LOCUS AF016833 6513 bp mRNA linear HUM 13-DEC-2001
DEFINITION Homo sapiens maltase-glucoamylase mRNA, complete cds.
ACCESSION AF016833
VERSION AF016833.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6513)
AUTHORS Nichols,B.L., Eldering,J., Avery,S., Hahn,D., Quaroni,A. and
Sterchi,E.
TITLE Human small intestinal maltase-glucoamylase cDNA cloning. Homology
to sucrase-isomaltase
JOURNAL J. Biol. Chem. 273 (5), 3076-3081 (1998)
PUBMED 9446624
REFERENCE 2 (bases 1 to 6513)
AUTHORS Nichols,B.L., Eldering,J.A., Avery,S.E., Hahn,D., Quaroni,A. and
Sterchi,E.E.
TITLE Direct Submission
JOURNAL Submitted (31-JUL-1997) Pediatrics, Baylor College of Medicine,
1100 Bates, CNRC 10066, Houston, TX 77030-2600, USA
REFERENCE 3 (bases 1 to 6513)
AUTHORS Nichols,B.L., Eldering,J.A., Avery,S.E., Hahn,D., Quaroni,A. and
Sterchi,E.E.
TITLE Direct Submission
JOURNAL Submitted (13-DEC-2001) Pediatrics, Baylor College of Medicine,
1100 Bates, CNRC 10066, Houston, TX 77030-2600, USA
REMARK Sequence update by submitter
COMMENT On Dec 13, 2001 this sequence version replaced AF016833.1.
FEATURES Location/Qualifiers
source 1..6513
/db_xref="H-InvDB:HIT000062407"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/cell_type="enterocyte"
/tissue_type="small intestine"
CDS 55..5628
/EC_number="3.2.1.20"
/EC_number="3.2.1.3"
/note="brush border hydrolase; glucosyl hydrolase;
1,4-O-alpha-D-glucanohydrolase; has similarity to
sucrase-isomaltase"
/codon_start=1
/product="maltase-glucoamylase"
/protein_id="AAC39568.2"
/translation="MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAP
DPGTTGTPDPGTTGTPDPGTTGTTHARTTGPPDPGTTGTTPVSAECPVVNELERINCI
PDQPPTKATCDQRGCCWNPQGAVSVPWCYYSKNHSYHVEGNLVNTNAGFTARLKNLPS
SPVFGSNVDNVLLTAEYQTSNRFHFKLTDQTNNRFEVPHEHVQSFSGNAAASLTYQVE
ISRQPFSIKVTRRSNNRVLFDSSIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRH
DMNWKTWPIFNRDTTPNGNGTNLYGAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPA
PAITYRTIGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDN
MREVVERNRAAQLPYDVQHADIDYMDERRDFTYDSVDFKGFPEFVNELHNNGQKLVII
VDPAISNNSSSSKPYGPYDRGSDMKIWVNSSDGVTPLIGEVWPGQTVFPDYTNPNCAV
WWTKEFELFHNQVEFDGIWIDMNEVSNFVDGSVSGCSTNNLNNPPFTPRILDGYLFCK
TLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKTVFPNKRSFILTRSTFAGSGKFAAH
WLGDNTATWDDLRWSIPGVLEFNLFGIPMVGPDICGFALDTPEELCRRWMQLGAFYPF
SRNHNGQGYKDQDPASFGADSLLLNSSRHYLNIRYTLLPYLYTLFFRAHSRGDTVARP
LLHEFYEDNSTWDVHQQFLWGPGLLITPVLDEGAEKVMAYVPDAVWYDYETGSQVRWR
KQKVEMELPGDKIGLHLRGGYIFPTQQPNTTTLASRKNPLGLIIALDENKEAKGELFW
DDGETKDTVANKVYLLCEFSVTQNRLEVNISQSTYKDPNNLAFNEIKILGTEEPSNVT
VKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLGEAYTVEWSIKIRDEEKIDCYPDENG
ASAENCTARGCIWEASNSSGVPFCYFVNDLYSVSDVQYNSHGATADISLKSSVYANAF
PSTPVNPLRLDVTYHKNEMLQFKIYDPNKNRYEVPVPLNIPSMPSSTPEGQLYDVLIK
KNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFIRISTRLPSKYLYGFGETEHRSYRRDL
EWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGVLLLNSNAMDVTFQPLPALT
YRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYQNDSEIASL
YDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALINRMKADGMRVILILDPAI
SGNETQPYPAFTRGVEDDVFIKYPNDGDIVWGKVWPDFPDVVVNGSLDWDSQVELYRA
YVAFPDFFRNSTAKWWKREIEELYNNPQNPERSLKFDGMWIDMNEPSSFVNGAVSPGC
RDASLNHPPYMPHLESRDRGLSSKTLCMESQQILPDGSLVQHYNVHNLYGWSQTRPTY
EAVQEVTGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSIIGMMEFSLFGISYT
GADICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDVAFVNISRTVLQ
TRYTLLPYLYTLMHKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLGPAFLVSPVLER
NARNVTAYFPRARWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYILPWQEPALNT
HLSRQKFMGFKIALDDEGTAGGWLFWDDGQSIDTYGKGLYYLASFSASQNTMQSHIIF
NNYITGTNPLKLGYIEIWGVGSVPVTSVSISVSGMVITPSFNNDPTTQVLSIDVTDRN
ISLHNFTSLTWISTL"
misc_feature 103..165
/note="encodes membrane anchor region"
misc_feature 166..306
/note="encodes S-T rich stalk"
misc_feature 322..444
/note="encodes trefoil domain 1"
misc_feature 1633..1650
/note="encodes catalytic site 1"
misc_feature 2950..3042
/note="encodes trefoil domain 2"
misc_feature 4306..4323
/note="encodes catalytic site 2"
BASE COUNT 1750 a 1503 c 1559 g 1701 t
ORIGIN
1 attgctaagc catccttcag acagagaggg agcggctgca agaggtaatg agagatggca
61 agaaagaagc tgaaaaaatt tactactttg gagattgtgc tcagtgttct tctgcttgtg
121 ttgtttatca tcagtattgt tctaattgtg cttttagcca aagagtcact gaaatcaaca
181 gccccagatc ctgggacaac tggtacccca gatcctggga caactggtac cccagatcct
241 ggaacaactg gtaccacaca tgctaggaca acgggtcccc cagatcctgg aacaactggt
301 accactcctg tttctgctga atgtccagtg gtaaatgaat tggaacgaat taattgcatc
361 cctgaccagc cgccaacaaa ggccacatgt gaccaacgtg gctgttgctg gaatccccag
421 ggagctgtaa gtgttccctg gtgctactat tccaagaatc atagctacca tgtagagggc
481 aaccttgtca acacaaatgc aggattcaca gcccggttga aaaatctgcc ttcttcacca
541 gtgtttggaa gcaatgttga caatgttctt ctcacagcag aatatcagac atctaatcgt
601 ttccacttta agttgactga ccaaaccaat aacaggtttg aagtgcccca cgaacacgtg
661 cagtccttca gtggaaatgc tgctgcttct ttgacctacc aagttgaaat ctccagacag
721 ccatttagca tcaaagtgac cagaagaagc aacaatcgtg ttttgtttga ctcgagcatt
781 gggcccctac tgtttgctga ccagttcttg cagctctcca ctcgactgcc tagcactaac
841 gtgtatggcc tgggagagca tgtgcaccag cagtatcggc atgatatgaa ttggaagacc
901 tggcccatat ttaacagaga cacaactccc aatggaaacg gaactaattt gtatggtgcg
961 cagacattct tcttgtgcct tgaagatgct agtggattgt cctttggggt gtttctgatg
1021 aacagcaatg ccatggaggt tgtccttcag cctgcgccag ccatcactta ccgcaccatt
1081 gggggcattc tcgacttcta tgtgttcttg ggaaacactc cagagcaagt tgttcaagaa
1141 tatctagagc tcattgggcg gccagccctt ccctcctact gggcgcttgg atttcacctc
1201 agtcgttacg aatatggaac cttagacaac atgagggaag tcgtggagag aaatcgcgca
1261 gcacagctcc cttatgatgt tcagcatgct gatattgatt atatggatga gagaagggac
1321 ttcacttatg attcagtgga ttttaaaggc ttccctgaat ttgtcaacga gttacacaat
1381 aatggacaga agcttgtcat cattgtggat ccagccatct ccaacaactc ttcctcaagt
1441 aaaccctatg gcccatatga caggggttca gatatgaaga tatgggtgaa tagttcagat
1501 ggagtgactc cactcattgg ggaggtctgg cctggacaaa ctgtgtttcc tgattatacc
