LOCUS AF013956 1867 bp mRNA linear HUM 09-OCT-1997
DEFINITION Homo sapiens Polycomb 2 homolog (hPc2) mRNA, complete cds.
ACCESSION AF013956
VERSION AF013956.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1867)
AUTHORS Satijn,D.P., Olson,D.J., van der Vlag,J., Hamer,K.M.,
Lambrechts,C., Masselink,H., Gunster,M.J., Sewalt,R.G., van
Driel,R. and Otte,A.P.
TITLE Interference with the expression of a novel human polycomb protein,
hPc2, results in cellular transformation and apoptosis
JOURNAL Mol. Cell. Biol. 17 (10), 6076-6086 (1997)
PUBMED 9315667
REFERENCE 2 (bases 1 to 1867)
AUTHORS Satijn,D.P.E., Olson,D.J., Van der Vlag,J., Hamer,C.M.,
Lambrechts,A.C., Masselink,H., Gunster,M.J., Sewalt,R.G.A.B., Van
Driel,R. and Otte,A.P.
TITLE Direct Submission
JOURNAL Submitted (14-JUL-1997) Biochemistry, E.C.Slater, Plantage
Muidergracht 12, Amsterdam 1018 TV, The Netherlands
FEATURES Location/Qualifiers
source 1..1867
/db_xref="H-InvDB:HIT000062276"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1867
/gene="hPc2"
CDS 167..1843
/gene="hPc2"
/function="repressor of gene activity"
/note="chromatin associated protein"
/codon_start=1
/product="Polycomb 2 homolog"
/protein_id="AAB80718.1"
/translation="MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEP
EENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTD
NRAKLDLGAQGKGQGHQYELNSKKHHQYQPHSKEGKPRPPGKSGKYYYQLNSKKHHPY
QPDPKMYDLQYQGGHKEAPSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGA
PGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVK
IKSGEVAEGEARSPSHKKRAADERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVS
DPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHH
HHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLP
PAAALRQPEVILLDSDLDEPIDLRSVKSRSEAGEPPSSLQVKPETPASAAVAVAAAAA
PTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV"
BASE COUNT 400 a 626 c 635 g 206 t
ORIGIN
1 gggcgagcgc gacgcgggag ccggggcggc gcgggcagcg cgggccggcc gggctgtgcg
61 gggcgagcgg cggcgcggcg ggggccttcg gccggggcgg cagctgggcg ccggcgggag
121 ctagcagcgt ctgcagccgc gcccggccag ccccctccgg ctcggcatgg agctgccagc
181 tgttggcgag cacgtcttcg cggtggagag catcgagaag aagcggatcc gcaagggcag
241 agtggagtat ctggtgaaat ggagaggctg gtcgcccaaa tataacacgt gggaaccgga
301 ggagaacatc ctggacccca ggctgctgat cgccttccag aacagggaac ggcaggagca
361 gctgatggga tatcggaaga gagggccgaa gcccaaaccg ctagtggtgc aggtgcctac
421 ctttgcccgt cgttccaatg tcctgaccgg cctccaggac tcctccactg acaaccgtgc
481 caagctggat ttgggcgcgc aggggaaggg ccaggggcat cagtacgagc tcaacagcaa
541 gaagcaccac cagtaccagc cgcacagcaa ggaggggaag ccccggccgc cgggcaagag
601 cggcaagtac tactaccagc tcaacagcaa gaagcaccac ccctaccagc ccgaccccaa
661 aatgtacgac ctgcagtacc agggcggcca caaggaggcg cccagcccca cctgcccgga
721 cctgggggcc aagagccacc cgcccgacaa gtgggcgcaa ggtgcggggg ccaaaggcta
781 cctgggggcg gtgaagcccc tggccggtgc ggcgggtgct ccaggcaaag gctccgagaa
841 gggccccccc aacggaatga tgccggcccc caaagaggct gtgacgggca acgggattgg
901 gggcaagatg aagatagtca agaacaagaa caagaacgga cgcatcgtga tcgtgatgag
961 caaatacatg gagaacggca tgcaggcggt gaagatcaag tccggcgagg tggcagaggg
1021 ggaggctcgc tcccccagcc acaagaagcg ggcagccgac gagcgccacc ctcctgccga
1081 caggactttt aaaaaggcgg cgggcgcaga ggagaagaag gtggaggcgc cgcccaagag
1141 gagggaggag gaggtgtccg gggttagcga tccgcagccc caggatgccg gctcccgcaa
1201 gctgtccccg accaaggagg cctttggaga gcagcccctg cagctcacca ccaagcccga
1261 cctgcttgcc tgggacccgg cccggaacac gcacccgccc tcacaccacc cgcacccgca
1321 cccccatcac caccaccacc accaccacca ccaccaccac gccgtcggcc tgaatctctc
1381 ccacgtgcgc aagcgctgcc tctccgagac ccacggcgag cgcgagccct gcaagaagcg
1441 gctgactgcg cgcagcatca gcacccccac ctgcctgggg ggcagcccag ccgctgagcg
1501 cccggccgac ctgccaccag ccgccgccct ccggcagccc gaggtcatcc tgctagactc
1561 agacctggat gaacccatag acttgcgctc ggtcaagagc cgcagcgagg ccggggagcc
1621 gcccagctcc ctccaggtga agcccgagac accggcgtcg gcggcggtgg cggtggcggc
1681 ggcagcggca cccaccacga cggcggagaa gcctccagcc gaggcccagg acgaacctgc
1741 agagtcgctg agcgagttca agcccttctt tgggaatata attatcaccg acgtcaccgc
1801 gaactgcctc accgttactt tcaaggagta cgtgacggtg tagccggagg gcgtcggaag
1861 gggcgcc
//