 2200 bp long"
                     /number=12
     gap             3242..3341
                     /estimated_length=unknown
     intron          <3342..3371
                     /gene="AOX1"
                     /note="intron is approximately 2200 bp long"
                     /number=12
     exon            3372..3481
                     /gene="AOX1"
                     /number=13
     intron          3482..>3511
                     /gene="AOX1"
                     /note="intron is approximately 1400 bp long"
                     /number=13
     gap             3512..3611
                     /estimated_length=unknown
     intron          <3612..3633
                     /gene="AOX1"
                     /note="intron is approximately 1400 bp long"
                     /number=13
     exon            3634..3818
                     /gene="AOX1"
                     /number=14
     intron          3819..>3843
                     /gene="AOX1"
                     /note="intron is approximately 1000 bp long"
                     /number=14
     gap             3844..3943
                     /estimated_length=unknown
     intron          <3944..3973
                     /gene="AOX1"
                     /note="intron is approximately 1000 bp long"
                     /number=14
     exon            3974..4136
                     /gene="AOX1"
                     /number=15
     intron          4137..>4165
                     /gene="AOX1"
                     /note="intron is approximately 2000 bp long"
                     /number=15
     gap             4166..4265
                     /estimated_length=unknown
     intron          <4266..4295
                     /gene="AOX1"
                     /note="intron is approximately 2000 bp long"
                     /number=15
     exon            4296..4388
                     /gene="AOX1"
                     /number=16
     intron          4389..>4418
                     /gene="AOX1"
                     /note="intron is approximately 4200 bp long"
                     /number=16
     gap             4419..4518
                     /estimated_length=unknown
     intron          <4519..4548
                     /gene="AOX1"
                     /note="intron is approximately 4200 bp long"
                     /number=16
     exon            4549..4718
                     /gene="AOX1"
                     /number=17
     intron          4719..>4748
                     /gene="AOX1"
                     /note="intron is approximately 500 bp long"
                     /number=17
     gap             4749..4848
                     /estimated_length=unknown
     intron          <4849..4878
                     /gene="AOX1"
                     /note="intron is approximately 500 bp long"
                     /number=17
     exon            4879..5005
                     /gene="AOX1"
                     /number=18
     intron          5006..>5030
                     /gene="AOX1"
                     /note="intron is approximately 2600 bp long"
                     /number=18
     gap             5031..5130
                     /estimated_length=unknown
     intron          <5131..5160
                     /gene="AOX1"
                     /note="intron is approximately 2600 bp long"
                     /number=18
     exon            5161..5283
                     /gene="AOX1"
                     /number=19
     intron          5284..>5313
                     /gene="AOX1"
                     /note="intron is approximately 3500 bp long"
                     /number=19
     gap             5314..5413
                     /estimated_length=unknown
     intron          <5414..5443
                     /gene="AOX1"
                     /note="intron is approximately 3500 bp long"
                     /number=19
