LOCUS AF015041 2823 bp mRNA linear HUM 14-DEC-2016
DEFINITION Homo sapiens NUMB-R protein (NUMB-R) mRNA, complete cds.
ACCESSION AF015041
VERSION AF015041.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2823)
AUTHORS Wong,W.T., Schumacher,C., Salcini,A.E., Romano,A., Castagnino,P.,
Pelicci,P.G. and Di Fiore,P.
TITLE A protein-binding domain, EH, identified in the receptor tyrosine
kinase substrate Eps15 and conserved in evolution
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (21), 9530-9534 (1995)
PUBMED 7568168
REFERENCE 2 (bases 1 to 2823)
AUTHORS Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E.,
Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P.
TITLE Binding specificity and in vivo targets of the EH domain, a novel
protein-protein interaction module
JOURNAL Genes Dev. 11 (17), 2239-2249 (1997)
PUBMED 9303539
REFERENCE 3 (bases 1 to 2823)
AUTHORS Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E.,
Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P.
TITLE Direct Submission
JOURNAL Submitted (21-JUL-1997) Experimental Oncology, European Institute
of Oncology, Via Ripamonti 435, Milan 20141, Italy
REFERENCE 4 (bases 1 to 2823)
AUTHORS Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E.,
Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P.
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2016) Experimental Oncology, European Institute
of Oncology, Via Ripamonti 435, Milan 20141, Italy
REMARK Sequence update by database staff to remove vector contamination
COMMENT On Dec 14, 2016 this sequence version replaced AF015041.1.
FEATURES Location/Qualifiers
source 1..2823
/db_xref="H-InvDB:HIT000062300"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..2823
/gene="NUMB-R"
CDS 180..2009
/gene="NUMB-R"
/note="similar to human NUMB"
/codon_start=1
/product="NUMB-R protein"
/protein_id="AAD01549.1"
/translation="MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNK
LRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDA
VKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYI
CRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTS
FAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGE
AGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTL
QRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWG
EPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASV
APVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVV
GITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEP
APAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL"
BASE COUNT 569 a 968 c 826 g 460 t
ORIGIN
1 gatccgtcga cggccattac caatcgcgaa accgctcgcg cgcgtgcatc ccgcaccatc
61 ccccggcccc gggccctggc cggcgtcaga ccgagctgcc gccgccacca ccgcagcagc
121 agcagtcggg gagccaggcc cagccagggc cgcgggaggc gggggcgccc gggccctgga
181 tgtcccgcag cgcggcggcc agcggcggac cccggaggcc tgagcggcac ctgcccccag
241 ccccctgtgg ggccccgggg cccccagaaa cctgcaggac ggagccagac ggggcgggca
301 ccatgaacaa gttacggcag agcctgcggc ggaggaagcc agcctacgtg cccgaggcgt
361 cgcgcccgca ccagtggcag gcagacgagg acgcggtgcg gaagggcacg tgcagcttcc
421 cggtcaggta cctgggtcac gtggaggtag aggagtcccg gggaatgcac gtgtgtgaag
481 atgcggtgaa gaagctgaag gcgatgggcc gaaagtccgt gaagtctgtc ctgtgggtgt
541 cagccgatgg gctccgagtg gtggacgaca aaaccaagga tcttctggtc gaccagacca
601 tcgaaaaggt ctccttttgt gctcctgacc gcaacctgga caaggctttc tcctatatct
661 gtcgtgacgg gactacccgc cgctggatct gccactgttt tctggcactg aaggactccg
721 gcgagaggct gagccacgct gtgggctgtg cttttgccgc ctgcctggag cgaaaacagc
781 gacgggagaa ggaatgtggg gtcacggccg ccttcgatgc cagccgcacc agcttcgccc
841 gcgagggctc cttccgcctg tctgggggtg ggcggcctgc tgagcgagag gccccggaca
901 agaagaaagc agaggcagca gctgccccca ctgtggctcc tggccctgcc cagcctgggc
961 acgtgtcccc gacaccagcc accacatccc ctggtgagaa gggtgaggca ggcacccctg
1021 tggctgcagg caccactgcg gccgccatcc cccggcgcca tgcacccctg gagcagctgg
1081 ttcgccaggg ctccttccgt gggttcccag cactcagcca gaagaactcg cctttcaaac
1141 ggcagctgag cctacggctg aatgagctgc catccacgct gcagcgccgc actgacttcc
1201 aggtgaaggg cacagtgcct gagatggagc ctcctggtgc cggcgacagt gacagcatca
1261 acgctctgtg cacacagatc agttcatctt ttgccagtgc tggagcgcca gcaccagggc
1321 caccacctgc cacaacaggg acttctgcct ggggtgagcc ctccgtgccc cctgcagctg
1381 ccttccagcc tgggcacaag cggacacctt cagaggctga gcgatggctg gaggaggtgt
1441 cacaggtggc caaggcccag cagcagcagc agcagcaaca gcaacagcag cagcagcagc
1501 agcagcaaca gcagcaagca gcctcagtgg ccccagtgcc caccatgcct cctgccctgc
1561 agcctttccc cgcccccgtg gggccctttg acgctgcacc tgcccaagtg gccgtgttcc
1621 tgccaccccc acacatgcag cccccttttg tgcccgccta cccgggcttg ggctacccac
1681 cgatgccccg ggtgcccgtg gtgggcatca caccctcaca gatggtggca aacgccttct
1741 gctcagccgc ccagctccag cctcagcctg ccactctgct tgggaaagct ggggccttcc
1801 cgccccctgc catacccagt gcccctggga gccaggcccg ccctcgcccc aatggggccc
1861 cctggccccc tgagccagcg cctgccccag ctccagagtt ggaccccttt gaggcccagt
1921 gggcggcatt agaaggcaaa gccactgtag agaaaccctc caaccccttt tctggtgacc
1981 tgcaaaagac attcgagatt gaactgtagt ccgagccgcc ccacccactc catcatctcc
2041 aggtgcccca cgcctggggg tggaggcaca acctctcccc taaccctgct ccctggggct
2101 gcgcccctca acaccctctc aacacccccc tccctcaacc accccgacaa ccactacaga
2161 accaacattg tgacgcccag gttgcaacag gatggaattc agggacggac ccagcctggc
2221 taagggaacc atttcactgc cggacttagg ctggcaatgc ccccttcccc aaccccagac
2281 acaggggttg gccacaatcc cactgaatgc ccttggttca cactccattt cccagtttct
2341 gttgaccccc accttccagt gttggacagg atggaggggg gacacttgct taggggctct
2401 cctgggcccc acaccagtgc ccaccccaaa tctggtcgtc tcctcccccc atgcacagca
2461 caagctaagg gctgccctct gaccacacgc tgcgttcact gccaatgctg tactcacctc
2521 catcaccctc caactttggg gcccatgtct tccttgggcc aaggtctcat gggggctagc
2581 gccaagttgg gggcccagga ggcggggagg gaggaggagg agaagatgcg cagttacctc
2641 atgtcggtgc ccgctgggga ggggtccggg aagaagggga aggggtgcct ggcgggtact
2701 tttctatctt ttatttccag attttttttg tatctaaact tgaagatttg tattatacaa
2761 ggacagccaa taaaggaaga atataaaaaa aaaaaaaaaa aaaaaaaaaa aaaaacaaaa
2821 aaa
//