LOCUS AF013717 6154 bp mRNA linear HUM 27-MAR-1998
DEFINITION Homo sapiens periplakin (PPL) mRNA, partial cds.
ACCESSION AF013717
VERSION AF013717.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6154)
AUTHORS Aho,S., McLean,W.H., Li,K. and Uitto,J.
TITLE cDNA cloning, mRNA expression, and chromosomal mapping of human and
mouse periplakin genes
JOURNAL Genomics 48 (2), 242-247 (1998)
PUBMED 9521878
REFERENCE 2 (bases 1 to 6154)
AUTHORS McLean,W.H.I.
TITLE Direct Submission
JOURNAL Submitted (14-JUL-1997) Dermatology, Jefferson Medical College, 233
South 10th Street, Philadelphia, PA 19107, USA
FEATURES Location/Qualifiers
source 1..6154
/db_xref="H-InvDB:HIT000062273"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16p13"
/map="between D16S509 and D16S510"
/cell_type="epidermal keratinocyte"
gene 1..6154
/gene="PPL"
CDS 12..5282
/gene="PPL"
/note="epithelial cell junction protein; member of the
plakin family; similar to envoplakin"
/codon_start=1
/product="periplakin"
/protein_id="AAC39668.1"
/translation="MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKN
IVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDM
IAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPL
VDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDY
MQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSE
GDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQE
LLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLK
YRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCF
VIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLL
AGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRS
TAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQS
WELLATHENHLNQDDTVPESSRVLDSKGQELAPMACELQAQKSLLGEVEQNLQAAKQC
SSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD
HVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAV
KDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQR
LQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVK
STQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELE
ALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAE
VLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQE
EELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARA
SQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRG
AEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLI
ERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQK
KQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVE
LRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAE
AREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAE
VKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNS
KSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDS
RLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRE
LSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQ
SGRLTPAQYDRYVNKDMSIQELAVLVSGQK"
BASE COUNT 1592 a 1633 c 2005 g 924 t
ORIGIN
1 cgagcgccac catgaactcg ctcttcagga agagaaacaa aggcaaatac agccccactg
61 tgcagacccg gagcatctct aacaaggagc tctcggagct gatcgagcag ctgcagaaga
121 atgccgacca ggtggagaag aacatcgtgg acacagaggc caagatgcag agtgacctgg
181 ctcggctgca ggagggtcgg cagcctgagc accgggacgt gaccctgcag aaggtgttgg
241 actctgagaa gctgctctat gtgctagagg cggatgcggc cattgccaag cacatgaagc
301 acccacaggg ggacatgatc gccgaggata tccgccagct gaaggagcgt gtgaccaacc
361 tgcgcgggaa acacaagcag atctacaggc tggcggtgaa ggaagtggat ccacaggtca
421 actgggcggc actggtggag gagaagctgg acaagctgaa caaccagagc tttgggactg