     exon            5444..5540
                     /gene="AOX1"
                     /number=20
     intron          5541..>5570
                     /gene="AOX1"
                     /note="intron is approximately 1100 bp long"
                     /number=20
     gap             5571..5670
                     /estimated_length=unknown
     intron          <5671..5693
                     /gene="AOX1"
                     /note="intron is approximately 1100 bp long"
                     /number=20
     exon            5694..5818
                     /gene="AOX1"
                     /number=21
     intron          5819..>5848
                     /gene="AOX1"
                     /note="intron is approximately 2200 bp long"
                     /number=21
     gap             5849..5948
                     /estimated_length=unknown
     intron          <5949..5978
                     /gene="AOX1"
                     /note="intron is approximately 2200 bp long"
                     /number=21
     exon            5979..6112
                     /gene="AOX1"
                     /number=22
     intron          6113..>6142
                     /gene="AOX1"
                     /note="intron is approximately 1500 bp long"
                     /number=22
     gap             6143..6242
                     /estimated_length=unknown
     intron          <6243..6271
                     /gene="AOX1"
                     /note="intron is approximately 1500 bp long"
                     /number=22
     exon            6272..6359
                     /gene="AOX1"
                     /number=23
     intron          6360..>6389
                     /gene="AOX1"
                     /note="intron is approximately 3500 bp long"
                     /number=23
     gap             6390..6489
                     /estimated_length=unknown
     intron          <6490..6519
                     /gene="AOX1"
                     /note="intron is approximately 3500 bp long"
                     /number=23
     exon            6520..6606
                     /gene="AOX1"
                     /number=24
     intron          6607..>6637
                     /gene="AOX1"
                     /note="intron is approximately 1700 bp long"
                     /number=24
     gap             6638..6737
                     /estimated_length=unknown
     intron          <6738..6763
                     /gene="AOX1"
                     /note="intron is approximately 1700 bp long"
                     /number=24
     exon            6764..6955
                     /gene="AOX1"
                     /number=25
     intron          6956..>6985
                     /gene="AOX1"
                     /note="intron is approximately 1300 bp long"
                     /number=25
     gap             6986..7085
                     /estimated_length=unknown
     intron          <7086..7114
                     /gene="AOX1"
                     /note="intron is approximately 1300 bp long"
                     /number=25
     exon            7115..7342
                     /gene="AOX1"
                     /number=26
     intron          7343..>7372
                     /gene="AOX1"
                     /note="intron is approximately 2000 bp long"
                     /number=26
     gap             7373..7472
                     /estimated_length=unknown
     intron          <7473..7502
                     /gene="AOX1"
                     /note="intron is approximately 2000 bp long"
                     /number=26
     exon            7503..7598
                     /gene="AOX1"
                     /number=27
     intron          7599..>7628
                     /gene="AOX1"
                     /note="intron is approximately 2600 bp long"
                     /number=27
     gap             7629..7728
