LOCUS AF015040 2995 bp mRNA linear HUM 14-JUN-1999 DEFINITION Homo sapiens NUMB protein (NUMB) mRNA, complete cds. ACCESSION AF015040 VERSION AF015040.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2995) AUTHORS Wong,W.T., Schumacher,C., Salcini,A.E., Romano,A., Castagnino,P., Pelicci,P.G. and Di Fiore,P. TITLE A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (21), 9530-9534 (1995) PUBMED 7568168 REFERENCE 2 (bases 1 to 2995) AUTHORS Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E., Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P. TITLE Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module JOURNAL Genes Dev. 11 (17), 2239-2249 (1997) PUBMED 9303539 REFERENCE 3 (bases 1 to 2995) AUTHORS Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E., Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P. TITLE Direct Submission JOURNAL Submitted (21-JUL-1997) Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, Milan 20141, Italy FEATURES Location/Qualifiers source 1..2995 /db_xref="H-InvDB:HIT000062299" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" gene 1..2995 /gene="NUMB" CDS 279..2090 /gene="NUMB" /note="similar to Drosophila NUMB" /codon_start=1 /product="NUMB protein" /protein_id="AAD01548.1" /translation="MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYL GHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKT KDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGC AFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKK AETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGS FRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQI TNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQGTEWGQSSGAASPGLFQAGHRRTPSEA DRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVV PALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSL VRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVD PFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL" BASE COUNT 837 a 733 c 696 g 729 t ORIGIN 1 ccgaggtaga ggcagtggcg cttgagttgg tcgggggcag cggcagattt gaggcttaag 61 caacttcttc cggggaagag tgccagtgca gccactgtta caattcaaga tcttgatcta 121 tatccataga ttggaatatt ggtgggccag caatcctcag acgcctcact taggacaaat 181 gaggaaactg aggcttggtg aagttacgaa acttgtccaa aatcacacaa cttgtaaagg 241 gcacagccaa gattcagagc caggctgtaa aaattaaaat gaacaaatta cggcaaagtt 301 ttaggagaaa gaaggatgtt tatgttccag aggccagtcg tccacatcag tggcagacag 361 atgaagaagg cgttcgcacc ggaaaatgta gcttcccggt taagtacctt ggccatgtag 421 aagttgatga atcaagagga atgcacatct gtgaagatgc tgtaaaaaga ttgaaagctg 481 aaaggaagtt cttcaaaggc ttctttggaa aaactggaaa gaaagcagtt aaagcagttc 541 tgtgggtctc agcagatgga ctcagagttg tggatgaaaa aactaaggac ctcatagttg 601 accagacgat agagaaagtt tctttctgtg ccccagacag gaactttgat agagcctttt 661 cttacatatg ccgtgatggc accactcgtc gctggatctg tcactgcttc atggctgtca 721 aggacacagg tgaaaggttg agccatgcag taggctgtgc ttttgcagcc tgtttagagc 781 gcaagcagaa gcgggagaag gaatgtggag tgactgctac ttttgatgct agtcggacca 841 cttttacaag agaaggatca ttccgtgtca caacagccac tgaacaagca gaaagagagg 901 agatcatgaa acaaatgcaa gatgccaaga aagctgaaac agataagata gtcgttggtt 961 catcagttgc ccctggcaac actgccccat ccccatcctc tcccacctct cctacttctg 1021 atgccacgac ctctctggag atgaacaatc ctcatgccat cccacgccgg catgctccaa 1081 ttgaacagct tgctcgccaa ggctctttcc gaggttttcc tgctcttagc cagaagatgt 1141 caccctttaa acgccaacta tccctacgca tcaatgagtt gccttccact atgcagagga 1201 agactgattt ccccattaaa aatgcagtgc cagaagtaga aggggaggca gagagcatca 1261 gctccctgtg ctcacagatc accaatgcct tcagcacacc tgaggacccc ttctcatctg 1321 ctccgatgac caaaccagtg acagtggtgg caccacaatc tcctaccttc caagggaccg 1381 agtggggtca atcttctggt gctgcctctc caggtctctt ccaggccggt catagacgta 1441 ctccctctga ggccgaccga tggttagaag aggtgtctaa gagcgtccgg gctcagcagc 1501 cccaggcctc agctgctcct ctgcagccag ttctccagcc tcctccaccc actgccatct 1561 cccagccagc atcacctttc caagggaatg cattcctcac ctctcagcct gtgccagtgg 1621 gtgtggtccc agccctgcaa ccagcctttg tccctgccca gtcctatcct gtggccaatg 1681 gaatgcccta tccagcccct aatgtgcctg tggtgggcat cactccctcc cagatggtgg 1741 ccaacgtatt tggcactgca ggccaccctc aggctgccca tccccatcag tcacccagcc 1801 tggtcaggca gcagacattc cctcactacg aggcaagcag tgctaccacc agtcccttct 1861 ttaagcctcc tgctcagcac ctcaacggtt ctgcagcttt caatggtgta gatgatggca 1921 ggttggcctc agcagacagg catacagagg ttcctacagg cacctgccca gtggatcctt 1981 ttgaagccca gtgggctgca ttagaaaata agtccaagca gcgtactaat ccctccccta 2041 ccaacccttt ctccagtgac ttacagaaga cgtttgaaat tgaactttaa gcaatcatta 2101 tggctatgta tcttgtccat accagacagg gagcaggggg tagcggtcaa aggagcaaaa 2161 cagactttgt gtcctgatta gtactctttt cactaatccc aaaggtccca aggaacaagt 2221 ccaggcccag agtactgtga ggggtgattt tgaaagacat gggaaaaagc attcctagag 2281 aaaagctgcc ttgcaattag gctaaagaag tcaaggaaat gttgctttct gtactccctc 2341 ttcccttacc cccttacaaa tctctggcaa cagagaggca aagtatctga acaagaatct 2401 atattccaag cacatttact gaaatgtaaa acacaacagg aagcaaagca atctcccttt 2461 gtttttcagg ccattcacct gcctcctgtc agtagtggcc tgtattagag atcaagaaga 2521 gtggtttgtg ctcaggctgg ggaacagaga ggcacgctat gctgccagaa ttcccaggag 2581 ggcatatcag caactgccca gcagagctat attttggggg agaagttgag cttccatttt 2641 gagtaacaga ataaatatta tatatatcaa aagccaaaat ctttattttt atgcatttag 2701 aatattttaa atagttctca gatattaaga agttgtatga gttgtaagta atcttgccaa 2761 aggtaaaggg gctagttgta agaaattgta cataagattg atttatcatt gatgcctact 2821 gaaataaaaa gaggaaaggc tggaagctgc agacaggatc cctagcttgt tttctgtcag 2881 tcattcattg taagtagcac attgcaacaa caatcatgct tatgaccaat acagtcacta 2941 ggttgtagtt ttttttaaat aaaggaaaag cagtattgtc ctggttttaa accta //