481 acctgccgct ggtggaccac caagtggagg agcataacat cttccacaat gaggtcaagg
541 ccatcgggcc ccacctggcc aaggacgggg acaaggagca gaacagcgaa ctccgggcca
601 agtaccagaa actgctggca gcatcacagg cccggcagca gcacctgagt tcgctgcagg
661 actacatgca gcgctgcacc aatgagctgt actggctgga ccagcaggcc aagggccgca
721 tgcagtacga ctggagtgac cgcaacctcg actaccccag ccgccggcgc cagtatgaga
781 atttcatcaa ccggaacctg gaggccaaag aggagagaat caacaaactg cacagcgagg
841 gcgaccagct gctggcggcc gagcaccccg ggaggaactc cattgaggcg cacatggagg
901 ctgtgcacgc agactggaag gagtacctga acctgctcat ctgcgaggag agccacctca
961 agtacatgga ggactaccac cagtttcacg aagacgtgaa ggacgctcag gagctgctgc
1021 gcaaggtgga ctcggacctg aaccagaagt atggccctga cttcaaggac cggtaccaga
1081 ttgagctgct gctgcgggag ctggatgacc aggagaaggt gctggacaag tatgaggacg
1141 tggtgcaggg gctgcagaag cgaggccagc aggtggtgcc cctcaagtac cgccgggaga
1201 ctccgctcaa gcccatcccc gtggaggcac tctgtgactt tgagggggag cagggcctga
1261 tctcgcgggg ctacagctac accctgcaga agaacaacgg ggagagctgg gagctcatgg
1321 acagcgctgg gaacaagctg attgctccgg ccgtctgttt tgtgatcccc cccacagacc
1381 ctgaggccct ggctctggct gacagcctgg gcagccagta ccggagcgtg cggcagaagg
1441 cagctgggag caaacgcacg ctgcagcagc ggtatgaggt gctgaagacc gagaatcccg
1501 gagatgcctc tgacctacag gggcggcagc tgctggctgg cttggacaag gtggccagcg
1561 acctggaccg gcaggagaag gccatcacag ggatcctgcg gccaccactg gagcaaggcc
1621 gggctgtgca ggacagtgcc gagcgggcca aggacctcaa gaacatcacc aacgagctac
1681 tgcggattga acctgagaag acgcggagca cggctgaggg cgaagccttc atccaggccc
1741 tcccaggcag tggcaccaca cccctgctga ggacccgggt ggaggacacc aaccggaaat
1801 acgagcacct cctgcagctg ctggacttgg cccaggagaa ggttgatgtg gccaaccgcc
1861 tggagaagag cctgcagcag agctgggagt tgctggccac acacgagaac catctgaatc
1921 aggatgacac agtgcctgag agcagccgtg tcctggacag caaggggcag gagctggcgc
1981 ccatggcctg tgagttacag gcccagaagt ccctcctggg tgaggtggag cagaacttgc
2041 aggcggccaa gcagtgctcg agcacactgg ccagccgctt ccaggagcac tgcccggacc
2101 tggagcgcca ggaggccgag gtgcacaagc tgggccagcg tttcaacaac ctgcgccagc
2161 aggtggaacg cagggcgcag agcctacaga gcgccaaggc agcctacgag cacttccacc
2221 gcggccatga ccacgtgctg cagttcctag tcagcatccc cagttacgag ccccaggaga
2281 cagacagcct cagccagatg gagaccaagc tgaagaacca gaagaacctg ctagatgaga
2341 tagcaagtag ggagcaggaa gtacagaaga tctgtgccaa ttcccagcag taccagcaag
2401 ctgtaaagga ctatgagtta gaagcagaaa aactaaggtc tcttctcgac ttggagaatg
2461 gaaggagcag ccacgtgagc aagagagcca ggctccaatc tcctgccacc aaagtgaagg
2521 aagaggaagc agcacttgcc gccaagttca ctgaagttta tgccatcaac agacagaggc
2581 tgcagaatct ggagtttgct ctgaatctcc tcagacagca gccggaagta gaagtgaccc
2641 atgagaccct gcaaaggaat aggccggact ctggagtgga ggaggcgtgg aagatcagga
2701 aggaactgga tgaggagact gagcggaggc ggcagctgga gaacgaggtc aagagcaccc
2761 aggaagaaat ctggaccttg aggaatcagg ggcctcagga atcggtggtg aggaaggagg
2821 tgctcaagaa ggtgccggat cccgtgctgg aggagagctt ccagcagctg cagcggacgc
2881 tggcagagga gcagcacaag aaccagctgc tgcaggagga gctggaggca ctgcagctgc
2941 agctgcgtgc cctggagcag gagaccagag acggggggca ggagtacgtg gtcaaggagg
3001 tcctgcgcat cgagcctgac agggcccagg cggatgaggt cttgcagctg cgggaggagc
3061 tggaggcact gaggcggcag aagggcgccc gggaggcaga ggtgctcctc ctgcagcagc
3121 gtgtggccgc cctggctgaa gagaagagcc gggcgcagga gaaggtcaca gagaaagagg
3181 tggtgaaact gcagaatgac ccccagctgg aggcagagta ccagcagctg caggaggacc
3241 accagcgcca ggaccagctc agggagaagc aggaggagga gctgagcttc ctccaggaca