                     /estimated_length=unknown
     intron          <7729..7758
                     /gene="AOX1"
                     /note="intron is approximately 2600 bp long"
                     /number=27
     exon            7759..7887
                     /gene="AOX1"
                     /number=28
     intron          7888..>7917
                     /gene="AOX1"
                     /note="intron is approximately 916 bp long"
                     /number=28
     gap             7918..8017
                     /estimated_length=unknown
     intron          <8018..8047
                     /gene="AOX1"
                     /note="intron is approximately 916 bp long"
     exon            8048..8122
                     /gene="AOX1"
                     /number=29
     intron          8123..>8152
                     /gene="AOX1"
                     /note="intron is approximately 1900 bp long"
                     /number=29
     gap             8153..8252
                     /estimated_length=unknown
     intron          <8253..8275
                     /gene="AOX1"
                     /note="intron is approximately 1900 bp long"
                     /number=29
     exon            8276..8328
                     /gene="AOX1"
                     /number=30
     intron          8329..>8357
                     /gene="AOX1"
                     /note="intron is approximately 1250 bp long"
                     /number=30
     gap             8358..8457
                     /estimated_length=unknown
     intron          <8458..8487
                     /gene="AOX1"
                     /note="intron is approximately 1250 bp long"
                     /number=30
     exon            8488..8602
                     /gene="AOX1"
                     /number=31
     intron          8603..>8632
                     /gene="AOX1"
                     /note="intron is approximately 3700 bp long"
                     /number=31
     gap             8633..8732
                     /estimated_length=unknown
     intron          <8733..8762
                     /gene="AOX1"
                     /note="intron is approximately 3700 bp long"
                     /number=31
     exon            8763..8828
                     /gene="AOX1"
                     /number=32
     intron          8829..>8858
                     /gene="AOX1"
                     /note="intron is approximately 1350 bp long"
                     /number=32
     gap             8859..8958
                     /estimated_length=unknown
     intron          <8959..8988
                     /gene="AOX1"
                     /note="intron is approximately 1350 bp long"
                     /number=32
     exon            8989..9177
                     /gene="AOX1"
                     /number=33
     intron          9178..>9207
                     /gene="AOX1"
                     /note="intron is approximately 830 bp long"
                     /number=33
     gap             9208..9307
                     /estimated_length=unknown
     intron          <9308..9337
                     /gene="AOX1"
                     /note="intron is approximately 830 bp long"
                     /number=33
     exon            9338..9505
                     /gene="AOX1"
                     /number=34
     intron          9506..>9535
                     /gene="AOX1"
                     /note="intron is approximately 974 bp long"
                     /number=34
     gap             9536..9635
                     /estimated_length=unknown
     intron          <9636..9665
                     /gene="AOX1"
                     /note="intron is approximately 974 bp long"
                     /number=34
     exon            9666..10526
                     /gene="AOX1"
                     /number=35
