LOCUS       AF015040                2995 bp    mRNA    linear   HUM 14-JUN-1999
DEFINITION  Homo sapiens NUMB protein (NUMB) mRNA, complete cds.
ACCESSION   AF015040
VERSION     AF015040.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2995)
  AUTHORS   Wong,W.T., Schumacher,C., Salcini,A.E., Romano,A., Castagnino,P.,
            Pelicci,P.G. and Di Fiore,P.
  TITLE     A protein-binding domain, EH, identified in the receptor tyrosine
            kinase substrate Eps15 and conserved in evolution
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (21), 9530-9534 (1995)
   PUBMED   7568168
REFERENCE   2  (bases 1 to 2995)
  AUTHORS   Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E.,
            Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Binding specificity and in vivo targets of the EH domain, a novel
            protein-protein interaction module
  JOURNAL   Genes Dev. 11 (17), 2239-2249 (1997)
   PUBMED   9303539
REFERENCE   3  (bases 1 to 2995)
  AUTHORS   Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E.,
            Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-JUL-1997) Experimental Oncology, European Institute
            of Oncology, Via Ripamonti 435, Milan 20141, Italy
FEATURES             Location/Qualifiers
     source          1..2995
                     /db_xref="H-InvDB:HIT000062299"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..2995
                     /gene="NUMB"
     CDS             279..2090
                     /gene="NUMB"
                     /note="similar to Drosophila NUMB"
                     /codon_start=1
                     /product="NUMB protein"
                     /protein_id="AAD01548.1"
                     /translation="MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYL
                     GHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKT
                     KDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGC
                     AFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKK
                     AETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGS
                     FRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQI
                     TNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQGTEWGQSSGAASPGLFQAGHRRTPSEA
                     DRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVV
                     PALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSL
                     VRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVD
                     PFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL"
BASE COUNT          837 a          733 c          696 g          729 t
ORIGIN      
        1 ccgaggtaga ggcagtggcg cttgagttgg tcgggggcag cggcagattt gaggcttaag
       61 caacttcttc cggggaagag tgccagtgca gccactgtta caattcaaga tcttgatcta
      121 tatccataga ttggaatatt ggtgggccag caatcctcag acgcctcact taggacaaat
      181 gaggaaactg aggcttggtg aagttacgaa acttgtccaa aatcacacaa cttgtaaagg
      241 gcacagccaa gattcagagc caggctgtaa aaattaaaat gaacaaatta cggcaaagtt
      301 ttaggagaaa gaaggatgtt tatgttccag aggccagtcg tccacatcag tggcagacag
      361 atgaagaagg cgttcgcacc ggaaaatgta gcttcccggt taagtacctt ggccatgtag
      421 aagttgatga atcaagagga atgcacatct gtgaagatgc tgtaaaaaga ttgaaagctg
      481 aaaggaagtt cttcaaaggc ttctttggaa aaactggaaa gaaagcagtt aaagcagttc
      541 tgtgggtctc agcagatgga ctcagagttg tggatgaaaa aactaaggac ctcatagttg
      601 accagacgat agagaaagtt tctttctgtg ccccagacag gaactttgat agagcctttt
      661 cttacatatg ccgtgatggc accactcgtc gctggatctg tcactgcttc atggctgtca
      721 aggacacagg tgaaaggttg agccatgcag taggctgtgc ttttgcagcc tgtttagagc
      781 gcaagcagaa gcgggagaag gaatgtggag tgactgctac ttttgatgct agtcggacca
      841 cttttacaag agaaggatca ttccgtgtca caacagccac tgaacaagca gaaagagagg
      901 agatcatgaa acaaatgcaa gatgccaaga aagctgaaac agataagata gtcgttggtt
      961 catcagttgc ccctggcaac actgccccat ccccatcctc tcccacctct cctacttctg
     1021 atgccacgac ctctctggag atgaacaatc ctcatgccat cccacgccgg catgctccaa
     1081 ttgaacagct tgctcgccaa ggctctttcc gaggttttcc tgctcttagc cagaagatgt
     1141 caccctttaa acgccaacta tccctacgca tcaatgagtt gccttccact atgcagagga
     1201 agactgattt ccccattaaa aatgcagtgc cagaagtaga aggggaggca gagagcatca
     1261 gctccctgtg ctcacagatc accaatgcct tcagcacacc tgaggacccc ttctcatctg
     1321 ctccgatgac caaaccagtg acagtggtgg caccacaatc tcctaccttc caagggaccg
     1381 agtggggtca atcttctggt gctgcctctc caggtctctt ccaggccggt catagacgta
     1441 ctccctctga ggccgaccga tggttagaag aggtgtctaa gagcgtccgg gctcagcagc
     1501 cccaggcctc agctgctcct ctgcagccag ttctccagcc tcctccaccc actgccatct
     1561 cccagccagc atcacctttc caagggaatg cattcctcac ctctcagcct gtgccagtgg
     1621 gtgtggtccc agccctgcaa ccagcctttg tccctgccca gtcctatcct gtggccaatg
     1681 gaatgcccta tccagcccct aatgtgcctg tggtgggcat cactccctcc cagatggtgg
     1741 ccaacgtatt tggcactgca ggccaccctc aggctgccca tccccatcag tcacccagcc
     1801 tggtcaggca gcagacattc cctcactacg aggcaagcag tgctaccacc agtcccttct
     1861 ttaagcctcc tgctcagcac ctcaacggtt ctgcagcttt caatggtgta gatgatggca
     1921 ggttggcctc agcagacagg catacagagg ttcctacagg cacctgccca gtggatcctt
     1981 ttgaagccca gtgggctgca ttagaaaata agtccaagca gcgtactaat ccctccccta
     2041 ccaacccttt ctccagtgac ttacagaaga cgtttgaaat tgaactttaa gcaatcatta
     2101 tggctatgta tcttgtccat accagacagg gagcaggggg tagcggtcaa aggagcaaaa
     2161 cagactttgt gtcctgatta gtactctttt cactaatccc aaaggtccca aggaacaagt
     2221 ccaggcccag agtactgtga ggggtgattt tgaaagacat gggaaaaagc attcctagag
     2281 aaaagctgcc ttgcaattag gctaaagaag tcaaggaaat gttgctttct gtactccctc
     2341 ttcccttacc cccttacaaa tctctggcaa cagagaggca aagtatctga acaagaatct
     2401 atattccaag cacatttact gaaatgtaaa acacaacagg aagcaaagca atctcccttt
     2461 gtttttcagg ccattcacct gcctcctgtc agtagtggcc tgtattagag atcaagaaga
     2521 gtggtttgtg ctcaggctgg ggaacagaga ggcacgctat gctgccagaa ttcccaggag
     2581 ggcatatcag caactgccca gcagagctat attttggggg agaagttgag cttccatttt
     2641 gagtaacaga ataaatatta tatatatcaa aagccaaaat ctttattttt atgcatttag
     2701 aatattttaa atagttctca gatattaaga agttgtatga gttgtaagta atcttgccaa
     2761 aggtaaaggg gctagttgta agaaattgta cataagattg atttatcatt gatgcctact
     2821 gaaataaaaa gaggaaaggc tggaagctgc agacaggatc cctagcttgt tttctgtcag
     2881 tcattcattg taagtagcac attgcaacaa caatcatgct tatgaccaat acagtcacta
     2941 ggttgtagtt ttttttaaat aaaggaaaag cagtattgtc ctggttttaa accta
//