3301 agctcaagag gctagagaag gagcgggcca tggccgaggg caagatcacc gtcaaggagg
3361 tgctcaaggt ggagaaggac gcggccaccg agagggaggt cagcgatctc acccgccaat
3421 atgaggacga ggctgccaag gctcgcgcta gccagaggga gaagacggag ctgctccgaa
3481 agatatgggc cttggaggag gagaacgcca aagtggtggt acaggagaag gtgcgggaga
3541 tcgtgcggcc agaccccaag gcggaaagtg aagtggcgaa cctccgcctg gagcttgtgg
3601 agcaggagcg aaagtaccgg ggtgccgagg agcagctccg gagctaccag agtgagctgg
3661 aggccctcag gaggcgaggc ccccaggtgg aagtcaaaga ggtgactaag gaagtcatta
3721 agtacaagac tgaccctgag atggagaagg agcttcagcg gctcagggag gagatcgtgg
3781 acaagaccag actgatcgaa aggtgtgatt tagagatcta ccagctgaaa aaggaaatcc
3841 aggccctgaa agacaccaaa ccccaggtcc agaccaaaga ggtggtccag gagatcctcc
3901 aattccaaga agaccctcaa accaaggagg aggtggcgtc tctgagggca aagctctcag
3961 aggagcagaa gaaacaagtg gatctggaga gggaaagagc ttcccaggaa gagcagatcg
4021 cccggaaaga ggaggagctc tcgcgggtga aggaaagggt ggtgcagcag gaggtggtca
4081 ggtatgagga ggagccaggc ctgcgggccg aggcgagcgc ctttgccgag agcatcgatg
4141 tggagctgcg gcagattgac aagctgcggg cagagctgcg gcggctgcag cgccggcgca
4201 ccgagcttga gcggcagctg gaggagctag agcgcgagcg gcaggcccgc agggaggccg
4261 agcgcgaggt acagcggttg cagcagcggc tggcagcgct ggagcaggaa gaagctgagg
4321 cccgtgagaa ggtaacccat acgcagaagg tggtgctgca gcaggacccg cagcaggcgc
4381 gagagcatgc cctgctccga ctccagctgg aagaagagca gcaccggcgg cagctcctgg
4441 agggggagct cgagaccctc cggaggaaac tggctgcact ggagaaggcg gaggtcaagg
4501 agaaggtggt gctctccgag agtgtccagg tggagaaggg cgacaccgag caagagatcc
4561 agaggctcaa gagcagcctg gaggaggaga gccgcagcaa gcgcgagctg gacgtcgagg
4621 tgagccggct ggaagccagg ctttcggagc tggaattcca taactccaag tcatccaagg
4681 aactagactt tctgagggaa gagaaccaca aattacagct ggagaggcaa aacctgcagc
4741 tggagacccg aaggctccaa tcggaaatca acatggcagc gacggaaaca cgagacctgc
4801 ggaacatgac cgtggcggac tctgggacca accatgactc cagactgtgg tccctggaga
4861 gggaactgga tgacctcaag aggctctcca aggacaaaga cctcgagatc gacgagctgc
4921 agaagcgcct gggctccgtg gccgtcaagc gggagcagcg ggagaaccac ctgcggcgct
4981 ccatcgtagt catccaccct gacacaggcc gcgagctgtc cccggaggaa gcccaccgtg
5041 ccgggctcat tgactggaac atgttcgtga aactcagaag ccaggagtgc gactgggagg
5101 agatctcagt gaagggtccc aatggggagt cctcagtgat acacgacagg aagtctggca
5161 agaagttctc catcgaagag gccctgcaga gtggcaggct gacccctgct cagtatgacc
5221 gctatgtcaa caaggatatg tccatccagg agctggcggt cttggtatct gggcagaagt
5281 aggcacagct cttgcaactc ttcgtaacgg cagacgctgg ccctctccta cgacgcagtg
5341 acctccttgg tgtcgtcctc tccctagccc tggtgcaggc caagcatttt atacataccc
5401 tcgctgccag gctgctcaga gtcccgccca catatgagac aggcactggc tgaagacagg
5461 caactctcgt cccaaccatc attcaccctg agtgacgtac ttcatcctcc aatgactgga
5521 caactgcgat gccttttcct cccttttcct gtacactccc agcaacaaac tcctcatgat
5581 aactgcacac aatctgaaaa ccactgaagg acaagccaac cacagcagcc aagcccactc
5641 cttgcagcat gggtactggt ggcacaccag acagtgacac tgccccacaa aggcctgggc
5701 ccgtgggggc tgctgcctgg catgacatct ctccagattt ctggcttaaa accaactttc
5761 catccgagaa gcctcctcag tagttactct gctcatgaga cagatctggg ctccaagcca
5821 ggaaaggtga acagaaacca caagtgtcca gccctcggtg ctggagtgga cgttaattgt
5881 cagccaccag actgtcccgg cacctacaga gaatgtttca cagttctggc atttaaatcc
5941 tttgatagtg gattgtgctg ctgttagcct tagtttcagt gctttacaag tctcgcttat
6001 tatctcattg gtatttaggt atacaaaaca gttgattatt caccacgcca atatctgggt
6061 ctctgtatct catgtagaac ataagaaaat gggaactaat agggaacttt atttatagca
6121 tgaaaataaa cctggtggct ggagtctgct tgtt
//