BASE COUNT         1947 a         1497 c         1604 g         2077 t
ORIGIN      
        1 actggcgagg agatgaaggg gtcgtcttca tcttcgccgg atgatttccg cccacataga
       61 gggcgccagt gacgcccaca cacgtgctgg tgtcccggga agagttcctg gcaaagagct
      121 caggtaacgt tggatcttaa ttcaaggctt tctccgttcg gggtggatgg gttggtactt
      181 taggctccag caagccccgc cccactcggc gggtcggtgc cgccgggtcc caggtgcccg
      241 ctacttccca gaacctccgc ctcccgctcc gggccctcga accagcgcgg acaccacaat
      301 ggaccgggcg tccgagctgc tcttctacgt gaacggccgc aaggtgagcg cccgcattct
      361 ttcctctgct cccnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnctcttat
      481 tttccctttg gtataggtga tagaaaaaaa tgtcgatcct gaaacaatgc tgttgcctta
      541 tttgaggaag aagcgtatcc ttttctttac tttgactgtg tatgnnnnnn nnnnnnnnnn
      601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      661 nnnnnnnnnn nnnnnnnnnn nnnnacatat gatctttaac tatacctctt ccagttcgac
      721 tcacaggaac tccgtatggc tgtggaggag gaggctgtgg tgcttgtaca gtgatgatat
      781 cacgatacaa ccccatcacc aagaggataa ggtaccgtgc agcaaagtcc agatatggtt
      841 cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntaatttgtg cttttctttt
      961 gcattctgaa ggcatcaccc agccaatgcc tgtctgattc ccatctgttc tctgtatggt
     1021 gctgccgtca ccacagtaga aggcatagga agcacccaca ccagaattca tcctgttcag
     1081 gtgaggatgt gcctcttcct tataggcttt nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1201 nnnnnnnnnn tctgcatttc taacctttct gtgcttccag gagaggattg ccaagtgtca
     1261 tggcacccag tgtggcttct gcacacctgg gatggtgatg tccatctacc ccctgctcag
     1321 gaaccaccca gagcccactc tggatcagtt aactgatgcc cttggtggta ggttatatat
     1381 gcatgctttt attttttnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnggc
     1501 taacagagct gggtttttct ccttcaggta acctgtgccg ttgccatgga tacaggccca
     1561 taattgatgc atgcaagact ttctgtaaag tagtggaaag gaccacatgt ttgagtatgt
     1621 tttnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnttcccta gtaatttgtt
     1741 ttttgtccac tagacttcgg gttgctgtca aagtaaagaa aatggggttt gctgtttgga
     1801 tcaaggaatc aatggattgc cagaatttga ggaaggaagt aaggtcagtg aaatgtaaag
     1861 cttttataag gctnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnaacagta
     1981 atttctgata tgttctcttt ttagacaagt ccaaaactct tcgcagaaga ggagtttctg
     2041 ccattggatc caacccagga actgatattt cctcctgagc taatggtgag taaagcaatg
     2101 ttgagctcat cctagnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnggtac
     2221 cttgaatccc tattgctttt tcaatagata atggctgata aacagtcgca aaggaccagg
     2281 gtgtttggca gtgagagaat gatgtggttt tcccccgtga ccctgaagga actgctggaa
     2341 tttaaattca agtatcccca ggctcctgtt atcatgggaa acacctctgt gggtatgtag
     2401 aaccccaggg attttttata ggnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2521 nntagttcga tttttttttt ttgatccttt agggcctgaa gtgaaattta aaggcgtctt
     2581 tcacccaggt tataattctc ctgatagaat tgaagaacct gagtgttgta aaccatgcat
     2641 atatggtgag ttctcaagtc cctgttttct tagttnnnnn nnnnnnnnnn nnnnnnnnnn
     2701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2761 nnnnnnnnnn nnnnntgtgt tatttacaaa tgacttcatt tcaggactca cccttggtgc
     2821 tggtctcagc ctagcccagg tgaaggacat tttggctgat gtagtccaga agcttccaga
     2881 ggagaagaca cagatgtacc atgctctcct gaagcatttg ggaactctgg ctgggtccca
     2941 gatcaggaac atggctgtat gtatcttatt acagttaact ctggtannnn nnnnnnnnnn
     3001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3061 nnnnnnnnnn nnnnnnnnnn nnnnnntaaa tgaaaataac tcattatttt taaaagtctt
     3121 tagggggaca catcattagc aggcatccag attcagatct gaatcccatc ctggctgtgg
     3181 gtaactgtac cctcaacttg ctatcaaaag gtagtgacag cccctacttg gagattatta
     3241 annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntcccaggga aagtgtcatt
     3361 tctttccaca gaaggaaaac gacagattcc tttaaatgag caattcctca gcaagtgccc
     3421 taatgcagat cttaagcctc aagaaatctt ggtctcagtg aacatcccca tctcaaggaa