1561 aatcccaact gtgctgtttg gtggacaaag gaatttgagc tttttcacaa tcaagtagag
1621 tttgatggaa tctggattga tatgaatgaa gtctccaact ttgttgatgg ttcggtctca
1681 ggatgttcca caaacaacct aaataatccc ccattcactc ccagaatcct ggatgggtac
1741 ctgttctgca agactctctg tatggatgca gtgcagcact ggggcaagca gtatgacatt
1801 cacaatctgt atggctactc catggcggtc gccacagcag aagctgccaa gactgtgttc
1861 cctaataaga gaagcttcat tctgacccgt tctacctttg cgggctctgg caagtttgca
1921 gcacattggt taggagacaa cactgccacc tgggatgacc tgagatggtc catccctggc
1981 gtgcttgagt tcaacctttt tggcatccca atggtgggtc ctgacatatg tggctttgct
2041 ttggacaccc ctgaggagct ctgtaggcgg tggatgcagt tgggtgcatt ttatccgttt
2101 tctagaaatc acaatggcca aggctacaag gaccaggatc ctgcctcctt tggagctgac
2161 tccctgctgt tgaattcctc caggcactac cttaacatcc gctatactct attgccctac
2221 ctatacaccc ttttcttccg tgctcacagc cgaggggaca cggtggccag gccccttttg
2281 catgagttct acgaggacaa cagcacttgg gatgtgcacc aacagttctt atgggggccc
2341 ggcctcctca tcactccagt tctggatgaa ggtgcagaga aagtgatggc atatgtgcct
2401 gatgctgtct ggtatgacta cgagactggg agccaagtga gatggaggaa gcaaaaagtc
2461 gagatggaac ttcctggaga caaaattgga cttcaccttc gaggaggcta catcttcccc
2521 acacagcagc caaatacaac cactctggcc agtcgaaaga accctcttgg tcttatcatt
2581 gccctagatg agaacaaaga agcaaaagga gaacttttct gggatgatgg ggaaacgaag
2641 gatactgtgg ccaataaagt gtatctttta tgtgagtttt ctgtcactca aaaccgcttg
2701 gaggtgaata tttcacaatc aacctacaag gaccccaata atttagcatt taatgagatt
2761 aaaattcttg ggacggagga acctagcaat gttacagtga aacacaatgg tgtcccaagt
2821 cagacttctc ctacagtcac ttatgattct aacctgaagg ttgccattat cacagatatt
2881 gatcttctcc tgggagaagc atacacagtg gaatggagca taaagataag ggatgaagaa
2941 aaaatagact gttaccctga tgagaatggt gcttctgccg aaaactgcac tgcccgtggc
3001 tgtatctggg aggcatccaa ttcttctgga gtcccttttt gctattttgt caacgaccta
3061 tactctgtca gtgatgttca gtataattcc catggggcca cagctgacat ctccttaaag
3121 tcttccgttt atgccaatgc cttcccctcc acacccgtga acccccttcg cctggatgtc
3181 acttaccata agaatgaaat gctgcagttc aagatttatg atcccaacaa gaatcggtat
3241 gaagttccag tccctctgaa catacccagc atgccatcca gcacccctga gggtcaactc
3301 tatgatgtgc tcattaagaa gaatccattt gggattgaaa ttcgccggaa gagtacaggc
3361 actataattt gggactctca gctccttggc tttaccttca gtgacatgtt tatccgcatc
3421 tccacccgcc ttccctccaa gtacctctat ggctttgggg aaactgagca caggtcctat
3481 aggagagact tggagtggca cacttggggg atgttctccc gagaccagcc cccagggtac
3541 aagaagaatt cctatggtgt ccacccctac tacatggggc tggaggagga cggcagtgcc
3601 catggagtgc tcctgctgaa cagcaatgcc atggatgtga cgttccagcc cctgcctgcc
3661 ttgacatacc gcaccacagg gggagttctg gacttttatg tgttcttggg gccgactcca
3721 gagcttgtca cccagcagta cactgagttg attggccggc ctgtgatggt accttactgg
3781 tctttggggt tccagctgtg tcgctatggc taccagaatg actctgagat cgccagcttg
3841 tatgatgaga tggtggctgc ccagatccct tatgatgtgc agtactcaga catcgactac
3901 atggagcggc agctggactt caccctcagc cccaagtttg ctgggtttcc agctctgatc
3961 aatcgcatga aggctgatgg gatgcgggtc atcctcattc tggatccagc catttctggc