     3481 ggtgagaaca tcccactgtc aatttcccag tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3601 nnnnnnnnnn ngccacttan ctgtatctat cagtgggaat ttgtgtcagc cttccgacaa
     3661 gcccagcgac aggagaatgc gctagcgata gtcaattcag gaatgagagt cttttttgga
     3721 gaaggggatg gcattattag agagttatgc atctcatatg gaggcgttgg tccagccacc
     3781 atctgtgcca agaattcctg ccagaaactc attggaaggt aagaaaaagt gttccattcc
     3841 tttnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnggctagg agtcttctct
     3961 ttggactttc caggcactgg aacgaacaga tgctggatat agcctgcagg cttattctga
     4021 atgaactctc ccttttgggc tcggcgccag gtgggaaagt ggagttcaag aggactctca
     4081 tcatcagctt cctcttcaag ttctacctgg aagtgtcaca gattttgaaa aagatggtaa
     4141 acaactgttt acacattaac ttcccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4261 nnnnntaaaa tatctgcaat ggttctactt ttcaggatcc agttcactat cctagccttg
     4321 cagacaagta tgaaagtgct ttagaagatc ttcattccaa acatcactgc agtacattaa
     4381 agtaccaggt gagcggtatt tcttgttttt aaaaattcnn nnnnnnnnnn nnnnnnnnnn
     4441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4501 nnnnnnnnnn nnnnnnnnca aagtatattt tggttattta ttaaacagaa tataggccca
     4561 aagcagcatc ctgaagaccc aattggccac cccatcatgc atctgtctgg tgtgaagcat
     4621 gccacggggg aggccatcta ctgtgatgac atgcctctgg tggaccagga acttttcttg
     4681 acttttgtga ctagttcaag agctcatgct aagattgtgt aagtgggaag gggctgactc
     4741 aatgggctnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnct aaggagctct
     4861 gctgtgtata tcatctaggt ctaatgatct gtcagaagct ctcagcatgc ccggtgtggt
     4921 ggacatcatg acagcagaac atcttagtga cgtcaactcc ttctgctttt ttactgaagc
     4981 tgagaaattt ctggcgacag ataaggtact gcatttttgc tttctatttg nnnnnnnnnn
     5041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn cttgacaaca aaggtctttc tgtgtcgtag
     5161 gtgttctgtg tgggtcagct tgtctgtgct gtgcttgccg attctgaggt tcaggcaaag
     5221 cgagctgcta agcgagtgaa gattgtctat caagacttgg agccgctgat actaacaatt
     5281 gaggtaatga gttctgtgga atggtggtgc cagnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5401 nnnnnnnnnn nnnagctgcc tcattcctct gttctctttc taggaaagta tacaacacaa
     5461 ctcctccttc aagccagaaa ggaaactgga atatggaaat gttgacgaag catttaaagt
     5521 ggttgatcaa attcttgaag gtaaaaagta atggaagagt aaacaaccct nnnnnnnnnn
     5581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ttttatgtat tttcctgtaa caggtgaaat
     5701 acatatggga ggtcaagaac atttttatat ggaaacccaa agcatgcttg tcgttcccaa
     5761 gggagaggat caagaaatgg atgtctacgt gtccacacag tttcccaaat atatacaggt
     5821 aacatggggc cattgtcgag acgacatgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5941 nnnnnnnnca gattaatcag aactattatt gttcacagga cattgttgcc tcaaccttga
     6001 agctcccagc taacaaggtc atgtgccatg taaggcgtgt tggtggagcg tttggaggga
     6061 aggtgttaaa aaccggaatc attgcagccg tcactgcatt tgccgcaaac aagtaagtgg
     6121 agaaaatctg ctaaaaataa agnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6241 nnttacctca cttacttttt ttctgtttta gacatggccg tgcagttcgc tgtgttctgg
     6301 aacgaggaga agacatgtta ataactggag gccgccatcc ttaccttgga aagtacaaag
     6361 tgagtacaag agggatggag gaaggatttn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6481 nnnnnnnnnt ccagcattcg atatcggttc tcttcccagg ctggattcat gaacgatggc
     6541 agaatcttgg ccctggacat ggagcattac agcaatgcag gcgcctcctt ggatgaatca
     6601 ttattcgtaa gtcttttaag gagcaagttc acattccnnn nnnnnnnnnn nnnnnnnnnn
     6661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6721 nnnnnnnnnn nnnnnnnata acatcaaatc tggatatcac caggtgatag aaatgggact
     6781 tctgaaaatg gacaatgctt acaagtttcc caatctccgc tgccggggtt gggcatgcag
     6841 aaccaacctt ccatccaaca cagcttttcg tgggtttggc tttcctcagg cagtgctgat
     6901 caccgaatct tgtatcacgg aagttgcagc caaatgtgga ctatcccctg agaaggtaat
     6961 actaaatcag cttcacagaa actagnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7081 nnnnntccca gctttaactc cttttctttc ataggtgcga atcataaaca tgtacaagga