4021 aatgagacac agccttatcc tgccttcact cggggcgtgg aggatgacgt cttcatcaaa
4081 tacccaaatg atggagacat tgtctgggga aaggtctggc ctgattttcc tgatgttgtt
4141 gtgaatgggt ctctagactg ggacagccaa gtggagctat atcgagctta tgtggccttc
4201 ccagactttt tccgtaattc aactgccaag tggtggaaga gggaaataga agaactatac
4261 aacaatccac agaatccaga gaggagcttg aagtttgatg gcatgtggat tgatatgaat
4321 gaaccatcaa gcttcgtgaa tggggcagtt tctccaggct gcagggacgc ctctctgaac
4381 caccctccct acatgccaca tttggagtcc agggacaggg gcctgagcag caagaccctt
4441 tgtatggaga gtcagcagat cctcccagac ggctccctgg tgcagcacta caacgtgcac
4501 aacctgtatg ggtggtccca gaccagaccc acatacgaag ccgtgcagga ggtgacggga
4561 cagcgagggg tcgtcatcac ccgctccaca tttccctctt ctggccgctg ggcaggacat
4621 tggctgggag acaacacggc cgcatgggat cagctgaaga agtctatcat tggcatgatg
4681 gagttcagcc tcttcggcat atcctatacg ggagcagata tctgtgggtt ctttcaagat
4741 gctgaatatg agatgtgtgt tcgctggatg cagctggggg ccttttaccc cttctcaaga
4801 aaccacaaca ccattgggac caggagacaa gaccctgtgt cctgggatgt tgcttttgtg
4861 aatatttcca gaactgtcct gcagaccaga tacaccctgt tgccatatct gtataccttg
4921 atgcataagg cccacacgga gggcgtcact gttgtgcggc ctctgctcca tgaatttgtg
4981 tcagaccagg tgacatggga catagacagt cagttcctgc tgggcccagc cttcctggtc
5041 agccctgtcc tggagcgtaa tgccagaaat gtcactgcat atttccctag agcccgctgg
5101 tatgattact acacgggtgt ggatattaat gcaagaggag agtggaagac cttgccagcc
5161 cctcttgacc acattaatct tcatgtccgt gggggctaca tcctgccctg gcaagagcct
5221 gcactgaaca cccacttaag ccgccagaaa ttcatgggct tcaaaattgc cttggatgat
5281 gaaggaactg ctgggggctg gctcttctgg gatgatgggc aaagcattga tacctatggg
5341 aaaggactct attacttggc cagcttttct gccagccaga atacgatgca aagccatata
5401 attttcaaca attacatcac tggtacaaat cctttgaaac tgggctacat tgaaatctgg
5461 ggagtgggca gtgtccccgt taccagtgtc agcatctctg tgagtggcat ggtcataaca
5521 ccctccttca acaatgaccc cacgacacag gtattaagca tcgatgtgac tgacagaaac
5581 atcagcctac ataattttac ttcattgacg tggataagca ctctgtgaat ttttacagca
5641 agattctaac taactatgaa tgactttgaa actacttata cttcatactc ataaaaatta
5701 ttgtgtgttg ctaatttgtt catacccact attggtgaaa tatttctgtt aattttgtta
5761 tatgtttttt gtgtgaaccc taaaggttaa accttagccc tgtgggatag gcagttaggg
5821 aggtgtggaa aatctatgca ttaccttaat gtctctgtgt ggttagtatg gtagtgactg
5881 ttcatcatat gacatttact gaagatgaac tgggtccatg atgaagtgtg tgtatgtcca
5941 cgtttgtaat catagaatgg accccattct tttgttaaat acacaagaga aagctttctg
6001 tgacagttcc aggtcttgaa gctaatcagc atctcaagaa agtatccaga aagaacatct
6061 gctagttggt tataggcggt gggaggaata atatacctaa ttggttatag gtggggggag
6121 catgataagc aaagaaaagg caaacacaag gaaagatcag atgaaacaga agatgatagt
6181 aaaagtgatc ctaagtaaga acataatgta aaattgtcag cagcctcatg gggaggaaaa
6241 aggaagagtc aactcacttg aagaagaggg tcttgagaaa tccttagcat aaagggctac
6301 tggtgagatt gagatctgag caggcaaagc tcaaaagaga gtttggaggt taaaaataat
6361 ttatttttgc agtagtgtgc tttgaaatgt gtaaatctta tttctaatgt atacaaccac
6421 atttcacata aaaatatgca atttatatgc cagataaaaa taaaacaagt gaatttgcaa
6481 gtgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//