     7141 aattgatcaa acaccctaca aacaagagat caatgccaag aacctaatcc agtgttggag
     7201 agaatgtatg gccatgtctt cctactcctt gaggaaagtt gctgtggaaa agttcaatgc
     7261 agagaattat tggaagaaga aaggactggc catggtcccc ctgaagtttc ctgttggcct
     7321 tgcgtcacgt gctgctggtc aggtgagttc tccaaacgca catgagatgc tgnnnnnnnn
     7381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnacagaaac agttttcgtc ttttctgctc
     7501 aggctgctgc cttggttcac atttatcttg atggctctgt gctggtcact cacggtggaa
     7561 ttgaaatggg gcagggggtc cacactaaaa tgattcaggt aagaatgcaa taactcgatt
     7621 gagttgggnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntt taaaaggaaa
     7741 ctctctctta aaattcaggt ggtcagccgt gaattaagaa tgccaatgtc gaatgtccac
     7801 ctgcgtggaa caagcacaga aactgtccct aatgcaaata tctctggagg ttctgtggtg
     7861 gcagatctca acggtttggc agtaaaggta acagtcactg cagtggcgtc caaatcannn
     7921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntta ggagcataat tttaatggaa
     8041 actctaggat gcctgtcaaa ctcttctaaa acgcctcgaa cccatcatca gcaagaatcc
     8101 taaaggaact tggaaagact gggtgaaatg gttctctgta ttttatttta gannnnnnnn
     8161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntgctatgc tctcttcctt cacaggcaca
     8281 gactgctttt gatgaaagca ttaacctttc agctgttgga tacttcaggt aaacacctct
     8341 gatcacatgc tatggagnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntca
     8461 cttaacaaca ctcactgttt cttccagagg ttatgagtca gacatgaact gggagaaagg
     8521 cgaaggccag cccttcgaat actttgttta tggagctgcc tgttccgagg ttgaaataga
     8581 ctgcctgacg ggggatcata aggtcagtac cggttggaaa ggtcttcaag ttnnnnnnnn
     8641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnataaacat tttaactttt ttttaatact
     8761 agaacatcag aacagacatt gtcatggatg ttggctgcag tataaatcca gccattgaca
     8821 taggccaggt acgtgtaact gatgtgtctc actttctann nnnnnnnnnn nnnnnnnnnn
     8881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8941 nnnnnnnnnn nnnnnnnngt ggaaattctt tttttgttct tgcctcagat tgaaggtgca
     9001 tttattcaag gcatgggact ttatacaata gaggaactga attattctcc ccagggcatt
     9061 ctgcacactc gtggtccaga ccaatataaa atccctgcca tctgtgacat gcccacggag
     9121 ttgcacattg ctttgttgcc tccttctcaa aactcaaata ctctttattc atctaaggta
     9181 agtaatgttc tatgggtaaa tatgcatnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9301 nnnnnnntat aatctagttg gcatgcttcc tttcaagggt ctgggagagt cgggggtgtt
     9361 cctggggtgt tccgtgtttt tcgctatcca tgacgcagtg agtgcagcac gacaggagag
     9421 aggcctgcat ggacccttga cccttaatag tccactgacc ccggagaaga ttaggatggc
     9481 ctgtgaagac aagttcacaa aaatggtacg tttgcatggt agaaaaaaaa tagtgnnnnn
     9541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntttga acatccagat ttgtttttat
     9661 tttagattcc gagagatgaa cctggatcct acgttccttg gaatgtaccc atctgaatca
     9721 aatgcaaact tctggagaaa acagagtgcc tcttcccaga tggcaatctg tcctatctct
     9781 gtgctggaag atgctagatc tgaaagacag agtttccaca gttcagaaat catcccacag
     9841 tgttgctttt ctctggagct gatttaaagt attccattta gatttgatag atatgcttaa
     9901 gcaatctata aatcattttc aatgttataa acactaattg gtttcctcta gggtgatatt
     9961 cgtcattact ctgtctcttc aatccatcca gctaaatgga ataggtgatg acttggatgt
    10021 gactcctact tggcttctat caccaacaga aattatacca tatagtgaaa ggcaattttc
    10081 taaataattt cattactaat atgaactgtg aagttgtcat tttttcattt gtccttttct
    10141 gctatcacct tcctcttgtc agaatgaata tagacacatg tatctaagtg ggaccaaaga
    10201 aaaaatagcg aactttcacc aaagttttca tgaaaaccca aaagctttaa aagttactat
    10261 caagaaattg aaaggaaacc cacagaatag gataaaatat ttgtaaatca tatttgataa
    10321 aagtcttgta accagataca taaagagctc ttacaactca ataaaaggca agtaatttaa
    10381 aaataggcaa aagaattgct ggatggtatg gtagttctat ttttagtttt taccctaact
    10441 actctgactt gatcatttaa cattctgtgt atgtaacaaa atatcacatg cataaatatt
    10501 atgtgtcaat aaaatttttt aatggg
//